The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells
Open accessAbstract
BACKGROUND AND OBJECTIVE: Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are nuclear effectors of the Hippo pathway. Although they are abundantly expressed in the cytoplasm and nuclei of human colorectal cancer (CRC), and related to tumor proliferation status, there have been few studies on the predictive role of YAP and TAZ expression on the overall survival of patients with CRC. This study investigated YAP and TAZ expression in both CRC patients and colon cancer cell lines, and assessed their prognostic value. METHODS: Paraffin-embedded specimens from 168 eligible patients were used to investigate YAP and TAZ expression by immunohistochemistry, and compared with experimental results in colon cancer HCT116 cell line to explore their clinical significance in CRC. RESULTS: Statistically significant positive correlations were found between protein expression of YAP and TAZ in CRC tissues. Patients with higher YAP or TAZ expression showed a trend of shorter survival times; more importantly, our cohort study indicated that patients with both YAP and TAZ overexpression presented the worst outcomes. This was supported by multivariate analysis. In HCT116 colon cancer cells, the capacity for proliferation, metastasis, and invasion was dramatically reduced by knockdown of YAP and TAZ expressions by siRNA. CONCLUSIONS: Co-overexpression of YAP and TAZ is an independent predictor of prognosis for patients with CRC, and may account for the higher proliferation, metastasis, and poor survival outcome of these patients.
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YAP1 increases organ size and expands undifferentiated progenitor cells
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“Several possible reasons may account for the synergy in function between YAP and TAZ: firstly, both YAP and TAZ are major downstream targets of the Hippo pathway, and share many upstream and downstream proteins, such as TEAD [30–33], Angiomotin (AMOT) family proteins [34], and Wbp2 [35,36].”
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YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970
Zhang, W., Nandakumar, N., Shi, Y., Manzano, M., Smith, A., Graham, G., Gupta, S., Vietsch, E. E., Laughlin, S. Z., Wadhwa, M., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005049 · Cited by 360
The Hippo pathway in intestinal regeneration and disease
Hong, A. W., Meng, Z., & Guan, K.-L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.59 · Cited by 326
Zhang, S., Yang, Y., Weng, W., Guo, B., Cai, G., Ma, Y., & Cai, S. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0985-y · Cited by 316
Analysis of the role of the Hippo pathway in cancer
Han, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1869-4 · Cited by 287
Metadata
- Authors
- Wang, L., Shi, S., Guo, Z., Zhang, X., Han, S., Yang, A., Wen, W., & Zhu, Q.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-06-10
- Volume
- 8
- Issue
- 6
- Pages
- e65539
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2041401454
- Cited by
- 267
- References
- 5
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- Wang, L., Shi, S., Guo, Z., Zhang, X., Han, S., Yang, A., Wen, W., & Zhu, Q. (2013). Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells. PLoS ONE. https://doi.org/10.1371/journal.pone.0065539
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