From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

The gut microbiota as an environmental factor that regulates fat storage

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The Microbiota-Gut-Brain Axis

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Richness of human gut microbiome correlates with metabolic markers

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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

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Human Genetics Shape the Gut Microbiome

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Metabolite profiles and the risk of developing diabetes

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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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Psychosomatic medicine in Germany: more timely than ever

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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

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Human gut microbes impact host serum metabolome and insulin sensitivity

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The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

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Dietary fiber and prebiotics and the gastrointestinal microbiota

Holscher, H. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290756 · Cited by 1,808

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

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Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle

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The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

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Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Chambers, E. S., Viardot, A., Psichas, A., Morrison, D. J., Murphy, K. G., Zac-Varghese, S. E. K., MacDougall, K., Preston, T., Tedford, C., Finlayson, G. S., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307913 · Cited by 1,424

Gut microbial metabolites as multi-kingdom intermediates

Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335

Leptin regulation of bone resorption by the sympathetic nervous system and CART

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Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299

Pleiotropic Roles of Bile Acids in Metabolism

de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.013 · Cited by 1,209

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

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γ-Aminobutyric acid production by culturable bacteria from the human intestine

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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

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Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076

Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition

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Mediterranean Diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

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Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

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Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

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Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

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Prevalence and correlates of DSM-5-defined eating disorders in a nationally representative sample of U.S. Adults

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Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

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Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

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Gut hormones and the regulation of energy homeostasis

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Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

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Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

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Daily sampling reveals personalized diet-microbiome associations in humans

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Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

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Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

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Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

Li, Z., Yi, C.-X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C. K., Gao, Y., van den Heuvel, J. K., Meijer, O. C., Berbée, J. F. P., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314050 · Cited by 674

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

Barton, W., Penney, N. C., Cronin, O., Garcia-Perez, I., Molloy, M. G., Holmes, E., Shanahan, F., Cotter, P. D., & O'Sullivan, O. (2018) · Gut · doi:10.1136/gutjnl-2016-313627 · Cited by 647

Toward a Wiring Diagram Understanding of Appetite Control

Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 633

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

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Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

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Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

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Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

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Metabolic and hedonic drives in the neural control of appetite: who is the boss?

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Accumulation of succinate controls activation of adipose tissue thermogenesis

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Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

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Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

Javdan, B., Lopez, J. G., Chankhamjon, P., Lee, Y.-C. J., Hull, R., Wu, Q., Wang, X., Chatterjee, S., & Donia, M. S. (2020) · Cell · doi:10.1016/j.cell.2020.05.001 · Cited by 492

Ghrelin action in the brain controls adipocyte metabolism

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Microbiota modulate sympathetic neurons via a gut–brain circuit

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Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials

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Microbiota-gut-brain axis: Modulator of host metabolism and appetite

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Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

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Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

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Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

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Microbiota depletion promotes browning of white adipose tissue and reduces obesity

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Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour

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Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling

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Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

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GABA production and structure of gadB / gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota

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Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

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Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

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Deciphering a neuronal circuit that mediates appetite

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Leptin secretion and leptin receptor in the human stomach

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Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice—a new potential probiotic for appetite and body weight management

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NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons

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Altered host-gut microbes symbiosis in severely malnourished anorexia nervosa (AN) patients undergoing enteral nutrition: An explicative factor of functional intestinal disorders?

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A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding

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Identifying Microbiome-Mediated Behaviour in Wild Vertebrates

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Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic β-Cell Growth and Insulin Secretion

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Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

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Effects of Intraduodenal Infusion of L-Tryptophan on ad Libitum Eating, Antropyloroduodenal Motility, Glycemia, Insulinemia, and Gut Peptide Secretion in Healthy Men

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Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

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On the origin of eating disorders: altered signaling between gut microbiota, adaptive immunity and the brain melanocortin system regulating feeding behavior

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Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway

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The combined effects of probiotics and restricted calorie diet on the anthropometric indices, eating behavior, and hormone levels of obese women with food addiction: a randomized clinical trial

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Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

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Regional differences in nutrient‐induced secretion of gut serotonin

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Association of Bulimia Nervosa With Long-term Risk of Cardiovascular Disease and Mortality Among Women

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Colonic Absorption of Low-Molecular-Weight Metabolites Influenced by the Intestinal Microbiome: A Pilot Study

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Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival

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Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa

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Chemogenetics defines receptor-mediated functions of short chain free fatty acids

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Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

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Gut microbiota alteration in a mouse model of Anorexia Nervosa

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Emerging role of autoantibodies against appetite-regulating neuropeptides in eating disorders

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Effects of rumen-protected γ-aminobutyric acid on feed intake, lactation performance, and antioxidative status in early lactating dairy cows

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A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

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Mixture of Two Lactobacillus plantarum Strains Modulates the Gut Microbiota Structure and Regulatory T Cell Response in Diet‐Induced Obese Mice

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Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice

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The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

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Effects of gut microbiota on leptin expression and body weight are lessened by high-fat diet in mice

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Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

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Dietary tryptophan affects growth performance, digestive and absorptive enzyme activities, intestinal antioxidant capacity, and appetite and GH–IGF axis-related gene expression of hybrid catfish (Pelteobagrus vachelli♀ × Leiocassis longirostris♂)

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Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress

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Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy

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A novel function of intestinal gluconeogenesis: Central signaling in glucose and energy homeostasis

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Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity

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Tryptophan Supplementation Increases Reproduction Performance, Milk Yield, and Milk Composition in Lactating Sows and Growth Performance of Their Piglets

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Investigation the effect of oleoylethanolamide supplementation on the abundance of Akkermansia muciniphila bacterium and the dietary intakes in people with obesity: A randomized clinical trial

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Glucagon-Like Peptide-1 Inhibits Blood-Brain Glucose Transfer in Humans

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Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders

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Regulation of Enteroendocrine Cell Networks by the Major Human Gut Symbiont Bacteroides thetaiotaomicron

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Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia

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Placental miR-340 mediates vulnerability to activity based anorexia in mice

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Gut Microbiota: FFAR Reaching Effects on Islets

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Intestinal nutrients elicit satiation through concomitant activation of CCK1 and 5-HT3 receptors

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives

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Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases

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Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living

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Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling

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Endocrine Regulation of Appetite: Interactions between Gut Microbiota, Microbial Metabolites, and Appetite-related Hormones

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The effects of gut microbiota on appetite regulation and the underlying mechanisms

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Microbiome and metabolome analyses indicate variations in the gut microbiota that disrupt regulation of appetite

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