The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer
Open accessAbstract
BACKGROUND: Emerging evidence suggests a potential relationship between gut microbiota and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu). Fusobacterium nucleatum (Fn) has been linked to the initiation and progression of colorectal cancer (CRC). Unfortunately, little was known about the relationship between Fn infection and chemotherapeutic efficacy. Here, we investigate the potential relationship between Fn infection and chemotherapeutic efficacy of 5-Fu in CRC. METHODS: Differentially expressed genes of CRC cell lines induced by Fn infection were analyzed based on a whole genome microarray analysis Then, we explored the relationship between upregulation of BIRC3 induced by Fn infection and chemoresistance to 5-Fu in vitro and in vivo. Furthermore, we dissected the mechanisms involved in Fn-induced BIRC3 expression. Finally, we investigated the clinical relevance of Fn infection, BIRC3 protein expression and chemoresistance to 5-Fu treatment in CRC patients. RESULTS: BIRC3 was the most upregulated gene induced by Fn infection via the TLR4/NF-κB pathway in CRC cells; Fn infection reduced the chemosensitivity of CRC cells to 5-Fu through upregulation of BIRC3 in vitro and in vivo. High Fn abundance correlated with chemoresistance in advanced CRC patients who received standard 5-Fu-based adjuvant chemotherapy after radical surgery. CONCLUSIONS: Our evidence suggests that Fn and BIRC3 may serve as promising therapeutic targets for reducing chemoresistance to 5-Fu treatment in advanced CRC.
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Gut microbiota in colorectal cancer development and therapy
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Abed, J., Maalouf, N., Manson, A. L., Earl, A. M., Parhi, L., Emgård, J. E. M., Klutstein, M., Tayeb, S., Almogy, G., Atlan, K. A., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00400 · Cited by 267
Wang, N., Wu, S., Huang, L., Hu, Y., He, X., He, J., Hu, B., Xu, Y., Rong, Y., Yuan, C., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01117-x · Cited by 62
Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer
Chen, W.-D., Zhang, X., Zhang, M.-J., Zhang, Y.-P., Shang, Z.-Q., Xin, Y.-W., & Zhang, Y. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i30.4120 · Cited by 38
Metadata
- Authors
- Zhang, S., Yang, Y., Weng, W., Guo, B., Cai, G., Ma, Y., & Cai, S.
- Venue
- Journal of Experimental & Clinical Cancer Research
- Published
- 2019-01-10
- Volume
- 38
- Issue
- 1
- Pages
- 14-14
- ISSN
- 0392-9078 (ISSN-L)
- 1756-9966
- OpenAlex
- W2909798892
- Cited by
- 316
- References
- 54
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, S., Yang, Y., Weng, W., Guo, B., Cai, G., Ma, Y., & Cai, S. (2019). Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-018-0985-y
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