The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
Open accessAbstract
The term epigenetics is defined as heritable changes in gene expression that are not due to alterations of the DNA sequence. In the last years, it has become more and more evident that dysregulated epigenetic regulatory processes have a central role in cancer onset and progression. In contrast to DNA mutations, epigenetic modifications are reversible and, hence, suitable for pharmacological interventions. Reversible histone methylation is an important process within epigenetic regulation, and the investigation of its role in cancer has led to the identification of lysine methyltransferases and demethylases as promising targets for new anticancer drugs. In this review, we describe those enzymes and their inhibitors that have already reached the first stages of clinical trials in cancer therapy, namely the histone methyltransferases DOT1L and EZH2 as well as the demethylase LSD1.
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Cited by
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Metadata
- Authors
- Morera, L., Lübbert, M., & Jung, M.
- Venue
- Clinical Epigenetics
- Published
- 2016-05-24
- Volume
- 8
- Issue
- 1
- Pages
- 57-57
- ISSN
- 1868-7075 (ISSN-L)
- 1868-7083
- OpenAlex
- W2407406252
- Cited by
- 395
- References
- 187
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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