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Cited by 161Nutritional Studies and DietCancer Risks and FactorsGlobal Cancer Incidence and Screening

Associations between dietary patterns and the risk of breast cancer: A systematic review and meta-analysis of observational studies

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Xiao, Yunjun, Xia, Junjie, Li, Liping, Ke, Yuebin, Cheng, Jinquan, Xie, Yaojie, Chu, Winnie, Cheung, Polly +4 more·2019·Breast Cancer Research
DOI 10.1186/s13058-019-1096-1PMC PMC6352362
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Abstract

BACKGROUND: Epidemiologic evidence suggests that certain dietary patterns were associated with breast cancer risk, but the results have been inconclusive. We assessed the associations between different dietary patterns and the risk of breast cancer by conducting a meta-analysis of observational studies. METHODS: Relevant articles were searched in PubMed, Embase, and Cochrane library databases through September 2017. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) comparing the highest and lowest categories of Western and prudent dietary patterns were combined by using the random-effects meta-analyses. RESULTS: We identified 32 eligible articles including 14 cohort and 18 case-control studies (34 Western and 35 prudent studies). The pooled analyses found that a Western dietary pattern was associated with a 14% increased risk (RR 1.14, 95% CI 1.02, 1.28), whereas a prudent dietary pattern was associated with an 18% reduced risk of breast cancer (RR 0.82, 95% CI 0.75, 0.89). In addition, sub-group analyses showed that the positive association between a Western dietary pattern and breast cancer risk was significant among postmenopausal (RR 1.20, 95% CI 1.06, 1.35), but not premenopausal women (RR 1.18, 95% CI 0.99, 1.40), and significant for hormone receptor-positive tumors (RR 1.18, 95% CI 1.04, 1.33), but not receptor-negative tumors (RR 0.97, 95% CI 0.83, 1.12). In contrast, the inverse association between a prudent dietary pattern and breast cancer was significant in premenopausal (RR 0.77, 95% CI 0.61, 0.98), but not postmenopausal women (RR 0.88, 95% CI 0.74, 1.03), and significant for both hormone receptor-positive and receptor-negative tumors. CONCLUSIONS: The results of the current meta-analysis suggest a possible increased risk of breast cancer associated with a Western dietary pattern and a reduced risk with a prudent dietary pattern. Large-scale cohort studies with a high quality need to be conducted to further confirm the findings of the current meta-analysis. As dietary patterns are modifiable, these findings may provide viable strategies for breast cancer prevention through changes in dietary intake.

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  • In an updated meta-analysis, adherence to Western diet was positively associated with breast malignancies in post-menopausal women.

    “The pooled analysis resulted in a positive association between adherence to Western diet and breast malignancies in post-menopausal women”

    From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [166]

  • In the same meta-analysis, adherence to a prudent dietary pattern was associated with reduced risk (−23%) of breast malignancies in premenopausal women.

    “whereas adherence to a “prudent” dietary pattern, that complies well with WHO healthy eating recommendations and rich in vegetables, fruit, fish, poultry and low-fat dairy products, was associated with reduced risk (−23%) of breast malignancies in premenopausal women.”

    From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [166]

  • Adherence to a prudent dietary pattern was significantly associated with a lowered risk of both ER+ and/or PR+ and ER− and PR− breast tumors.

    “As a corollary, adherence to a prudent dietary pattern was significantly associated with a lowered risk of both ER+ and/or PR+ and ER− and PR− breast tumors [166].”

    From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [166]

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Authors
Xiao, Y., Xia, J., Li, L., Ke, Y., Cheng, J., Xie, Y., Chu, W., Cheung, P., Kim, J. H., Colditz, G. A., Tamimi, R. M., & Su, X.
Affiliations
  • Shenzhen Center for Disease Control and Prevention (CN)
  • Shantou University (CN)
  • Hong Kong Breast Cancer Foundation (HK)
  • Chinese University of Hong Kong (HK)
  • Washington University in St. Louis (US)
  • Brigham and Women's Hospital (US)
Corresponding author
  • Tamimi, Rulla M.
  • Su, Xuefen
ORCID
Venue
Breast Cancer Research
Publisher
Springer Science and Business Media LLC
Published
2019-01-29
Volume
21
Issue
1
Pages
16-16
ISSN
  • 1465-5411 (ISSN-L)
  • 1465-542X
DOI
10.1186/s13058-019-1096-1
PMC
PMC6352362
OpenAlex
W2920235314
Cited by
161
References
95
Citations by year
2026: 13 · 2025: 16 · 2024: 26 · 2023: 24 · 2022: 29 · 2021: 27 · 2020: 20 · 2019: 6
FWCI
3.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Breast Cancer Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Hong Kong Research Grants Council General Research Fund (2140904)
  • Chinese University of Hong Kong Office of Research and Knowledge Transfer Services Knowledge Transfer Project Fund (KPF15ICF16)
  • National Natural Science Foundation of China (81402672)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
patterns, breast cancer risk, Western dietary pattern, prudent diet, postmenopausal women, hormone receptor-positive breast cancer, premenopausal women, Mediterranean diet, dietary fat intake, alcohol consumption, fruit and vegetable intake, dairy consumption, dietary fiber, dietary cholesterol, dietary sodium, dietary calcium, dietary protein, energy intake
MeSH terms
Diet, Healthy, Breast Neoplasms, Feeding Behavior, Female, Humans, Risk Factors, Nutrition Assessment, Observational Studies as Topic, Diet, Western

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