Mitochondria as biosynthetic factories for cancer proliferation

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

Metformin and reduced risk of cancer in diabetic patients

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990

Novel Mitochondria-targeted Drugs for Cancer Therapy

Fialová, J. L., Raudenská, M., Jakubek, M., Kejík, Z., Pavel Martasek, E., Babula, P., Matkowski, A., Filipenský, P., & Masařík, M. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201118153242 · Cited by 22

Homozygous variants in pyrroline‐5‐carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy

Meng, L., Donti, T., Xia, F., Niu, Z., Shamsi, A. A., Hertecant, J., Al-Jasmi, F. A., Gibson, J. B., Nagakura, H., Zhang, J., et al. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38049 · Cited by 22

The Role of MicroRNAs in Lung Cancer Metabolism

Azizi, M. I. H. N., Othman, I., & Naidu, R. (2021) · Cancers · doi:10.3390/cancers13071716 · Cited by 22

Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells

Cimmino, T. P., Pagano, E., Stornaiuolo, M., Esposito, G., Ammendola, R., & Cattaneo, F. (2022) · Antioxidants · doi:10.3390/antiox11091692 · Cited by 23

Green chemistry approach towards Piperazine: anticancer agents

Sharma, V., Das, R., Sharma, D., Mujwar, S., & Mehta, D. K. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.136089 · Cited by 21

Amino Acid Profiling of Zinc Resistant Prostate Cancer Cell Lines: Associations With Cancer Progression

Kratochvílová, M., Raudenská, M., Heger, Z., Richtera, L., Cernei, N., Adam, V., Babula, P., Novàkovâ, M., Masařík, M., & Gumulec, J. (2017) · The Prostate · doi:10.1002/pros.23304 · Cited by 21

Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line

Ościłowska, I., Rolkowski, K., Baszanowska, W., Huynh, T. Y. L., Lewoniewska, S., Nizioł, M., Sawicka, M., Bielawska, K., Szoka, P., Miltyk, W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042354 · Cited by 21

BET inhibitors ( BETi ) influence oxidative phosphorylation metabolism by affecting mitochondrial dynamics leading to alterations in apoptotic pathways in triple‐negative breast cancer ( TNBC ) cells

Rossi, T., Iorio, E., Chirico, M., Pisanu, M. E., Amodio, N., Cantafio, M. E. G., Perrotta, I. D., Colciaghi, F., Fiorillo, M., Gianferrari, A., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13730 · Cited by 22

Role of Mitochondrial Dynamics in Skin Homeostasis: An Update

Quan, T., Li, R., & Gao, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051803 · Cited by 23

Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities

Sarwar, A., Zhu, M., Su, Q., Zhu, Z., Yang, T., Chen, Y., Peng, X., & Zhang, Y. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103858 · Cited by 20

Cancer: Linking Powerhouses to Suicidal Bags

Martínez-Carreres, L., Nasrallah, A., & Fajas, L. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00204 · Cited by 21

Breast cancer risk in relation to plasma metabolites among Hispanic and African American women

Zhao, H., Shen, J., Moore, S. C., Ye, Y., Wu, X., Esteva, F. J., Tripathy, D., & Chow, W. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05165-4 · Cited by 20

DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention

Gautam, S., Rawat, A. K., Sammi, S. R., Roy, S., Singh, M., Devi, U., Yadav, R. K., Singh, L., Rawat, J. K., Ansari, M. N., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00314 · Cited by 19

Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies

Genovese, I., Vezzani, B., Danese, A., Modesti, L., Vitto, V. A. M., Corazzi, V., Pelucchi, S., Pinton, P., & Giorgi, C. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102308 · Cited by 21

Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer

Ni, J., Wang, Y., Cheng, X., Fang, T., Wang, C., Han, S., Chen, X., & Guo, W. (2020) · Cancer Management and Research · doi:10.2147/cmar.s277724 · Cited by 19

Dissecting the regulation and function of ATP at the single-cell level

Zhang, J., Xu, H., & Lin, Y. (2018) · PLoS Biology · doi:10.1371/journal.pbio.3000095 · Cited by 21

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer

Bassal, M. A. (2023) · Biomolecules · doi:10.3390/biom13060944 · Cited by 19

Elevated mitochondrial DNA copy numbers in pediatric acute lymphoblastic leukemia: A potential biomarker for predicting inferior survival

Jain, A., Bakhshi, S., Thakkar, H., Gerards, M., & Singh, A. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26874 · Cited by 19

MicroRNA-519d-3p inhibits cell proliferation and cell cycle G1/S transition in glioma by targeting CCND1

Ma, L., & Li, J. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1682510 · Cited by 18

Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors

Bindra, S., McGill, M. A., Triplett, M. K., Tyagi, A., Thaker, P. H., Dahmoush, L., Goodheart, M. J., Ogden, R. T., Owusu-Ansah, E., Karan, K. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89934-6 · Cited by 17

RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism

Dumas, L., Shin, S., Rigaud, Q., Cargnello, M., Suárez, B. H., Herviou, P., Saint‐Laurent, N., Leduc, M., Gall, M. L., Monchaud, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58118-5 · Cited by 21

Increased heterogeneity in expression of genes associated with cancer progression and drug resistance

Bose, A., Datta, S., Mandal, R., Ray, U., & Dhar, R. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101879 · Cited by 23

Bile Metabolites and Risk of Carcinogenesis in Patients With Pancreaticobiliary Maljunction: A Pilot Study

Mori, H., Morine, Y., Mawatari, K., CHIBA, A., Yamada, S., Saito, Y., ISHIBASHI, H., Takahashi, A., & Shimada, M. (2021) · Anticancer Research · doi:10.21873/anticanres.14779 · Cited by 16

Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function

Xu, H., Qing, X., Wang, Q., Li, C., & Lai, L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100572 · Cited by 17

Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells

Cruz, P., Ahumada-Castro, U., Bustos, G., Molgó, J., Sauma, D., Lovy, A., & Cárdenas, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020651 · Cited by 17

The unusual metabolism of germinal center B cells

Gracie, C. J., Mitchell, R., Johnstone, J. C., & Clarke, A. J. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.02.015 · Cited by 21

Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer

Ragni, M., Ruocco, C., & Nisoli, E. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00080-3 · Cited by 18

Ellagic acid inhibits mitochondrial fission protein Drp-1 and cell proliferation in cancer

Yakobov, S., Dhingra, R., Margulets, V., Dhingra, A., Crandall, M., & Kirshenbaum, L. A. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04627-6 · Cited by 16

Outer mitochondrial membrane E3 Ub ligase MARCH5 controls de novo peroxisome biogenesis

Verhoeven, N. A., Oshima, Y., Cartier, E. A., Bippes, C. C., Neutzner, A., Boyman, L., & Karbowski, M. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.09.010 · Cited by 16

Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease

Aryaman, J., Johnston, I. G., & Jones, N. S. (2017) · Biochemical Journal · doi:10.1042/bcj20170651 · Cited by 15

Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats

Kong, X., Wei, J., Wang, D., Zhu, X., Zhou, Y., Wang, S., Xu, G., & Jiang, G. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0195-1 · Cited by 16

InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer

Lovy, A., Foskett, J. K., & Cárdenas, C. (2016) · Molecular & Cellular Oncology · doi:10.1080/23723556.2016.1185563 · Cited by 15

Sustained IP3-linked Ca2+ signaling promotes progression of triple negative breast cancer cells by regulating fatty acid metabolism

Filadi, R., Mario, A. D., Audano, M., Romani, P., Pedretti, S., Cárdenas, C., Dupont, S., Mammucari, C., Mitro, N., & Pizzo, P. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1071037 · Cited by 15

Targeting metabolic dependencies in pediatric cancer

Issaq, S. H., & Heske, C. M. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000853 · Cited by 15

Cancer and pulmonary hypertension: Learning lessons and real-life interplay

Pullamsetti, S. S., Nayakanti, S. R., Chelladurai, P., Mamazhakypov, A., Mansouri, S., Savai, R., & Seeger, W. (2020) · Global Cardiology Science and Practice · doi:10.21542/gcsp.2020.10 · Cited by 15

Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives

Soon, J. W., Manca, M. A., Laskowska, A., Starková, J., Rohlenová, K., & Rohlena, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167451 · Cited by 15

Crosstalk between Metabolic Alterations and Altered Redox Balance in PTC-Derived Cell Lines

Tronci, L., Caria, P., Frau, D. V., Liggi, S., Piras, C., Murgia, F., Santoru, M. L., Pibiri, M., Deiana, M., Griffin, J. L., et al. (2019) · Metabolites · doi:10.3390/metabo9020023 · Cited by 14

Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration

Gudenschwager, C., Chavez, I., Cárdenas, C., & González-Billault, C. E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5586052 · Cited by 12

Current Status of the Use of Multifunctional Enzymes as Anti-Cancer Drug Targets

Teixeira, C. S. S., & Sousa, S. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010010 · Cited by 14

The role of metabolomics in hepatocellular carcinoma

Khalil, A. A., Elfert, A., Ghanem, S. E., Helal, M., Abdelsattar, S., Gedawy, G. A. E., Obada, M., Abdel-Samiee, M., & El‐Said, H. (2021) · Egyptian Liver Journal · doi:10.1186/s43066-021-00085-9 · Cited by 12

Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications

Psvv, C., Sunil, S., Thuyyath, N., Kokkanti, R. R., & Lavudi, K. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1741800 · Cited by 13

The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer

Vadlakonda, L., Indracanti, M., Kalangi, S. K., Gayatri, B. M., Gajula, N. N., & Reddy, A. B. M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00566-5 · Cited by 11

Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

Farook, M. R. Y., Croxford, Z., Morgan, S., Horlock, A. D., Holt, A. K., Rees, A., Jenkins, B. J., Tse, C., Stanton, E., Davies, D. M., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101900 · Cited by 11

Nanoplastics trigger the aging and inflammation of porcine kidney cells

Lu, G., & Wei, S. (2024) · Toxicology · doi:10.1016/j.tox.2024.153870 · Cited by 11

Molecular mechanism of genetic, epigenetic, and metabolic alteration in lung cancer

Fatima, S., Kumar, V., & Kumar, D. (2025) · Medical Oncology · doi:10.1007/s12032-025-02608-5 · Cited by 11

FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling

Zhang, F., Wu, L., Feng, S., Zhao, Z., Zhang, K., Thakur, A., Xu, Z., Liang, Q., Liu, Y., Liu, W., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14264 · Cited by 11

Regulation of protein metabolism in cancer

Han, C., Lu, X., & Nagrath, D. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1285384 · Cited by 11

Machine learning improves classification of preclinical models of pancreatic cancer with chemical exchange saturation transfer MRI

Goldenberg, J. M., Cárdenas‐Rodríguez, J., & Pagel, M. D. (2019) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27439 · Cited by 10

Insecticidal Activity and Molecular Target by Morphological Analysis, RNAseq, and Molecular Docking of the Aryltetralin Lignan Lactone Helioxanthin, Isolated from Taiwania flousiana Gaussen

Bi, X., Lin, M., Zhou, Y., Li, D., Xu, Z., Zhou, L., & Huang, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06384 · Cited by 10

Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting

Bonomo, R., Cavaletti, G., & Skene, D. J. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1782746 · Cited by 10

The LncRNA FEZF1-AS1 promotes tumor proliferation in colon cancer by regulating the mitochondrial protein PCK2

WANG, H., Wu, Y., WANG, Z., CHEN, Y., MO, J., GUAN, W., ZHANG, Y., & Yao, H. (2021) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.03553 · Cited by 10

Metabolic/hypoxial axis predicts tamoxifen resistance in breast cancer

Azzam, H. N., El-Derany, M. O., Wahdan, S. A., Faheim, R. M., Helal, G. K., & El‐Demerdash, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-19977-w · Cited by 10

Mitocans: Mitochondrially Targeted Anti-cancer Drugs

Boukalová, Š., Rohlenová, K., Rohlena, J., & Neužil, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_27 · Cited by 12

Tuberculosis and lung cancer: metabolic pathways play a key role

Ferdosnejad, K., Zamani, M. S., Soroush, E., Fateh, A., Siadat, S. D., & Tarashi, S. (2024) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2024.2308522 · Cited by 9

Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer

Lai, T., Lee, Y., Lee, W.-J., Hung, W.-Y., Cheng, G.-Z., Chen, J., Hsiao, M., Chien, M., & Chang, J. (2022) · Cancers · doi:10.3390/cancers14112750 · Cited by 9

The role of mitochondrial/metabolic axis in development of tamoxifen resistance in breast cancer

Azzam, H. N., El-Derany, M. O., Wahdan, S. A., Faheim, R. M., Helal, G. K., & El‐Demerdash, E. (2023) · Human Cell · doi:10.1007/s13577-023-00977-5 · Cited by 9

Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer

Belkacemi, L., Atkins, J. L., Yang, L., Gadgil, P., Sater, A. K., Chow, D. S., Bose, R. N., & ZHANG, S. X. (2018) · Anticancer Research · doi:10.21873/anticanres.12267 · Cited by 9

Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics

Vanhove, K., Derveaux, E., Mesotten, L., Thomeer, M., Criel, M., Mariën, H., & Adriaensens, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105602 · Cited by 10

SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1

Olou, A. A., Ambrose, J., Jack, J. L., Walsh, M., Ruckert, M. T., Eades, A. E., Bye, B. A., Dandawate, P. R., & VanSaun, M. N. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00691-1 · Cited by 10

Identification and validation of a signature involving voltage-gated chloride ion channel genes for prediction of prostate cancer recurrence

Luo, Y., Liu, X., Li, X., Zhong, W., Lin, J., & Chen, Q.-B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1001634 · Cited by 9

Spatial profiles of markers of glycolysis, mitochondria, and proton pumps in a rat glioma suggest coordinated programming for proliferation

Grillon, E., Farion, R., Reuveni, M., Glidle, A., Rémy, C., & Coles, J. A. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1191-z · Cited by 9

Cytochrome C Oxidase Assembly Factor 1 Homolog Predicts Poor Prognosis and Promotes Cell Proliferation in Colorectal Cancer by Regulating PI3K/AKT Signaling

Xue, Y., Li, P., Tang, X., Yan, Z., Xia, S., Tian, H., Liu, Z.-L., Zhou, T., Tang, X., & Zhang, G.-J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s279024 · Cited by 9

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Hu, D.-W., Huang, C., He, Y., Wei, Y., Hu, S., Cheng, F., Huynh, T. K., Chen, B., Wang, B., Kuan, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202510811 · Cited by 8

MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance

Cardoso, A. M., Morais, C. M., Sousa, M., Rebelo, O., Tão, H., Barbosa, M., de Lima, M. C. P., & Jurado, A. S. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab193 · Cited by 8

Molecular and Clinical Oncology

Vahedi, A., Fazeli, S. A., Hashemi, S. M., Arabpour-Dahouei, F., Davarian, A., & Golabchifard, R. (2015) · Cited by 8

Physiological and molecular aspects of heat-treated cultured granulosa cells of Egyptian buffalo (Bubalus bubalis)

Faheem, M. S., Dessouki, S. M., Rahman, F. E. S. A., & Ghanem, N. (2020) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2020.106665 · Cited by 8

Cell Death and Transcriptional Responses Induced in Larvae of the Nematode Haemonchus contortus by Toxins/Toxicants with Broad Phylogenetic Efficacy

Jasmer, D. P., Rosa, B. A., & Mitreva, M. (2021) · Pharmaceuticals · doi:10.3390/ph14070598 · Cited by 8

Metabolic Features of Activated Memory CD4+ T-Cells Derived from HIV-Infected Immunological Non-responders to Highly Active Antiretroviral Therapy

Викторовна, В. В., Сайдакова, Е. В., Korolevskaya, L. B., Shmagel, N. G., Черешнев, В. А., & Shmagel, K. V. (2021) · Doklady Biological Sciences · doi:10.1134/s0012496621060090 · Cited by 8

Protein Folding Stability Profiling of Colorectal Cancer Chemoresistance Identifies Functionally Relevant Biomarkers

Quan, B., Bailey, M. A., Mantyh, J. B., Hsu, D. S., & Fitzgerald, M. C. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00045 · Cited by 8

Cancer/testis antigen SPATA 19 is frequently expressed in benign prostatic hyperplasia and prostate cancer

Wong, K. K., Hussain, F. A., Loo, S. K., & Lopez, J. I. (2017) · Apmis · doi:10.1111/apm.12775 · Cited by 8

New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma

Song, H. S., Song, Y. H., Singh, N., Kim, H., Jeon, H., Kim, I., Kang, S. C., & Chi, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-36755-9 · Cited by 8

Research progress and therapeutic strategies in hepatocellular carcinoma metabolic reprogramming

Wang, H., Lun, Y., Xu, D., Jiang, H., Yan, Y., & Yang, X. H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.023 · Cited by 7

Peri-mitochondrial actin filaments inhibit Parkin assembly by disrupting ER-mitochondria contacts

Fung, T. S., Ghosh, A., Zavala, M., Nichtová, Z., Shukal, D. K., Tigano, M., Csordás, G., Higgs, H. N., & Chakrabarti, R. (2025) · EMBO Reports · doi:10.1038/s44319-025-00561-y · Cited by 9

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

Kang, S., Zhang, Y., Li, H., Peng, S., Lyu, D., Zhou, C., Ding, S., Feng, Z., Huang, P., Zhang, C., et al. (2025) · BMEMat · doi:10.1002/bmm2.70046 · Cited by 8

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma

Gu, Z., Zhang, H., Li, Y., Shen, S., Yin, X., Zhang, W., Cheng, R., Zhang, Y., Zhang, X., Chen, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23107 · Cited by 7

Multi-omics analysis revealed the mitochondrial-targeted drug combination to suppress the development of lung cancer

Li, C., Zhang, Y., Xia, Q., Hao, B., Hong, Y., Yue, L., Zheng, T., Li, M., & Fan, L. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05376-9 · Cited by 7

Combination of low glucose and SCD1 inhibition impairs cancer metabolic plasticity and growth in MCF-7 cancer cells: a comprehensive metabolomic and lipidomic analysis

Zhu, W.-T., Lusk, J. A., Pascua, V., Djukovic, D., & Raftery, D. (2024) · Metabolomics · doi:10.1007/s11306-024-02179-y · Cited by 7

A Metabolism‐Oriented Strategy to Directly Generate Photosensitizer‐Engineered Extracellular Vesicles from Cancer Cells

Wang, D., Liu, X., Zhang, X., Pham, T. T., Zhuang, J., Li, B., Chong, K. C., Liu, C., Shan, Y., Wu, M., et al. (2025) · Advanced Materials · doi:10.1002/adma.202505726 · Cited by 7

Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia

Qiu, X., Lu, R., He, Q., Chen, S., Huang, C., & Lin, D. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023151 · Cited by 6

Porphyrin-based fluorescent probes for imaging mitochondria in living cells

Moon, H., Jeong, G., Reddy, T. S., Yang, D. H., & Choi, M. (2024) · Dyes and Pigments · doi:10.1016/j.dyepig.2024.112369 · Cited by 6

Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle

Nakazawa, H., Wong, L. P., Shelton, L. M., Sadreyev, R. I., & Kaneki, M. (2022) · Metabolites · doi:10.3390/metabo12090800 · Cited by 6

Cancer-specific metabolism: Promising approaches for colorectal cancer treatment

Jeong, K. (2019) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v11.i10.768 · Cited by 6

Mitochondrial respiration supports cancer growth independent of OXPHOS

Chinopoulos, C. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189593 · Cited by 5

Thyroid cancer cell metabolism: A glance into cell culture system-based metabolomics approaches

Abooshahab, R., Razavi, F., Ghorbani, F., Hooshmand, K., Zarkesh, M., & Hedayati, M. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113936 · Cited by 5

Gut microbiota and glycochenodeoxycholic role in liver metastasis of breast cancer

Yan, L., Tan, Q., Zhu, J. X., He, Y., Tao, P., & He, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117128 · Cited by 5

Metabolic Profiling of Praziquantel-mediated Prevention ofOpisthorchis viverrini-induced Cholangiocyte Transformation in the Hamster Model of Cholangiocarcinoma

PROMMAJUN, P., Phetcharaburanin, J., Namwat, N., Klanrit, P., Sa-Ngiamwibool, P., Thanee, M., Dokduang, H., Kittirat, Y., Li, J. V., & Loilome, W. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20239 · Cited by 5

Exploring conserved mRNA-miRNA interactions in colon and lung cancers.

Izadi, F., Azodi, M. Z., Mansouri, V., Khodadoostan, M., & Naderi, N. (2017) · Gastroenterology and hepatology from bed to bench. · Cited by 5

Mapping of population disparities in the cholangiocarcinoma urinary metabolome

Alsaleh, M., Leftley, Z., O’Connor, T. P., Hughes, T., Barbera, T. A., Koomson, L. K., Zabron, A., Reeves, H. L., Cramp, M., Ryder, S. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00530-0 · Cited by 5

Anticancer Potential of Pineapple and its Bioactive Compound Bromelain

Kumar, D., Suchitra, S., Mundlia, J., Yadav, S. K., Yadav, D., Aggarwal, N., Chopra, H., Kumar, V., & Kamal, M. A. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128303910240713180835 · Cited by 4

Mitochondrial metabolic vulnerabilities in high-grade serous ovarian cancer

Prasad, A., Kaufmann, S. H., & Kanakkanthara, A. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189570 · Cited by 4

Mitochondrial proteostasis and cellular health: insights from chaperones and autophagy

Jagtap, Y. A., Choudhary, A., Kinger, S., Kumar, P., Bhattacharyya, S., Jha, H. C., Dhiman, R., Sharma, V., Suresh, A. K., Poluri, K. M., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287635 · Cited by 4

Enhanced metabolism as a common feature of cancer plasticity

Pánisová, E., Kery, M., Kopáček, J., Pastoreková, S., & Švastová, E. (2016) · Neoplasma · doi:10.4149/neo_2016_602 · Cited by 4

Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation

Schoonjans, C. A., & Gallez, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_6 · Cited by 4

Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation

Buczyńska, A., Sidorkiewicz, I., Hameed, A., Kretowski, A. J., & Zbucka-Krętowska, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071787 · Cited by 5

Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data

Zhou, Z., Tang, J., Lu, Y., Jia, J., Luo, T., Su, K., Dai, X., Zhang, H., & Liu, O. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02880-3 · Cited by 4

Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency

Uittenbogaard, M. N., Gropman, A. L., Whitehead, M. T., Brantner, C. A., Gropman, E., & Chiaramello, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031386 · Cited by 4

Poly I:C'nin İndüklediği TLR3 Aktivasyonunun Prostat Kanseri Hücreleri Olan PC-3 (Hormona Duyarsız) ve LNCaP'ın (Hormona Duyarlı) Oksidatif Stres Düzeyine Etkileri

Özkan, A. D., & Yüksel, B. (2022) · Kocaeli Üniversitesi Sağlık Bilimleri Dergisi · doi:10.30934/kusbed.915511 · Cited by 4

Impact of Gender and Age on Hyperthermia-Induced Changes in Respiration of Liver Mitochondria

Šilkūnienė, G., Žūkienė, R., Naučienė, Z., Degutytė-Fomins, L., & Mildažienė, V. (2018) · Medicina · doi:10.3390/medicina54040062 · Cited by 4

Blood metabolites, mitochondrial biofunction, and cervical cancer: a bidirectional Mendelian randomization study

Yang, C., Qin, L.-H., Li, L., Lan, M.-N., Wei, Q.-Y., Li, Y., & Liao, J.-Y. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03909-7 · Cited by 3

Targeting mitochondria metabolism for cancer therapy

Weinberg, S. E., & Chandel, N. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1712 · Cited by 1,420

An Overview: The Diversified Role of Mitochondria in Cancer Metabolism

Liu, Y., Sun, Y., Guo, Y., Shi, X., Chen, X., Feng, W., Wu, L., Zhang, J., Yu, S., Wang, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81609 · Cited by 275

Mitochondria and Cancer

Zong, W., Rabinowitz, J. D., & White, E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.011 · Cited by 1,330

Mitochondrial metabolism and carcinogenesis

Aras, S., Purandare, N., & Grossman, L. I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822416-8.00001-4

Mitochondrial Metabolism and Cancer

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