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Clinical and imaging features of mixed Alzheimer and vascular pathologies
Open accessAbstract
The co-occurrence of both Alzheimer disease (AD) pathology and vascular brain injury (VBI) is very common, especially amongst the oldest of old. In neuropathologic studies, the prevalence of AD, VBI, and mixed AD/VBI lesions ranks ahead of Lewy bodies and hippocampal sclerosis. In the modern era of structural magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) imaging, this review examines 1) the prevalence of mixed AD and VBI pathology, 2) the significance of these pathologies for cognitive impairment (AD and vascular cognitive impairment (VCI)), and 3) the diagnosis and treatment of mixed AD/VCI. Although epidemiologic studies report that vascular risk factors for arteriosclerosis increase the risk of incident AD, both autopsy and amyloid PET studies indicate that AD and VBI contribute additively, but independently, to the risk of dementia. The literature confirms the malignancy of AD and highlights the adverse effects of microinfarcts on cognitive function. For the clinical diagnosis of mixed AD/VCI, the presence of AD can be recognized by neuropsychological profile, structural imaging, cerebrospinal fluid biomarkers, and glucose PET and amyloid PET imaging. The diagnosis of VBI, however, still hinges predominantly on the structural MRI findings. Severe amnesia and atrophy of the hippocampus are characteristic of early AD, whereas the cognitive profile for VCI is highly variable and dependent on size and location of VBI. The cognitive profile of mixed AD/VBI is dominated by AD. With the notable exception of microinfarcts (which elude in vivo detection), infarcts, hemorrhages, and white matter hyperintensities on structural MRI currently represent the best markers for the presence VBI. Better markers that reflect the health and reactivity of intracerebral blood vessels are needed. For prevention and treatment, the type of underlying cerebrovascular disease (for example, arteriosclerosis or cerebral amyloid angiopathy) should be considered. It is likely that reduction of vascular risk factors for arteriosclerosis can significantly reduce vascular contributions to mixed dementia.
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“Almost a quarter of AD patients develop Parkinsonian features, but the relative contribution of substantia nigra tangles and Lewy bodies to this presentation is unresolved [122].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [122]
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McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Self-citationNeurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
The projected effect of risk factor reduction on Alzheimer's disease prevalence
Barnes, D. E., & Yaffe, K. S. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70072-2 · Cited by 2,846
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,643
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DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329
“Almost a quarter of AD patients develop Parkinsonian features, but the relative contribution of substantia nigra tangles and Lewy bodies to this presentation is unresolved [122].”
BackgroundIadecola, C., Yaffe, K., Biller, J., Bratzke, L. C., Faraci, F. M., Gorelick, P. B., Gulati, M., Kamel, H., Knopman, D. S., Launer, L. J., et al. (2016) · Hypertension · doi:10.1161/hyp.0000000000000053 · Cited by 746
Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference
Morley, J. E., Morris, J. C., Berg‐Weger, M., Soo Borson, B., Carpenter, B. D., del Campo, N., Dubois, B., Fargo, K. N., Fitten, L. J., Flaherty, J. H., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.06.017 · Cited by 341
Bennett, R. E., Robbins, A. B., Hu, M., Cao, X., Betensky, R. A., Clark, T., Das, S., & Hyman, B. T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710329115 · Cited by 299
Hussain, B., Fang, C., & Chang, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.688090 · Cited by 255
Consensus statement for diagnosis of subcortical small vessel disease
Rosenberg, G. A., Wallin, A., Wardlaw, J. M., Markus, H. S., Montaner, J., WOLFSON, L. I., Iadecola, C., Zloković, B. V., Joutel, A., Dichgans, M., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.172 · Cited by 228
Self-citationMixed dementia: A review of the evidence
Custodio, N., Montesinos, R., Lira, D., Herrera-Pérez, E., Bardales, Y., & Valeriano-Lorenzo, L. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-040005 · Cited by 148
Kandiah, N., Ong, P. A., Turana, Y., Ng, L., Mamun, K., Merchant, R. A., Chen, C., Dominguez, J. C., Marasigan, S., Ampil, E. R., et al. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13095 · Cited by 146
Post-mortem assessment in vascular dementia: advances and aspirations
McAleese, K. E., Alafuzoff, I. I., Charidimou, A., Reuck, J. D., Grinberg, L. T., Hainsworth, A. H., Hortobágyi, T., Ince, P. G., Jellinger, K. A., Gao, J., et al. (2016) · BMC Medicine · doi:10.1186/s12916-016-0676-5 · Cited by 144
Endothelial Dysfunction in Neurodegenerative Diseases
Fang, Y., Hsieh, Y., Hu, C., & Tu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032909 · Cited by 102
Nagata, K., Yamazaki, T., Takano, D., Maeda, T., Fujimaki, Y., Nakase, T., & Sato, Y. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.001 · Cited by 97
Extra-virgin olive oil for potential prevention of Alzheimer disease
Román, G. C., Jackson, R. E., Reis, J. J., Roman, A., Toledo, J. B., & Toledo, E. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.017 · Cited by 95
Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment
Banerjee, G., Wilson, D., Jäger, H. R., & Werring, D. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.010 · Cited by 86
Incidence of Brain Infarcts, Cognitive Change, and Risk of Dementia in the General Population
Sigurdsson, S. O., Aspelund, T., Kjartansson, Ó., Gudmundsson, E. F., Jónsdóttir, M. K., Eiríksdóttir, G., Jónsson, P. V., van Buchem, M. A., Gudnason, V. G., & Launer, L. J. (2017) · Stroke · doi:10.1161/strokeaha.117.017357 · Cited by 79
Alzheimer’s/Vascular Spectrum Dementia: Classification in Addition to Diagnosis
Emrani, S., Lamar, M., Price, C. C., Wasserman, V., Matusz, E. F., Au, R., Swenson, R. A., Nagele, R. G., Heilman, K. M., & Libon, D. J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190654 · Cited by 84
Dias, I. H. K., Brown, C. L. R., Polidori, M. C., Lip, G. Y. H., & Griffiths, H. R. (2015) · Clinical Science · doi:10.1042/cs20150351 · Cited by 75
Dallaire‐Théroux, C., Callahan, B. L., Potvin, O., Saïkali, S., & Duchesne, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161028 · Cited by 71
Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment
van Dinther, M., Hooghiemstra, A. M., Bron, E. E., Versteeg, A., Leeuwis, A. E., Kalay, T., Moonen, J. E. F., Kuipers, S., Backes, W. H., Jansen, J. F. A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13408 · Cited by 66
Prabhakar, P., Chandra, S. R., & Christopher, R. (2017) · Age and Ageing · doi:10.1093/ageing/afx090 · Cited by 65
Hypertension and Alzheimer’s disease pathology at autopsy: A systematic review
Abdulrahman, H., van Dalen, J. W., den Brok, M., Latimer, C. S., Larson, E. B., & Richard, E. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12707 · Cited by 63
Ishii, M., & Iadecola, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.029 · Cited by 63
Alzheimer's disease with cerebrovascular disease: current status in the Asia–Pacific region
Chen, C., Homma, A., Mok, V., Krishnamoorthy, E. S., Alladi, S., Meguro, K., Abe, K., Dominguez, J. C., Marasigan, S., Kandiah, N., et al. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12495 · Cited by 65
Cerebrolysin for vascular dementia
Cui, S., Chen, N., Yang, M., Guo, J., Zhou, M., Zhu, C., & He, L. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008900.pub3 · Cited by 68
Sarro, L., Tosakulwong, N., Schwarz, C. G., Graff‐Radford, J., Przybelski, S. A., Lesnick, T. G., Zuk, S. M., Reid, R. I., Raman, M. R., Boeve, B. F., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.07.003 · Cited by 62
Kapasi, A., Leurgans, S. E., Arvanitakis, Z., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2021) · Stroke · doi:10.1161/strokeaha.120.031073 · Cited by 57
Ethnoracial differences in brain structure change and cognitive change.
Gavett, B. E., Fletcher, E., Harvey, D. J., Farias, S. T., Olichney, J., Beckett, L. A., DeCarli, C. S., & Mungas, D. (2018) · Neuropsychology · doi:10.1037/neu0000452 · Cited by 59
Smith, C. D., Johnson, E. S., Eldik, L. J. V., Jicha, G. A., Schmitt, F. A., Nelson, P. T., Kryscio, R. J., Murphy, R. R., & Wellnitz, C. V. (2016) · Brain and Behavior · doi:10.1002/brb3.438 · Cited by 54
Ramirez-Gomez, L. A., Zheng, L., Reed, B., Kramer, J. H., Mungas, D., Zarow, C., Vinters, H. V., Ringman, J. M., & Chui, H. C. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477344 · Cited by 53
Self-citationNicolini, P., Mari, D., Abbate, C., Inglese, S., Bertagnoli, L., Tomasini, E., Rossi, P. D., & Lombardi, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-68131-x · Cited by 52
Schreiber, S., Wilisch-Neumann, A., Schreiber, F., Assmann, A., Scheumann, V., Perosa, V., Jandke, S., Mawrin, C., Carare, R. O., & Werring, D. J. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12576 · Cited by 50
Lamar, M., Leurgans, S., Kapasi, A., Barnes, L. L., Boyle, P. A., Bennett, D. A., Arfanakis, K., & Schneider, J. A. (2021) · Stroke · doi:10.1161/strokeaha.121.034814 · Cited by 48
Of Energy and Entropy: The Ineluctable Impact of Aging in Old Age Dementia
Boccardi, V., Comanducci, C., Baroni, M., & Mecocci, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122672 · Cited by 47
Ding, J., Zhao, C., Hao, X., & Jiao, H. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70709 · Cited by 50
Tong, X., Trigiani, L. J., & Hamel, É. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1199-0 · Cited by 41
Effects of Plasma Lipids and Statins on Cognitive Function
Li, R., Wang, T., Lyu, P., Liu, Y., Chen, W., Fan, M., & Xu, J. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.225062 · Cited by 40
Anti-Amyloid Therapy, AD, and ARIA: Untangling the Role of CAA
Sin, M., ZAMRINI, E. Y., Ahmed, A., Nho, K. T., & Hajjar, I. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216792 · Cited by 39
Huang, D., Guo, Y., Guan, X., Pan, L., Zhu, Z., Chen, Z., Dijkhuizen, R. M., Duering, M., Yu, F., Boltze, J., et al. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221135353 · Cited by 36
Pathogenesis and Treatment of Vascular Cognitive Impairment
Jellinger, K. A. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.37 · Cited by 30
Low Prevalence of Mixed Dementia in a Cohort of 2,000 Elderly Patients in a Memory Clinic Setting
Claus, J. J., Staekenborg, S. S., Roorda, J. J., Stevens, M., Herderscheê, D., MAARSCHALKERWEERD, W. W. A. V., Schuurmans, L., Tielkes, C. E. M., Koster, P., Bavinck, C., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150796 · Cited by 31
Prabhakar, P., Chandra, S. R., Supriya, M., Issac, T. G., Prasad, C., & Christopher, R. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.10.050 · Cited by 28
Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2016) · Radiology · doi:10.1148/radiol.2016152685 · Cited by 22
Zhang, H., Zhu, W., Niu, T., Wang, Z., An, K., Cao, W., Shi, J., & Wang, S. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01534-5 · Cited by 26
Sokolovič, L., Hofmann, M., Mohammad, N., & Kukolja, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1267434 · Cited by 33
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Diagnosis and treatment of vascular damage in dementia
Biessels, G. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.009 · Cited by 22
Xie, J., Li, X., Zhou, Y., Wu, J., Tan, Y., Ma, X., Zhao, Y., Liu, X., & Zhao, Y. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02742-3 · Cited by 21
High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA
Lin, L., Miao, K., Qian, C., & Wei, L. (2021) · The Analyst · doi:10.1039/d1an00060h · Cited by 18
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Chui, H. C., & Gomez, L. A. R. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.007 · Cited by 19
Self-citationAli, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., Bahaa, M. M., Al-Ibrahim, F., & Batiha, G. E. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70118 · Cited by 17
McNeal, D. W., Brandner, D. D., Gong, X., Postupna, N. O., Montine, T. J., Keene, C. D., & Back, S. A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw032 · Cited by 17
Suchy‐Dicey, A. M., Oziel, K., Sawyer, C., Olufadi, Y., Ali, T., Fretts, A. M., Umans, J. G., Shibata, D. K., Longstreth, W. T., Rhoads, K., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000201261 · Cited by 16
Siafaka, P. I., Bülbül, E. Ö., Dilsiz, P., Karantas, I. D., Okur, M. E., & Okur, N. Ü. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1859516 · Cited by 16
Sex and gender differences in dementia
Salwierz, P., Davenport, C., Sumra, V., Iulita, M. F., Ferretti, M. T., & Tartaglia, M. C. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.07.002 · Cited by 16
Neuroimaging of Diseases Causing Dementia
Masdeu, J. C. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.08.003 · Cited by 16
Claus, J. J., Coenen, M., Staekenborg, S. S., Schuur, J., Tielkes, C. E. M., Koster, P., & Scheltens, P. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171111 · Cited by 14
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Bentvelzen, A. C., Kochan, N. A., Saks, D., Chander, R. J., Koncz, R., Aam, S., Alves, G. S., Briceño, E. M., Brodtmann, A. G., Cerami, C., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.47948 · Cited by 15
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Veličkaitė, V., Giedraitis, V., Ström, K., Alafuzoff, I. I., Zetterberg, H., Lannfelt, L., Kilander, L., Larsson, E., & Ingelsson, M. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0601-6 · Cited by 12
Briggs, R., Kennelly, S., & O’Neill, D. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_15 · Cited by 12
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Pavuluri, K., Huston, J., Ehman, R. L., Manduca, A., Jack, C. R., Senjem, M. L., Vemuri, P., & Murphy, M. C. (2024) · Brain Communications · doi:10.1093/braincomms/fcae073 · Cited by 15
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Bennett, R. E., Hu, M., Fernandes, A. R., Pérez-Rando, M., Robbins, A. B., Kamath, T. V., Dujardin, S., & Hyman, B. T. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01014-4 · Cited by 11
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Lange, C., Suppa, P., Maeurer, A., Ritter, K., Pietrzyk, U., Steinhagen‐Thiessen, E., Fiebach, J. B., Spies, L., & Buchert, R. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9647-x · Cited by 11
Cerebral Amyloid Angiopathy, Dementia, and Alzheimer Neuropathologic Changes
Sin, M., Cheng, Y., Ahmed, A., Roseman, J. M., Dowling, N. M., & ZAMRINI, E. Y. (2024) · Neurology · doi:10.1212/wnl.0000000000210009 · Cited by 10
Rosenberg, G. A., Prestopnik, J., Knoefel, J. E., Adair, J. C., Thompson, J., Raja, R., & Caprihan, A. (2019) · Brain Sciences · doi:10.3390/brainsci9080187 · Cited by 10
Choi, E.-J., Kim, B., Kim, H.-J., Kwon, M., Han, N. E., Lee, S.-M., Jo, S., Lee, S.-J., & Lee, J.-H. (2021) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000516230 · Cited by 7
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Eckerström, C., Eckerström, M., Göthlin, M., Molinder, A., Jonsson, M. A. G., Kettunen, P., Svensson, J., Rolstad, S., & Wallin, A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190651 · Cited by 11
Tsentidou, G., Μoraitou, D., Tsolaki, M., Masoura, E. V., & Papaliagkas, V. T. (2022) · Diagnostics · doi:10.3390/diagnostics12123017 · Cited by 9
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Gorina, Y. V., Komleva, Y. K., Osipova, E. D., Morgun, A. V., Malinovskaya, N. A., Lopatina, O. L., & Salmina, A. B. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2020-4-46-52 · Cited by 8
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Lee, H., Wiggermann, V., Rauscher, A., Kames, C., Beg, M. F., Popuri, K., Tam, R. C., Lam, K., Jacova, C., Shahinfard, E., et al. (2022) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2022.65 · Cited by 8
Garriga, M., Milà‐Alomà, M., Mir, M. A., Al-Baradie, R. S., Huertas, S., Castejon, C., Casas, L., Badenes, D., Giménez, N., Font, M. À., et al. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00099 · Cited by 8
Tabeeva, G. R., Kalimeeva, E. Y., Koberskaya, N. N., & Gereeva, S. I. (2017) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2017-3-36-41 · Cited by 8
Ali, D. G., Abner, E. L., Bahrani, A. A., El Khouli, R., Gold, B. T., Jiang, Y., Wilcock, D. M., & Jicha, G. A. (2023) · Brain Sciences · doi:10.3390/brainsci13020218 · Cited by 6
Holz, M. R., Kochhann, R., Ferreira, P. C. D. S., Tarrasconi, M., Chaves, M. L. F., & Fonseca, R. P. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-040013 · Cited by 7
Добрынина, Л. А., Gadzhieva, Z. S., Akhmetzyanov, B. M., Kalashnikova, L. A., & Кротенкова, М. В. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201911912281 · Cited by 7
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Heterogeneous Disease Progression in a Mouse Model of Vascular Cognitive Impairment
Lee, N. K., Kim, H., Yang, J., Kim, J., Son, J. P., Jang, H., & Na, D. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082820 · Cited by 6
Genetic and degenerative disorders primarily causing dementia
Masdeu, J. C., & Pascual, B. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53485-9.00026-x · Cited by 6
The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features
Sabayan, B., Wyman‐Chick, K. A., & Sedaghat, S. (2022) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2022.07.001 · Cited by 5
Castilla‐Martí, L., García‐Sánchez, A., Martínez, J., Rosende‐Roca, M., Vargas, L., Tartari, J. P., Casales, F., Rodríguez, J. N., Bein, N., Alegret, M., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01616-3 · Cited by 5
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Maki, Y., Ubuka, T., & Yamane, Y. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241301806 · Cited by 4
You, T., Wang, Y., Xu, J., Zhao, Y., Peng, S., Han, Q., Wang, X., Zhang, M., Shen, W., Guo, M., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01117-y · Cited by 4
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Grames, M. S., Dayton, R. D., Lu, X., Schilke, R. M., Alexander, J. S., Orr, A. W., Barmada, S. J., Woolard, M. D., & Klein, R. L. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180494 · Cited by 4
Medrano, M. Z., Castro-Tejada, G., Lantigua, R., Silvestre, G., Díaz, S., Mota, P., & Diaz‐Garelli, F. (2021) · Dementia & Neuropsychologia · doi:10.1590/1980-57642021dn15-010007 · Cited by 3
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DIABETES MELLITUS E A DOENÇA DE ALZHEIMER
Lopes, C. M., Monteiro, J. C. D. S., Pessôa, I. A., Wan-Meyl, F. D. S., & Burbano, R. M. R. (2018) · Arquivos Catarinenses de Medicina · doi:10.63845/t6dy5649 · Cited by 1
Metadata
- Authors
- Chui, H. C., & Ramirez-Gomez, L.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Chui, Helena C
- Venue
- Alzheimer's Research & Therapy
- Published
- 2015-02-27
- Volume
- 7
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1758-9193 (ISSN-L)
- PMC
- PMC4342006
- OpenAlex
- W2104703797
- Cited by
- 124
- References
- 70
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 16 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 9
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Alzheimer s Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG005142, P01AG012435)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, vascular brain injury, vascular cognitive impairment, dementia, microinfarcts, white matter hyperintensities, cerebral amyloid angiopathy, arteriosclerosis, amyloid PET, cerebrospinal fluid biomarkers, structural MRI, cognitive impairment, vascular risk factors, hippocampal atrophy, amnesia
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