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Cited by 23Cervical Cancer and HPV ResearchWomen's cancer prevention and managementReproductive tract infections research

Self-Sampling for human papillomavirus testing among rural young women of KwaZulu-Natal, South Africa

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Mbatha, J. N., Galappaththi-Arachchige, H. N., Mtshali, A., Taylor, M., Ndhlovu, P. D., Kjetland, E. F., Baay, M. F. D., Mkhize-Kwitshana, Z. L.·2017·BMC Research Notes
DOI 10.1186/s13104-017-3045-3PMC PMC5717820
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Abstract

BACKGROUND: Cervical cancer is a major problem in women and it is important to find a suitable and acceptable screening method, especially among young in low-resource areas for future human papillomavirus (HPV) vaccine follow-up investigations. The study sought to test the acceptability of self-sampling as well as the suitability of the specimen collecting devices. METHODS: Ninety-eight young women from rural KwaZulu-Natal were enrolled between March and July 2014. Collected genital specimens were transferred to colour indicator cards for HPV detection. Participants answered a questionnaire where they described their experiences with self-sampling. Samples were tested for high-risk HPV using GP5/6+ PCR. RESULTS: Of the enrolled participants, 91 answered questionnaires and indicated that self-sampling was preferred by 51/91 (56%) women while 40/91 (44%) indicated preference for sampling by a doctor (p = 0.023). The majority, 64% were comfortable using a swab, 22% preferred a brush while 11% were comfortable with both devices. Of the 98 self-sampled specimens 61 were negative for HPV in both specimens while 37 were HPV-positive in either brush or swab. Of the 37, 26 (70%) were HPV-positive in both brush and swab (kappa = 0.743) and 11 (30%) were discordant. CONCLUSIONS: Self-sampling was acceptable to the majority of participants in this rural area. The Dacron swab was the preferred device, and can be used in combination with colour indicator cards for comfortable self-sampling, easy storage and transport of specimens plus detection.

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Authors
Mbatha, J. N., Galappaththi-Arachchige, H. N., Mtshali, A., Taylor, M., Ndhlovu, P. D., Kjetland, E. F., Baay, M. F. D., & Mkhize-Kwitshana, Z. L.
Affiliations
  • Durban University of Technology (ZA)
  • University of KwaZulu-Natal (ZA)
  • Imperial College London (GB)
  • Oslo University Hospital (NO)
Corresponding author
Mbatha, J. N.
ORCID
Venue
BMC Research Notes
Publisher
Springer Science and Business Media LLC
Published
2017-12
Volume
10
Issue
1
Pages
702-702
ISSN
1756-0500 (ISSN-L)
DOI
10.1186/s13104-017-3045-3
PMC
PMC5717820
OpenAlex
W2774380378
Cited by
23
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 1
FWCI
0.86
Type
journal article
Language
en
Update notices
correction (2018-02-26)
Open access
Licence
cc-by
Locations
  • BMC Research Notes (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
Funders
  • Bill and Melinda Gates Foundation (OPPGH5344)
  • Durban University of Technology
  • European Commission (2007–2013, 269245, FP7 2007-2013, FP7/2007)
  • Inyuvesi Yakwazulu-Natali
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
self-sampling, HPV testing, cervical cancer screening, young women, rural women, swabs, brushes, acceptability, KwaZulu-Natal
MeSH terms
Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Surveys and Questionnaires, Rural Population, Self Care, South Africa, Papillomaviridae, Young Adult

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