Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy
Open accessAbstract
Our understanding of the tumor microenvironment (TME), including the interplay between tumor cells, stromal cells, immune cells, and extracellular matrix components, is mandatory for the innovation of new therapeutic approaches in cancer. The cell-cell communication within the TME plays a pivotal role in the evolution and progression of cancer. Cancer-associated fibroblasts (CAF) and tumor-associated macrophages (TAM) are major cell populations in the stroma of all solid tumors and often exert protumorigenic functions; however, the origin and precise functions of CAF and TAM are still incompletely understood. CAF and TAM hold significant potential as therapeutic targets to improve outcomes in oncology when combined with existing therapies. The regulation of CAF/TAM communication and/or their differentiation could be of high impact for improving the future targeted treatment strategies. Nevertheless, there is much scope for research and innovation in this field with regards to the development of novel drugs. In this review, we elaborate on the current knowledge on CAF and TAM in cancer and cancer immunotherapy. Additionally, by focusing on their heterogenous functions in different stages and types of cancer, we explore their role as potential therapeutic targets and highlight certain aspects of their functions that need further research.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fibroblasts constitute the dominant cellular mass among stromal cells within the tumor microenvironment.
“Among the various stromal cells within the TME, fibroblasts constitute the dominant cellular mass [27,28,29,30].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400 · see citing works
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,178 · see citing works
The consensus molecular subtypes of colorectal cancer
Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3967 · Cited by 5,170 · see citing works
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works
Macrophage plasticity, polarization, and function in health and disease
Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930 · see citing works
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367 · see citing works
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · cited 5× · see citing works
“Similarly, an initial expansion of local fibroblasts circumscribing early or premalignant lesions in response to tissue neoplasia was observed in mouse models and human tissue studies (14, 28, 29).”
BackgroundInfluentialOlive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170 · see citing works
The prognostic landscape of genes and infiltrating immune cells across human cancers
Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,097 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,693 · see citing works
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works
Macrophages as regulators of tumour immunity and immunotherapy
DeNardo, D. G., & Ruffell, B. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0127-6 · Cited by 2,542 · see citing works
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Aceto, N., Bardia, A., Miyamoto, D. T., Collier, M. D., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,438 · see citing works
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · see citing works
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296 · see citing works
Stromal fibroblasts in cancer initiation and progression
Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004) · Nature · doi:10.1038/nature03096 · Cited by 2,291 · see citing works
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel, J. J., Chowell, D., & Chan, T. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0116-x · Cited by 2,286 · see citing works
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
Gordon, S. R., Maute, R. L., Dulken, B. W., Hutter, G., George, B. M., McCracken, M. N., Gupta, R., Tsai, J. M., Sinha, R., Corey, D., et al. (2017) · Nature · doi:10.1038/nature22396 · Cited by 2,247 · see citing works
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241 · see citing works
Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100 · see citing works
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851 · see citing works
DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715 · see citing works
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
Costa, A., Kieffer, Y., Scholer-Dahirel, A., Pelon, F., Bourachot, B., Cardon, M., Sirven, P., Magagna, I., Fuhrmann, L., Bernard, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.011 · Cited by 1,705 · cited 2× · see citing works
“In human triple-negative breast cancer, a subset of CAF with myofibroblast characteristics (myCAF) (a-SMA/FAP or S1 CAF) was identified as a key player in immunosuppression through the attraction of Tregs and inhibition of effector T cell proliferation (36) and it was hypothesized that targeting the CAF-S1-mediated im…”
BackgroundPhenotype molding of stromal cells in the lung tumor microenvironment
Lambrechts, D., Wauters, E., Boeckx, B., Aibar, S., Nittner, D., Burton, O., Bassez, A., Decaluwé, H., Pircher, A., Van den Eynde, K., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0096-5 · Cited by 1,648 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Neutrophils escort circulating tumour cells to enable cell cycle progression
Szczerba, B. M., Castro-Giner, F., Vetter, M. H. F., Krol, I., Gkountela, S., Landin, J., Scheidmann, M. C., Donato, C., Scherrer, R., Singer, J., et al. (2019) · Nature · doi:10.1038/s41586-019-0915-y · Cited by 1,229 · see citing works
Targeting Tumor Microenvironment for Cancer Therapy
Roma-Rodrigues, C., Mendes, R., Baptista, P. V., & Fernandes, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040840 · Cited by 1,187 · see citing works
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., & Fearon, D. T. (2010) · Science · doi:10.1126/science.1195300 · Cited by 1,134 · see citing works
Targeting STAT3 in Cancer Immunotherapy
Zou, S., Tong, Q., Liu, B., Huang, W., Tian, Y., & Fu, X. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01258-7 · Cited by 1,075 · see citing works
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Calon, A., Lonardo, E., Berenguer-Llergo, A., Espinet, E., Hernando-Momblona, X., Iglesias, M., Sevillano, M., Palomo-Ponce, S., Tauriello, D. V. F., Byrom, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3225 · Cited by 1,070 · see citing works
Zhang, Q., Liu, L., Gong, C., Shi, H., Zeng, Y., Wang, X., Zhao, Y., & Wei, Y.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050946 · Cited by 1,041 · see citing works
Zeng, Z., Li, Y., Pan, Y., Lan, X.-L., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07810-w · Cited by 995 · see citing works
Fibroblast heterogeneity in the cancer wound
Öhlund, D., Elyada, E., & Tuveson, D. A. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140692 · Cited by 940 · see citing works
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Kieffer, Y., Hocine, H. R., Gentric, G., Pelon, F., Bernard, C., Bourachot, B., Lameiras, S., Albergante, L., Bonneau, C., Guyard, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1384 · Cited by 910 · see citing works
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Liu, T., Han, C., Wang, S., Fang, P., Ma, Z., Xu, L., & Yin, R. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0770-1 · Cited by 860 · see citing works
Dominguez, C. X., Müller, S., Keerthivasan, S., Koeppen, H., Hung, J., Gierke, S., Breart, B., Foreman, O., Bainbridge, T. W., Castiglioni, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0644 · Cited by 857 · see citing works
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
Jetten, N., Verbruggen, S. E. L., Gijbels, M. J., Post, M. J., de Winther, M. P. J., & Donners, M. M. P. C. (2013) · Angiogenesis · doi:10.1007/s10456-013-9381-6 · Cited by 841 · see citing works
Nywening, T. M., Wang‐Gillam, A., Sanford, D. E., Belt, B. A., Panni, R. Z., Cusworth, B. M., Toriola, A. T., Nieman, R., Worley, L. A., Yano, M., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)00078-4 · Cited by 818 · see citing works
Glutamine Metabolism in Cancer: Understanding the Heterogeneity
Cluntun, A. A., Lukey, M. J., Cerione, R. A., & Locasale, J. W. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.01.005 · Cited by 796 · see citing works
Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration
Das, A., Sinha, M., Datta, S., Abas, M., Chaffee, S. M., Sen, C. K., & Roy, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.001 · Cited by 747 · see citing works
Macrophages and cancer: from mechanisms to therapeutic implications
Ostuni, R., Kratochvill, F., Murray, P. J., & Natoli, G. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.004 · Cited by 685 · see citing works
André, T., de Gramont, A., Vernerey, D., Chibaudel, B., Bonnetain, F., Tijeras-Raballand, A., Scriva, A., Hickish, T., Tabernero, J., Van Laethem, J. L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.4238 · Cited by 683 · see citing works
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes
Winer, A., Adams, S., & Mignatti, P. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0646 · Cited by 655 · see citing works
Kumar, V., Donthireddy, L., Marvel, D., Condamine, T., Wang, F., Lavilla-Alonso, S., Hashimoto, A., Vonteddu, P., Behera, R., Goins, M. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.005 · Cited by 653 · see citing works
Iliopoulos, D., Hirsch, H. A., Wang, G., & Struhl, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018898108 · Cited by 642 · see citing works
Loeffler, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26532 · Cited by 633 · see citing works
Laklai, H., Miroshnikova, Y. A., Pickup, M. W., Collisson, E. A., Kim, G., Barrett, A., Hill, R. C., Lakins, J. N., Schlaepfer, D. D., Mouw, J. K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4082 · Cited by 598 · see citing works
Malignant cells facilitate lung metastasis by bringing their own soil
Duda, D. G., Duyverman, A. M. M. J., Kohno, M., Snuderl, M., Steller, E. J. A., Fukumura, D., & Jain, R. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016234107 · Cited by 594 · see citing works
Lakins, M. A., Ghorani, E., Munir, H., Martins, C. P., & Shields, J. D. (2018) · Nature Communications · doi:10.1038/s41467-018-03347-0 · Cited by 578 · see citing works
Xu, J., Escamilla, J., Mok, S., David, J., Priceman, S. J., West, B. L., Bollag, G. E., McBride, W. H., & Wu, L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3981 · Cited by 571 · see citing works
The impact of hypoxia on tumor-associated macrophages
Henze, A.-T., & Mazzone, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84427 · Cited by 565 · see citing works
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Amakye, D. D., Jagani, Z., & Dorsch, M. (2013) · Nature Medicine · doi:10.1038/nm.3389 · Cited by 547 · see citing works
Comito, G., Giannoni, E., Segura, C. P., Barcellos‐de‐Souza, P., Raspollini, M. R., Baroni, G., Lanciotti, M., Serni, S., & Chiarugi, P. (2013) · Oncogene · doi:10.1038/onc.2013.191 · Cited by 530 · see citing works
Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment
Teleanu, R. I., Chircov, C., Grumezescu, A. M., & Teleanu, D. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010084 · Cited by 508 · see citing works
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Lo, A., Wang, L.-C. S., Scholler, J., Monslow, J., Avery, D., Newick, K., O'Brien, S., Evans, R. A., Bajor, D. J., Clendenin, C., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3041 · Cited by 498 · see citing works
Yan, W., Wu, X., Zhou, W., Fong, M., Cao, M., Liu, J., Liu, X., Chen, C.-H., Fadare, O., Pizzo, D. P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0083-6 · Cited by 466 · see citing works
Jarnicki, A., Lysaght, J., Todryk, S. M., & Mills, K. H. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.896 · Cited by 446 · see citing works
Chen, W.-J., Ho, C., Chang, Y., Chen, H., Ling, T., Ling, T., Yuan, S., Yuan, S.-S., Chen, Y.-J. L., Lin, C.-Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4472 · Cited by 442 · see citing works
Cazet, A. S., Hui, M. N., Elsworth, B. L., Wu, S. Z., Roden, D., Chan, C.-L., Skhinas, J. N., Collot, R., Yang, J., Harvey, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05220-6 · Cited by 437 · see citing works
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., et al. (2019) · Nature · doi:10.1038/s41586-019-1130-6 · Cited by 431 · see citing works
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
Sanz-Moreno, V., Gaggioli, C., Yeo, M., Albrengues, J., Wallberg, F., Viros, A., Hooper, S., Mitter, R., Féral, C. C., Cook, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.018 · Cited by 409 · see citing works
Tsuyada, A., Chow, A., Wu, J., Somlo, G., Chu, P. G., Loera, S., Luu, T. H., Li, A. X., Wu, X., Ye, W., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3567 · Cited by 408 · see citing works
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Scherz-Shouval, R., Santagata, S., Mendillo, M. L., Sholl, L. M., Ben-Aharon, I., Beck, A. H., Dias-Santagata, D., Koeva, M., Stemmer, S. M., Whitesell, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.045 · Cited by 386 · see citing works
Zheng, P., Luo, Q., Wang, W., Li, J., Wang, T., Wang, P., Chen, L., Zhang, P., Chen, H., Liu, Y., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0465-5 · Cited by 381 · see citing works
Extracellular Matrix Alterations in Metastatic Processes
Paolillo, M., & Schinelli, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194947 · Cited by 378 · see citing works
Strachan, D. C., Ruffell, B., Oei, Y. A., Bissell, M. J., Coussens, L. M., Pryer, N., & Daniel, D. (2013) · OncoImmunology · doi:10.4161/onci.26968 · Cited by 376 · see citing works
Tumor macrophages are pivotal constructors of tumor collagenous matrix
Afik, R., Zigmond, E., Vugman, M., Klepfish, M., Shimshoni, E., Pasmanik‐Chor, M., Shenoy, A., Bassat, E., Halpern, Z., Geiger, T., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151193 · Cited by 376 · see citing works
Albrengues, J., Bertero, T., Grasset, E. M., Bonan, S., Maiel, M., Bourget, I., Philippe, C., Herráiz, C., Benamar, S., Croce, O., et al. (2015) · Nature Communications · doi:10.1038/ncomms10204 · Cited by 369 · see citing works
Durable antitumor responses to CD47 blockade require adaptive immune stimulation
Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., Ploegh, H. L., & Garcia, K. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604268113 · Cited by 366 · see citing works
Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
Vidak, E., Javoršek, U., Vizovišek, M., & Turk, B. (2019) · Cells · doi:10.3390/cells8030264 · Cited by 365 · see citing works
Zhang, R., Qi, F., Zhao, F., Li, G., Shao, S., Zhang, X., Yuan, L., & Feng, Y. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1435-2 · Cited by 343 · see citing works
Martinez‐Outschoorn, U., di Prisco, M., Ertel, A., Tsirigos, A., Lin, Z., Pavlides, S., Wang, C., Flomenberg, N., Knudsen, E. S., Howell, A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.8.15330 · Cited by 341 · see citing works
Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly
Atieh, Y., Clark, A. G., Graß, C., Richon, S., Pocard, M. D., Mariani, P., Elkhatib, N., Betz, T., Gurchenkov, B., & Vignjevic, D. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201702033 · Cited by 339 · see citing works
Binenbaum, Y., Fridman, E., Yaari, Z. A., Milman, N., Schroeder, A., David, G. B., Shlomi, T., & Gil, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0124 · Cited by 339 · see citing works
Loberg, R. D., Chi, Y., Craig, M., Day, L. L., Sargent, E., Neeley, C. K., Wojno, K. J., Snyder, L. A., Li, Y., & Pienta, K. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1286 · Cited by 333 · see citing works
Heichler, C., Koop, K., Schmied, A., Geppert, C. I., Schmid, B., Wirtz, S. J., Thoma, O., Kramer, V., Waldner, M. J., Büttner, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319200 · Cited by 330 · see citing works
Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship
Netea-Maier, R. T., Smit, J. W. A., & Netea, M. G. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.037 · Cited by 326 · see citing works
Goulet, C. R., Champagne, A., Bernard, G., Vandal, D., Chabaud, S., Pouliot, F., & Bolduc, S. (2019) · BMC Cancer · doi:10.1186/s12885-019-5353-6 · Cited by 322 · see citing works
The Promise of Targeting Macrophages in Cancer Therapy
Brown, J. M., Recht, L. D., & Strober, S. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3122 · Cited by 321 · see citing works
Yoshida, G. J. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01611-0 · Cited by 321 · see citing works
Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer
Sandfeld‐Paulsen, B., Jakobsen, K. R., Bæk, R., Folkersen, B. H., Rasmussen, T. R., Meldgaard, P., Varming, K., Jørgensen, M. M., & Sørensen, B. S. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.05.034 · Cited by 311 · see citing works
Chittezhath, M., Dhillon, M. K., Lim, J. Y., Laoui, D., Shalova, I. N., Teo, Y. L., Chen, J., Kamaraj, R., Raman, L. N. M., Lum, J., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.014 · Cited by 309 · see citing works
Lee, H., Mullins, S., Franco‐Barraza, J., Valianou, M., Cukierman, E., & Cheng, J. D. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-245 · Cited by 306 · see citing works
Neuzillet, C., Tijeras‐Raballand, A., Ragulan, C., Cros, J. F., Patil, Y., Martinet, M., Erkan, M., Kleeff, J. H., Wilson, J. S., Apte, M. V., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5224 · Cited by 296 · see citing works
Herrera, M., Herrera, A., Domínguez, G., Silva, J., García‐Barberán, V., García, J. M., Gómez, I., Soldevilla, B., Muñoz, C., Provencio, M., et al. (2013) · Cancer Science · doi:10.1111/cas.12096 · Cited by 289 · see citing works
Fearon, D. T. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0002 · Cited by 288 · see citing works
Gong, J., Lin, Y., Zhang, H., Liu, C., Cheng, Z., Yang, X., Zhang, J., Xiao, Y., Jie, H., Qian, X., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2434-z · Cited by 287 · see citing works
Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma
Asgharzadeh, S., Salo, J., Ji, L., Oberthuer, A., Fischer, M., Berthold, F., Hadjidaniel, M. D., Liu, C. W.-Y., Metelitsa, L. S., Piqué-Regi, R., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.9169 · Cited by 285 · see citing works
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Zhou, W., Guo, S., Liu, M., Burow, M. E., & Wang, G. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170830111531 · Cited by 279 · see citing works
Caro, G. D., Cortese, N., Castino, G. F., Grizzi, F., Gavazzi, F., Ridolfi, C., Capretti, G. L., Mineri, R., Todoric, J., Zerbi, A., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309193 · Cited by 275 · see citing works
Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses
Anfray, C., Ummarino, A., Andón, F. T., & Allavena, P. (2019) · Cells · doi:10.3390/cells9010046 · Cited by 275 · see citing works
Circulating giant macrophages as a potential biomarker of solid tumors
Adams, D. L., Martin, S. S., Alpaugh, R. K., Charpentier, M. S., Tsai, S., Bergan, R. C., Ogden, I., Catàlona, W. J., Chumsri, S., Tang, C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320198111 · Cited by 272 · see citing works
The Origin and Functions of Exosomes in Cancer
Rajagopal, C., & Harikumar, K. B. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00066 · Cited by 268 · see citing works
Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer
Liu, Q., Yu, Z., Yuan, S., Xie, W., Li, C., Hu, Z., Xiang, Y., Wu, N., Wu, L., Bai, L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14369 · Cited by 258 · see citing works
Loges, S., Schmidt, T., & Carmeliet, P. (2010) · Genes & Cancer · doi:10.1177/1947601909356574 · Cited by 257 · see citing works
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.002 · Cited by 245 · see citing works
Kong, J., Tian, H., Zhang, F., Zhang, Z., Li, J., Liu, X., Li, X., Liu, J., Li, X., Jin, D., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1101-4 · Cited by 239 · see citing works
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
Arina, A., Idel, C., Hyjek, E. M., Alegre, M.-L., Wang, Y., Bindokas, V. P., Weichselbaum, R. R., & Schreiber, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600363113 · Cited by 238 · see citing works
Ao, Z., Shah, S. H., Machlin, L., Parajuli, R., Miller, P. C., Rawal, S., Williams, A. J., Côté, R. J., Lippman, M. E., Datar, R. H., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1633 · Cited by 235 · see citing works
Tiainen, S., Tumelius, R., Rilla, K. J., Hämäläinen, K. M., Tammi, M., Tammi, R., Kosma, V., Oikari, S., & Auvinen, P. (2014) · Histopathology · doi:10.1111/his.12607 · Cited by 234 · see citing works
Shabo, I., Stål, O., Olsson, H., Doré, S., & Svanvik, J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23527 · Cited by 225 · see citing works
Extracellular Matrix, a Hard Player in Angiogenesis
Mongiat, M., Andreuzzi, E., Tarticchio, G., & Paulitti, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111822 · Cited by 221 · see citing works
Zheng, X., Weigert, A., Reu, S., Günther, S., Mansouri, S., Bassaly, B., Gattenlöhner, S., Grimminger, F., Pullamsetti, S. S., Seeger, W., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0069 · Cited by 218 · see citing works
Cho, H., Seo, Y., Loke, K. M., Kim, S.-W., Oh, S.-M., Kim, J.-H., Soh, J., Kim, H. S., Lee, H., Kim, J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0125 · Cited by 212 · see citing works
Cancer-associated fibroblasts—heroes or villains?
Gieniec, K. A., Butler, L. M., Worthley, D. L., & Woods, S. L. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0509-3 · Cited by 212 · see citing works
Patsialou, A., Wyckoff, J. B., Wang, Y., Goswami, S., Stanley, E. R., & Condeelis, J. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1868 · Cited by 207 · see citing works
Shin, K., Lim, A. Y.-L., Zhao, C., Sahoo, D., Pan, Y., Spiekerkoetter, E. F., Liao, J. C., & Beachy, P. A. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.001 · Cited by 200 · see citing works
TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts
Vallée, A., & Lecarpentier, Y. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0362-3 · Cited by 200 · see citing works
CAFs and TAMs: maestros of the tumour microenvironment
Komohara, Y., & Takeya, M. (2016) · The Journal of Pathology · doi:10.1002/path.4824 · Cited by 197 · see citing works
Gorchs, L., Moro, C. F., Bankhead, P., Kern, K. P., Sadeak, I., Meng, Q., Rangelova, E. B., & Kaipe, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00847 · Cited by 193 · see citing works
Fujii, N., Shomori, K., Shiomi, T., Nakabayashi, M., Takeda, C., Ryoke, K., & Ito, H. (2012) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2012.01127.x · Cited by 192 · see citing works
Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer
Yeo, E.-J., Cassetta, L., Qian, B., Lewkowich, I. P., Li, J., Stefater, J. A., Smith, A. N., Wiechmann, L., Wang, Y., Pollard, J. W., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2421 · Cited by 190 · see citing works
Hashimoto, O., Yoshida, M., Koma, Y., Yanai, T., Hasegawa, D., Kosaka, Y., Nishimura, N., & Yokozaki, H. (2016) · The Journal of Pathology · doi:10.1002/path.4769 · Cited by 190 · see citing works
Argyle, D. J., & Kitamura, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02629 · Cited by 190 · see citing works
Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects
Kamarudin, M. N. A., Sarker, M. M. R., Zhou, J., & Parhar, I. S. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1495-2 · Cited by 190 · see citing works
Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling
Chiang, C., Chao, T., Su, Y., Hsu, C., Chien, C., Chiu, K., Shiah, S., Lee, C.-H., Liu, S.-Y., & Shieh, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.14982 · Cited by 188 · see citing works
Tokuhisa, M., Ichikawa, Y., Kosaka, N., Ochiya, T., Yashiro, M., Hirakawa, K., Kosaka, T., Makino, H., Akiyama, H., Kunisaki, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130472 · Cited by 183 · see citing works
Macciò, A., Gramignano, G., Cherchi, M. C., Tanca, L., Melis, L., & Madeddu, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63276-1 · Cited by 182 · see citing works
Alyosef, H. A., Roggendorf, H., Schneider, D., Inayat, A., Welscher, J., Schwieger, W., Münster, T., Kloess, G. H., Ibrahim, S. S., & Enke, D. (2017) · Molecules · doi:10.3390/molecules23010001 · Cited by 180 · see citing works
Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
Tu, M. M., Abdel-Hafiz, H. A., Jones, R. T., Jean, A., Hoff, K. J., Duex, J. E., Chauca-Diaz, A., Costello, J. C., Dancik, G. M., Tamburini, B. A. J., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01441-y · Cited by 179 · see citing works
Bhagat, T. D., Ahrens, D. V., Dawlaty, M. M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., et al. (2019) · eLife · doi:10.7554/elife.50663 · Cited by 170 · see citing works
Lo, A., Li, C., Buza, E. L., Blomberg, R., Govindaraju, P. K., Avery, D., Monslow, J., Hsiao, M., & Puré, E. (2017) · JCI Insight · doi:10.1172/jci.insight.92232 · Cited by 160 · see citing works
Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization
Marcuzzi, E., Angioni, R., Molon, B., & Calì, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010096 · Cited by 158 · see citing works
Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site
Singh, S., Lomelino, C. L., Mboge, M. Y., Frost, S. C., & McKENNA, R. V. (2018) · Molecules · doi:10.3390/molecules23051045 · Cited by 156 · see citing works
Rai, A., Greening, D. W., Chen, M., Xu, R., Ji, H. L., & Simpson, R. J. (2018) · PROTEOMICS · doi:10.1002/pmic.201800148 · Cited by 156 · see citing works
Feng, Q., Chang, W., Mao, Y., He, G., Zheng, P., Tang, W., Wei, Y., Ren, L., Zhu, D., Ji, M., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2076 · Cited by 152 · see citing works
Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma
Liu, W., Hu, J., Zhou, K., Chen, F., Wang, Z., Liao, B., Dai, Z., Cao, Y., Fan, J., & Zhou, J. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s140062 · Cited by 141 · see citing works
M2 macrophages promote NSCLC metastasis by upregulating CRYAB
Guo, Z., Song, J., Hao, J., Zhao, H., Du, X., Li, E., Kuang, Y., Yang, F., Wang, W. T., Deng, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1618-x · Cited by 140 · see citing works
Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response
Sahraei, M., Chaube, B., Liu, Y., Sun, J., Kaplan, A. R., Price, N. L., Ding, W. Y., Oyaghire, S. N., García-Milian, R., Mehta, S. S., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127125 · Cited by 140 · see citing works
Zhang, H., Wang, X., Shen, Z., Xu, J., Qin, J., & Sun, Y. (2014) · Gastric Cancer · doi:10.1007/s10120-014-0422-7 · Cited by 139 · see citing works
Gandellini, P., Andriani, F., Merlino, G., D’Aiuto, F., Roz, L., & Callari, M. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.08.008 · Cited by 137 · see citing works
Frankenberger, C. A., Rabe, D. C., Bainer, R. O., Sankarasharma, D., Chada, K. K., Krausz, T. N., Gilad, Y., Becker, L., & Rosner, M. R. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3394 · Cited by 137 · see citing works
Gerling, M., Büller, N. V. J. A., Kirn, L. M., Joost, S., Frings, O., Englert, B., Bergström, Å., Kuiper, R., Blaas, L., Wielenga, M. C. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12321 · Cited by 129 · see citing works
Li, M., Zhou, Y., Xia, T., Xin Min, Z. H. O. U., Huang, Z., Zhang, H., Zhu, W., Ding, Q., & Wang, S. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4757-3 · Cited by 128 · see citing works
Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
Giacomoni, J., Bruzelius, A., Stamouli, C. A., & Ottosson, D. R. (2020) · Cells · doi:10.3390/cells9112451 · Cited by 128 · see citing works
Vindin, H., Mithieux, S. M., & Weiss, A. S. (2019) · Matrix Biology · doi:10.1016/j.matbio.2019.07.005 · Cited by 126 · see citing works
Kasashima, H., Durán, Á., Martínez-Ordóñez, A., Nakanishi, Y., Kinoshita, H., Linares, J. F., Reina‐Campos, M., Kudo, Y., L’Hermitte, A., Yashiro, M., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.10.014 · Cited by 116 · see citing works
Wang, J., Yang, K., Yuan, W., & Gao, Z. (2018) · Medical Science Monitor · doi:10.12659/msm.912018 · Cited by 115 · see citing works
Pelekanou, V., Villarroel‐Espíndola, F., Schalper, K. A., Pusztai, L., & Rimm, D. L. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1076-x · Cited by 109 · see citing works
Jia, C., Wang, G., Wang, T., Fu, B., Zhang, Y., Huang, L., Deng, Y., Chen, G., Wu, X., Chen, J., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45446 · Cited by 106 · see citing works
COX/mPGES-1/PGE 2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
Larsson, K., Kock, A., Idborg, H., Arsenian‐Henriksson, M., Martinsson, T., Johnsen, J. I., Korotkova, M., Kogner, P., & Jakobsson, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424355112 · Cited by 105 · see citing works
Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
An, Y.-Y., Liu, F., Chen, Y., & Yang, Q. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14745 · Cited by 98 · see citing works
miR-454-3p Is an Exosomal Biomarker and Functions as a Tumor Suppressor in Glioma
Shao, N., Xue, L., Wang, R., Luo, K., Zhi, F., & Lan, Q. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0725 · Cited by 96 · see citing works
Katsuya, Y., Horinouchi, H., Asao, T., Kitahara, S., Goto, Y., Kanda, S., Fujiwara, Y., Nokihara, H., Yamamoto, N., WATANABE, S.-I. I., et al. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.05.007 · Cited by 93 · see citing works
Liu, B., Guo, H., Xu, J., Qin, T. G., Guo, Q., Gu, N., Zhang, D., Qian, W., Dai, J., Hou, S., et al. (2017) · mAbs · doi:10.1080/19420862.2017.1409319 · Cited by 93 · see citing works
Ortiz-Otero, N., Clinch, A. B., Hope, J. M., Wang, W., Reinhart‐King, C. A., & King, M. R. (2020) · Oncotarget · doi:10.18632/oncotarget.27510 · Cited by 88 · see citing works
Biology and therapeutic targeting of tumour‐associated macrophages
Beltraminelli, T., & Palma, M. D. (2020) · The Journal of Pathology · doi:10.1002/path.5403 · Cited by 87 · see citing works
Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer
Aizawa, T., Karasawa, H., Funayama, R., Shirota, M., Suzuki, T., Maeda, S., Suzuki, H., Yamamura, A., Naitoh, T., Nakayama, K., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2523 · Cited by 82 · see citing works
Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site
Nasrollahzadeh, E., Razi, S., Keshavarz‐Fathi, M., Mazzone, M., & Rezaei, N. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02616-6 · Cited by 81 · see citing works
Wang, H., Hu, W., Xia, Z., Liang, Y., Lu, Y., Lin, S.-X., & Tang, H. (2019) · Journal of Cancer · doi:10.7150/jca.30102 · Cited by 76 · see citing works
Kretzschmar, K., Weber, C., Driskell, R. R., Calonje, E., & Watt, F. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.041 · Cited by 72 · see citing works
Gunderson, A. J., Yamazaki, T., McCarty, K., Phillips, M., Alice, A. F., Bambina, S., Zebertavage, L., Friedman, D. J., Cottam, B., Newell, P., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211117 · Cited by 70 · see citing works
Cancemi, P., Buttacavoli, M., Roz, E., & Feo, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163952 · Cited by 70 · see citing works
Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture
Chen, S., Giannakou, A., Wyman, S., Gruzas, J., Golas, J., Zhong, W., Loreth, C., Sridharan, L., Yamin, T.-T., Damelin, M. I., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803718115 · Cited by 67 · see citing works
Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy
Iessi, E., Logozzi, M., Mizzoni, D., Raimo, R. D., Supuran, C. T., & Fais, S. (2017) · Metabolites · doi:10.3390/metabo8010002 · Cited by 65 · see citing works
Kidney function during acute tubular necrosis: clinical studies and a theory.
Wh, M., & Rubini, M. E. (1959) · PubMed · Cited by 59 · see citing works
Ren, C.-X., Leng, R., Fan, Y., Pan, H., Li, B., Wu, C., Wu, Q., Wang, N., Xiong, Q., Geng, X., et al. (2017) · Oncology Reports · doi:10.3892/or.2017.5738 · Cited by 57 · see citing works
Mawalla, B. C., Yuan, X., Luo, X., & Chalya, P. L. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3137-8 · Cited by 53 · see citing works
Neutrophils: Homing in on the myeloid mechanisms of metastasis
Leach, J. D. G., Morton, J. P., & Sansom, O. J. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.12.013 · Cited by 51 · see citing works
Determinants of Resistance to Checkpoint Inhibitors
Tran, L. L., & Theodorescu, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051594 · Cited by 42 · see citing works
Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway
Wu, M., Lee, W.-J., Hua, K., Kuo, M., & Lin, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134122 · Cited by 41 · see citing works
Raskov, H., Orhan, A., Salanti, A., & Gögenür, I. (2019) · International Journal of Cancer · doi:10.1002/ijc.32820 · Cited by 40 · see citing works
Self-citationNET silencing by let-7i in postural tachycardia syndrome
Khan, A. W., Ziemann, M., Corcoran, S. J., Kaipananickal, H., Okabe, J., Rafehi, H., Maxwell, S., Esler, M., & El‐Osta, A. (2017) · JCI Insight · doi:10.1172/jci.insight.90183 · Cited by 37 · see citing works
Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., et al. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.02.015 · Cited by 34 · see citing works
Tokuda, K., Morine, Y., Miyazaki, K., Yamada, S., Saito, Y., Nishi, M., Tokunaga, T., Ikemoto, T., Imura, S., & Shimada, M. (2021) · Oncotarget · doi:10.18632/oncotarget.27881 · Cited by 33 · see citing works
Matteo, S. D., Nevi, L., Overi, D., Landolina, N., Faccioli, J., Giulitti, F., Napoletano, C., Oddi, A., Marziani, A. M., Costantini, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81172-0 · Cited by 32 · see citing works
Shi, R., Chai, Y., Duan, X., Bi, X., Huang, Q., Wang, Q., Tan, S., Gao, G. F., Zhu, J., & Yan, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0121-2 · Cited by 30 · see citing works
Schmid, B. C., & Oehler, M. K. (2015) · Current Treatment Options in Oncology · doi:10.1007/s11864-014-0318-0 · Cited by 27 · see citing works
Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies
Gustavsson, M. B., Zheng, Y., & Handel, T. M. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2015.10.003 · Cited by 27 · see citing works
Extracellular Matrix in Development and Disease
Oxford, J., Reeck, J., & Hardy, M. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010205 · Cited by 24 · see citing works
Marcuzzi, E., Angioni, R., Molon, B., & Calì, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112651 · Cited by 21 · see citing works
Eiró, N., Carrión, J. F., Cid, S., Andicoechea, A., García-Muñiz, J. L., González, L. O., & Vizoso, F. J. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00611-6 · Cited by 16 · see citing works
Olsson, P. O., Gustafsson, R., Zandt, R. I. ‘., Friman, T., Maccarana, M., Tykesson, E., Oldberg, Å., Rubin, K., & Kalamajski, S. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0026 · Cited by 14 · see citing works
Burmakin, M., van Wieringen, T., Olsson, P. O., Stuhr, L. E. B., Åhgren, A., Heldin, C., Reed, R. K., Rubin, K., & Hellberg, C. B. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1142-7 · Cited by 13 · see citing works
Hofheinz, R., Ronellenfitsch, U., Kubicka, S., Falcone, A., Burkholder, I., & Hacker, U. T. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/9189483 · Cited by 12 · see citing works
Lee, K., Park, J. W., Lee, K.-Y., Cho, S., Kwon, Y., Kim, M. J., Ryoo, S., Jeong, S., & Park, K. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48197-y · Cited by 12 · see citing works
Honda, H., Takamura, M., Yamagiwa, S., Genda, T., Horigome, R., Kimura, N., Setsu, T., Tominaga, K., Kamimura, H., Matsuda, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15800-z · Cited by 10 · see citing works
Gerling, M., Büller, N. V. J. A., Kirn, L. M., Joost, S., Frings, O., Englert, B., Bergström, Å., Kuiper, R., Blaas, L., Wielenga, M. C. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12936 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Macrophages at the interface of the co-evolving cancer ecosystem
Kloosterman, D. J., & Akkari, L. (2023) · Cell · doi:10.1016/j.cell.2023.02.020 · Cited by 436 · see citing works
Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
Zhang, H., Liu, L., Liu, J., Dang, P., Hu, S., Yuan, W., Sun, Z., Liu, Y., & Wang, C. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01725-x · Cited by 399 · see citing works
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lü, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Cañadas, I., Tian, Y., Niu, X., Wang, Y. Z., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 376 · see citing works
Tumor-associated macrophages: an effective player of the tumor microenvironment
Basak, U., Sarkar, T., Mukherjee, S., Chakraborty, S., Dutta, A., Dutta, S., Nayak, D., Kaushik, S., Das, T., & Sa, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295257 · Cited by 346 · see citing works
Cancer-associated fibroblasts: The chief architect in the tumor microenvironment
Sarkar, M., Nguyen, T., Gundre, E., Ogunlusi, O., El-Sobky, M. H., Giri, B., & Sarkar, T. R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1089068 · Cited by 135 · see citing works
Recent Advances and Challenges in Cancer Immunotherapy
Peterson, C. M., Denlinger, N., & Yang, Y. (2022) · Cancers · doi:10.3390/cancers14163972 · Cited by 135 · see citing works
CAFs orchestrates tumor immune microenvironment—A new target in cancer therapy?
Zhang, C., Fei, Y., Wang, H., Hu, S., Liu, C., Hu, R., & Du, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1113378 · Cited by 129 · see citing works
Mori, Y., Novruzov, E., Schmitt, D. R., Cardinale, J., Watabe, T., Choyke, P. L., Alavi, A. A., Haberkorn, U., & Giesel, F. L. (2024) · npj Imaging · doi:10.1038/s44303-024-00053-z · Cited by 122 · see citing works
Feng, S., Xu, Y., Dai, Z., Yin, H., Zhang, K., & Shen, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951582 · Cited by 117 · see citing works
Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development
Samarelli, A. V., Masciale, V., Aramini, B., Coló, G. P., Tonelli, R., Marchioni, A., Bruzzi, G., Gozzi, F., Andrisani, D., Castaniere, I., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212179 · Cited by 92 · see citing works
Exosome as a Delivery Vehicle for Cancer Therapy
Moon, B., & Chang, S. (2022) · Cells · doi:10.3390/cells11030316 · Cited by 88 · see citing works
Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis
Mughees, M., Kaushal, J., Sharma, G., Wajid, S., Batra, S. K., & Siddiqui, J. A. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.017 · Cited by 84 · see citing works
Xu, T., Yu, S., Zhang, J., & Wu, S. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01198-9 · Cited by 78 · see citing works
Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works
“Among the various stromal cells within the TME, fibroblasts constitute the dominant cellular mass [27–30].”
Shao, S., Miao, H., & Ma, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295684 · Cited by 66 · see citing works
Piwócka, O., Piotrowski, I., Suchorska, W. M., & Kulcenty, K. I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1343523 · Cited by 64 · see citing works
Electroporation and Immunotherapy—Unleashing the Abscopal Effect
Justesen, T. F., Orhan, A., Raskov, H., Nolsøe, C., & Gögenür, I. (2022) · Cancers · doi:10.3390/cancers14122876 · Cited by 63 · see citing works
Self-citationRuiz-Martínez, Á., Gong, C., Wang, H., Sové, R. J., Mi, H., Kimko, H. H. C., & Popel, A. S. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010254 · Cited by 62 · see citing works
Long, F., Zhong, W., Zhao, F., Xu, Y., Hu, X., Jia, G., Huang, L., Yi, K., Wang, N., Si, H., et al. (2024) · Theranostics · doi:10.7150/thno.99046 · Cited by 62 · see citing works
Mohammadzadeh, V., Atapour‐Mashhad, H., Shahvali, S., Salehi, B., Shaban, M., Shirzad, M., Salahvarzi, A., & Mohammadi, M. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03613-6 · Cited by 60 · see citing works
McCaffrey, C., Jahangir, C. A., Murphy, C. L., Burke, C., Gallagher, W. M., & Rahman, A. (2024) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2024.2346545 · Cited by 60 · see citing works
Mitochondrial Heteroplasmy Shifting as a Potential Biomarker of Cancer Progression
Pérez-Amado, C. J., Bazan-Cordoba, A., Hidalgo‐Miranda, A., & Jiménez‐Morales, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147369 · Cited by 52 · see citing works
Pradhan, R., Paul, S., Das, B., Sinha, S., Dash, S. R., Mandal, M., & Kundu, C. N. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109257 · Cited by 51 · see citing works
Ramundo, V., Zanirato, G., & Aldieri, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212216 · Cited by 46 · see citing works
Therapeutic strategies for gastric cancer targeting immune cells: Future directions
Zhao, Y. F., Bai, Y., Shen, M., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.992762 · Cited by 44 · see citing works
Role of extracellular matrix architecture and signaling in melanoma therapeutic resistance
Popovic, A., & Tartare‐Deckert, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.924553 · Cited by 42 · see citing works
Aramini, B., Masciale, V., Arienti, C., Dominici, M., Stella, F., Martinelli, G., & Fabbri, F. (2022) · Cancers · doi:10.3390/cancers14102408 · Cited by 43 · see citing works
Pradhan, R., Paul, S., Acharya, S. S., Sinha, S., Dash, S. R., & Kundu, C. N. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109568 · Cited by 42 · see citing works
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
Cauli, E., Polidoro, M. A., Marzorati, S., Bernardi, C., Rasponi, M., & Lleò, A. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00372-6 · Cited by 41 · see citing works
Biomaterials to regulate tumor extracellular matrix in immunotherapy
Zhang, Y., Dong, X., Zhang, Y., Chen, Z., Zhou, G., Chen, N., Shen, W., Yang, K., & Pei, P. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.010 · Cited by 40 · see citing works
Shimizu, M., Koma, Y., Sakamoto, H., Tsukamoto, S., Kitamura, Y., Urakami, S., Tanigawa, K., Kodama, T., Higashino, N., Nishio, M., et al. (2021) · Cancers · doi:10.3390/cancers13184552 · Cited by 39 · see citing works
Liao, T., Chen, X., Qiu, F., Zhang, X., Wu, F., Zhao, Z., Xu, M., Chen, M., Shen, J., Shen, Q., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03217-0 · Cited by 38 · see citing works
Eskandari-Malayeri, F., & Rezaei, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.996145 · Cited by 38 · see citing works
Kara, G., & Özpolat, B. (2024) · Biomedical Microdevices · doi:10.1007/s10544-024-00698-y · Cited by 36 · see citing works
Xu, C., Chen, J., Tan, M., & Tan, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1543096 · Cited by 35 · see citing works
Gu, H., Deng, W., Zhang, Y., Chang, Y., Shelat, V. G., Tsuchida, K., Lino-Silva, L. S., & Wang, Z. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-311 · Cited by 34 · see citing works
Han, J., Dong, L., Wu, M., & Ma, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1160340 · Cited by 35 · see citing works
Circular RNA vaccines: Pioneering the next-gen cancer immunotherapy
Das, U., Banerjee, S., Sarkar, M., Fathah Muhammad, L., Soni, T. K., Saha, M., Pradhan, G., & Chatterjee, B. (2024) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2024.11.003 · Cited by 32 · see citing works
Yan, Y., Yang, Y., Chen, M., Chen, J., Wang, J., Ma, Y., & Qian, H. (2021) · Biomaterials Science · doi:10.1039/d1bm01053k · Cited by 31 · see citing works
Malik, S., Sureka, N., Ahuja, S., Aden, D., Zaheer, S., & Zaheer, S. (2024) · Cell Biology International · doi:10.1002/cbin.12226 · Cited by 30 · see citing works
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy
Masoudi-Khoram, N., Soheilifar, M. H., Ghorbanifar, S., Nobari, S., Hakimi, M., & Hassani, M. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.103967 · Cited by 30 · see citing works
Immunomodulatory glycomedicine: Introducing next generation cancer glycovaccines
Freitas, R., Peixoto, A., Ferreira, E., Miranda, A., Santos, L. L., & Ferreira, J. A. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108144 · Cited by 29 · see citing works
Czekay, R., Higgins, C. E., Aydin, H. B., Samarakoon, R., Subasi, N. B., Higgins, S. P., Lee, H., & Higgins, P. J. (2024) · Cells · doi:10.3390/cells13100796 · Cited by 27 · see citing works
Chen, E., Zeng, Z., & Zhou, W. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189198 · Cited by 29 · see citing works
Microfluidic-based human prostate-cancer-on-chip
Jiang, L., Khawaja, H., Tahsin, S., Clarkson, T. A., Miranti, C. K., & Zohar, Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1302223 · Cited by 26 · see citing works
Sathe, A., Ayala, C. I., Bai, X., Grimes, S. M., Lee, B., Kin, C., Shelton, A. A., Poultsides, G. A., & Ji, H. P. (2023) · Genome Medicine · doi:10.1186/s13073-023-01259-3 · Cited by 27 · see citing works
Ahuja, S., Sureka, N., & Zaheer, S. (2024) · Apmis · doi:10.1111/apm.13447 · Cited by 25 · see citing works
Chiu, K.-J., Chiou, H.-Y. C., Huang, C.-H., Lu, P.-C., Kuo, H.-R., Wang, J., & Lin, M. (2022) · Biomedicines · doi:10.3390/biomedicines10030713 · Cited by 25 · see citing works
Cancer-associated fibroblasts: Versatile mediators in remodeling the tumor microenvironment
Zhang, Q., Wang, Y., & Liu, F. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110567 · Cited by 23 · see citing works
Progress in the application of hydrogels in immunotherapy of gastrointestinal tumors
Zheng, H., Li, M., Wu, L., Liu, W., Liu, Y., Gao, J., & Lu, Z. (2023) · Drug Delivery · doi:10.1080/10717544.2022.2161670 · Cited by 19 · see citing works
Tumour microenvironment and heterotypic interactions in pancreatic cancer
Velasco, R. M., García, A. G., Sánchez, P. J., Sellart, I. M., & Lobo, V. J. S.-A. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00875-8 · Cited by 18 · see citing works
Exosomal miRNAs in the Tumor Microenvironment of Multiple Myeloma
Alipoor, S. D., & Chang, H. (2023) · Cells · doi:10.3390/cells12071030 · Cited by 18 · see citing works
Primary cancer-associated fibroblasts exhibit high heterogeneity among breast cancer subtypes
Piwócka, O., Musielak, M., Piotrowski, I., Kulcenty, K. I., Adamczyk, B., Fundowicz, M., Suchorska, W. M., & Malicki, J. (2023) · Reports of Practical Oncology & Radiotherapy · doi:10.5603/rpor.a2023.0026 · Cited by 17 · see citing works
Wu, T., Li, X., Zheng, F., Liu, H., & Yu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1560998 · Cited by 16 · see citing works
Targeting Cancer Through Thymoquinone: From Molecular Mechanisms to Clinical Prospects
Al-Damook, N., Sakkal, M., Khair, M., Mousa, W. K., Khoder, G., & Ghemrawi, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211029 · Cited by 15 · see citing works
Cholangiocarcinoma in the Era of Immunotherapy
Manthopoulou, E., Ramai, D., Dhar, J., Samanta, J., Ioannou, A., Lusina, E., Sacco, R., & Facciorusso, A. (2023) · Vaccines · doi:10.3390/vaccines11061062 · Cited by 15 · see citing works
Schulz, W. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-16286-2_9 · Cited by 15 · see citing works
Li, Y., & Wang, L. (2026) · Immunology · doi:10.1111/imm.70103 · Cited by 14 · see citing works
Mesenchymal stem cells-macrophages crosstalk and myeloid malignancy
Li, K., Nie, H., Jin, R., & Wu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397005 · Cited by 13 · see citing works
Instigation of the epoch of nanovaccines in cancer immunotherapy
Shah, S., Famta, P., Tiwari, V. K., Kotha, A. K., Kashikar, R., Chougule, M. B., Chung, Y. H., Steinmetz, N. F., Uddin, M. N., Singh, S. B., et al. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1870 · Cited by 13 · see citing works
Chen, Y., Zhang, F., Zhang, B., Trojanowicz, B., Hämmerle, M., Kleeff, J. H., & Sunami, Y. (2024) · Cancer Reports · doi:10.1002/cnr2.1990 · Cited by 12 · see citing works
Cheon, I., Lee, S., Oh, S., & Ahn, Y. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102194 · Cited by 12 · see citing works
Dhungel, N., & Dragoi, A. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1379971 · Cited by 12 · see citing works
Fouillet, J., Torchio, J., Rubira, L., & Fersing, C. (2024) · Biology · doi:10.3390/biology13120967 · Cited by 12 · see citing works
Łabędź, N., Stachowicz-Suhs, M., Psurski, M., Anisiewicz, A., Banach, J., Piotrowska, A., Dzięgiel, P., Maciejczyk, A., Matkowski, R., & Wietrzyk, J. (2022) · Cancers · doi:10.3390/cancers14194585 · Cited by 12 · see citing works
Mun, K., Han, J. W., Roh, P., Park, J. G., Kim, G., Hur, W., Jang, J. W., Choi, J., Yoon, S. K., You, Y.-K., et al. (2023) · Journal of Liver Cancer · doi:10.17998/jlc.2023.04.30 · Cited by 12 · see citing works
Tsai, C., Hsu, Y., Chu, T.-Y., Hsu, P.-C., & Kuo, C. (2025) · Cancers · doi:10.3390/cancers17152590 · Cited by 11 · see citing works
Biomedical Applications of Calcium Carbonate Nanoparticles: A Review of Recent Advances
Popova, V. K., Pyshnyi, D. V., & Dmitrienko, E. V. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00992 · Cited by 11 · see citing works
Jiao, F., Wang, Z., Yuan, J., Shi, F., & Zhang, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1787060 · Cited by 11 · see citing works
Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics
Urbano‐Gámez, J. D., Guzzi, C., Bernal, M., Solivera, J., Martínez-Zubiaurre, I., Caro, C., & García‐Martín, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105213 · Cited by 13 · see citing works
Xu, Y., Wang, T., Liang, X., Yang, J., Zhang, Y., & Bao, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1571800 · Cited by 11 · see citing works
Fu, Y., Li, M., Wu, S., Wang, J., & Wang, S. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08685-2 · Cited by 10 · see citing works
Dual effect of vitamin D3 on breast cancer-associated fibroblasts
Łabędź, N., Anisiewicz, A., Stachowicz-Suhs, M., Banach, J., Kłopotowska, D., Maciejczyk, A., Gazińska, P., Piotrowska, A., Dzięgiel, P., Matkowski, R., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-11961-z · Cited by 10 · see citing works
Morphometry and mechanical instability at the onset of epithelial bladder cancer
Lampart, F. L., Vetter, R., Yamauchi, K. A., Wang, Y., Runser, S. V. M., Strohmeyer, N., Meer, F., Hussherr, M., Camenisch, G., Seifert, H., et al. (2025) · Nature Physics · doi:10.1038/s41567-024-02735-2 · Cited by 10 · see citing works
Wu, C., Mao, Y., Qi, X., Wang, X., Li, P., Zhang, W., & Tang, B. (2024) · Aggregate · doi:10.1002/agt2.530 · Cited by 9 · see citing works
Tumor cell-derived osteopontin promotes tumor fibrosis indirectly via tumor-associated macrophages
Tan, Y., Yang, Y., Zhang, X., Zhao, L., Wang, X., & Liu, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06444-z · Cited by 9 · see citing works
SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer
Yu, J., Yu, S., Bai, J., Zhu, Z., Gao, Y., & Li, Y. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00758-8 · Cited by 8 · see citing works
Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation
Swetha, K. L., Maravajjala, K. S., Li, S., Singh, M. S., & Roy, A. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01194-7 · Cited by 8 · see citing works
Germain, A., & Kim, Y. T. (2023) · Oncology · doi:10.1159/000533773 · Cited by 8 · see citing works
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression
Zhou, Y., Wang, X., Li, H., Fan, M., Wang, M., Gao, W., Shi, Z., Wang, J., Tan, J., & Liu, F. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01558-9 · Cited by 7 · see citing works
Garate-Soraluze, E., Martínez-Zubiaurre, I., & Rodriguez-Ruiz, M. E. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009702 · Cited by 8 · see citing works
Cen, K., Wu, Z., Mai, Y., Dai, Y., Hong, K. M., & Guo, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1074900 · Cited by 7 · see citing works
Doi, T., Matsubara, N., Naito, Y., Kuboki, Y., Harano, K., Ono, M., Urasaki, T., Ohmoto, A., Kawanai, T., Hisai, T., et al. (2023) · Cancer · doi:10.1002/cncr.34788 · Cited by 7 · see citing works
Cancer-associated fibroblasts in neoadjuvant setting for solid cancers
Gu, Y., Chen, Q., Yin, H., Zeng, M., Gao, S., & Wang, X. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104226 · Cited by 7 · see citing works
Silver, F. H. (2025) · Biomolecules · doi:10.3390/biom15040457 · Cited by 6 · see citing works
Bai, R., & Sun, W. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05405-w · Cited by 7 · see citing works
The Role of Lactate Metabolism in Tumors
Tian, Z., Zhang, K., Sheng, S., Kan, C., Han, F., & Sun, X. (2025) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000001276 · Cited by 6 · see citing works
Kattner, N., Bashir, A., & Shaw, J. A. M. (2026) · Diabetologia · doi:10.1007/s00125-026-06678-6 · Cited by 6 · see citing works
Wang, Z., Wang, Z., Jiang, J., Yang, L., Li, C., Deng, X., Li, Y., Yuan, J., Jiang, P., & Wang, J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02600-1 · Cited by 6 · see citing works
Azadi, S., Torkashvand, E., Mohammadi, E., & Tafazzoli‐Shadpour, M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121545 · Cited by 6 · see citing works
Moorthy, T., Yalamandala, B. N., Huynh, T. M. H., Lien, H., Pan, W.-C., Iao, H. M., Chang, Y., & Hu, S. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01935-4 · Cited by 5 · see citing works
Jones, C. F., Dias, D., Moreira, A. C., Gonçalves, G., Cinti, S., Djamgoz, M. B. A., Ferreira, F. C., Sanjuan‐Alberte, P., & Moreddu, R. (2025) · iScience · doi:10.1016/j.isci.2025.113579 · Cited by 5 · see citing works
Understanding the Dual Role of Macrophages in Tumor Growth and Therapy: A Mechanistic Review
Summer, M., Riaz, S., Ali, S., Noor, Q., Ashraf, R., & Khan, R. R. M. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402976 · Cited by 6 · see citing works
Fang, Y., Tan, C., Zheng, Z., Yang, J., Tang, J., Guo, R., Silli, E. K., Chen, Z., Chen, J., Ge, R., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116849 · Cited by 5 · see citing works
Endothelial dysfunction determines vascular mechanisms of metastatic progression in breast cancer
Mirzaeva, M., Mirzayev, A., Iriskulov, B., Бахадировна, А. С., Nizamkhodjaev, S., & Asrorov, A. M. (2026) · Discover Oncology · doi:10.1007/s12672-026-04437-y · Cited by 4 · see citing works
Leveraging selection for function in tumor evolution: System-level cancer therapies
Frédéric Thomas, A., Capp, J., Dujon, A. M., Marusyk, A., Asselin, K., Campone, M., Pujol, P., Alix‐Panabières, C., Roche, B., Újvári, B., et al. (2025) · Evolution Medicine and Public Health · doi:10.1093/emph/eoaf022 · Cited by 4 · see citing works
Pan‐cancer analysis of DCTN2 and its tumour‐promoting role in HCC by modulating the AKT pathway
Xu, S., Xing, J., Li, K., Qiao, L., Zhang, C., Ren, Y., & Liu, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18450 · Cited by 4 · see citing works
Tie, C., Zhu, J., Yu, Z., Dou, L., Wang, M.-L., Wang, G., & Ni, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1310376 · Cited by 3 · see citing works
Rifaat, R. M., Kamel, M., Sharaky, M. M., Attia, Y. M., & Shouman, S. A. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.100953 · Cited by 3 · see citing works
Cancer-Associated Fibroblasts: Clinical Applications in Imaging and Therapy
Nilforoushan, N., Khavaran, A., Palihati, M., Patel, Y., Giarratana, A. O., Das, J. P., & Capaccione, K. M. (2025) · Tomography · doi:10.3390/tomography11120143 · Cited by 3 · see citing works
- Authors
- Raskov, H., Orhan, A., Gaggar, S., & Gögenur, I.
- Affiliations
- Zealand University Hospital Køge (DK)
- University of Copenhagen (DK)
- Corresponding author
- Raskov, Hans
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2021-05-20
- Volume
- 11
- Pages
- 668731-668731
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC8172975
- OpenAlex
- W3163457197
- Cited by
- 150
- References
- 184
- Citations by year
- 2026: 29 · 2025: 32 · 2024: 37 · 2023: 26 · 2022: 20 · 2021: 6
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- cancer-associated fibroblasts, tumor-associated macrophages, tumor microenvironment, cancer immunotherapy, tumor stroma, therapeutic target, intercellular communication, extracellular matrix
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review