The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex
Open accessAbstract
BACKGROUND: Circular RNAs are a class of endogenous RNAs with various functions in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently, nothing is known about their role in head and neck squamous cell carcinoma (HNSCC). The identification of circular RNAs in HNSCC might become useful for diagnostic and therapeutic strategies in HNSCC. RESULTS: Using samples from 115 HNSCC patients, we find that circPVT1 is over-expressed in tumors compared to matched non-tumoral tissues, with particular enrichment in patients with TP53 mutations. circPVT1 up- and down-regulation determine, respectively, an increase and a reduction of the malignant phenotype in HNSCC cell lines. We show that circPVT1 expression is transcriptionally enhanced by the mut-p53/YAP/TEAD complex. circPVT1 acts as an oncogene modulating the expression of miR-497-5p and genes involved in the control of cell proliferation. CONCLUSIONS: This study shows the oncogenic role of circPVT1 in HNSCC, extending current knowledge about the role of circular RNAs in cancer.
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Self-citationNatural RNA circles function as efficient microRNA sponges
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Self-citationExon-intron circular RNAs regulate transcription in the nucleus
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
The emerging roles of circRNAs in cancer and oncology
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The circ RNA–micro RNA code: emerging implications for cancer diagnosis and treatment
Verduci, L., Strano, S., Yarden, Y., & Blandino, G. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12468 · Cited by 438
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Functions of Circular RNA in Human Diseases and Illnesses
Gu, A., Jaijyan, D. K., Yang, S., Zeng, M., Pei, S., & Zhu, H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9040038 · Cited by 65
Metadata
- Authors
- Verduci, L., Ferraiuolo, M., Sacconi, A., Ganci, F., Vitale, J., Colombo, T., Paci, P., Strano, S., Macino, G., Rajewsky, N., & Blandino, G.
- Venue
- Genome Biology
- Published
- 2017-12
- Volume
- 18
- Issue
- 1
- Pages
- 237-237
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- OpenAlex
- W2779615732
- Cited by
- 267
- References
- 57
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Verduci, L., Ferraiuolo, M., Sacconi, A., Ganci, F., Vitale, J., Colombo, T., Paci, P., Strano, S., Macino, G., Rajewsky, N., & Blandino, G. (2017). The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex. Genome Biology. https://doi.org/10.1186/s13059-017-1368-y
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