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Cited by 301

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis

Open access
de Haan, Kim, Groeneveld, AB Johan, de Geus, Hilde RH, Egal, Mohamud, Struijs, Ard·2014·Critical Care
DOI 10.1186/s13054-014-0660-4
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Abstract

Introduction: In Europe, vitamin D deficiency is highly prevalent varying between 40% and 60% in the healthy general adult population. The consequences of vitamin D deficiency for sepsis and outcome in critically ill patients remain controversial. We therefore systematically reviewed observational cohort studies on vitamin D deficiency in the intensive care unit. Methods: Fourteen observational reports published from January 2000 to March 2014, retrieved from Pubmed and Embase, involving 9,715 critically ill patients and serum 25-hydroxyvitamin D 3 (25 (OH)-D) concentrations, were meta-analysed. Results: Levels of 25 (OH)-D less than 50 nmol/L were associated with increased rates of infection (risk ratio (RR) 1.49, 95% (confidence interval (CI) 1.12 to 1.99), P = 0.007), sepsis (RR 1.46, 95% (CI 1.27 to 1.68), P <0.001), 30-day mortality (RR 1.42, 95% (CI 1.00 to 2.02), P = 0.05), and in-hospital mortality (RR 1.79, 95% (CI 1.49 to 2.16), P <0.001). In a subgroup analysis of adjusted data including vitamin D deficiency as a risk factor for 30-day mortality the pooled RR was 1.76 (95% CI 1.37 to 2.26, P <0.001). Conclusions: This meta-analysis suggests that vitamin D deficiency increases susceptibility for severe infections and mortality of the critically ill.

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Metadata

Authors
de Haan, K., Groeneveld, A. J., de Geus, H. R., Egal, M., & Struijs, A.
Venue
Critical Care
Publisher
Springer Science and Business Media LLC
Published
2014-12-05
Volume
18
Issue
6
Pages
660-660
ISSN
1364-8535 (ISSN-L)
DOI
10.1186/s13054-014-0660-4
OpenAlex
W2125663148
Cited by
301
References
37
FWCI
2.52
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. https://app.cochat.ai/papers/10.1186/s13054-014-0660-4
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de Haan, K., Groeneveld, A. J., de Geus, H. R., Egal, M., & Struijs, A. (2014). Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. Critical Care. https://doi.org/10.1186/s13054-014-0660-4

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