Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics
Open accessAbstract
Meta-analyses of genome-wide association study data have begun to lead to promising new discoveries for behavioral and psychiatrically relevant phenotypes (e.g., schizophrenia, educational attainment). We outline how this methodology can similarly lead to novel discoveries in genomic studies of substance use disorders, and discuss challenges that will need to be overcome to accomplish this goal. We illustrate our approach with the work of the newly established Substance Use Disorders workgroup of the Psychiatric Genomics Consortium.
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The presence of a psychiatric disorder, including mood, anxiety, psychotic and personality disorders, and ADHD, is associated with an increased risk for SUDs.
“The presence of a psychiatric disorder - including mood, anxi ety, psychotic and personality disorders, and ADHD - is associ ated with an increased risk for SUDs.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [121]
The Comorbidity section (page not provided) says SUDs commonly co-occur with other psychiatric illnesses and gives major depressive disorder as an example. It does not establish that the presence of each listed disorder—mood, anxiety, psychotic and personality disorders, and ADHD—is associated with increased SUD risk. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe association between psychiatric disorders and SUDs likely reflects bidirectional links, such that having a mental disorder increases risk of maladaptive drug use to self-medicate, and having a SUD increases risk for developing a mental disorder, as drugs affect neurocircuits relevant to other mental disorders.
“These associations are likely to reflect bidirectional links, such that hav ing a mental disorder increases risk of maladaptive use of drugs to self- medicate, and having a SUD increases risk for developing a mental disorder, as drugs affect neurocircuits relevant to other mental disorders.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [121]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredCommon genetic and environmental risk factors for both SUDs and mental disorders contribute to their high degree of comorbidity.
“Common genetic and environmental risk fac tors for both SUDs and mental disorders also contribute to their high degree of comorbidity 121- 123 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [121]
The “(c) Comorbidity” section (page not provided) says SUDs commonly co-occur with psychiatric illnesses and that some of this comorbidity is attributable to shared genetic effects. It does not say that shared environmental risk factors contribute to their comorbidity; its discussion of environmental effects concerns SUDs generally. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSUDs are associated with an increased risk for a mental disorder.
“On the other hand, SUDs are also associated with increased risk for a mental disorder.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [121]
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- Authors
- Agrawal, A., Edenberg, H. J., & Gelernter, J.
- Affiliations
- Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
- Indiana University School of Medicine (US)
- Yale University (US)
- Venue
- Journal of Studies on Alcohol and Drugs
- Publisher
- Alcohol Research Documentation, Inc.
- Published
- 2016-09
- Volume
- 77
- Issue
- 5
- Pages
- 676-680
- ISSN
- 1937-1888 (ISSN-L)
- 1938-4114
- PMC
- PMC5015465
- OpenAlex
- W2518651629
- Cited by
- 32
- References
- 39
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 6
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Studies on Alcohol and Drugs (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- PMC
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA008401, U10AA008401)
- National Institute of Mental Health (U01MH109528, U01MH094421, U01MH109532)
- National Institute on Drug Abuse (R01DA012690, K02DA032573)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- meta-analysis, genome-wide association study, addiction genetics, substance use disorders, Psychiatric Genomics Consortium, psychiatric phenotypes, schizophrenia, educational attainment, genetic discovery
- MeSH terms
- Humans, Phenotype, Statistics as Topic, Case-Control Studies, Behavior, Addictive, Genetic Predisposition to Disease, Genome-Wide Association Study
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