IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

Thiem, Alexander; Hesbacher, Sonja; Kneitz, Hermann; di Primio, Teresa; Heppt, Markus V.; Hermanns, Heike M.; Goebeler, Matthias; Meierjohann, Svenja; Houben, Roland; Schrama, David

doi:10.1186/s13046-019-1403-9

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

Background Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274 ) expression is associated with better clinical response and increased survival to anti-PD-1 the…