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Cited by 12Exercise and Physiological ResponsesMitochondrial Function and PathologyAdipose Tissue and Metabolism

Effects of aerobic exercise training in oxidative metabolism and mitochondrial biogenesis markers on prefrontal cortex in obese mice

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de Sousa Fernandes, Matheus Santos, Aidar, Felipe J., da Silva Pedroza, Anderson Apolônio, de Andrade Silva, Severina Cássia, Santos, Gabriela Carvalho Jurema, dos Santos Henrique, Rafael, Clemente, Filipe Manuel, Silva, Ana Filipa +5 more·2022·BMC Sports Science, Medicine and Rehabilitation
DOI 10.1186/s13102-022-00607-xPMC PMC9758933
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Abstract

Background: To evaluate the effects of 8 weeks of Aerobic Physical Training (AET) on the mitochondrial biogenesis and oxidative balance in the Prefrontal Cortex (PFC) of leptin deficiency-induced obese mice (ob/ob mice). Methods: Then, the mice were submitted to an 8-week protocol of aerobic physical training (AET) at moderate intensity (60% of the maximum running speed). In the oxidative stress, we analyzed Malonaldehyde (MDA) and Carbonyls, the enzymatic activity of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione S Transferase (GST), non-enzymatic antioxidant system: reduced glutathione (GSH), and Total thiols. Additionally, we evaluated the gene expression of PGC-1α SIRT-1, and ATP5A related to mitochondrial biogenesis and function. Results: In our study, we did not observe a significant difference in MDA ( p = 0.2855), Carbonyl’s ( p = 0.2246), SOD ( p = 0.1595), and CAT ( p = 0.6882) activity. However, the activity of GST ( p = 0.04), the levels of GSH ( p = 0.001), and Thiols ( p = 0.02) were increased after 8 weeks of AET. Additionally, there were high levels of PGC-1α ( p = 0.01), SIRT-1 ( p = 0.009), and ATP5A ( p = 0.01) gene expression after AET in comparison with the sedentary group. Conclusions: AET for eight weeks can improve antioxidant defense and increase the expression of PGC-1α, SIRT-1, and ATP5A in PFC of ob/ob mice.

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  • The effects of physical activity on glucose levels in overweight or obese individuals may be associated with weight loss and a reduction in %BF or an increase in lipid oxidation capacity.

    “This may be associated with weight loss and a reduction in %BF or an increase in lipid oxidation capacity in these obese individuals (Franczyk et al., 2023; De Sousa Fernandes et al., 2022).”

    From Effect of water-based aerobic training on anthropometric, biochemical, cardiovascular, and explosive strength parameters in young overweight and obese women: a randomized controlled trial (2025) · cites this paper as De Sousa Fernandes et al., 2022

    The Background says exercise can improve lipolysis and oxidative metabolism, but it does not link those effects to glucose levels. The Results concern exercise adaptation and markers in the prefrontal cortex of obese mice; searches for glucose levels, weight loss, body-fat percentage, and lipid oxidation capacity found no passage establishing the proposed association. (LLM, conf=0.74)

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Authors
de Sousa Fernandes, M. S., Aidar, F. J., da Silva Pedroza, A. A., de Andrade Silva, S. C., Santos, G. C. J., dos Santos Henrique, R., Clemente, F. M., Silva, A. F., de Souza, R. F., Ferreira, D. J., Badicu, G., Lagranha, C., & Nobari, H.
Affiliations
  • Universidade Federal de Sergipe (BR)
  • Universidade Federal de Pernambuco (BR)
  • Universidade Politécnica de Viana do Castelo (PT)
  • Universidade Federal do Vale do São Francisco (BR)
ORCID
Venue
BMC Sports Science, Medicine and Rehabilitation
Publisher
Springer Science and Business Media LLC
Published
2022-12-16
Volume
14
Issue
1
Pages
213-213
ISSN
2052-1847 (ISSN-L)
DOI
10.1186/s13102-022-00607-x
PMC
PMC9758933
OpenAlex
W4312067073
Cited by
12
References
3
Citations by year
2026: 1 · 2025: 8 · 2024: 2 · 2023: 1
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Sports Science Medicine and Rehabilitation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Financiadora de Estudos e Projetos
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
aerobic exercise training, oxidative stress, mitochondrial biogenesis, prefrontal cortex, obesity, leptin deficiency, ob/ob mice, antioxidant defense, PGC-1α, SIRT1, ATP5A, glutathione, superoxide dismutase, catalase, glutathione S-transferase, malondialdehyde, protein carbonyls

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