Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial
Open accessAbstract
Background: Little is known about whether treatment in a specialised out-patient mood disorder clinic improves long-term prognosis for patients discharged from initial psychiatric hospital admissions for bipolar disorder. Aims: To assess the effect of treatment in a specialised out-patient mood disorder clinic v. standard decentralised psychiatric treatment among patients discharged from one of their first three psychiatric hospital admissions for bipolar disorder. Method: Patients discharged from their first, second or third hospital admission with a single manic episode or bipolar disorder were randomised to treatment in a specialised out-patient mood disorder clinic or standard care (ClinicalTrials.gov: NCT00253071). The primary outcome measure was readmission to hospital, which was obtained from the Danish Psychiatric Central Register. Results: A total of 158 patients with mania/bipolar disorder were included. The rate of readmission to hospital was significantly decreased for patients treated in the mood disorder clinic compared with standard treatment (unadjusted hazard ratio 0.60, 95% CI 0.37–0.97, P =0.034). Patients treated in the mood disorder clinic more often used a mood stabiliser or an antipsychotic and satisfaction with treatment was more prevalent than among patients who received standard care. Conclusions: Treatment in a specialised mood disorder clinic early in the course of bipolar disorder substantially reduces readmission to a psychiatric hospital and increases satisfaction with care.
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Specialized, team-approach-based interventions combining pharmacotherapy and psychoeducation are more effective than standard community care for BD.
“There is evidence that specialized, team‐approach‐based interventions combining pharmacotherapy and psychoeducation are more effective than standard community care.63”
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- Authors
- Kessing, L. V., Hansen, H. V., Hvenegaard, A., Christensen, E. M., Dam, H., Gluud, C., Wetterslev, J., & The Early Intervention Affective Disorders (EIA) Trial Group
- Affiliations
- Copenhagen University Hospital (DK)
- Capital Region of Denmark (DK)
- Corresponding author
- Kessing, Lars Vedel
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-03
- Volume
- 202
- Issue
- 3
- Pages
- 212-219
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2120389926
- Cited by
- 219
- References
- 45
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 17 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 28 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 25 · 2015: 18 · 2014: 17 · 2013: 10
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Lundbeckfonden (R44-2009-4195)
- Rigshospitalet
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- bipolar disorder, hospital readmission, manic episodes, psychiatric hospital discharge, mood stabilizers, antipsychotic drugs, treatment satisfaction
- MeSH terms
- Adolescent, Adult, Aged, Ambulatory Care, Ambulatory Care Facilities, Bipolar Disorder, Denmark, Female, Follow-Up Studies, Hospitalization, Hospitals, Psychiatric, Humans, Male, Middle Aged, Patient Discharge, Patient Education as Topic, Psychotherapy, Group, Recurrence, Antipsychotic Agents, Health Care Costs, Patient Satisfaction, Outcome Assessment, Health Care, Antimanic Agents, Young Adult, Time-to-Treatment
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