The challenge of developing human 3D organoids into medicines
Open accessAbstract
The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the fields of developmental and stem cell biology. We are currently establishing the foundations for translational applications of organoids such as drug screening, personalized medicine and launching the future of cell therapy using organoids. However, clinical translation of organoids into cell replacement therapies is halted due to (A) a few preclinical studies demonstrating their efficacy and (B) the lack of robust, reproducible, and scalable methods of production in compliance with current pharmaceutical standards. In this issue of Stem Cell Research & Therapy [ref], Dossena and collaborators present a validated bioprocess design for large-scale production of human pancreatic organoids from cadaveric tissue in accordance with current good manufacturing practice. The authors also propose a set of specifications of starting materials and critical quality attributes of final products that are of interest to other developments provided that this type of medicines are different than any other medicinal product due to their complex composition and living nature of the active ingredient. Although large-scale production of functional cells secreting insulin is still a challenge, the development of methods such as the one presented by Dossena and collaborators contributes to move toward clinical use of organoids in the treatment of type 1 diabetes and opens avenues for future clinical use of organoids in degenerative pathologies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intestinal organoids can fuse into tubular structures resembling in vivo intestines.
“Sachs and colleagues showed that intestinal organoids could fuse into tubular structures resembling in vivo intestines148,149.”
From Organoids (2022) · cites this paper as [149]
The Background says organoids can resemble native organs, but it does not describe intestinal organoids fusing into tubular structures or attribute such a finding to Sachs. Searches for intestinal tubular fusion and Sachs found no passage addressing that specific claim. (LLM, conf=0.74)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Modeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196 · see citing works
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170 · see citing works
Broutier, L., Andersson-Rolf, A., Hindley, C. J., Boj, S. F., Clevers, H., Koo, B.-K., & Huch, M. (2016) · Nature Protocols · doi:10.1038/nprot.2016.097 · Cited by 834 · see citing works
Dekkers, J. F., Berkers, G., Kruisselbrink, E., Vonk, A., de Jonge, H. R., Janssens, H. M., Bronsveld, I., van de Graaf, E. A., Nieuwenhuis, E. E. S., Houwen, R. H. J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8278 · Cited by 548 · see citing works
Takebe, T., & Wells, J. M. (2019) · Science · doi:10.1126/science.aaw7567 · Cited by 417 · see citing works
Cell-Based Therapeutics: The Next Pillar of Medicine
Fischbach, M., Bluestone, J., & Lim, W. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005568 · Cited by 410 · see citing works
Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells
Takebe, T., Sekine, K., Kimura, M., Yoshizawa, E., Ayano, S., Koido, M., Funayama, S., Nakanishi, N., Hisai, T., Kobayashi, T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.005 · Cited by 405 · see citing works
Challenges with advanced therapy medicinal products and how to meet them
Schneider, C. K., & Celis, P. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3052 · Cited by 230 · see citing works
Organoids for Drug Discovery and Personalized Medicine
Takahashi, T. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021108 · Cited by 202 · see citing works
Reconstruction of the Human Colon Epithelium In Vivo
Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2017.11.012 · Cited by 196 · see citing works
Gagliardi, G., M’Barek, K. B., Chaffiol, A., Slembrouck-Brec, A., Conart, J., Nanteau, C., Rabesandratana, O., Sahel, J., Duebel, J., Orieux, G., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.07.005 · Cited by 176 · see citing works
Loomans, C. J. M., Giuliani, N. W., Balak, J. R. A., Ringnalda, F. C. A., van Gurp, L., Huch, M., Boj, S., Sato, T., Kester, L., Lopes, S. M. C. D. S., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.005 · Cited by 145 · see citing works
Standardized GMP-compliant scalable production of human pancreas organoids
Dossena, M., Piras, R., Cherubini, A., Barilani, M., Dugnani, E., Salanitro, F., Moreth, T., Pampaloni, F., Piemonti, L., & Lazzari, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-1585-2 · Cited by 84 · see citing works
Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling
Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 64 · see citing works
Dayem, A. A., Lee, S., Kim, K., Lim, K. M., Jeon, T.-I., & Cho, S. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.5.089 · Cited by 27 · see citing works
Álvarez-Palomo, B., Vives, J., Casaroli-Marano, R. P., Gomez, S. G., Gómez, L. R., Edel, M. J., & Querol, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040476 · Cited by 26 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [6]Vives J, Carmona G, Vives J, Carmona G. Guide to Cell Therapy GxP. 1st ed. London: Academic Press (Elsevier); 2015. p. 266.
Cited by
Sorted by citations
Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,001 · see citing works
Bioengineering Approaches for the Advanced Organoid Research
Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218 · see citing works
Pereira, J. D., DuBreuil, D. M., Devlin, A., Held, A., Sapir, Y., Berezovski, E., Hawrot, J., Dorfman, K., Chander, V., & Wainger, B. J. (2021) · Nature Communications · doi:10.1038/s41467-021-24776-4 · Cited by 155 · see citing works
Automated high-speed 3D imaging of organoid cultures with multi-scale phenotypic quantification
Béghin, A., Grenci, G., Sahni, G., Guo, S., Rajendiran, H., Delaire, T., Raffi, S. B. M., Blanc, D., Mets, R. D. M. D., Ong, H. T., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01508-0 · Cited by 141 · see citing works
In Vitro Strategies to Vascularize 3D Physiologically Relevant Models
Dellaquila, A., Le Bao, C., Letourneur, D., & Simon‐Yarza, T. (2021) · Advanced Science · doi:10.1002/advs.202100798 · Cited by 115 · see citing works
Xiang, D., He, A., Zhou, R., Wang, Y., Xiao, X., Gong, T., Kang, W., Lin, X., Wang, X., Consortium11, P.-B. D., et al. (2024) · Theranostics · doi:10.7150/thno.96027 · Cited by 108 · see citing works
Advances in Gold Nanoparticle-Based Combined Cancer Therapy
Bromma, K., & Chithrani, D. B. (2020) · Nanomaterials · doi:10.3390/nano10091671 · Cited by 95 · see citing works
Levelling the Translational Gap for Animal to Human Efficacy Data
Ferreira, G. S., Veening-Griffioen, D. H., Boon, W., Moors, E. H. M., & van Meer, P. J. K. (2020) · Animals · doi:10.3390/ani10071199 · Cited by 89 · see citing works
Future regenerative medicine developments and their therapeutic applications
Altyar, A. E., El-Sayed, A., Abdeen, A., Piscopo, M., Mousa, S. A., Najda, A., & Abdel‐Daim, M. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114131 · Cited by 92 · see citing works
Engineered organoids for biomedical applications
de Barros, N. R., Wang, C., Maity, S., Peirsman, A., Nasiri, R., Herland, A., Ermis, M., Kawakita, S., de Carvalho, B. G., Kouchehbaghi, N. H., et al. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115142 · Cited by 56 · see citing works
de Melo, B. A. G., Benincasa, J. C., Cruz, E. M., Maricato, J. T., & Porcionatto, M. A. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.11.009 · Cited by 51 · see citing works
Kidney organoids: current knowledge and future directions
Rad, N. K., Ahmadi, A., & Moghadasali, R. (2022) · Cell and Tissue Research · doi:10.1007/s00441-021-03565-x · Cited by 46 · see citing works
Advancement of Organoid Technology in Regenerative Medicine
Arjmand, B., Rabbani, Z. H., Soveyzi, F., Tayanloo-Beik, A., Rezaei–Tavirani, M., Biglar, M., Adibi, H., & Larijani, B. A. (2022) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-022-00271-0 · Cited by 45 · see citing works
Recent advances in organoid engineering: A comprehensive review
Unagolla, J. M., & Jayasuriya, A. C. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101582 · Cited by 44 · see citing works
<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing
Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Contessi Negrini, N., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Święszkowski, W., et al. (2023) · Biomaterials Science · doi:10.1039/d1bm01872h · Cited by 40 · see citing works
Liu, C., Niu, K., & Xiao, Q. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa313 · Cited by 31 · see citing works
Salivary gland organoid transplantation as a therapeutic option for radiation-induced xerostomia
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03833-x · Cited by 22 · see citing works
A pancreas tumor derived organoid study: from drug screen to precision medicine
Yao, J., Yang, M., Atteh, L. L., Liu, P., Mao, Y., Meng, W., & Li, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02044-1 · Cited by 19 · see citing works
Intestinal organoids: roadmap to the clinic
Kasendra, M. J., Troutt, M. L., Broda, T. R., Bacon, W. C., Wang, T. C., Niland, J. C., & Helmrath, M. A. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00425.2020 · Cited by 18 · see citing works
Organoid Models and Next-Generation Sequencing for Bone Marrow and Related Disorders
Rausch, M., Iqbal, N., Pathak, S., Owston, H. E., & Ganguly, P. (2023) · Organoids · doi:10.3390/organoids2030010 · Cited by 18 · see citing works
Fan, T. W. ‐., Higashi, R. M., Chernayavskaya, Y., & Lane, A. N. (2020) · Metabolites · doi:10.3390/metabo10060249 · Cited by 16 · see citing works
Organoids as a new approach for improving pediatric cancer research
Lampis, S., Galardi, A., Paolo, V. D., & Giannatale, A. D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1414311 · Cited by 16 · see citing works
Elvira, R., Tan, E., & Zhou, Z. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04660-4 · Cited by 14 · see citing works
Béghin, A., Grenci, G., Rajendiran, H., Delaire, T., Raffi, S. B. M., Blanc, D., Mets, R. D. M. D., Ong, H. T., Acharya, V., Sahini, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.26.437121 · Cited by 12 · see citing works
Yoo, S., & Lee, H. J. (2024) · Cells Tissues Organs · doi:10.1159/000541416 · Cited by 13 · see citing works
Shen, Y., & Kokaia, Z. (2025) · Cells · doi:10.3390/cells14141074 · Cited by 12 · see citing works
Induced Pluripotent Stem Cell-Derived Cardiomyocytes: From Regulatory Status to Clinical Translation
Soares, C. S. P., & Ribeiro, M. H. L. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0080 · Cited by 10 · see citing works
Highly Efficient Methods to Culture Mouse Cholangiocytes and Small Intestine Organoids
Chen, W., Yao, Q., Wang, R., Fen, B., Chen, J., Xu, Y., Yu, J., Li, L., & Cao, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.907901 · Cited by 9 · see citing works
Generation of Individualized, Standardized, and Electrically Synchronized Human Midbrain Organoids
Harane, S. E., Nazari, B., Harane, N. E., Locatelli, M., Zidi, B., Durual, S., Karmime, A., Ravier, F., Roux, A., Stoppini, L., et al. (2025) · Cells · doi:10.3390/cells14151211 · Cited by 8 · see citing works
Hong, C.-E., & Lyu, S. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17101258 · Cited by 8 · see citing works
Gibeaud, A., Pizzorno, A., & Terrier, O. (2025) · Current Opinion in Virology · doi:10.1016/j.coviro.2025.101452 · Cited by 7 · see citing works
Stem Cell-Derived Organoids for Cancer Therapy: Precision Medicine and Drug Selection
Azim, M. M. N., Bhajan, S. K., Park, J. H., Abass, K. S., Rahman, A., Choi, M., Choi, J., Park, S., Kim, H. J., Akter, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27072954 · Cited by 7 · see citing works
Porcine Kidney Organoids Derived from Naïve-like Embryonic Stem Cells
Li, M., Guo, X., Cheng, L., Zhang, H., Zhou, M., Zhang, M., Yin, Z., Guo, T., Zhao, L., Liu, H., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010682 · Cited by 7 · see citing works
Liput, M., Magliaro, C., Kuczynska, Z., Zayat, V., Ahluwalia, A. D., & Bużańska, L. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22818 · Cited by 7 · see citing works
Organoids and Commercialization
Mukherjee, A., Sinha, A., Maibam, M., Bisht, B., & Paul, M. K. (2022) · Biomedical engineering · doi:10.5772/intechopen.104706 · Cited by 6 · see citing works
Enacting Authenticity: Changing Ontologies of Biological Entities
Hogle, L. F. (2022) · Springer eBooks · doi:10.1007/978-981-16-7084-8_28 · Cited by 5 · see citing works
Computational and stem cell biology
Kumar, R., Jastrzębska, A. M., Cucchiarin, M., Chhillar, N., & Chhillar, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13222-3.00003-4 · Cited by 4 · see citing works
Jalali, H., Rahimian, S., Shahsavarian, N., Norouzi, R., Ahmadiyeh, Z., Najafi, H., & Golchin, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123198 · Cited by 4 · see citing works
Pistollato, F., Campia, I., Daskalopoulos, E. P., Bernasconi, C., Desaintes, C., Virgilio, S. D., Kyriakopoulou, C., Whelan, M., & Deceuninck, P. (2023) · Health Research Policy and Systems · doi:10.1186/s12961-023-00981-z · Cited by 4 · see citing works
Veterinary Regenerative Medicine: The Evolving Role of Stem Cell-Based Therapies
Aeri, A., Gorla, M., & Sharma, G. T. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10963-z · Cited by 3 · see citing works
Setiawan, J., Rizal, D. M., Sofyantoro, F., Priyono, D. S., Septriani, N. I., Mafiroh, W. U., Kotani, T., Matozaki, T., & Putri, W. A. (2024) · Regenerative Medicine · doi:10.2217/rme-2023-0176 · Cited by 3 · see citing works
Ni, K., Che, B., Yang, C., Qin, Y., Gu, R., Wang, C., Luo, M., & Deng, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1033043 · Cited by 3 · see citing works
Potency Assays: The ‘Bugaboo’ of Stem Cell Therapy
Torrents, S., Grau-Vorster, M., & Vives, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-30040-0_3 · Cited by 2 · see citing works
Self-citationHazra, M. (2022) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2022.v75i01.007 · Cited by 1 · see citing works
Developmental Pattern Formation: Spanish Contributions from a Biophysical Perspective
Buceta, J., & Guitou, L. (2023) · Biophysica · doi:10.3390/biophysica3020022 · Cited by 1 · see citing works
Recent advances and current limitations of vascular organoids
Yoon, N., Kim, S., & Park, J. (2026) · Organoid · doi:10.51335/organoid.2026.6.e6 · Cited by 1 · see citing works
Tools to enable animal to human translation
Ferreira, G. S. (2020) · doi:10.33540/157 · Cited by 1 · see citing works
A Cultured Sensorimotor Organoid Model Forms Human Neuromuscular JunctionsPreprint
Pereira, J. D., DuBreuil, D. M., Devlin, A., Held, A., Sapir, Y., Berezovski, E., Hawrot, J., Dorfman, K., Chander, V., & Wainger, B. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.03.433128 · Cited by 1 · see citing works
Cell isolation and Organoid Culture from Mouse Liver and Small IntestinePreprint
Chen, W., Yao, Q., Wang, R., Xu, Y., Yu, J., Wu, J., Li, L., & Cao, H. (2021) · Research Square · doi:10.21203/rs.3.rs-673633/v1
(2022) · nternational Journal of Public Health Pharmacy and Pharmacology · doi:10.37745/ijphpp.15/vol7no2pp.1-8
(2022) · nternational Journal of Public Health Pharmacy and Pharmacology · doi:10.37745/ijphpp.15/vol10n3pp1421
Hazra, M. (2022) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2022.v75i02.004
Organoids: a powerful evolutive tool
Fernández‐Gutiérrez, B. (2023) · ANALES RANM · doi:10.32440/ar.2023.140.01.ed01
Cryopreservation and utility of cancer organoids and cartilage microtissues
Shajib, M. S. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.244762
Regulatory and clinical translation
Vilela, C. A., Lucas, J., Cunha, P., Cerqueira, R. J., Costa, J., da Costa, J. C., Rocha, M., Macedo, F., & Marquet, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91821-3.00010-4
Regenerative Medicine and Bioprinting
Ghezelayagh, Z., Qashqaie, A., Tahamtani, Y., Hasanzad, M., & Aghayan, H. R. (2024) · Springer eBooks · doi:10.1007/978-981-97-4974-4_6
Modeling human kidney in vitro - the potential of renal organoids and tubuloids for urology
Filipková, V., Pelikán, T., Zachoval, R., & Heneberg, P. (2025) · Česká urologie · doi:10.48095/cccu2025019
Pistollato, F., Campia, I., Daskalopoulos, E. P., Bernasconi, C., Desaintes, C., Virgilio, S. D., Kyriakopoulou, C., Whelan, M., & Deceuninck, P. (2023) · Figshare · doi:10.6084/m9.figshare.23606929
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943075
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943078
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943066
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943072
Pistollato, F., Campia, I., Daskalopoulos, E. P., Bernasconi, C., Desaintes, C., Virgilio, S. D., Kyriakopoulou, C., Whelan, M., & Deceuninck, P. (2023) · Figshare · doi:10.6084/m9.figshare.23606932
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943069
Organoids in biliary tract cancers: Advances in modeling strategies and translational applications
Yang, X.-H., Liu, D.-Y., Zhao, W., Yang, C.-W., Wang, J.-X., & Yao, H. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105468
Huang, Y., Zhang, T., Chen, S., Zhou, H., Xu, H., Zhang, F., Li, L., & Lyu, F. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103676
- Authors
- Vives, J., & Batlle-Morera, L.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Vives, Joaquim
- ORCID
- Vives, Joaquim
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-03-04
- Volume
- 11
- Issue
- 1
- Pages
- 72-72
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7055107
- OpenAlex
- W3012339302
- Cited by
- 65
- References
- 16
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 9 · 2020: 6
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Funders
- Ministerio de Ciencia, Innovación y Universidades (PI19/01788)
- Instituto de Salud Carlos III (RD16/0011/0028)
- Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (2017-SGR-719)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- current good manufacturing practice, type 1 diabetes, cell replacement therapy, insulin-secreting cells, cadaveric tissue, critical quality attributes, drug screening, personalized medicine, cell therapy
- MeSH terms
- Humans, Organoids, Imaging, Three-Dimensional, Tissue Engineering, Regenerative Medicine, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
