Cited by 292Ovarian function and disordersGut microbiota and healthDiet, Metabolism, and Disease

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Open access

He, Fang-fang, Li, Yu-mei·2020·Journal of Ovarian Research

DOI 10.1186/s13048-020-00670-3PMC PMC7301991

Open this paper in CoChat — free account Open PDF

Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder. Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction, menstrual disorders and infertility. To date, its pathogenesis remains unclear. However, insulin resistance (IR) is considered as the primary pathological basis for its reproductive dysfunction. On the other hand, a condition in which insulin is over-secreted is called hyperinsulinemia. IR/Hyperinsulinemia is associated with chronic inflammation, hormonal changes, follicular dysplasia, endometrial receptivity changes, and abortion or infertility. Additionally, it increases incidence of complications during pregnancy and has been associated with anxiety, depression, and other psychological disorders. Gut microbiota, the “second genome” acquired by the human body, can promote metabolism, immune response through interaction with the external environment. Gut microbiota dysbiosis can cause IR, which is closely linked to the occurrence of PCOS. This article reviewed recent findings on the roles of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s13048-020-00670-3

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 Crosstalk between the gut microbiota and the mammalian host in inflammation and metabolism. The gut microbiota can contribute to host insulin resistance, low-grade inflammation, and hyperandrogenism(HA) through a range of molecular interactions with the host and therefore can indirectly participate in the onset of PCOSCC BY · PubMed Central

Fig. 2 ①Gut microbiota can cause IR by affecting lipopolysaccharide (LPS) and its receptor CD14(LPS-CD14; ②SCFAs protect intestinal barrier integrity and act on beta cells to promote insulin secretion, thus improving metabolism; ③Bile acids (BAs) are signaling molecules that regulate glucose metabolism and promote insulin sensitivity; ④The metabolic disorder of amino acids might aggravate IR by changing glucose metabolism or inducing inflammation;⑤A vicious cycle between hyperandrogenemia and IR in PCOS, thus promoting the occurrence and development of PCOS; ⑥Gut microbiota and its metabolites cause insulin resistance and hyperinsulinemia by stimulating the secretion of gut-brain peptides and regulating inflammation pathway activation. LPS: lipopolysaccharide; SCFA: short-chain fatty acid; BCAA: branch-chain amino acid; BA: Bile acidsCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Ahmadi, S., Jamilian, M., Karamali, M., Ebrahimi, M. T., Jafari, P., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2017) · Human Fertility · doi:10.1080/14647273.2017.1283446 · Cited by 96
Retracted
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Introduction to the human gut microbiota
Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913

Show all 102 references

Research works printed but not linked: 2

Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JFWM, et al. Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome. Gastroenterology. 2012;143(4):913–6.e7. · DOI · Paper page
Chen Fangyuan, LAI Zhiwen, XU Zusen. Analysis of the gut microbial composition in polycystic ovary syndrome with acne. Zigong Maternal and Child Health Hospital. 2019;35(14):2246–51.

Sorted by citations

The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 675
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020583 · Cited by 445
Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment
Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-022-01091-0 · Cited by 408
Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites
Chen, W., & Pang, Y. (2021) · Metabolites · doi:10.3390/metabo11120869 · Cited by 228
Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., et al. (2021) · Nutrients · doi:10.3390/nu13061848 · Cited by 183
Microbiome and PCOS: State-of-Art and Future Aspects
Giampaolino, P., Foreste, V., Filippo, C. D., Gallo, A., Mercorio, A., Serafino, P., Improda, F. P., Verrazzo, P., Zara, G., Buonfantino, C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042048 · Cited by 175
Female Fertility and the Nutritional Approach: The Most Essential Aspects
Skoracka, K., Ratajczak, A. E., Rychter, A. M., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab068 · Cited by 177
Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction
Li, T., Zhang, T., Gao, H., Liu, R., Gu, M., Yang, Y., Cui, T., Lu, Z., & Yin, C. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101886 · Cited by 145
Dysregulation of immune response in PCOS organ system
Wang, J., Yin, T., & Liu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1169232 · Cited by 157
Immune regulation in polycystic ovary syndrome
Luan, Y., Zhang, L., Peng, Y., Li, Y., Liu, R., & Yin, C. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.04.234 · Cited by 130
Self-citation
Female reproductive dysfunctions and the gut microbiota
Chadchan, S. B., Singh, V., & Kommagani, R. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-21-0238 · Cited by 126
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114
“Insulin resistance can be caused by a wide variety of mechanisms that have the ability to disrupt any part of this metabolic signaling system [53,161].”
Background
The latest reports and treatment methods on polycystic ovary syndrome
Stańczak, N. A., Grywalska, E., & Dudzińska, E. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2357737 · Cited by 161
Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions
Ashonibare, V. J., Akorede, B. A., Ashonibare, P. J., Akhigbe, T. M., & Akhigbe, R. E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1346035 · Cited by 107
The Gut Microbiome and Female Health
Siddiqui, R., Makhlouf, Z., Alharbi, A. M., Alfahemi, H. H., & Khan, N. A. (2022) · Biology · doi:10.3390/biology11111683 · Cited by 111
Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome
Wang, K., & Lǐ, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1191759 · Cited by 106
Insulin Resistance in Polycystic Ovarian Syndrome
Purwar, A., & Nagpure, S. (2022) · Cureus · doi:10.7759/cureus.30351 · Cited by 109
Do GLP-1 Analogs Have a Place in the Treatment of PCOS? New Insights and Promising Therapies
Szczesnowicz, A., Szeliga, A., Niwczyk, O., Bala, G., & Meczekalski, B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185915 · Cited by 83
Polycystic ovary syndrome: a brain disorder characterized by eating problems originating during puberty and adolescence
Steegers-Theunissen, R. P. M., Wiegel, R. E., Jansen, P. W., Laven, J. S. E., & Sinclair, K. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218211 · Cited by 82
Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation
Fabozzi, G., Verdone, G., Allori, M., Cimadomo, D., Tatone, C., Stuppia, L., Franzago, M., Ubaldi, N., Vaiarelli, A., Ubaldi, F. M., et al. (2022) · Nutrients · doi:10.3390/nu14091918 · Cited by 101
Advances in the study of the correlation between insulin resistance and infertility
Lei, R., Chen, S., & Li, W. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1288326 · Cited by 90
Gut microbiota: a hidden player in polycystic ovary syndrome
Senthilkumar, H., & Arumugam, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06315-7 · Cited by 87
A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions
Emanuel, R. H. K., Roberts, J., Docherty, P. D., Lunt, H., Campbell, R. E., & Möller, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1017468 · Cited by 87
Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development
Zhou, Z., Tu, Z., Zhang, J., Tan, C., Shen, X., Wan, B.-B., Li, Y., Wang, A., Zhao, L.-Q., Hu, J.-J., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02714-1 · Cited by 56
Self-citation
Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies
Corrie, L., Awasthi, A., Kaur, J., Vishwas, S., Gulati, M., Kaur, I. P., Gupta, G., Kommineni, N., Dua, K., & Singh, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16020197 · Cited by 76
β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota
Yu, Y., Cao, Y., Huang, W., Liu, Y., Lü, Y., & Zhao, J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.667130 · Cited by 73
Effectiveness of Probiotics, Prebiotics, and Synbiotics in Managing Insulin Resistance and Hormonal Imbalance in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review of Randomized Clinical Trials
Guevara, D. M., Vidal-Cañas, S., Palacios, I., Gómez, A., Estrada, M., Gallego, J., & Liscano, Y. (2024) · Nutrients · doi:10.3390/nu16223916 · Cited by 77
Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance
Herman, R., Sikonja, J., Jensterle, M., Janez, A., & Dolzan, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043140 · Cited by 69
A review on critical appraisal and pathogenesis of polycystic ovarian syndrome
Hajam, Y. A., Rather, H., Neelam, N., Kumar, R., Basheer, M., & Reshi, M. S. (2024) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2024.100162 · Cited by 86
Polycystic Ovary Syndrome: Pathophysiology and Controversies in Diagnosis
Fahs, D., Salloum, D., Nasrallah, M., & Ghazeeri, G. S. (2023) · Diagnostics · doi:10.3390/diagnostics13091559 · Cited by 77
Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis
Wang, T., Ishikawa, T., Sasaki, M., & Chiba, T. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.822190 · Cited by 64
Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue
Rabah, H. M., Mohamed, D. A., Mariah, R. A., El‐Khalik, S. R. A., Khattab, H. A., AbuoHashish, N. A., Abdelsattar, A. M., Raslan, M. A., Farghal, E. E., & Eltokhy, A. K. (2023) · Redox Report · doi:10.1080/13510002.2022.2160569 · Cited by 62
The role of macrophages in polycystic ovarian syndrome and its typical pathological features: A narrative review
Feng, Y., Tang, Z., & Zhang, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115470 · Cited by 63
Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review
Bai, X., Zheng, L., Li, D., & Xu, Y. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00802-4 · Cited by 58
Environmental pollutants exposure and gestational diabetes mellitus: Evidence from epidemiological and experimental studies
Yao, X., Geng, S., Zhu, L., Jiang, H., & Wen, J. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138866 · Cited by 61
Recent advances in the effect of adipose tissue inflammation on insulin resistance
Yan, K. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111229 · Cited by 64
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., Dey, A., Babu, A., Renu, K., Vellingiri, B., et al. (2023) · Metabolites · doi:10.3390/metabo13010129 · Cited by 56
Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review
Luo, E., Jiang, H., Chen, W., Wang, Y., Tang, M., Guo, W., Diao, H., Cai, N.-Y., Yang, X., Bian, Y., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065243 · Cited by 54
Prevalence and Etiology of Eating Disorders in Polycystic Ovary Syndrome: A Scoping Review
Lalonde-Bester, S., Malik, M., Masoumi, R., Ng, K., Sidhu, S., Ghosh, M., & Vine, D. F. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100193 · Cited by 56
Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota
Ni, Y., Zheng, L., Nan, S., Ke, L., Fu, Z., & Jin, J. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022140 · Cited by 46
A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome
Parker, J., O'Brien, C., & Hawrelak, J. (2022) · Obstetrics & Gynecology Science · doi:10.5468/ogs.21185 · Cited by 42
Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome
Tang, S., Liang, C.-H., Liu, Y., Wei, W., Deng, X., Shi, X., Wang, L., Zhang, L., & Yuan, H. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i21.2320 · Cited by 41
Modified Banxia Xiexin Decoction Ameliorates Polycystic Ovarian Syndrome With Insulin Resistance by Regulating Intestinal Microbiota
Zhao, H., Chen, R., Zheng, D., Xiong, F., Jia, F., Liu, J., Zhang, L., Zhang, N., Zhu, S., Liu, Y., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854796 · Cited by 41
The Influence of Diet on Ovulation Disorders in Women—A Narrative Review
Jurczewska, J., & Szostak-Węgierek, D. E. (2022) · Nutrients · doi:10.3390/nu14081556 · Cited by 39
Changes in Vaginal Microbiome Diversity in Women With Polycystic Ovary Syndrome
Lu, C., Wang, H., Yang, J., Zhang, X., Chen, Y., Feng, R., & Qian, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.755741 · Cited by 38
The relationship between polycystic ovary syndrome and insulin resistance from 1983 to 2022: A bibliometric analysis
Chen, T., Yu, Y., Jia, F., Luan, P., & Liu, X. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.960965 · Cited by 37
Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome
Su, Y.-N., Wang, M., Yang, J.-P., Wu, X.-L., Xia, M., Bao, M., Ding, Y., Feng, Q., & Fu, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1122709 · Cited by 37
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy
Kukaev, E., Дмитриевна, К. Е., Tokareva, A., Rimskaya, E. N., Starodubtseva, N. L., Евгеньевна, Ч. Г., Priputnevich, T. V., Евгеньевич, Ф. В., & Sukhikh, G. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910636 · Cited by 43
Dietary Patterns and Polycystic Ovary Syndrome: a Systematic Review
XENOU, M., & Gourounti, K. (2021) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2020.16.3.516 · Cited by 36
Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study
Chen, Y., Guo, J., Zhang, Q., & Zhang, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853473 · Cited by 36
Gut Microbiota Modulation in Osteoporosis: Probiotics, Prebiotics, and Natural Compounds
Chu, X.-F., Xing, H., Chao, M., Xie, P., & Jiang, L. (2025) · Metabolites · doi:10.3390/metabo15050301 · Cited by 38
Effects of intestinal flora on polycystic ovary syndrome
Liu, J., Liu, Y., & Li, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1151723 · Cited by 35
Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review
Chen, T., Jia, F., Yu, Y., Zhang, W., Wang, C., Zhu, S., Zhang, N., & Liu, X. (2022) · Molecules · doi:10.3390/molecules27144476 · Cited by 33
Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad
Fabozzi, G., Rebuzzini, P., Cimadomo, D., Allori, M., Franzago, M., Stuppia, L., Garagna, S., Ubaldi, F. M., Zuccotti, M., & Rienzi, L. F. (2022) · Cells · doi:10.3390/cells11213335 · Cited by 33
Circulating bile acid profile characteristics in PCOS patients and the role of bile acids in predicting the pathogenesis of PCOS
Yu, J., Zhang, Y., Zhu, Y., Li, Y., Lin, S., Liu, W., & Tao, T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1239276 · Cited by 32
Self-citation
Unraveling the gut microbiota’s role in PCOS: a new frontier in metabolic health
Li, C., Cheng, D., Ren, H., & Zhang, T. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1529703 · Cited by 40
Strategies to Combat Antimicrobial Resistance from Farm to Table
Freeland, G., HETTIARACHCHY, N. S., Atungulu, G. G., APPLE, J. K., & Mukherjee, S. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1893744 · Cited by 32
An Update on the Progress of Endometrial Receptivity in Women with Polycystic Ovary Syndrome
Zhao, J., Chen, Q., & Xue, X. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00641-z · Cited by 34
Lactiplantibacillus plantarum CCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut–brain mechanism
He, Y., Mei, L., Wang, L., Xiu, L., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2022) · Food & Function · doi:10.1039/d1fo01744f · Cited by 35
Eight-Hour Time-Restricted Feeding: A Strong Candidate Diet Protocol for First-Line Therapy in Polycystic Ovary Syndrome
Feyzioğlu, B. S., Güven, C. M., & Avul, Z. (2023) · Nutrients · doi:10.3390/nu15102260 · Cited by 35
Molecular mechanisms of gut microbiota in diabetic nephropathy
Cheng, G., Liu, Y., Guo, R., Wang, H., Zhang, W., & Wang, Y. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111726 · Cited by 32
Ovarian Biomechanics: From Health to Disease
Sun, C. H., Yang, X., Wang, T., Cheng, M., & Han, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.744257 · Cited by 30
Microbial composition across body sites in polycystic ovary syndrome: a systematic review and meta-analysis
Sola‐Leyva, A., Pérez‐Prieto, I., Molina, N. M., Vargas, E., Ruíz-Durán, S., Leonés-Baños, I., Canha-Gouveia, A., & Altmäe, S. (2023) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2023.03.016 · Cited by 38
Investigation of common risk factors between polycystic ovary syndrome and Alzheimer’s disease: a narrative review
Sarahian, N., Sarvazad, H., Sajadi, E., Rahnejat, N., & Eskandari Roozbahani, N. (2021) · Reproductive Health · doi:10.1186/s12978-021-01203-x · Cited by 30
The gut microbiota: emerging biomarkers and potential treatments for infertility-related diseases
Wang, M., Zheng, L., Ma, S., Zhao, D.-H., & Xu, Y. D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1450310 · Cited by 33
Potential biomarkers of infertility associated with microbiome imbalances
Azpiroz, M. A., Orguilia, L., Palacio, M. I., Malpartida, A., Mayol, S., Gil, M., & Gutiérrez, G. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13438 · Cited by 36
Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate
Su, J., Tang, L., Luo, Y., Xu, J., & Ouyang, S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115830 · Cited by 32
Role of Akkermansia muciniphila in insulin resistance
Zeng, Z., Chen, M., Liu, Y., Zhou, Y., Liu, H., Wang, S., & Ji, Y. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16747 · Cited by 30
Effects of Gut Microbiota on Omega-3-Mediated Ovary and Metabolic Benefits in Polycystic Ovary Syndrome Mice
Zhang, H., Zheng, L., Li, C., Jing, J., Li, Z., Sun, S., Xue, T., Zhang, K., Xue, M., Cao, C., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01227-w · Cited by 27
Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Preliminary Study
Cutillas-Tolín, A., Árense-Gonzalo, J. J., Mendiola, J., Adoamnei, E., Navarro-Lafuente, F., Sánchez-Ferrer, M. L., Prieto‐Sánchez, M. T., Carmona‐Barnosi, A., Vioqué, J., & Torres-Cantero, A. M. (2021) · Nutrients · doi:10.3390/nu13020313 · Cited by 29
Study on the mechanism of Orthosiphon aristatus (Blume) Miq. in the treatment of hyperuricemia by microbiome combined with metabonomics
Zhu, C., Niu, H., Bian, M., Zhang, X., Zhang, X., & Zhou, Z. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116805 · Cited by 28
Effects of inulin‐type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized, double‐blind, placebo‐controlled trial
Ziaei, R., Shahshahan, Z., Tehrani, H. G., Heidari, Z., & Ghiasvand, R. (2022) · Clinical Endocrinology · doi:10.1111/cen.14712 · Cited by 26
Bacterial Atlas of Mouse Gut Microbiota
Chu, M., & Zhang, X. (2022) · Cellular Microbiology · doi:10.1155/2022/5968814 · Cited by 24
Impact of Insulin Resistance on Ovarian Sensitivity and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing IVF
Luo, Z., Wang, L., Wang, Y., Fan, Y., Jiang, L., Xu, X. P., Du, Y., & Hao, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030818 · Cited by 24
Immunonutrients involved in the regulation of the inflammatory and oxidative processes: implication for gamete competence
Renzo, L. D., LORENZO, A. D., Fontanari, M., Gualtieri, P., Monsignore, D., Schifano, G., Alfano, V., Marchetti, M., & SIERR, O. B. O. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02472-6 · Cited by 28
Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how
Hou, K., Zhang, S., Wu, Z., Zhu, D., Chen, F., Lei, Z.-N., Liu, W., Xiao, C., & Chen, Z.-S. (2021) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2021.6323 · Cited by 24
Unveiling the complex interplay between gut microbiota and polycystic ovary syndrome: A narrative review
Gautam, R., Maan, P., Patel, A. K., Vasudevan, S., & Arora, T. K. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.10.028 · Cited by 25
Effect of the ketogenic diet on gut microbiome composition and metabolomics in polycystic ovarian syndrome rats induced by letrozole and a high-fat diet
Wang, R., Zhao, Y., Fang, X., Miao, C., Ren, N., Chen, Y., Cheng, W., & Zhang, Q. (2023) · Nutrition · doi:10.1016/j.nut.2023.112127 · Cited by 21
Metagenomics study on taxonomic and functional change of gut microbiota in patients with obesity with PCOS treated with exenatide combination with metformin or metformin alone
Gan, J., Chen, J., Ma, R., Deng, Y., Ding, X., Zhu, S., & Sun, A. (2023) · Gynecological Endocrinology · doi:10.1080/09513590.2023.2219342 · Cited by 21
Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management
Kumar, A., Sakhare, K. R., Bhattacharya, D., Chattopadhyay, R., Parikh, P. M., Narayan, K. P., & Mukherjee, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.966152 · Cited by 22
Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS
Eepho, O.-I., Bashir, A.-A. M., Oniyide, A. A., Aturamu, A., Owolabi, O. V., Ajadi, I. O., Fafure, A. A., Ajadi, M. B., Areloegbe, S. E. J., & Olaniyi, K. S. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00834-z · Cited by 20
Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients
Yu, L., Chen, X., Bai, X., Fang, J., & Sui, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03744-7 · Cited by 20
Inulin‐type fructans with different degrees of polymerization improve insulin resistance, metabolic parameters, and hormonal status in overweight and obese women with polycystic ovary syndrome: A randomized double‐blind, placebo‐controlled clinical trial
Ziaei, R., Shahshahan, Z., Tehrani, H. G., Heidari, Z., Campbell, M. S., & Ghiasvand, R. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3899 · Cited by 23
Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence
Palomba, S., Costanzi, F., Caserta, D., & Vitagliano, A. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104381 · Cited by 22
Dysbiotic alteration in the fecal microbiota of patients with polycystic ovary syndrome
Chen, K., Geng, H., Ye, C., & Liu, J. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.04291-23 · Cited by 19
Recognizing the Role of Insulin Resistance in Polycystic Ovary Syndrome: A Paradigm Shift from a Glucose-Centric Approach to an Insulin-Centric Model
Parker, J., Briden, L., & Gersh, F. L. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124021 · Cited by 29
Pesticides and insulin resistance-related metabolic diseases: Evidences and mechanisms
Arab, A., & Mostafalou, S. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105521 · Cited by 19
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory
Annunziata, G., Ciampaglia, R., Capó, X., Guerra, F., Sureda, A., Tenore, G. C., & Novellino, E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112171 · Cited by 18
Positive Effects of α-Lactalbumin in the Management of Symptoms of Polycystic Ovary Syndrome
Cardinale, V., Lepore, E., Basciani, S., Artale, S. A., Nordio, M., Bizzarri, M., & Unfer, V. (2022) · Nutrients · doi:10.3390/nu14153220 · Cited by 18
Distinct Gut Microbiota Structure and Function of Children with Idiopathic Central and Peripheral Precocious Puberty
Huang, C., Liu, H., Yang, W., Li, Y., Wu, B., Chen, J., Yang, Z., Liao, C., Liu, L., & Zhang, X. (2022) · International Journal of Endocrinology · doi:10.1155/2022/7175250 · Cited by 16
Self-citation
Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study
Ikewaki, N., Sonoda, T., Kurosawa, G., Iwasaki, M., Dedeepiya, V. D., Senthilkumar, R., Preethy, S., & Abraham, S. J. (2023) · Journal of Aging Research and Lifestyle · doi:10.14283/jarlife.2023.11 · Cited by 20
Neuroendocrine, neurotransmitter, and gut microbiota imbalance contributing to potential psychiatric disorder prevalence in polycystic ovarian syndrome
Sarkisian, K. I., Ho, L., Yang, J. E., Mandelbaum, R. S., & Stanczyk, F. Z. (2023) · F&S Reports · doi:10.1016/j.xfre.2023.08.009 · Cited by 17
Dendrobium nobile-derived polysaccharides stimulate the glycolytic pathway by activating SIRT2 to regulate insulin resistance in polycystic ovary syndrome granulosa cells
Hu, R., Nong, W., Huo, P., Hu, L., Jiang, W., Yang, Z., Liao, A., Chen, X., Huang, Z., & Lei, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134780 · Cited by 17
Probiotic supplement for the treatment of polycystic ovarian syndrome
Ramzan, H., Bukhari, D. A., Bibi, Z., Arifullah, Isha, I., Nawaz, A., & Rehman, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108785 · Cited by 19
Shared postulations between bipolar disorder and polycystic ovary syndrome pathologies
Dai, W., Liu, J., Qiu, Y., Teng, Z., Li, S., Huang, J., Xiang, H., Tang, H., Wang, B., Chen, J., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110498 · Cited by 15
Gut bacteriome and mood disorders in women with PCOS
Lee, S., Tejesvi, M. V., Hurskainen, E., Aasmets, O., Plaza‐Díaz, J., Franks, S., Morin-Papunen, L. C., Tapanainen, J. S., Ruuska, T. S., Altmäe, S., et al. (2024) · Human Reproduction · doi:10.1093/humrep/deae073 · Cited by 16
Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19
Ilias, Ι., Goulas, S., & Zabulienė, L. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i12.2711 · Cited by 15
Cistanche tubulosa phenylethanoid glycosides suppressed adipogenesis in 3T3-L1 adipocytes and improved obesity and insulin resistance in high-fat diet induced obese mice
Abudujilile, D., Wang, W., Aimaier, A., Chang, L., Dong, Y., Wang, Y., Fan, X., Ma, Y., Wang, Y., Ziyayiding, D., et al. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03743-6 · Cited by 17

Authors: He, F.-F., & Li, Y.-M.
Affiliations: Central South University (CN)
Corresponding author: Li, Yu-mei
ORCID: Li, Yu-mei
Venue: Journal of Ovarian Research
Publisher: Springer Science and Business Media LLC
Published: 2020-06-17
Volume: 13
Issue: 1
Pages: 73-73
ISSN: 1757-2215 (ISSN-L)
DOI: 10.1186/s13048-020-00670-3
PMC: PMC7301991
OpenAlex: W3036640353
Cited by: 289
References: 102
Citations by year: 2026: 41 · 2025: 50 · 2024: 62 · 2023: 57 · 2022: 48 · 2021: 28 · 2020: 2
FWCI: 4.99
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Journal of Ovarian Research (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: gut microbiota, polycystic ovary syndrome, insulin resistance, hyperinsulinemia, dysbiosis, chronic inflammation, reproductive disorders, infertility, hyperandrogenism, pregnancy complications, anxiety and depression
MeSH terms: Gastrointestinal Microbiome, Animals, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks