Schizophrenia and substance use comorbidity: a genome-wide perspective
Open accessAbstract
Dual diagnosis with substance use disorders (SUDs) consistently contributes to the premature mortality and increased disability observed in schizophrenia. Large genome-wide association studies are providing the information needed to investigate the genetic architecture of psychiatric disorders. Here, we discuss recent genetic investigations of dual diagnosis (i.e., schizophrenia plus a SUD) and how these findings can inform public health messages.
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The presence of a psychiatric disorder, including mood, anxiety, psychotic and personality disorders, and ADHD, is associated with an increased risk for SUDs.
“The presence of a psychiatric disorder - including mood, anxi ety, psychotic and personality disorders, and ADHD - is associ ated with an increased risk for SUDs.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [122]
Theories of dual diagnosis (page unavailable) says people with schizophrenia are more likely to use several substances than people without it. Genetic overlap between schizophrenia and SUDs (page unavailable) reports associations with several substance-use disorders. The paper does not establish the claimed increased SUD risk for mood, anxiety, or personality disorders, or ADHD. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSUDs are associated with an increased risk for a mental disorder.
“On the other hand, SUDs are also associated with increased risk for a mental disorder.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [122]
The Causal relationships section (page unavailable) reports that genetic liability to cannabis use was associated with a modestly increased risk of schizophrenia. That supports an association in this specific case, but the paper does not establish the claim for SUDs generally or for mental disorders beyond schizophrenia. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe association between psychiatric disorders and SUDs likely reflects bidirectional links, such that having a mental disorder increases risk of maladaptive drug use to self-medicate, and having a SUD increases risk for developing a mental disorder, as drugs affect neurocircuits relevant to other mental disorders.
“These associations are likely to reflect bidirectional links, such that hav ing a mental disorder increases risk of maladaptive use of drugs to self- medicate, and having a SUD increases risk for developing a mental disorder, as drugs affect neurocircuits relevant to other mental disorders.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [122]
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Experimental — accuracy not yet measuredCommon genetic and environmental risk factors for both SUDs and mental disorders contribute to their high degree of comorbidity.
“Common genetic and environmental risk fac tors for both SUDs and mental disorders also contribute to their high degree of comorbidity 121- 123 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [122]
The ‘Genetic overlap between schizophrenia and SUDs’ section says shared genetic variation is implicated in their comorbidity. The ‘Theories of dual diagnosis’ section discusses poor social environments as a possible contributor to substance use among people with schizophrenia, but does not establish shared environmental risk factors for both conditions. The paper addresses schizophrenia specifically, not mental disorders generally. (LLM, conf=0.85)
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- Authors
- Polimanti, R., Agrawal, A., & Gelernter, J.
- Affiliations
- Yale University (US)
- Corresponding author
- Polimanti, Renato
- Venue
- Genome Medicine
- Published
- 2017-03-21
- Volume
- 9
- Issue
- 1
- Pages
- 25-25
- ISSN
- 1756-994X (ISSN-L)
- PMC
- PMC5359801
- OpenAlex
- W2600181218
- Cited by
- 24
- References
- 11
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse
- Brain and Behavior Research Foundation
- U.S. Department of Veterans Affairs
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- schizophrenia, substance use disorders, dual diagnosis, psychiatric comorbidity, genetic architecture, genome-wide association study
- MeSH terms
- Humans, Schizophrenia, Diagnosis, Dual (Psychiatry), Substance-Related Disorders, Genome-Wide Association Study
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