Cited by 42Bipolar Disorder and TreatmentMental Health Research TopicsPersonality Disorders and Psychopathology

Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study

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Faurholt-Jepsen, Maria, Frost, Mads, Busk, Jonas, Christensen, Ellen Margrethe, Bardram, Jakob E., Vinberg, Maj, Kessing, Lars Vedel·2019·International Journal of Bipolar Disorders

Abstract

Background: Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated. Methods: Patients with bipolar disorder type I (n = 53) and type II (n = 31) used a daily smartphone-based self-monitoring system for 9 months. Data in the present reflect 15.975 observations of daily collected smartphone-based data on patient-evaluated mood. Results: In models adjusted for age, gender, illness duration and psychopharmacological treatment, patients with bipolar disorder type II experienced more mood instability during depression compared with patients with bipolar disorder type I (B: 0.27, 95% CI 0.007; 0.53, p = 0.044), but lower intensity of manic symptoms. Patients with bipolar disorder type II did not experience lower mean mood or higher intensity of depressive symptoms compared with patients with bipolar disorder type I. Conclusions: Compared to bipolar disorder type I, patients with bipolar disorder type II had higher mood instability for depression. Clinically it is of importance to identify these inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability measures are warranted. Trial registration NCT02221336

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Authors
Faurholt-Jepsen, M., Frost, M., Busk, J., Christensen, E. M., Bardram, J. E., Vinberg, M., & Kessing, L. V.
Affiliations
  • IT University of Copenhagen (DK)
  • Technical University of Denmark (DK)
  • Rigshospitalet (DK)
Venue
International Journal of Bipolar Disorders
Published
2019-02-01
Volume
7
Issue
1
Pages
5-5
ISSN
2194-7511 (ISSN-L)
OpenAlex
W2916311422
Cited by
42
References
32
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 3
FWCI
4.98
Type
journal article
Language
en
Open access
Locations
  • International Journal of Bipolar Disorders (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
mood instability, bipolar I disorder, bipolar II disorder, depressive symptoms, manic symptoms, relapse risk

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