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Cited by 194

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts

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Vallée, Alexandre, Lecarpentier, Yves·2019·Cell & Bioscience
DOI 10.1186/s13578-019-0362-3
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Abstract

Myofibroblasts are non-muscle contractile cells that play a key physiologically role in organs such as the stem villi of the human placenta during physiological pregnancy. They are able to contract and relax in response to changes in the volume of the intervillous chamber. Myofibroblasts have also been observed in several diseases and are involved in wound healing and the fibrotic processes affecting several organs, such as the liver, lungs, kidneys and heart. During the fibrotic process, tissue retraction rather than contraction is correlated with collagen synthesis in the extracellular matrix, leading to irreversible fibrosis and, finally, apoptosis of myofibroblasts. The molecular motor of myofibroblasts is the non-muscle type IIA and B myosin (NMMIIA and NMMIIB). Fibroblast differentiation into myofibroblasts is largely governed by the transforming growth factor-β1 (TGF-β1). This system controls the canonical WNT/β-catenin pathway in a positive manner, and PPARγ in a negative manner. The WNT/β-catenin pathway promotes fibrosis, while PPARγ prevents it. This review focuses on the contractile properties of myofibroblasts and the conductor, TGF-β1, which together control the opposing interplay between PPARγ and the canonical WNT/β-catenin pathway.

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Metadata

Authors
Vallée, A., & Lecarpentier, Y.
Venue
Cell & Bioscience
Publisher
Springer Science and Business Media LLC
Published
2019-12
Volume
9
Issue
1
Pages
98-98
ISSN
2045-3701 (ISSN-L)
DOI
10.1186/s13578-019-0362-3
OpenAlex
W2995002380
Cited by
194
References
22
FWCI
6.16
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts. https://app.cochat.ai/papers/10.1186/s13578-019-0362-3
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Vallée, A., & Lecarpentier, Y. (2019). TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts. Cell & Bioscience. https://doi.org/10.1186/s13578-019-0362-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.