Cell toxicity mechanism and biomarker
Open accessAbstract
Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent oxidative stress, cause cell toxicity. Mitochondrion dysfunction maybe the subsequent consequence of oxidative stress and has been recognized as another contributing factor in cell toxicity. Besides, oxidative products induced by some toxicants may also produce the compounds that damage cell DNA, leading to toxicity. Especially, the significance of nanoparticle induced cell toxicity was disclosed recently and attract more concern. The mechanism mainly includes inflammation, oxidative stress and DNA damage. On the other side, some biomarkers of cell toxicity including autophagy, cytokines, miRNA has been identified. The understanding of these phenomenon may enable us to clarify the cell toxicity mechanism then contribute to cell toxicity protection, disease treatment and drug side effect prevention.
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Leaked chemicals can elevate reactive oxygen species levels, inducing oxidative stress that may damage cellular DNA, proteins, and lipids.
“Moreover, these chemicals can elevate reactive oxygen species levels, inducing oxidative stress by increasing the concentration of reactive oxygen species (ROS) that may damage cellular DNA, proteins, and lipids (Zhang, 2018).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Zhang, 2018
The 'ROS and oxidative stress' section says toxic agents can increase ROS production and cause subsequent oxidative stress. The 'DNA damage' section discusses DNA damage alongside oxidative stress, but the copy does not establish the claimed ROS-mediated damage to proteins and lipids or specifically address leaked chemicals. (LLM, conf=0.86)
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1 retracted
Zhou, Y., Wang, Z., Li, W., Hong, H., Chen, J., Tian, Y., & Liu, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26700 · Cited by 59 · see citing works
RetractedNitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
DNA damage-induced cell death by apoptosis
Roos, W. P., & Kaina, B. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.07.007 · Cited by 1,500 · see citing works
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
Roos, W. P., & Kaina, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.01.007 · Cited by 879 · see citing works
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review
Wang, W., Zhou, H., & Liu, L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.027 · Cited by 565 · see citing works
Mitochondrial Function, Biology, and Role in Disease
Murphy, E., Ardehali, H., Balaban, R. S., DiLisa, F., Dorn, G. W., Kitsis, R. N., Otsu, K., Ping, P., Rizzuto, R., Sack, M. N., et al. (2016) · Circulation Research · doi:10.1161/res.0000000000000104 · Cited by 459 · see citing works
Djurišić, A. B., Leung, Y. H., Ng, A. M. C., Xu, X. Y., Lee, P. K. H., Degger, N., & Wu, R. S. S. (2014) · Small · doi:10.1002/smll.201303947 · Cited by 393 · see citing works
Primary concept of nickel toxicity – an overview
Das, K. K., Reddy, R. C., Bagoji, I. B., Das, S. N., Bagali, S., Mullur, L. M., Khodnapur, J. P., & Biradar, M. S. (2018) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2017-0171 · Cited by 357 · see citing works
Nano-sized and micro-sized polystyrene particles affect phagocyte function
Prietl, B., Meindl, C., Roblegg, E., Pieber, T. R., Lanzer, G., & Fröhlich, E. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9265-y · Cited by 239 · see citing works
Deng, X., Rui, W., Zhang, F., & Ding, W. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9242-5 · Cited by 227 · see citing works
Sun, J., Wang, S., Zhao, D., Hun, F. H., Weng, L., & Liu, H. (2011) · Cell Biology and Toxicology · doi:10.1007/s10565-011-9191-9 · Cited by 221 · see citing works
Journal of Basic and Clinical Physiology and Pharmacology
(2011) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp · Cited by 202 · see citing works
Athinarayanan, J., Periasamy, V. S., Alsaif, M. A., Al‐Warthan, A., & Alshatwi, A. A. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9271-8 · Cited by 180 · see citing works
Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns
Kharchoufa, L., Merrouni, I. A., Yamani, A., & Elachouri, M. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.09.003 · Cited by 176 · see citing works
Mondragón‐Rodríguez, S., Perry, G. L., Zhu, X., Moreira, P. I., Acevedo, M., & Williams, S. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/940603 · Cited by 155 · see citing works
Hu, G., Mancl, M. E., & Barnes, B. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0583 · Cited by 122 · see citing works
Kalashnikova, I. V., Mazar, J., Neal, C. J., Rosado, A., Das, S., Westmoreland, T. J., & Seal, S. (2017) · Nanoscale · doi:10.1039/c7nr02770b · Cited by 104 · see citing works
Evaluating the Toxicity of Selected Types of Nanochemicals
Kumar, V., Kumari, A., Guleria, P., & Yadav, S. K. (2011) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4614-1463-6_2 · Cited by 96 · see citing works
Han, S., Lemire, J. A., Appanna, V. D., Auger, C., Castonguay, Z., & Appanna, V. D. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9239-0 · Cited by 92 · see citing works
Chalew, T. E. A., & Schwab, K. J. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9241-6 · Cited by 87 · see citing works
Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill
van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0501oc · Cited by 85 · see citing works
Buie, J. N. J., Renaud, L., Muise‐Helmericks, R. C., & Oates, J. C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600108 · Cited by 85 · see citing works
Chen, C., Shi, L., Li, Y., Wang, X., & Yang, S. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9322-4 · Cited by 84 · see citing works
Bittar, A., Jun, J., La, J., Wang, J., Leem, J. W., & Chung, J. M. (2017) · Pain · doi:10.1097/j.pain.0000000000001014 · Cited by 73 · see citing works
Ganta, K. K., Mandal, A., & Chaubey, B. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9362-9 · Cited by 71 · see citing works
Effects of formaldehyde on mitochondrial dysfunction and apoptosis in SK-N-SH neuroblastoma cells
Zerin, T., Kim, J., Gil, H., Song, H., & Hong, S. (2015) · Cell Biology and Toxicology · doi:10.1007/s10565-015-9309-6 · Cited by 66 · see citing works
Pallocca, G., Fabbri, M., Sacco, M. G., Gribaldo, L., Pamies, D., Laurenza, I., & Bal‐Price, A. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9250-5 · Cited by 61 · see citing works
Du, F., Zhang, Z., Li, H., Yu, Q., Douglas, J. T., Bratasz, A., Kuppusamy, P., & Yan, S. S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150917 · Cited by 48 · see citing works
Chiang, S., Kalinowski, D. S., Jansson, P. J., Richardson, D. R., & Huang, M. L. H. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.08.002 · Cited by 48 · see citing works
Oxidative damage induced by retching; antiemetic and neuroprotective role of Sambucus ebulus L.
Fathi, H., Ebrahimzadeh, M. A., Ziar, A., & Mohammadi, H. (2015) · Cell Biology and Toxicology · doi:10.1007/s10565-015-9307-8 · Cited by 48 · see citing works
Giromini, C., Rebucci, R., Fusi, E., Rossi, L., Saccone, F., & Baldi, A. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9332-2 · Cited by 43 · see citing works
Reactive Oxygen Species‐Regulating Polymersome as an Antiviral Agent against Influenza Virus
Kim, H., Yeom, M., Kim, J., Kukreja, A., Na, W., Choi, J., Kang, A., Yun, D., Lim, J., Song, D., et al. (2017) · Small · doi:10.1002/smll.201700818 · Cited by 42 · see citing works
Vedi, M., & Prince, S. E. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9340-2 · Cited by 41 · see citing works
Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity
Chambers, T. P., Santiesteban, L., Gomez, D. F., & Chambers, J. W. (2017) · Toxicology · doi:10.1016/j.tox.2017.03.006 · Cited by 38 · see citing works
Cytotoxicity of water-soluble mPEG-SH-coated silver nanoparticles in HL-7702 cells
Song, X., Li, B., Xu, K., Liu, J., Ju, W., Wang, J., Liu, X., Li, J., & Qi, Y. (2012) · Cell Biology and Toxicology · doi:10.1007/s10565-012-9218-x · Cited by 37 · see citing works
The role of mitochondria in cellular toxicity as a potential drug target
Wu, D., Wang, X., & Sun, H. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9425-1 · Cited by 37 · see citing works
Genotoxicity of hydroquinone in A549 cells
Peng, C., Arthur, D. M., Liu, F. F., Lee, J., Xia, Q., Lavin, M. F., & Ng, J. C. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9247-0 · Cited by 37 · see citing works
Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds
Schultze, N., Wanka, H., Zwicker, P., Lindequist, U., & Haertel, B. (2016) · Toxicology · doi:10.1016/j.tox.2016.12.006 · Cited by 32 · see citing works
Faust, J. J., Zhang, W., Chen, Y., & Capco, D. G. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9267-9 · Cited by 29 · see citing works
Venkatesan, T., Choi, Y.-W., Mun, S. P., & Kim, Y. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9346-9 · Cited by 29 · see citing works
Leclerc, É., Hamon, J., Claude, I., Jellali, R., Naudot, M., & Bois, F. Y. (2015) · Cell Biology and Toxicology · doi:10.1007/s10565-015-9302-0 · Cited by 29 · see citing works
Keta, O. D., Bulat, T., Golić, I., Incerti, S., Korać, A., Petrović, I., & Ristic‐Fira, A. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9319-z · Cited by 25 · see citing works
Meng, N., Han, L., Pan, X., Su, L., Jiang, Z., Lin, Z., Zhao, J., Zhang, S., Zhang, Y., Zhao, B., et al. (2015) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9291-4 · Cited by 25 · see citing works
Self-citationPietsch, C., Hollender, J., Dorusch, F., & Burkhardt‐Holm, P. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9283-4 · Cited by 25 · see citing works
Zhang, K., Zheng, W., Zheng, H., Wang, C., Wang, M., Li, T., Wang, X., Zhang, L., Xiao, S., Fei, C., et al. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9287-0 · Cited by 24 · see citing works
FK506 affects mitochondrial protein synthesis and oxygen consumption in human cells
Palacín, M., Coto, E., Llobet, L., Pacheu‐Grau, D., Montoya, J., & Ruiz‐Pesini, E. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9263-0 · Cited by 21 · see citing works
Nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia
Wang, J., Lee, C.-T., & Wang, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.048 · Cited by 17 · see citing works
Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux
Dooley, C. T., Li, L., Misler, J. A., & Thompson, J. H. (2012) · Cell Biology and Toxicology · doi:10.1007/s10565-011-9209-3 · Cited by 17 · see citing works
Yang, X., Mao, X., Ding, X., Guan, F., Jia, Y., Luo, L., Li, B., Tan, H., & Cao, C. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9424-2 · Cited by 15 · see citing works
A new method for classifying different phenotypes of kidney transplantation
Zhu, D., Liu, Z., Pan, Z., Qian, M., Wang, L., Zhu, T., Xue, Y., & Wu, D. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9337-x · Cited by 14 · see citing works
Bennett, R. A. O., Behrens, E., Zinn, A., Duncheon, C., & Lamkin, T. J. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9279-0 · Cited by 14 · see citing works
Nitric Oxide Potentiates TNF-α-Induced Neurotoxicity Through Suppression of NF-κB
Nakaizumi, A., Horie, T., Kida, T., Kurimoto, T., Sugiyama, T., Ikeda, T., & Oku, H. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9739-5 · Cited by 12 · see citing works
Fabris, S. A., & MacLean, D. A. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9325-1 · Cited by 11 · see citing works
Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers
Miyata, S., Noda, A., Hara, Y., Ueyama, J., Kitaichi, K., Kondo, T., & Koike, Y. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-110054 · Cited by 11 · see citing works
Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina
Mossoba, M. E., Flynn, T. J., Vohra, S., Wiesenfeld, P. L., & Sprando, R. L. (2015) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9311-7 · Cited by 10 · see citing works
The role of ribosylated-BSA in regulating PC12 cell viability
Kuo, T.-Y., Huang, C., Yang, J.-M., Huang, W.-J., Huang, N., Chen, Y.-W., Lin, R.-J., & Yang, Y.-C. (2012) · Cell Biology and Toxicology · doi:10.1007/s10565-012-9220-3 · Cited by 9 · see citing works
Inhibition of reactive oxygen species limits expansion of chronic lymphocytic leukemia cells
Yigit, B., Wang, N., Chen, S.-S., Chiorazzi, N., & Terhorst, C. (2017) · Leukemia · doi:10.1038/leu.2017.241 · Cited by 8 · see citing works
Bestwick, C. S., Ralton, L. D., Milne, L., Lin, P. K. T., & Duthie, S. J. (2011) · Cell Biology and Toxicology · doi:10.1007/s10565-011-9199-1 · Cited by 7 · see citing works
FURUE, H. (1995) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications
Ettlinger, R. L., Lächelt, U., Gref, R., Horcajada, P., Lammers, T., Serre, C., Couvreur, P., Morris, R. E., & Wuttke, S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00918d · Cited by 432 · see citing works
Recent advances in metal-organic frameworks: Synthesis, application and toxicity
Zhang, Q., Yan, S., Yan, X., & Lv, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165944 · Cited by 276 · see citing works
Halappanavar, S., van den Brule, S., Nymark, P., Gaté, L., Seidel, C., Valentino, S., Zhernovkov, V., Høgh Danielsen, P., De Vizcaya, A., Wolff, H., et al. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00344-4 · Cited by 246 · see citing works
Towards the overcoming of anticancer drug resistance mediated by p53 mutations
Cao, X., Hou, J., An, Q., Assaraf, Y. G., & Wang, X. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100671 · Cited by 176 · see citing works
Toxic Effects of Cadmium on Fish
Liu, Y., Chen, Q., Li, Y., Bi, L., Jin, L., & Peng, R. (2022) · Toxics · doi:10.3390/toxics10100622 · Cited by 171 · see citing works
Implantable bioelectronics toward long-term stability and sustainability
Li, Y., Li, N., Oliveira, N. D., & Wang, S. (2021) · Matter · doi:10.1016/j.matt.2021.02.001 · Cited by 160 · see citing works
Omran, B. A., Whitehead, K. A., & Baek, K.-H. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111578 · Cited by 74 · see citing works
Pinheiro, L. D. S. M., Sangoi, G. G., Vizzotto, B. S., Ruiz, Y. P. M., Galembeck, A., Pavoski, G., Espinosa, D. C. R., Machado, A. K., & da Silva, W. L. (2024) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2024.129715 · Cited by 58 · see citing works
Abbas, M., Liang, Z., Chen, M., Qu, W., Khan, S., Ashaq, M. S., Chen, D., & Xie, S. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04712-z · Cited by 49 · see citing works
Anti-Aging Effects of GDF11 on Skin
Rochette, L., Mazini, L., Méloux, A., Zeller, M., Cottin, Y., Vergely, C., & Malka, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072598 · Cited by 41 · see citing works
Săvucă, A., Nicoară, M., Ciobica, A. S., Gorgan, L., Ureche, D., & Balmuș, I.-M. (2023) · Animals · doi:10.3390/ani13111810 · Cited by 38 · see citing works
Rifa, R. A., & Lavado, R. (2023) · Emerging contaminants · doi:10.1016/j.emcon.2023.100296 · Cited by 32 · see citing works
Chang, Y., Shih, Y., Chen, C., Liu, K., Lee, M., Lee, M., Hou, H., Huang, H., Lu, H., Peng, S., et al. (2019) · Environmental Toxicology · doi:10.1002/tox.22834 · Cited by 31 · see citing works
Desbiolles, B. X. E., de Coulon, E., Maïno, N., Bertsch, A., Rohr, S., & Renaud, P. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-0178-7 · Cited by 30 · see citing works
Shi, L., Hou, J., Wang, L., Fu, H., Zhang, Y., Song, Y., & Wang, X. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.486 · Cited by 28 · see citing works
Self-citationZhang, L., Yan, F., Li, L., Fu, H., Song, D., Wu, D., & Wang, X. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.626 · Cited by 24 · see citing works
Ikhlas, S., Usman, A., & Ahmad, M. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.06.001 · Cited by 24 · see citing works
Paudel, S., Cerbu, C. G., Astete, C. E., Louie, S. M., Sabliov, C. M., & Rodrigues, D. F. (2019) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b00970 · Cited by 24 · see citing works
Yuan, H., Li, J., Pan, L., Li, X., Yuan, Y., Zhong, Q., Wu, X., Luo, J., & Yang, S. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114275 · Cited by 23 · see citing works
Forouz, F., Dabbaghi, M., Namjoshi, S., Mohammed, Y., Roberts, M. S., & Grice, J. E. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100947 · Cited by 22 · see citing works
Comparative analysis of energy transfer mechanisms for neural implants
Miziev, S., Pawlak, W. A., & Howard, N. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1320441 · Cited by 21 · see citing works
Cytotoxicity - Understanding Cellular Damage and Response
Sukumaran, A., & Mansour, M. A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100956 · Cited by 20 · see citing works
Guo, P., An, X., Pan, X., Xu, J., Wu, X., Zheng, Y., & Dong, F. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166969 · Cited by 20 · see citing works
Biomarkers for respiratory diseases: Present applications and future discoveries
Liu, X., Cui, B., Wang, Q., Ma, Y., Li, L., & Chen, Z. H. (2021) · Clinical and Translational Discovery · doi:10.1002/ctd2.11 · Cited by 17 · see citing works
Krutskikh, E. P., Potanina, D. V., Samoylova, N. A., Vladimirovna, G. M., Sadovnikova, I. S., Gureev, A. P., & Popov, V. N. (2022) · Pharmaceuticals · doi:10.3390/ph15070815 · Cited by 17 · see citing works
Sadeghian, I., Heidari, R., Raee, M. J., & Negahdaripour, M. (2022) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgac038 · Cited by 14 · see citing works
Implant-derived CoCrMo alloy nanoparticle disrupts DNA replication dynamics in neuronal cells
Bijukumar, D. R., Segu, A., Chastain, P. D., & Mathew, M. T. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-020-09577-7 · Cited by 15 · see citing works
Inhibitory Effect of Ginsenosides Rh1 and Rg2 on Oxidative Stress in LPS-Stimulated RAW 264.7 Cells
Jin, Y., Baek, N., Back, S., Myung, C., & Heo, K. (2018) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2018.48.4.156 · Cited by 15 · see citing works
Song, D., Tang, L., Huang, J., Wang, L., Zeng, T., & Wang, X. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02181-2 · Cited by 15 · see citing works
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Machado, V., Marinho, A., de Castro, P. V., & Silva, T. L. (2025) · Textiles · doi:10.3390/textiles5020016 · Cited by 14 · see citing works
Growth differentiation factor 11 mitigates cardiac radiotoxicity via activating AMPKα
Li, X., Ding, D., Chen, W., Liu, Y., Pan, H., & Hu, J. X. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1885653 · Cited by 14 · see citing works
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Ustun-Karatop, E., Çimenci, Ç. E., & Aksu, A. M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105772 · Cited by 14 · see citing works
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Poli, D., Mattei, G., Ucciferri, N., & Ahluwalia, A. D. (2020) · Annals of Biomedical Engineering · doi:10.1007/s10439-020-02449-5 · Cited by 13 · see citing works
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McNamara, K., Tofail, S. A. M., Thorat, N. D., Bauer, J., & Mulvihill, J. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819847-6.00016-4 · Cited by 13 · see citing works
Tekin, V., Aweda, T. A., Güldü, Ö. K., Müftüler, F. Z. B., Bartels, J. L., Lapi, S. E., & Ünak, P. (2021) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2020.12.005 · Cited by 13 · see citing works
Bhuia, M. S., Chowdhury, R., Shill, M. C., Chowdhury, A. K., Coutinho, H. D. M., Silva, D. A. E., Raposo, A., & Islam, M. T. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202400443 · Cited by 12 · see citing works
Fuentes, C., Fuentes, A., Byrne, H. J., Baviera, J. M. B., & Ruiz, M.-J. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112778 · Cited by 12 · see citing works
Tang, Y., Shu, X., He, G., Zhang, Y., Zhao, Y., Yuan, H., Yu, J., Guo, J., & Chen, Q. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb02084c · Cited by 11 · see citing works
Self-citationZheng, N., Wang, T., Wei, A., Chen, W., Zhao, C., Li, H., & Wang, L. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3821 · Cited by 11 · see citing works
Yeni, Y., & Rachmania, R. A. (2023) · Jurnal Sains dan Kesehatan · doi:10.25026/jsk.v5i5.1975 · Cited by 10 · see citing works
Shahriar, S. I. M., Islam, N., Emon, F. J., Nepal, V., Khan, S., & Shahjahan, M. (2025) · Emerging contaminants · doi:10.1016/j.emcon.2025.100520 · Cited by 10 · see citing works
Research Advances on DNA Methylation in Idiopathic Pulmonary Fibrosis
Luo, Q., Zhang, H., & Li, L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-4494-1_6 · Cited by 10 · see citing works
Chandrasekaran, K., Kokkarachedu, V., Sisubalan, N., Vijayan, A., Panneerselvam, H. M., Godwin, P. E. R., Charles, K. A., Gowri, S. S., Mathews, J. J., Hameed, A. S. H., et al. (2024) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-50093-0_10 · Cited by 9 · see citing works
Wu, Y., Tang, K., Wang, C., Hao, S., Zhou, F., & Guo, Y. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.02.009 · Cited by 9 · see citing works
Baghani, M., Habibollahi, H., & Es‐haghi, A. (2025) · Journal of Sol-Gel Science and Technology · doi:10.1007/s10971-025-06741-5 · Cited by 9 · see citing works
Leveraging printability and biocompatibility in materials for printing implantable vessel scaffolds
Chen, T., Jiang, H., Zhang, R., He, F., Han, N., Wang, Z., & Jia, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101366 · Cited by 8 · see citing works
Haque, M. A., Anwar, M. C., Hossain, A. A., Ahmed, S. S., Zahangir, M. M., & Shahjahan, M. (2025) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2025.100840 · Cited by 7 · see citing works
Marin, D. E., Bulgaru, C. V., Perțea, A.-M., Grosu, I. A., Pistol, G. C., & Țăranu, I. (2024) · Toxins · doi:10.3390/toxins16050223 · Cited by 6 · see citing works
Ganeshkar, P., Sharma, R. K., Kumar, T., Kumar, P., Reddy, K. S., & Kumar, N. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04594-1 · Cited by 6 · see citing works
Anitha, J., Muthusankar, A., Sangeetha, M., Kishore, V. L., Sherin, P. J., Selvakumar, R., Chandraprakash, K., & Premkumar, T. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145995 · Cited by 6 · see citing works
Radwan, M., Malki, J. S. A., Mohammadein, A., Manaa, E. A., Fares, M., Metwally, M. G., & Eliraqy, E. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04744-5 · Cited by 6 · see citing works
Ma, H., Han, X., Lan, Z., Wu, T., Qin, J., & Cui, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120915 · Cited by 5 · see citing works
da Silva, L. C., da Luz, J. Z., Bezerra, A. G., Machado, T. N., Santurio, M. T. K., Ribeiro, C. A. D. O., & Neto, F. F. (2020) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2020.1805663 · Cited by 5 · see citing works
Winckers, L., Willighagen, E., Evelo, C. T., & Kutmon, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179432 · Cited by 4 · see citing works
Sadeghian, I., Akbarpour, M., Chafjiri, F. M. A., Chafjiri, P. M. A., Heidari, R., Morowvat, M. H., Sadeghian, R., Raee, M. J., & Negahdaripour, M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02683-3 · Cited by 4 · see citing works
Pognonec, P., Gustovic, A., Djabari, Z., Pourcher, T., & Barlaud, M. (2021) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2021.3115876 · Cited by 4 · see citing works
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Samrit, T., Osodprasit, S., Chaiwichien, A., Savedvanich, G., Changklungmoa, N., Kueakhai, P., Athipornchai, A., Tamtin, M., Sobhon, P., & Jaikua, W. (2023) · Trends in Sciences · doi:10.48048/tis.2024.7287 · Cited by 3 · see citing works
Naserzadeh, P., Razmı, A., Yeşildal, R., & Ashtari, B. (2022) · Toxicology Research · doi:10.1093/toxres/tfac007 · Cited by 3 · see citing works
Singh, S., Zeh, G., Freiherr, J., Bauer, T., Turkmen, I., & Grasskamp, A. T. (2024) · Journal of Cheminformatics · doi:10.1186/s13321-024-00835-y · Cited by 3 · see citing works
Fan, W., Liu, S., Wu, Y., Cao, X., Lu, T., Huang, C., Shi, X., & Song, S. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121478 · Cited by 3 · see citing works
Jayakumar, T., Sheu, J., Yuan, K.-C., Yen, T., Hsia, C., Huang, W.-C., Tseng, L.-N., Chen, C., & Hsia, C.-H. (2023) · Natural Product Communications · doi:10.1177/1934578x231201029 · Cited by 2 · see citing works
Park, Y., Kang, H., Kang, S. J., Ku, H., Zarbl, H., Fang, M., & Park, J. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03686-6 · Cited by 2 · see citing works
Ghosh, A. K., Panda, S. K., Hu, H., Schoofs, L., & Luyten, W. H. M. L. (2024) · Journal of Essential Oil Research · doi:10.1080/10412905.2024.2353648 · Cited by 2 · see citing works
Tsymbalyuk, О. V., Davydovska, T. L., Naumenko, A. M., Liashevych, A. N., Lupaina, І. S., Voiteshenko, I., Nuryshchenko, N. Y., & Skryshevsky, V. A. (2021) · Regulatory Mechanisms in Biosystems · doi:10.15421/022179 · Cited by 1 · see citing works
Ratnayake, P., Samaratunga, U., Perera, I. C., Seneviratne, J., & Udagama, P. V. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117763 · Cited by 2 · see citing works
Metabolomics-based biomarkers of probiotic efficacy in toxicological settings
Emegano, D. I., Battal, D., & Kocadal, K. (2024) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-024-00546-1 · Cited by 2 · see citing works
Sang, R., Zhao, X., Sun, K.-T., Zhang, Y., & Luo, B. (2025) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0868 · Cited by 1 · see citing works
Self-citationRTGill-W1 Cells Response to Salmonella enterica Metabolites
Jawdhari, A., Wolff, R. J., Tihăuan, B.-M., Ghitoc, I.-T., & Crăciun, N. (2025) · Bacteria · doi:10.3390/bacteria4040058 · Cited by 1 · see citing works
Cancer through the ayurvedic lens: An agadatantra path to healing
Divyashri, S., Venkateshperumal, S. K., Mishra, B., & Muzzammel, M. (2024) · Ayush journal of integrative oncology. · doi:10.4103/ajio.ajio_12_24 · Cited by 1 · see citing works
Alijagić, A., Seilitz, F., Bredberg, A., Hakonen, A., Larsson, M., Selin, E., Sjöberg, V., Kotlyar, O., Scherbak, N. N., Repsilber, D., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120929 · Cited by 1 · see citing works
Fish, Genetic and Cellular Toxicity
Saxena, A. K., & Kumar, A. (2020) · SpringerBriefs in applied sciences and technology · doi:10.1007/978-981-15-4700-3_6
Tandelilin, R. T., Widita, E., Puspita, R. M., & Mun, T. S. (2021) · Jurnal Teknosains · doi:10.22146/teknosains.43852
A Natural Bioactive Compound Lycopene and Its Role on Cancer Related to Oxidative Stress
Araç, F. Ö. Ö., Aldemir, O., & Duru, Ö. A. (2022) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-9258-8.ch019
Gürel, A. K., Özkan, T., Güneş, B. A., Sunguroğlu, A., & Aktan, F. (2021) · The Annals of Clinical and Analytical Medicine · doi:10.4328/acam.20379
Toxicokinetics and organ-specific toxicity
Dixit, P. V., Mishra, D. K., Rajpoot, K., Tekade, M., Achanta, N. S. K., Anup, N., & Tekade, R. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15840-7.00016-6
Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
Chen, L., Guo, Y., Yu, J., Liu, R., Tang, W., Zhou, F., Zhang, B., Yuan, X., & Yu, C. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00500-9
Introductory Chapter: Methods for Determining Cytotoxic Potential of Cosmetics and Medical Devices
Erkekoğlu, P. (2025) · Biochemistry · doi:10.5772/intechopen.1009517
Yeni, Y., & Rachmania, R. A. (2024) · Jurnal Sains dan Kesehatan · doi:10.30872/jsk.v5i5.564
Cellular electrochemical analysis of cytotoxicity mechanisms of typical antibiotics
Cai, Y., Wu, G., Zuo, R., Wang, C., Wang, J., & Ng, H. Y. (2025) · Measurement · doi:10.1016/j.measurement.2025.119562
In Vitro Evaluation of Cytocompatibility of B4C-Reinforced CoCrMo, Ti, and 17-4 PH Alloys
Güder, Ö. F., Ercan, S., & Ersoy, A. (2026) · Journal of Composites Science · doi:10.3390/jcs10040197
Nazir, S., & Ahmad, M. K. (2026) · Mutagenesis · doi:10.1093/mutage/geag022
Advanced guar gum/polyvinyl alcohol/CS-MnP smart hydrogel for promoting osteoblastic proliferation
Valdez-Salas, B., Guillén-Carvajal, K. M., Salvador‐Carlos, J., Chairez-González, J., Beltrán‐Partida, E., & Curiel, M. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae7524
Mondal, T., Mia, M. J., Chowdhury, K., Amin, M. R., Zahangir, M. M., & Shahjahan, M. (2026) · Environmental Challenges · doi:10.1016/j.envc.2026.101553
Gao, T., Xu, Y., Song, J., Lou, M., Shen, C., & Xiong, J. (2026) · PeerJ · doi:10.7717/peerj.21528
Hosseini, S. H., Younesi, H., Sinkakarimi, M. H., Ahmadpour, M., & Zakeritabar, S. F. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120623
Yahsin, A. S., Tabelin, C. B., Phengsaart, T., Andalan, J. R., Mondejar, A. J. S., Subebe, M. J. B., Orbecido, A. H., Tse, W. K. F., Ogino, Y., & Villacorte-Tabelin, M. (2026) · Microplastics · doi:10.3390/microplastics5030173
Giri, R. V., Vishwanatha, U., & Kamath, S. (2026) · Ayush journal of integrative oncology. · doi:10.4103/ajio.ajio_31_26
- Authors
- Zhang, Y.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Zhang, Yong
- ORCID
- Zhang, Yong
- Venue
- Clinical and Translational Medicine
- Publisher
- Wiley
- Published
- 2018-10-29
- Volume
- 7
- Issue
- 1
- Pages
- 34-34
- ISSN
- 2001-1326 (ISSN-L)
- PMC
- PMC6206310
- OpenAlex
- W2898771680
- Cited by
- 89
- References
- 59
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 15 · 2020: 9 · 2019: 6 · 2018: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical and Translational Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shanghai Leading Academic Discipline Project (B115)
- National Natural Science Foundation of China (31400713)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- cytotoxicity, toxicity mechanisms, oxidative stress, reactive oxygen species, nitric oxide, mitochondrial dysfunction, DNA damage, nanoparticle toxicity, inflammation, biomarkers, autophagy, cytokines, microRNA
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