The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials
Open accessAbstract
Driving pressure (ΔPrs) across the respiratory system is suggested as the strongest predictor of hospital mortality in patients with acute respiratory distress syndrome (ARDS). We wonder whether this result is related to the range of tidal volume (VT). Therefore, we investigated ΔPrs in two trials in which strict lung-protective mechanical ventilation was applied in ARDS. Our working hypothesis was that ΔPrs is a risk factor for mortality just like compliance (Crs) or plateau pressure (Pplat,rs) of the respiratory system. We performed secondary analysis of data from 787 ARDS patients enrolled in two independent randomized controlled trials evaluating distinct adjunctive techniques while they were ventilated as in the low VT arm of the ARDSnet trial. For this study, we used VT, positive end-expiratory pressure (PEEP), Pplat,rs, Crs, ΔPrs, and respiratory rate recorded 24 hours after randomization, and compared them between survivors and nonsurvivors at day 90. Patients were followed for 90 days after inclusion. Cox proportional hazard modeling was used for mortality at day 90. If colinearity between ΔPrs, Crs, and Pplat,rs was verified, specific Cox models were used for each of them. Both trials enrolled 805 patients of whom 787 had day-1 data available, and 533 of these survived. In the univariate analysis, ΔPrs averaged 13.7 ± 3.7 and 12.8 ± 3.7 cmH2O (P = 0.002) in nonsurvivors and survivors, respectively. Colinearity between ΔPrs, Crs and Pplat,rs, which was expected as these variables are mathematically coupled, was statistically significant. Hazard ratios from the Cox models for day-90 mortality were 1.05 (1.02–1.08) (P = 0.005), 1.05 (1.01–1.08) (P = 0.008) and 0.985 (0.972–0.985) (P = 0.029) for ΔPrs, Pplat,rs and Crs, respectively. PEEP and VT were not associated with death in any model. When ventilating patients with low VT, ΔPrs is a risk factor for death in ARDS patients, as is Pplat,rs or Crs. As our data originated from trials from which most ARDS patients were excluded due to strict inclusion and exclusion criteria, these findings must be validated in independent observational studies in patients ventilated with a lung protective strategy. Clinicaltrials.gov NCT00299650 . Registered 6 March 2006 for the Acurasys trial. Clinicaltrials.gov NCT00527813 . Registered 10 September 2007 for the Proseva trial.
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Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · cited 1×
“ARDS was identified based on the American-European consensus definition criteria [6].”
MethodBellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766
Prone positioning in severe acute respiratory distress syndrome.
Guérin, C., Reignier, J., Richard, J.-C., Beuret, P., Gacouin, A., Boulain, T., Mercier, E., Badet, M., Mercat, A., Baudin, O., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214103 · Cited by 4,040
Self-citationEffect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Driving pressure and survival in the acute respiratory distress syndrome.
Amato, M. B. P., Meade, M. O., Slutsky, A. S., Brochard, L., Costa, E. L. V., Schoenfeld, D. A., Stewart, T. E., Briel, M., Talmor, D., Mercat, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmsa1410639 · Cited by 2,801
Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005372 · Cited by 2,432
Self-citationVentilator-related causes of lung injury: the mechanical power
Gattinoni, L., Tonetti, T., Cressoni, M., Cadringher, P., Herrmann, P., Moerer, O., Protti, A., Gotti, M., Chiurazzi, C., Carlesso, E., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4505-2 · Cited by 1,055
Mekontso Dessap, A., Boissier, F., Charron, C., Bégot, E., Repessé, X., Legras, A., Brun-Buisson, C., Vignon, P., & Vieillard-Baron, A. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4141-2 · Cited by 550
Mechanical Power and Development of Ventilator-induced Lung Injury
Cressoni, M., Gotti, M., Chiurazzi, C., Massari, D., Algieri, I., Amini, M., Cammaroto, A., Brioni, M., Montaruli, C., Nikolla, K., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001056 · Cited by 483
Cited by
Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators, Cavalcanti, A. B., Suzumura, É. A., Laranjeira, L. N., Paisani, D. D. M., Damiani, L. P., Guimarães, H. P., Romano, E. R., Regenga, M. D. M., Taniguchi, L. N. T., et al. (2017) · JAMA · doi:10.1001/jama.2017.14171 · Cited by 1,018
Formal guidelines: Management of acute respiratory distress syndrome.
Papazian, L., Aubron, C., Brochard, L., Chiche, J.-D., Combes, A., Dreyfuss, D., Forel, J.-M., Guérin, C., Jaber, S., Mekontso-Dessap, A., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0540-9 · Cited by 761
Self-citationGorman, E. A., O’Kane, C. M., & McAuley, D. F. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01439-8 · Cited by 423
Chiumello, D., Mongodi, S., Algieri, I., Vergani, G. L., Orlando, A., Via, G., Crimella, F., Cressoni, M., & Mojoli, F. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003340 · Cited by 308
Driving pressure and mechanical power: new targets for VILI prevention
Tonetti, T., Vasques, F., Rapetti, F., Maiolo, G., Collino, F., Romitti, F., Camporota, L., Cressoni, M., Cadringher, P., Quintel, M., et al. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.07.08 · Cited by 258
Metadata
- Authors
- on behalf of the investigators of the Acurasys and Proseva trials, Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., & Forel, J.-M.
- Venue
- Critical Care
- Published
- 2016-11-29
- Volume
- 20
- Issue
- 1
- Pages
- 384-384
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2552328820
- Cited by
- 266
- References
- 21
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- on behalf of the investigators of the Acurasys and Proseva trials, Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., & Forel, J.-M. (2016). Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials. Critical Care. https://doi.org/10.1186/s13054-016-1556-2
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