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From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Open accessAbstract
Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders.
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“The gut microbiome, along with its metabolites, has been reported to modulate ghrelin secretion and CNS functions.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [553]
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Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
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Metadata
- Authors
- Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H.
- Affiliations
- University of Liège (BE)
- Chinese Academy of Agricultural Sciences (CN)
- Hunan Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Yin, Jie
- Zhang, Hongfu
- Venue
- Microbiome
- Published
- 2021-07-20
- Volume
- 9
- Issue
- 1
- Pages
- 162-162
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC8293578
- OpenAlex
- W3184092071
- Cited by
- 292
- References
- 238
- Citations by year
- 2026: 45 · 2025: 67 · 2024: 71 · 2023: 61 · 2022: 41 · 2021: 7
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation (31702119, 31672428)
- Agricultural Science and Technology Innovation Program (CAAS-ZDRW202006-02, ASTIP-IAS07)
- Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences (Y2021GH01-4)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, appetite regulation, hunger and satiety, microbial metabolites, appetite-regulating hormones, hypothalamic neurons, immune system, metabolic disorders, microbiome manipulation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Appetite, Appetite Regulation, Humans, Immune System
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