The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
Open accessAbstract
Background: Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. Methods: Plasma concentrations of 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (DBP) and LL-37 in critically ill adult subjects admitted to intensive care units (ICUs) with sepsis and without sepsis were compared to healthy controls. Results: Critically ill subjects had significantly lower plasma 25(OH)D concentrations compared to healthy controls. Mean plasma LL-37 levels were significantly lower in critically ill subjects compared to healthy controls. Vitamin D binding protein levels in plasma were significantly lower in critically ill subjects with sepsis compared to critically ill subjects without sepsis. There was a significant positive association between circulating 25(OH)D and LL-37 levels. Conclusion: This study demonstrates an association between critical illness and lower 25(OH)D and DBP levels in critically ill patients as compared to healthy controls. It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Optimal vitamin D status may be important for innate immunity especially in the setting of sepsis. Further invention studies to examine this association are warranted.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S. M., Vincent, J.-L., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,995
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Hypovitaminosis D in Medical Inpatients
Thomas, M. K., Lloyd-Jones, D. M., Thadhani, R. I., Shaw, A. C., Deraska, D. J., Kitch, B. T., Vamvakas, E. C., Dick, I. M., Prince, R. L., & Finkelstein, J. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803193381201 · Cited by 1,423
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
Heaney, R. P., Davies, K. M., Chen, T. C., Holick, M. F., & Barger-Lux, M. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.204 · Cited by 1,396
Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients
Board, A. S. P. E. N. (1993) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719301700401 · Cited by 1,111
LL-37, the only human member of the cathelicidin family of antimicrobial peptides
Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049
Epidemic influenza and vitamin D
CANNELL, J. J., VIETH, R., UMHAU, J. C., HOLICK, M. F., GRANT, W. B., MADRONICH, S., GARLAND, C. F., & GIOVANNUCCI, E. (2006) · Epidemiology and Infection · doi:10.1017/s0950268806007175 · Cited by 1,034
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E. I., & Willnow, T. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80655-8 · Cited by 1,027
Cited by
Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity
Kamen, D. L., & Tangpricha, V. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0590-9 · Cited by 560
Self-citationAn update on vitamin D and human immunity
Hewison, M. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04261.x · Cited by 543
Cellular Metabolism and Macrophage Functional Polarization
Zhu, L., Zhao, Q., Yang, T., Ding, W., & Zhao, Y. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2014.969421 · Cited by 428
Vitamin D and immune function: an overview
Hewison, M. (2012) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111001650 · Cited by 419
Schwalfenberg, G. K. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000174 · Cited by 414
Metadata
- Authors
- Jeng, L., Yamshchikov, A. V., Judd, S. E., Blumberg, H. M., Martin, G. S., Ziegler, T. R., & Tangpricha, V.
- Venue
- Journal of Translational Medicine
- Published
- 2009-04-23
- Volume
- 7
- Issue
- 1
- Pages
- 28-28
- ISSN
- 1479-5876 (ISSN-L)
- OpenAlex
- W2154408193
- Cited by
- 440
- References
- 31
- FWCI
- 21.87
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. https://app.cochat.ai/papers/10.1186/1479-5876-7-28
- The paper
- Jeng, L., Yamshchikov, A. V., Judd, S. E., Blumberg, H. M., Martin, G. S., Ziegler, T. R., & Tangpricha, V. (2009). Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. Journal of Translational Medicine. https://doi.org/10.1186/1479-5876-7-28
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
