Poor drug adherence and lack of awareness of hypertension among hypertensive stroke patients in Kampala, Uganda: a cross sectional study
Open accessAbstract
BACKGROUND: Raised blood pressure (BP) remains an important risk factor for cardiovascular diseases such as stroke. Adherence to therapeutic recommendations especially antihypertensive drugs is important in BP control. The aim of the study was to assess the stroke risk factors and levels of adherence among hypertensive patients with stroke in Kampala Uganda. METHODS: In a cross-sectional study we describe 112 hypertensive subjects with stroke from two Kampala city hospitals. A standardized pre-tested questionnaire was used to collect medical history, clinical details, radiological findings and laboratory data. RESULTS: A total of 112 hypertensive subjects with stroke were enrolled between May 2013 and April 2014. The median ages were 63.5 years (52.5-75.0) for the cases. Seventy percent (78/112) of the study participants had ischemic strokes. Only 17% were adherent to anti-hypertensive medications. The main cause of non-adherence appears to be lack of knowledge. CONCLUSIONS: Poor adherence of anti-hypertensive medications among hypertensive patients remains a big challenge in our setting. This has been attributed to lack of adequate knowledge and cost of the prescribed drugs. There is therefore an urgent need to promptly diagnose and educate hypertensive patients with emphasis on adherence to anti hypertensive drugs.
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Patient adherence to hypertension treatment in other sub-Saharan African countries has been assessed through surveys, with adherence levels ranging from 17% in Kampala, Uganda to 61.8% in Ethiopia.
“These surveys have found levels of adherence ranging from 17% in a survey of 112 hypertensive patients in two city hospitals in Kampala, Uganda, to 61.8% of patients compliant with antihypertensive medications at Jimma University Specialised Hospital in Ethiopia.9,10”
The study's findings of inadequate medication possession ratios are congruent with some of the lower estimates of medication adherence previously measured in sub-Saharan Africa.
“our findings of inadequate medication possession ratios and thereby treatment adherence, with more than 80% of patients assessed not having medication for more than 40% of the time period studied, are congruent with some of the lower estimates of medication adherence previously measured in sub-Saharan Africa”
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Self-citation
- Authors
- Mugwano, I., Kaddumukasa, M., Mugenyi, L., Kayima, J., Ddumba, E., Sajatovic, M., Sila, C., DeGeorgia, M., & Katabira, E.
- Affiliations
- Uganda Martyrs University (UG)
- Makerere University (UG)
- Infectious Diseases Research Collaboration (UG)
- University Hospitals Cleveland Medical Center (US)
- Corresponding author
- Kaddumukasa, Mark
- Venue
- BMC Research Notes
- Published
- 2016-01-02
- Volume
- 9
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1756-0500 (ISSN-L)
- PMC
- PMC4698320
- OpenAlex
- W2198007511
- Cited by
- 47
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 6 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Research Notes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Scholarly Commons @ Case Western Reserve University (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R25NS080968)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication adherence, hypertension, stroke, antihypertensive drugs, patient knowledge, ischemic stroke, stroke risk factors, Kampala, Uganda
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antihypertensive Agents, Awareness, Blood Pressure, Cholesterol, Cross-Sectional Studies, Demography, Female, Humans, Hypertension, Life Style, Male, Middle Aged, Uganda, Stroke, Medication Adherence
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