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Cited by 34Clinical Laboratory Practices and Quality ControlSystemic Lupus Erythematosus ResearchAdvanced Biosensing Techniques and Applications

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The perspective on standardisation and harmonisation: the viewpoint of the EASI president

Open access
Damoiseaux, Jan·2020·Autoimmunity Highlights
DOI 10.1186/s13317-020-0127-3PMC PMC7065346
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Abstract

Standardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may offer an alternative approach to better align requesting, testing, reporting and interpretation of autoimmune diagnostics. The European Autoimmunity Standardisation Initiative (EASI) was founded to facilitate both standardisation as well as harmonisation of autoantibody tests, but over the years the focus has drifted away from standardisation in favour of harmonisation. In the current paper the options for harmonisation are highlighted.

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  • Classification criteria for a disease should be rather robust in order to enable widespread usage, but as far as autoantibodies are concerned, detection of autoantibodies is not standardized and only poorly harmonized.

    “Altogether, it is obvious that classification criteria for a disease should be rather robust in order to enable widespread usage, but as far as autoantibodies are concerned, it should be realized that detection of autoantibodies is not standardized and only poorly harmonized [33].”

    From Anti-dsDNA antibodies in the classification criteria of systemic lupus erythematosus (2022) · cites this paper as [33]

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Research works printed but not linked: 41

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Metadata

Authors
Damoiseaux, J.
Affiliations
Maastricht University Medical Centre (NL)
Corresponding author
Damoiseaux, Jan
ORCID
Damoiseaux, Jan
Venue
Autoimmunity Highlights
Publisher
Springer Science and Business Media LLC
Published
2020-02-06
Volume
11
Issue
1
Pages
4-4
ISSN
  • 2038-0305 (ISSN-L)
  • 2038-3274
DOI
10.1186/s13317-020-0127-3
PMC
PMC7065346
OpenAlex
W3012219282
Cited by
34
References
2
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 2
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Autoimmunity Highlights (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
Keywords
assay standardization, harmonization, international reference standards

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