Markers of T Cell Senescence in Humans
Open accessAbstract
Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers.
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Some markers used to identify naïve and memory T cell subsets in humans such as CD45RA are not suitable for phenotyping murine T cell subsets, mainly because they do not allow reasonable separation in discrete positive and negative fractions.
“Some markers that are used to identify naïve and memory T cell subsets in humans such as CD45RA [352] (see section III.9 Immune senescence (aging) of human T cells) are not suitable for phenotyping murine T cell subsets, mainly because they do not allow reasonable separation in discrete positive and negative fractions.”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [352]
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Experimental — accuracy not yet measuredPhenotyping of naïve and memory T cell subsets by flow cytometry relies on a combination of markers that are acquired or lost during T cell differentiation, from naïve and memory to terminally differentiated T cells.
“Phenotyping of naïve and memory T cell subsets by flow cytometry relies on a combination of markers that are acquired or lost during T cell differentiation, from naïve and memory to terminally differentiated T cells [352].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [352]
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Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,314 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878 · see citing works
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062 · see citing works
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 3,960 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Weber, J. S., D’Angelo, S. P., Minor, D. R., Hodi, F. S., Gutzmer, R., Neyns, B., Höeller, C., Khushalani, N. I., Miller, W. H., Lao, C. D., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70076-8 · Cited by 2,676 · see citing works
Pathogen Recognition by the Innate Immune System
Kumar, H., Kawai, T., & Akira, S. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2010.529976 · Cited by 2,264 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932 · see citing works
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865 · see citing works
CD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,796 · see citing works
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666 · see citing works
Rizvi, N. A., Mazières, J., Planchard, D., Stinchcombe, T. E., Dy, G. K., Antonia, S. J., Horn, L., Lena, H., Minenza, E., Mennecier, B., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70054-9 · Cited by 1,415 · see citing works
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410 · see citing works
HIV Infection, Inflammation, Immunosenescence, and Aging
Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349 · see citing works
NAD <sup>+</sup> in aging, metabolism, and neurodegeneration
Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319 · see citing works
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,175 · see citing works
CD8+ T Cells: Foot Soldiers of the Immune System
Zhang, N., & Bevan, M. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.010 · Cited by 1,102 · see citing works
Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073 · see citing works
cGAS is essential for cellular senescence
Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705499114 · Cited by 1,009 · see citing works
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991 · see citing works
Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer
Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221309787158371 · Cited by 923 · see citing works
The who's who of <scp>T</scp> ‐cell differentiation: Human memory <scp>T</scp> ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817 · cited 1× · see citing works
“Lastly, terminal effector (TE) T cells (CD45RA+, CD45RO−, CD27−, CD28− and CCR7−) have limited proliferative capacity but tend to secrete a wider range of cytokines following activation [34].”
BackgroundHayflick, his limit, and cellular ageing
Shay, J. W., & Wright, W. E. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036093 · Cited by 764 · see citing works
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
Crespo, J., Sun, H., Welling, T. H., Tian, Z., & Zou, W. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.003 · Cited by 752 · see citing works
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 709 · see citing works
Vaccines: past, present and future
Plotkin, S. A. (2005) · Nature Medicine · doi:10.1038/nm1209 · Cited by 597 · see citing works
Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00489.x · Cited by 509 · see citing works
The Effect of Age on Thymic Function
Palmer, D. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00316 · Cited by 494 · see citing works
T cell responses to cytomegalovirus
Klenerman, P., & Oxenius, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.38 · Cited by 483 · see citing works
Maio, M., Grob, J., Aamdal, S., Bondarenko, I., Robert, C., Thomas, L., Garbe, C., Chiarion‐Sileni, V., Testori, A., Chen, T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.6018 · Cited by 480 · see citing works
Shi, F., Shi, M., Zeng, Z., Qi, R., Liu, Z., Zhang, J., Yang, Y., Tien, P., & Wang, F. (2010) · International Journal of Cancer · doi:10.1002/ijc.25397 · Cited by 466 · see citing works
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
Bernadotte, A., Mikhelson, V. M., & Spivak, I. M. (2016) · Aging · doi:10.18632/aging.100871 · Cited by 466 · see citing works
Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · see citing works
Reversing T-cell Dysfunction and Exhaustion in Cancer
Zarour, H. M. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1849 · Cited by 462 · see citing works
When cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404 · see citing works
Insights into thymic aging and regeneration
Taub, D. D., & Longo, D. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00275.x · Cited by 393 · see citing works
T-cell activation by dendritic cells in the lymph node: lessons from the movies
Bousso, P. (2008) · Nature reviews. Immunology · doi:10.1038/nri2379 · Cited by 363 · see citing works
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
Koch, S. D., Larbi, A., Derhovanessian, E., Özcelik, D., Naumova, E. J., & Pawelec, G. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-6 · Cited by 360 · see citing works
Self-citationCancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells
Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.002 · Cited by 360 · see citing works
From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality
Larbi, A., & Fulop, T. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22351 · Cited by 359 · see citing works
Self-citationNaive T Cell Maintenance and Function in Human Aging
Goronzy, J. J., Fang, F., Cavanagh, M., Qi, Q., & Weyand, C. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500046 · Cited by 348 · see citing works
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works
Self-citationRosenblum, M. D., Way, S. S., & Abbas, A. K. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.1 · Cited by 346 · see citing works
Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 336 · see citing works
Gains in Life Expectancy from Medical Interventions — Standardizing Data on Outcomes
Wright, J. C., & Weinstein, M. C. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808063390606 · Cited by 334 · see citing works
Lanna, A., Henson, S. M., Escors, D., & Akbar, A. N. (2014) · Nature Immunology · doi:10.1038/ni.2981 · Cited by 328 · see citing works
T Cell Replicative Senescence in Human Aging
P. Chou, J., & B. Effros, R. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219711 · Cited by 323 · see citing works
Hodes, R. J., Hathcock, K. S., & Weng, N. (2002) · Nature reviews. Immunology · doi:10.1038/nri890 · Cited by 315 · see citing works
Davey, M. S., Willcox, C. R., Joyce, S. P., Ladell, K., Kasatskaya, S. A., McLaren, J. E., Hunter, S., Salim, M., Mohammed, F., Price, D. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14760 · Cited by 299 · see citing works
Weber, J. S. (2007) · The Oncologist · doi:10.1634/theoncologist.12-7-864 · Cited by 284 · see citing works
Dominguez, C. X., Amezquita, R., Guan, T.-X., Marshall, H. D., Joshi, N., Kleinstein, S., & Kaech, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150186 · Cited by 265 · see citing works
Kamel, H. K. (2003) · Nutrition Reviews · doi:10.1301/nr.2003.may.157-167 · Cited by 265 · see citing works
Henson, S. M., Franzese, O., Macaulay, R., Libri, V., Azevedo, R. I., Kiani-Alikhan, S., Plunkett, F. J., Masters, J. E., Jackson, S., Griffiths, S. J., et al. (2009) · Blood · doi:10.1182/blood-2009-01-199588 · Cited by 262 · see citing works
Cellular senescence controls fibrosis in wound healing
Jun, J.-I., & Lau, L. F. (2010) · Aging · doi:10.18632/aging.100201 · Cited by 255 · see citing works
Epigenomics of human CD8 T cell differentiation and aging
Moskowitz, D. M., Zhang, D. W., Hu, B., Le Saux, S., Yanes, R. E., Ye, Z., Buenrostro, J. D., Weyand, C. M., Greenleaf, W. J., & Goronzy, J. J. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag0192 · Cited by 252 · cited 1× · see citing works
“On the epigenetic level, CD4 and CD8 T cells have been shown to have an overall decrease in methylation as they progressed from Naïve to TE [103,104].”
BackgroundEffectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence
Lang, P. O., Mendès, Socquet, Assir, Govind, & Aspinall, R. (2012) · Clinical Interventions in Aging · doi:10.2147/cia.s25215 · Cited by 242 · see citing works
Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7710 · Cited by 222 · see citing works
Wencker, M., Turchinovich, G., Barros, R. D. M., Deban, L., Jandke, A., Cope, A. P., & Hayday, A. (2013) · Nature Immunology · doi:10.1038/ni.2773 · Cited by 221 · see citing works
New insights into the differentiation and function of T follicular helper cells
King, C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2644 · Cited by 214 · see citing works
Challenges for vaccination in the elderly
Aspinall, R., Giudice, G. D., Effros, R. B., Grubeck‐Loebenstein, B., & Sambhara, S. R. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-9 · Cited by 205 · see citing works
The precursors of memory: models and controversies
Ahmed, R., Bevan, M. J., Reiner, S. L., & Fearon, D. T. (2009) · Nature reviews. Immunology · doi:10.1038/nri2619 · Cited by 199 · see citing works
Durek, P., Nordström, K. J. V., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K. E., Ulas, T., Schmidt, F., Xiong, J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.022 · Cited by 197 · see citing works
Regeneration of the aged thymus by a single transcription factor
Bredenkamp, N., Nowell, C. S., & Blackburn, C. C. (2014) · Development · doi:10.1242/dev.103614 · Cited by 194 · see citing works
KLRG1—more than a marker for T cell senescence
Henson, S. M., & Akbar, A. N. (2009) · AGE · doi:10.1007/s11357-009-9100-9 · Cited by 191 · see citing works
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Ademowo, O. S., Dias, H. K. I., Burton, D. G. A., & Griffiths, H. R. (2017) · Biogerontology · doi:10.1007/s10522-017-9710-z · Cited by 184 · see citing works
Memory CD4 T cells: generation, reactivation and re‐assignment
MacLeod, M. K. L., Kappler, J. W., & Marrack, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03260.x · Cited by 159 · see citing works
Telomerase, senescence and ageing
Shawi, M., & Autexier, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.007 · Cited by 156 · see citing works
Palmer, B. E., Blyveis, N., Fontenot, A. P., & Wilson, C. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8415 · Cited by 156 · see citing works
Memory CD8+ T cell differentiation
Obar, J. J., & Lefrançois, L. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05126.x · Cited by 155 · see citing works
The effect of aging of the immune system on vaccination responses
Lord, J. M. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.24696 · Cited by 153 · see citing works
New advances in CMV and immunosenescence
Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y.-L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.020 · Cited by 150 · see citing works
Novák, J., Dobrovolný, J., Nováková, L., & Kozák, T. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12193 · Cited by 148 · see citing works
ELDERLY-ONSET RHEUMATOID ARTHRITIS
Yazıcı, Y., & Paget, S. A. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70154-x · Cited by 127 · see citing works
MicroRNA Regulation of Oxidative Stress‐Induced Cellular Senescence
Bu, H., Wedel, S., Cavinato, M. S., & Jansen‐Dürr, P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2398696 · Cited by 123 · see citing works
Ryan, P. L., Sumaria, N., Holland, C. J., Bradford, C. M., Izotova, N., Grandjean, C. L., Jawad, A. S., Bergmeier, L. A., & Pennington, D. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611098113 · Cited by 108 · see citing works
Effros, R. B. (1998) · The American Journal of Human Genetics · doi:10.1086/301845 · Cited by 105 · see citing works
Shades of grey — the blurring view of innate and adaptive immunity
Lanier, L. L. (2013) · Nature reviews. Immunology · doi:10.1038/nri3389 · Cited by 103 · see citing works
The NAD+/PARP1/SIRT1 Axis in Aging
Mendelsohn, A. R., & Larrick, J. W. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1980 · Cited by 95 · see citing works
Linking the “two-hit” response following injury to enhanced TLR4 reactivity
Murphy, T. J., Paterson, H. M., Kriynovich, S. J., 臧焰, Kurt‐Jones, E. A., Mannick, J. A., & Lederer, J. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704382 · Cited by 90 · see citing works
Macieira‐Coelho, A. (1986) · Experimental Gerontology · doi:10.1016/0531-5565(86)90001-x · Cited by 89 · see citing works
SASP regulation by noncoding RNA
Panda, A. C., Abdelmohsen, K., & Gorospe, M. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.05.004 · Cited by 86 · see citing works
Tumor suppression by p53: making cells senescent.
Qian, Y., & Chen, X. (2010) · PubMed · doi:10.14670/hh-25.515 · Cited by 85 · see citing works
Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
Yu, D., Jung, S. H., An, H., Lee, S., Hong, J. H., Park, J. S., Lee, H., Lee, H., Bahn, M., Lee, H. C., et al. (2017) · Aging Cell · doi:10.1111/acel.12606 · Cited by 66 · see citing works
Stubbe, M., Vanderheyde, N., Goldman, M., & Marchant, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.8185 · Cited by 63 · see citing works
γ/δ T cell subsets in human aging using the classical α/β T cell model
Vasudev, A., Ying, C., Ayyadhury, S., Puan, K. J., Andiappan, A. K., Nyunt, M. S. Z., Shadan, N. B., Mustafa, S., Low, I., Rötzschke, O., et al. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a1213-650rr · Cited by 63 · see citing works
Self-citationDistinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems
Schuyler, R. P., Merkel, A., Raineri, E., Altucci, L., Vellenga, E., Martens, J. H. A., Pourfarzad, F., Kuijpers, T. W., Burden, F., Farrow, S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.054 · Cited by 62 · see citing works
Clonal expansion of human T lymphocytes initiated by dendritic cells.
Langhoff, E., & Steinman, R. M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.315 · Cited by 58 · see citing works
OMIP ‐030: Characterization of human T cell subsets via surface markers
Wingender, G., & Kronenberg, M. (2015) · Cytometry Part A · doi:10.1002/cyto.a.22788 · Cited by 56 · see citing works
Immunity in the Elderly: The Role of the Thymus
Aspinall, R., Pitts, D. G., Lapenna, A., & Mitchell, W. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.10.022 · Cited by 55 · see citing works
Wistuba-Hamprecht, K., Frasca, D., Blomberg, B., Pawelec, G., & Derhovanessian, E. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-26 · Cited by 52 · see citing works
Yu, D., Du, Z., Pian, L., Li, T., Wen, X., Li, W., Kim, S., Xiao, J., Cohen, P., Cui, J., et al. (2017) · Stem Cells International · doi:10.1155/2017/1764549 · Cited by 48 · see citing works
Human Vγ9/Vδ2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)
Eberl, M., Engel, R., Aberle, S., Fisch, P., Jomaa, H., & Pircher, H. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0204096 · Cited by 38 · see citing works
Long non‐coding RNA s in aging organs and tissues
Xing, W., Gao, W., Mao, G., Zhang, J., Lv, X., Wang, G., & Yan, J. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12795 · Cited by 35 · see citing works
CD28 and Cd27 Costimulation of Cd8+ T Cells: A Story of Survival
Dolfi, D. V., & Katsikis, P. D. (2007) · Springer eBooks · doi:10.1007/978-0-387-34814-8_11 · Cited by 27 · see citing works
Vδ2+ and α/β T cells show divergent trajectories during human aging
Tan, C. T. Y., Wistuba‐Hamprecht, K., Xu, W., Nyunt, M. S. Z., Vasudev, A., Lee, B. T. K., Pawelec, G., Puan, K. J., Rötzschke, O., Ng, T. P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10096 · Cited by 24 · see citing works
Self-citationHere's the visual proof of why vaccines do more good than harm
(2017) · AAAS Articles DO Group · doi:10.1126/science.aal1107 · Cited by 18 · see citing works
Gains in life expectancy from medical interventions.
Messori, A., Trippoli, S., & Tendi, E. (1998) · PubMed · Cited by 11 · see citing works
Zhu, Y., Xiong, K., Shi, J., Cui, Q., & Xue, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179034 · Cited by 10 · see citing works
NAD+: A big player in cardiac and skeletal muscle remodeling and aging
Chaturvedi, P., & Tyagi, S. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26014 · Cited by 9 · see citing works
Flagged first, then by citations
4 of the 107 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [3]The World Bank Investing in Health: World Development Indicators Oxford University Press New York, NY, USA 1993
- [25]Janeway C.A. Jr. Travers P. Walport M. Shlomchik M.J. B-cell activation by armed helper T cells Immunobiology: The Immune System in Health and Disease 5th ed. Garland Science New York, NY, USA 2001 Available online: https://www.ncbi.nlm.nih.gov/books/NBK27142/ (accessed on 10 June 2017)
- [26]Janeway C.A. Jr. Travers P. Walport M. Shlomchik M.J. Macrophage activation by armed CD4 TH1 cells Immunobiology: The Immune System in Health and Disease 5th ed. Garland Science New York, NY, USA 2001 Available online: https://www.ncbi.nlm.nih.gov/books/NBK27153/ (accessed on 11 June 2017)
- [27]Janeway C.A. Jr. Travers P. Walport M. Shlomchik M.J. T cell-mediated cytotoxicity Immunobiology: The Immune System in Health and Disease 5th ed. Garland Science New York, NY, USA 2001 Available online: https://www.ncbi.nlm.nih.gov/books/NBK27101/ (accessed on 12 June 2017)
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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
McLane, L. M., Abdel-Hakeem, M. S., & Wherry, E. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055318 · Cited by 1,975 · see citing works
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
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Self-citationGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Immunology of aging: the birth of inflammaging
Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464 · see citing works
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Herati, R. S., Silva, L. V., Vella, L. A., Muselman, A., Alanio, C., Bengsch, B., Kurupati, R. K., Kannan, S., Manne, S., Kossenkov, A. V., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100262 · Cited by 60 · see citing works
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Goto, M., Takahashi, H., Yoshida, R., Itamiya, T., Nakano, M., Nagafuchi, Y., Harada, H., Shimizu, T., Maeda, M. H., Kubota, A., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adk1643 · Cited by 58 · see citing works
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Yang, J., Zhang, N., Luo, T., Yang, M., Shen, W., Tan, Z., Xia, Y., Zhang, L., Zhou, X., Lei, Q., et al. (2024) · iMeta · doi:10.1002/imt2.231 · Cited by 57 · see citing works
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Guan, L., Crasta, K., & Maier, A. B. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101634 · Cited by 53 · see citing works
Bruni, E., Cazzetta, V., Donadon, M., Cimino, M., Torzilli, G., Spata, G., Leonardi, G., Dieli, F., Mikulak, J., & Mavilio, D. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0825-4 · Cited by 50 · see citing works
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Janelle, V., & Delisle, J. (2021) · Cancers · doi:10.3390/cancers13040598 · Cited by 47 · see citing works
Ligotti, M. E., Aiello, A., Accardi, G., Aprile, S., Bonura, F., Bulati, M., Gervasi, F., Giammanco, G. M., Pojero, F., Zareian, N., et al. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13606 · Cited by 45 · see citing works
Ramello, M. C., Núñez, N. G., Tosello, J., Bossio, S., Canale, F. P., Abrate, C., Ponce, N. E., del Castillo, A., Ledesma, M., Viel, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713132 · Cited by 45 · see citing works
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Elsayed, R., Elashiry, M., Liu, Y., Morandini, A. C., El-Awady, A., Elashiry, M. M., Hamrick, M., & Cutler, C. W. (2023) · Aging and disease · doi:10.14336/ad.2022.0623 · Cited by 40 · see citing works
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Egui, A., Ledesma, D., Pérez-Antón, E., Montoya, A., Gómez, I., Robledo, S. M., Infante, J. J., Vélez, I. D., López, M. C., & Thomas, M. C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00393 · Cited by 37 · see citing works
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Edwards, E. S. J., Bosco, J. J., Ojaimi, S., O’Hehir, R. E., & van Zelm, M. C. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00520-8 · Cited by 36 · see citing works
Xu, W., Lau, Z. W. X., Fülöp, T., & Larbi, A. (2020) · Cells · doi:10.3390/cells9051181 · Cited by 35 · see citing works
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Poloni, C., Szyf, M., Cheishvili, D., & Tsoukas, C. M. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab365 · Cited by 32 · see citing works
Luo, X., Meng, Q., Rao, M., Liu, Z., Paraschoudi, G., Dodoo, E., & Maeurer, M. J. (2018) · Immunology · doi:10.1111/imm.12991 · Cited by 32 · see citing works
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Braz, I. F. L., Gomes, R. A. D., Azevedo, M. S. D., ALVES, F. D. C. M., Seabra, D. S., Lima, F. P., & Pereira, J. D. S. (2018) · Einstein (São Paulo) · doi:10.1590/s1679-45082018ao4155 · Cited by 30 · see citing works
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Giller, A., Andrawus, M., Gutman, D., & Atzmon, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101093 · Cited by 30 · see citing works
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Batatinha, H., Diniz, T. A., Teixeira, A. A. D. S., Krüger, K., & Neto, J. C. R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28318 · Cited by 29 · see citing works
Levite, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.357903 · Cited by 29 · see citing works
Fantecelle, C. H., Covre, L. P., de Moura, R. G., Guedes, H. L. D. M., Amorim, C. F., Scott, P., Mosser, D. M., Falqueto, A., Akbar, A. N., & Gomes, D. C. O. (2021) · Immunology · doi:10.1111/imm.13410 · Cited by 28 · see citing works
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Sharma, R., & Padwad, Y. S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101141 · Cited by 27 · see citing works
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Hopkin, S. J., Lord, J. M., & Chimen, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105323 · Cited by 25 · see citing works
Mancinetti, F., Marinelli, A., Boccardi, V., & Mecocci, P. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111998 · Cited by 24 · see citing works
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Marsh‐Wakefield, F., Kruzins, A., McGuire, H. M., Yang, S., Bryant, C. E., Groth, B. F. D. S., Nassif, N. T., Byrne, S. N., Gibson, J., Brown, C. M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01596 · Cited by 24 · see citing works
Nakanjako, D., Nabatanzi, R., Ssinabulya, I., Bayigga, L., Kiragga, A. K., Banturaki, G., & Castelnuovo, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31910 · Cited by 22 · see citing works
Fernandes, S. B., Patil, N. D., Mériaux, S. B., Thérésine, M., Muller, C. P., Leenen, F. A. D., Elwenspoek, M. M. C., Zimmer, J., & Turner, J. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674532 · Cited by 22 · see citing works
Mika, T., Ladigan‐Badura, S., Maghnouj, A., Mustafa, B., Klein‐Scory, S., Baraniskin, A., Döhring, S., Fuchs, I., Ehl, S. R., Hahn, S. A., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.568056 · Cited by 22 · see citing works
Riese, P., Trittel, S., Akmatov, M. K., May, M., Prokein, J., Illig, T., Schindler, C., Sawitzki, B., Elfaki, Y., Floess, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34487-z · Cited by 21 · see citing works
Gatya, M., Fibri, D. L. N., Utami, T., Suroto, D. A., & Rahayu, E. S. (2022) · Microorganisms · doi:10.3390/microorganisms10091748 · Cited by 21 · see citing works
Age-Related Adaptive Immune Changes in Parkinson’s Disease
Kouli, A., & Williams-Gray, C. H. (2022) · Journal of Parkinson's Disease · doi:10.3233/jpd-223228 · Cited by 20 · see citing works
CD8 + T Cells Exhibit an Exhausted Phenotype in Hemophagocytic Lymphohistiocytosis
Kelkar, M. G., Bargir, U. A., Yadav, R. M., Gupta, M., Dalvi, A. D., Jodhawat, N., Shinde, S., & Madkaikar, M. R. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01109-0 · Cited by 20 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2025) · Biogerontology · doi:10.1007/s10522-025-10353-5 · Cited by 19 · see citing works
Gliwiński, M., Iwaszkiewicz‐Grześ, D., Wołoszyn‐Durkiewicz, A., Tarnowska, M., Żalińska, M., Hennig, M., Zielińska, H., Dukat-Mazurek, A., Dębska-Zielkowska, J., Zieliński, M., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000873 · Cited by 19 · see citing works
Cellular senescence in vivo: From cells to tissues to pathologies
Kumar, A., Bano, D., & Ehninger, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111308 · Cited by 19 · see citing works
Kirsch‐Volders, M., & Fenech, M. F. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108395 · Cited by 19 · see citing works
Immune system aging and the aging-related diseases in the COVID-19 era
Witkowski, J. M. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.01.005 · Cited by 19 · see citing works
Machahua, C., Buendía-Roldán, I., Ocaña‐Guzmán, R., Molina‐Molina, M., Pardo, A., Chávez‐Galán, L., & Selman, M. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215520 · Cited by 18 · see citing works
Vavilova, J. D., Boyko, A. A., Пономарева, Н. В., Fokin, V. F., Fedotova, E. Y., Streltsova, M. A., Kust, S. A., Grechikhina, M. V., Витальевна, Б. Е., Zimnyakova, O. S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313119 · Cited by 18 · see citing works
Decoding T cell senescence in cancer: Is revisiting required?
Magkouta, S., Markaki, E., Evangelou, K., Petty, R., Verginis, P., & Gorgoulis, V. G. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.003 · Cited by 17 · see citing works
Mazidi, M., Shekoohi, N., Katsiki, N., Rakowski, M., Mikhailidis, D. P., & Banach, M. (2021) · Archives of Medical Science · doi:10.5114/aoms/119965 · Cited by 17 · see citing works
Yin, F., He, Y., Li, J., & Gao, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1596686 · Cited by 16 · see citing works
Granic, A., Martin-Ruiz, C. M., Dodds, R. M., Robinson, L. A., Spyridopoulos, I., Kirkwood, T. B. L., von Zglinicki, T., & Sayer, A. A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111321 · Cited by 16 · see citing works
Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients
Rodríguez, I. J., Bernal-Estévez, D. A., Llano-León, M., Bonilla, C., & Parra-López, C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280851 · Cited by 16 · see citing works
Liisborg, C., Skov, V., Kjær, L., Hasselbalch, H. C., & Sørensen, T. L. (2021) · Aging · doi:10.18632/aging.203803 · Cited by 15 · see citing works
Senescent T Cells in Age-Related Diseases
Yu, P.-J., Zhou, M. L., Liu, Y., & Du, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0219 · Cited by 15 · see citing works
The role of T cells in vascular aging, hypertension, and atherosclerosis
DeConne, T. M., Buckley, D. J., Trott, D. W., & Martens, C. R. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00570.2024 · Cited by 15 · see citing works
- Authors
- Xu, W., & Larbi, A.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Larbi, Anis
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-08-10
- Volume
- 18
- Issue
- 8
- Pages
- 1742
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5578132
- OpenAlex
- W2744554795
- Cited by
- 261
- References
- 107
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 47 · 2023: 24 · 2022: 32 · 2021: 48 · 2020: 28 · 2019: 23 · 2018: 16 · 2017: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Funders
- Graduiertenakademie, Technische Universität Dresden
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- T cell senescence, immunosenescence, T-cell markers, aging, older adults, influenza vaccination, age-related immune decline
- MeSH terms
- Immunosenescence, Aging, Cell Differentiation, Humans, T-Lymphocytes, Immunophenotyping, Cellular Senescence
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