The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site
Open accessAbstract
Background: Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the recipient’s immune system. Therefore, a detailed understanding of the innate or adaptive immune cells-derived responses against allogeneic transplanted hepatic cells is the key to rationalize cell-based therapies. Methods: Here, we induced an acute inflammatory regenerative niche (3–96 h) on the surface of the liver by the application of cryo-injury (CI) to systematically evaluate the innate immune response against transplanted allogeneic hepatic progenitors in a sustained micro-inflammatory environment. Results: The resulting data highlighted that the injured site was significantly repopulated by alternating numbers of innate immune cells, including neutrophils, monocytes and Kupffer cells (KCs), from 3 to 96 h. The transplanted allo-HPs, engrafted 6 h post-injury, were collectively eliminated by the innate immune response within 24 h of transplantation. Selective depletion of the KCs demonstrated a delayed recruitment of monocytes from day 2 to day 6. In addition, the intrasplenic engraftment of the hepatic progenitors 54 h post-transplantation was dismantled by KCs, while a time-dependent better survival and translocation of the transplanted cells into the injured site could be observed in samples devoid of KCs. Conclusion: Overall, this study provides evidence that KCs ablation enables a better survival and integration of allo-HPs in a sustained liver inflammatory environment, having implications for rationalizing the cell-based therapeutic interventions against liver defects.
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“Consequently, KCs depletion impairs these MoMFs response (21, 30).”
From Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics (2026) · cites this paper as [30]
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Liver inflammation and fibrosis
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“Since wound repair is the manifestation of trans-differentiated HSCs into collagen-producing myofibroblasts after an injury [51, 52], the αSMA IHC analysis revealed active HSCs appeared in injured site at 24 h post-injury, it was 12 h later compared to appearance of KCs (Fig.”
ResultTreatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation
Fox, I. J., Chowdhury, J. R., Kaufman, S. S., Goertzen, T. C., Chowdhury, N. R., Warkentin, P. I., Dorko, K., Sauter, B. V., & Strom, S. C. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382004 · Cited by 1,022
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860
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Macrophage niche imprinting as a determinant of macrophage identity and function
Kloc, M., Hałasa, M., & Ghobrial, R. M. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104825 · Cited by 5
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Self-citationEngineering strategies for the clinical translation of organoids
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Human 3D liver spheroids support productive infection of a novel tick-borne phenuivirus
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Metadata
- Authors
- Abbas, N., You, K., Getachew, A., Wu, F., Hussain, M., Huang, X., Chen, Y., Pan, T., & Li, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of Alabama at Birmingham (US)
- New York University (US)
- Zhujiang Hospital (CN)
- Corresponding author
- Li, Yinxiong
- Venue
- Stem Cell Research & Therapy
- Published
- 2024-02-20
- Volume
- 15
- Issue
- 1
- Pages
- 48-48
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC10877762
- OpenAlex
- W4391965420
- Cited by
- 5
- References
- 67
- Citations by year
- 2026: 4 · 2024: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Key R&D Program of China (2019YFA0111300)
- China-New Zealand Joint Laboratory on Biomedicine and Health (2022YFE0210600)
- Guangdong Basic and Applied Basic Research Foundation (2021A1515220095)
- Guangzhou Science and technology planning project (202102021138)
- Guangzhou Science and Technology Program (2023B01J1004)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- Kupffer cells, hepatocyte transplantation, cell engraftment, innate immune response, cryoinjury, liver regeneration, monocytes, neutrophils, Kupffer cell depletion, allogeneic rejection, cell therapy
- MeSH terms
- Kupffer Cells, Liver, Liver Regeneration, Hematopoietic Stem Cell Transplantation, Hepatocytes
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