Interactions of clinical relevance associated with concurrent administration of prescription drug and food or medicinal plants: a systematic review protocol
Open accessAbstract
Background: An inadequate combination of prescription drugs with food or medicinal plants could cause adverse effects in patients or produce negative therapeutic results. Therefore, this generic systematic review protocol aims to identify and synthesize the literature on clinical characteristics and safety issues of these types of pharmacological interactions occurring in children, adolescents, adults, pregnant/lactating women, and older adults. Methods/design: This generic protocol follows the stated guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement. A literature search will be performed in PubMed, Scopus, and Virtual Health Library (VHL) electronic databases from 1960 till present for studies reporting clinical characteristics and safety issues associated with pharmacological interactions occurring between prescription drugs and food or medicinal plants in participants from birth-age to ≥ 65-year-old, including pregnant/lactating women. Lateral searching will be carried out in PubMed via related citation. Two reviewers will carry out an independent evaluation of eligible studies as well as the corresponding data extraction of the selected ones. Subsequently, the methodological quality evaluation of the selected articles will be completed using the corresponding Joanna Briggs Institute Checklists. Moreover, the quality of evidence will be graded according to the criteria of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group. Quantitative research in humans comprising clinical trials and clinical, comparative and, observational studies will be included. The main outcomes of this protocol involve reported potential food-drug and herb-drug interactions, associated safety issues, and adverse reactions along with the generic name of the prescribed drug and the scientific name of the food and medicinal plants involved in these types of pharmacological interactions. Finally, findings extracted from the selected studies will be summarized in a narrative synthesis. Discussion: This generic systematic review protocol seeks to synthesize and critically evaluate current knowledge besides to identify any comprehension gaps in the concurrent administration of prescription drugs with food and herbs. By achieving a better understanding of this topic, this information will allow healthcare professionals to develop useful strategies to recognize, manage, and prevent these types of pharmacological interactions at different age stages, including pregnant/lactating women. Systematic review registration: PROSPERO CRD42018117308
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Compared to Tsou et al., our results indicate that Rayyan might have a sensitivity superior to Abstrackr at the threshold of <2.5 for exclusion, but it is not possible to compare specificity because Tsou et al. did not report this metric.
“Compared to the results of the study of Tsou et al. [20], our results indicate that Rayyan might have a sensitivity superior to Abstrackr at the threshold of < 2.5 (0.5 and 1.5) for exclusion, but it is not possible to compare the specificity of the tools as they did not report this metric.”
From Abstract screening using the automated tool Rayyan: results of effectiveness in three diagnostic test accuracy systematic reviews (2022) · cites this paper as [20]
The Methods/design > Study selection process describes manual screening by two reviewers, not a comparison of Rayyan and Abstrackr. Searches for those tools, Tsou et al., sensitivity, specificity, and the <2.5 exclusion threshold found no passage addressing the claim in our copy. No page numbers were provided. (LLM, conf=0.78)
Experimental — accuracy not yet measuredTsou et al. in 2020 reported that EPPI-Reviewer achieved a sensitivity of 100% for identifying eligible records after manually screening 39.9-89.8% of records.
“They reported better results with the EPPI-Reviewer, achieving a sensitivity of 100% for identifying eligible records after manually screening 39.9-89.8% of records.”
From Abstract screening using the automated tool Rayyan: results of effectiveness in three diagnostic test accuracy systematic reviews (2022) · cites this paper as [20]
The Methods/design > Study selection process passage describes two reviewers manually screening records using Zotero, but gives no EPPI-Reviewer results. Searches for EPPI-Reviewer, Tsou, 100% sensitivity, and the 39.9–89.8% screening range found no passage addressing the claim; page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredTsou et al. reported that for EPPI-Reviewer, sensitivity was 100% after manually screening 30.1-97.1% of records, while for Abstrackr, sensitivity was 100% after manually screening 39.8-100% of records for identifying eligible reports.
“For the EPPI-Reviewer, they achieved a sensitivity of 100% after manually screening 30.1-97.1% of records, while for Abstrackr, they achieved the same sensitivity value after manually screening 39.8-100% of records.”
From Abstract screening using the automated tool Rayyan: results of effectiveness in three diagnostic test accuracy systematic reviews (2022) · cites this paper as [20]
The Methods/design > Study selection process passage describes two reviewers manually screening titles and abstracts, but gives no results for EPPI-Reviewer or Abstrackr. Searches for those tools, Tsou, and the stated screening percentages found no passage in our copy reporting the claimed sensitivity or ranges; page numbers were not available. (LLM, conf=0.75)
Experimental — accuracy not yet measured
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- Authors
- Orellana-Paucar, A., & Vintimilla-Rojas, D.
- Affiliations
- University of Cuenca (EC)
- Corresponding author
- Orellana-Paucar, Adriana
- Venue
- Systematic Reviews
- Published
- 2020-01-06
- Volume
- 9
- Issue
- 1
- Pages
- 1-1
- ISSN
- 2046-4053 (ISSN-L)
- PMC
- PMC6945643
- OpenAlex
- W3005919160
- Cited by
- 53
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 11
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Systematic Reviews (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Repositorio Institucional (Universidad de Cuenca) (submittedVersion)
- Funders
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu
- Universidad de Cuenca
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- food-drug interactions, herb-drug interactions, prescription drugs, medicinal plants, adverse drug reactions, drug safety, drug interactions, pregnant and lactating women, children and adolescents, older adults
- MeSH terms
- Systematic Reviews as Topic, Drug Therapy, Combination, Humans, Plants, Medicinal, Prescription Drugs, Patient Safety, Drug-Related Side Effects and Adverse Reactions
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