The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
Open accessAbstract
Background: This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA). Methods: The BMSCs were extracted from rat bone marrow of the femur and tibia. Chondrocytes were treated with IL-1β to establish the in vitro model of OA. Chondrocyte proliferation and migration were assessed by CCK-8 and transwell assay, respectively. A rat model of OA was established by injection of sodium iodoacetate. At 6 weeks after the model was established, the knee joint specimens and dorsal root ganglion (DRG) of rats were collected for histologic analyses. For pain assessment, paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were evaluated before model establishment and at 1, 2, 4, and 6 weeks after model establishment. Results: Exosomes can be endocytosed with the chondrocytes in vitro. Exosome treatment significantly attenuated the inhibitory effect of IL-1β on the proliferation and migration of chondrocytes. Exosome pre-treatment significantly attenuated IL-1β-induced downregulation of COL2A1 and ACAN and upregulation of MMP13 and ADAMTS5. In the animal study, exosome treatment significantly upregulated COL2A1 protein and downregulated MMP13 protein in the cartilage tissue of the OA rat. At weeks 2, 4, and 6, the PWL value was significantly improved in the exosome-treated OA rats as compared with the untreated OA animals. Moreover, exosome treatment significantly alleviated the upregulation of CGRP and iNOS in the DRG tissue of OA rats. Conclusion: BMSC-derived exosomes can effectively promote cartilage repair and extracellular matrix synthesis, as well as alleviate knee pain in the OA rats.
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Citations
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Glyn-Jones, S., Palmer, A. J. R., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015) · The Lancet · doi:10.1016/s0140-6736(14)60802-3 · Cited by 3,151
Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,076
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.-P., & Fahmi, H. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.196 · Cited by 2,778 · cited 10×
“2a, IL-1β treatment significantly downregulated COL2A1 and ACAN and upregulated MMP13 and ADAMTS5 mRNA expressions (all P < 0.01); however, exosome pretreatment (40 μg) significantly attenuated IL-1β-induced changes in the expression of these genes (all P < 0.05).”
BackgroundInfluentialKraus, V. B., Huebner, J. L., DeGroot, J., & Bendele, A. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.04.015 · Cited by 1,771
Nociceptors: the sensors of the pain pathway
Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,409
Matrix Metalloproteinases: Role In Arthritis
Burrage, P. (2006) · Frontiers in Bioscience · doi:10.2741/1817 · Cited by 1,292
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Chen, D., Shen, J., Zhao, W., Wang, T., Han, L., Hamilton, J. L., & Im, H.-J. (2017) · Bone Research · doi:10.1038/boneres.2016.44 · Cited by 1,187
Using exosomes, naturally-equipped nanocarriers, for drug delivery
Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,041
Felson, D. T. (2006) · New England Journal of Medicine · doi:10.1056/nejmcp051726 · Cited by 986
Cited by
Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review
Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 163
Fan, L., Guan, P., Xiao, C., Wen, H., Wang, Q., Liu, C., Luo, Y., Ma, L., Tan, G., Yu, P., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.005 · Cited by 152
Self-citationChen, X., Zheng, J., Yin, L., Li, Y., & Liu, H. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04846-1 · Cited by 34
Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration
Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32
Gerami, M. H., Khorram, R., Rasoolzadegan, S., Mardpour, S., Nakhaei, P., Hashemi, S., Al-Naqeeb, B. Z. T., Aminian, A., & Samimi, S. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01034-5 · Cited by 27
Retracted
Metadata
- Authors
- He, L., He, T., Xing, J., Zhou, Q., Fan, L., Liu, C., Chen, Y., Wu, D., Tian, Z., Liu, B., & Rong, L.
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-07-10
- Volume
- 11
- Issue
- 1
- Pages
- 276-276
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W3042195964
- Cited by
- 435
- References
- 47
- FWCI
- 29.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. https://app.cochat.ai/papers/10.1186/s13287-020-01781-w
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- He, L., He, T., Xing, J., Zhou, Q., Fan, L., Liu, C., Chen, Y., Wu, D., Tian, Z., Liu, B., & Rong, L. (2020). Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-020-01781-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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