Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
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Abstract
Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to identify the strains of Aβ that might arise prior to the onset of clinical symptoms and understand how they may change with progressing disease. Down syndrome (DS), as the most common genetic cause of AD, presents promising opportunities to compare such features between early and advanced AD. In this work, we evaluate the neuropathology and Aβ strain profile in the post-mortem brain tissues of 210 DS, AD, and control individuals. We assayed the levels of various Aβ and tau species and used conformation-sensitive fluorescent probes to detect differences in Aβ strains among individuals and populations. We found that these cohorts have some common but also some distinct strains from one another, with the most heterogeneous populations of Aβ emerging in subjects with high levels of AD pathology. The emergence of distinct strains in DS at these later stages of disease suggests that the confluence of aging, pathology, and other DS-linked factors may favor conditions that generate strains that are unique from sporadic AD.
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α-synuclein and Aβ oligomers exhibit distinct strains that influence disease phenotypes.
“Like tau, α‐synuclein and Aβ oligomers also exhibit distinct strains that influence disease phenotypes.”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [170]
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642 · see citing works
2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353 · see citing works
Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
A review on Alzheimer's disease pathophysiology and its management: an update
Kumar, A., Singh, A., & Ekavali (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.09.004 · Cited by 1,578 · see citing works
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.003 · Cited by 817 · see citing works
Self-citationTau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease
Bejanin, A., Schonhaut, D. R., La Joie, R., Kramer, J. H., Baker, S. L., Sosa, N., Ayakta, N., Cantwell, A., Janabi, M., Lauriola, M., et al. (2017) · Brain · doi:10.1093/brain/awx243 · Cited by 778 · see citing works
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
Condello, C., Yuan, P., Schain, A., & Grutzendler, J. (2015) · Nature Communications · doi:10.1038/ncomms7176 · Cited by 718 · see citing works
Self-citationTau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease
Wesseling, H., Mair, W., Kumar, M., Schlaffner, C. N., Tang, S., Beerepoot, P., Fatou, B., Guise, A. J., Cheng, L., Takeda, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.029 · Cited by 688 · see citing works
Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
Qiang, W., Yau, W., Lu, J., Collinge, J., & Tycko, R. (2017) · Nature · doi:10.1038/nature20814 · Cited by 634 · see citing works
La Joie, R., Visani, A. V., Baker, S. L., Brown, J. A., Bourakova, V., Cha, J., Chaudhary, K., Edwards, L., Iaccarino, L., Janabi, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aau5732 · Cited by 612 · see citing works
Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584 · cited 1× · see citing works
“Our finding of the presence of Aβ in the frontal cortex as early as 9 years and some tau pathology as young as 19 years old in DS is earlier than some others have reported [25, 28, 50, 53].”
ResultBateman, R. J., Aisen, P. S., De Strooper, B., Fox, N. C., Lemere, C. A., Ringman, J. M., Salloway, S., Sperling, R. A., Windisch, M., & Xiong, C. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt59 · Cited by 573 · see citing works
A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.056 · Cited by 570 · see citing works
Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise
van Dyck, C. H. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.010 · Cited by 568 · see citing works
Bennett, D. A., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Arnold, S. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.378 · Cited by 526 · see citing works
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
The apolipoprotein ε4 allele in patients with Alzheimer's disease
Mayeux, R. P., Stern, Y., Ottman, R., Tatemichi, T. K., Tang, M., Maestre, G. E., Ngai, C. I., Tycko, B., & Ginsberg, H. N. (1993) · Annals of Neurology · doi:10.1002/ana.410340527 · Cited by 414 · see citing works
Congo red and protein aggregation in neurodegenerative diseases
Frid, P., Anisimov, S. V., & Popović, N. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.001 · Cited by 398 · see citing works
Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
Lam, B., Masellis, M., Freedman, M., Stuss, D. T., & Black, S. E. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt155 · Cited by 386 · see citing works
Dementia in Down syndrome: unique insights for Alzheimer disease research
Lott, I. T., & Head, E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0132-6 · Cited by 383 · see citing works
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
Iwatsubo, T., Mann, D. M. A., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Annals of Neurology · doi:10.1002/ana.410370305 · Cited by 380 · see citing works
Fluorescent stains, with special reference to amyloid and connective tissues.
Ps, V., & Cf, C. (1959) · PubMed · Cited by 363 · see citing works
Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions
Stöhr, J., Watts, J. C., Mensinger, Z. L., Oehler, A., Grillo, S. K., DeArmond, S. J., Prusiner, S. B., & Giles, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206555109 · Cited by 359 · see citing works
Tau Aggregation and Its Interplay with Amyloid-β
Nisbet, R. M., Polanco, J.-C., Ittner, L. M., & Götz, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1371-2 · Cited by 359 · see citing works
Molecular basis for amyloid-β polymorphism
Colletier, J., Laganowsky, A., Landau, M., Zhao, M.-L., Soriaga, A., Goldschmidt, L., Flot, D., Cascio, D., Sawaya, M., & Eisenberg, D. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1112600108 · Cited by 350 · see citing works
Fortea, J., Vilaplana, E., Carmona-Iragui, M., Benejam, B., Videla, L., Barroeta, I., Fernández, S., Altuna, M., Pegueroles, J., Montal, V., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30689-9 · Cited by 340 · see citing works
Ossenkoppele, R., Smith, R., Mattsson-Carlgren, N., Groot, C., Leuzy, A., Strandberg, O., Palmqvist, S., Olsson, T., Jögi, J., Stormrud, E., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.1858 · Cited by 311 · see citing works
Amyloid Structure: Conformational Diversity and Consequences
Toyama, B. H., & Weissman, J. S. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-090908-120656 · Cited by 305 · see citing works
ApoE facilitates the microglial response to amyloid plaque pathology
Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171265 · Cited by 297 · see citing works
DYRK1A-mediated Hyperphosphorylation of Tau
Ryoo, S., Jeong, H. K., Radnaabazar, C., Yoo, J.-J., Cho, H.-J., Lee, H. W., Kim, I.-S., Cheon, Y. H., Ahn, Y. S., Chung, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707358200 · Cited by 285 · see citing works
Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients
Watts, J. C., Condello, C., Stöhr, J., Oehler, A., Lee, J., DeArmond, S. J., Lannfelt, L., Ingelsson, M., Giles, K., & Prusiner, S. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408900111 · Cited by 279 · see citing works
Self-citationBallard, C. G., Mobley, W. C., Hardy, J., Williams, G. H., & Corbett, A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00063-6 · Cited by 274 · see citing works
Tau Mutations Cause Frontotemporal Dementias
Goedert, M., Crowther, R. A., & Spillantini, M. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80615-7 · Cited by 268 · see citing works
Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP
Doran, E., Keator, D., Head, E., Phelan, M. J., Kim, R., Totoiu, M., Barrio, J. R., Small, G. W., Potkin, S. G., & Lott, I. T. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160836 · Cited by 244 · see citing works
Hof, P. R. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540280065020 · Cited by 234 · see citing works
Rasmussen, J., Mahler, J., Beschörner, N., Kaeser, S. A., Häsler, L. M., Baumann, F., Nyström, S., Portelius, E., Blennow, K., Lashley, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713215114 · Cited by 228 · see citing works
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
Strohäker, T., Jung, B. C., Liou, S.-H., Fernández, C. O., Riedel, D., Becker, S., Halliday, G. M., Bennati, M., Kim, W. S., Lee, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13564-w · Cited by 224 · see citing works
Leverenz, J. B., & Raskind, M. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6777 · Cited by 214 · see citing works
Alzheimer disease and aducanumab: adjusting our approach
Selkoe, D. J. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0205-1 · Cited by 208 · see citing works
Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β
Cohen, M. L., Kim, C., Haldiman, T., ElHag, M., Mehndiratta, P., Termsarasab, P., Lissemore, F. M., Shea, M., Cohen, Y., Chen, W., et al. (2015) · Brain · doi:10.1093/brain/awv006 · Cited by 202 · see citing works
The pattern of amyloid accumulation in the brains of adults with Down syndrome
Annus, T., Wilson, L. R., Hong, Y. T., Acosta‐Cabronero, J., Fryer, T. D., Cárdenas‐Blanco, A., Smith, R. V., Boros, I., Coles, J., Aigbirhio, F. I., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.07.490 · Cited by 182 · see citing works
Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice
Stöhr, J., Condello, C., Watts, J. C., Bloch, L., Oehler, A., Nick, M., DeArmond, S. J., Giles, K., DeGrado, W. F., & Prusiner, S. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408968111 · Cited by 173 · see citing works
Self-citationSchöll, M., Wall, A., Thordardottir, S., Ferreira, D., Bogdanovic, N., Långström, B., Almkvist, O., Graff, C., & Nordberg, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31825fdf18 · Cited by 169 · see citing works
Drug resistance confounding prion therapeutics
Berry, D. B., Lü, D., Geva, M., Watts, J. C., Bhardwaj, S., Oehler, A., Renslo, A. R., DeArmond, S. J., Prusiner, S. B., & Giles, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317164110 · Cited by 158 · see citing works
The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer's disease.
Armstrong, R. A. (2009) · PubMed · Cited by 155 · see citing works
Condello, C., Lemmin, T., Stöhr, J., Nick, M., Wu, Y., Maxwell, A. M., Watts, J. C., Caro, C. D., Oehler, A., Keene, C. D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714966115 · Cited by 145 · see citing works
Self-citationDavidson, Y. S., Robinson, A., Prasher, V. P., & Mann, D. M. A. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0559-4 · Cited by 141 · see citing works
Self-citationWiseman, F. K., Pulford, L. J., Barkus, C., Liao, F., Portelius, E., Webb, R., Chávez-Gutiérrez, L., Cleverley, K., Noy, S., Sheppard, O., et al. (2018) · Brain · doi:10.1093/brain/awy159 · Cited by 133 · see citing works
Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain
Aoyagi, A., Condello, C., Stöhr, J., Yue, W., Rivera, B. M., Lee, J. C., Woerman, A. L., Halliday, G. M., van Duinen, S. G., Ingelsson, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8462 · Cited by 130 · see citing works
Self-citationWęgiel, J., Dowjat, K., Kaczmarski, W., Kuchna, I., Nowicki, K., Frackowiak, J., Mazur‐Kolecka, B., Wegiel, J., Silverman, W. P., Reisberg, ., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0419-6 · Cited by 113 · see citing works
A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
Zhong, L., Xie, Y.-Z., Cao, T.-T., Wang, Z., Wang, T., Li, X., Shen, R.-C., Xu, H., Bu, G., & Chen, X. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0069-4 · Cited by 108 · see citing works
Further understanding the connection between Alzheimer's disease and Down syndrome
Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12112 · Cited by 105 · see citing works
Frontiers in Probing Alzheimer’s Disease Biomarkers with Fluorescent Small Molecules
Jun, Y. W., Cho, S. W., Jung, J., Huh, Y., Kim, Y. S., Kim, D., & Ahn, K. H. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00951 · Cited by 96 · see citing works
Prasher, V. P., Sajith, S. G., Rees, S. D., Patel, A., Tewari, S., Schupf, N., & Zigman, W. B. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2039 · Cited by 89 · see citing works
Self-citationAβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease
Condello, C., & Stöhr, J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.03.014 · Cited by 87 · see citing works
Self-citationDeficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer’s disease
Rosen, R. F., Ciliax, B. J., Wingo, T. S., Gearing, M., Dooyema, J. M., Lah, J. J., Ghiso, J. A., LeVine, H., & Walker, L. C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0583-3 · Cited by 82 · see citing works
A multispectral LED array for the reduction of background autofluorescence in brain tissue
Duong, H., & Han, M. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.08.018 · Cited by 76 · see citing works
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells
Stöhr, J., Wu, H., Nick, M., Wu, Y., Bhate, M., Condello, C., Johnson, N., Rodgers, J. M., Lemmin, T., Acharya, S., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2754 · Cited by 76 · see citing works
Self-citationMicroglial pathology in Down syndrome
Xue, Q., & Streit, W. J. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0864-5 · Cited by 72 · see citing works
Ovchinnikov, D. A., Korn, O., Virshup, I., Wells, C. A., & Wolvetang, E. J. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.05.004 · Cited by 71 · see citing works
Martini, A. C., Helman, A. M., McCarty, K. L., Lott, I. T., Doran, E., Schmitt, F. A., & Head, E. (2020) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12113 · Cited by 66 · see citing works
The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105–q21.05
Korenberg, J. R., Pulst, S.-M., Neve, R. L., & West, R. J. (1989) · Genomics · doi:10.1016/0888-7543(89)90095-5 · Cited by 57 · see citing works
Giles, K., Berry, D. B., Condello, C., Hawley, R. C., Gallardo‐Godoy, A., Bryant, C., Oehler, A., Elepano, M., Bhardwaj, S., Patel, S. S., et al. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.224659 · Cited by 55 · see citing works
Self-citationCastro, P., Zaman, S. H., & Holland, A. J. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8308-8 · Cited by 55 · see citing works
Harada, R., Okamura, N., Furumoto, S., Yoshikawa, T., Arai, H., Yanai, K., & Kudo, Y. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0667-2 · Cited by 51 · see citing works
Simon, R. A., Shirani, H., Åslund, A. K. O., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402890 · Cited by 48 · see citing works
Neuropathological correlates of amyloid PET imaging in Down syndrome
Abrahamson, E. E., Head, E., Lott, I. T., Handen, B. L., Mufson, E. J., Christian, B. T., Klunk, W. E., & Ikonomović, M. D. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22713 · Cited by 45 · see citing works
Matveev, S. V., Spielmann, H. P., Metts, B. M., Chen, J., Onono, F. O., Zhu, H., Scheff, S. W., Walker, L. C., & LeVine, H. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12815 · Cited by 24 · see citing works
Armstrong, R. A., & Smith, C. U. M. (1994) · Neurobiology of Disease · doi:10.1006/nbdi.1994.0017 · Cited by 15 · see citing works
Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates
Song, W., Song, E. C., Choi, S., Baik, H.-H., Jin, B. K., Kim, J. H., & Chung, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.08.066 · Cited by 15 · see citing works
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Yang, H., Yuan, P., Wu, Y., Shi, M., Caro, C. D., Tengeiji, A., Yamanoi, S., Inoue, M., DeGrado, W. F., & Condello, C. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300769120 · Cited by 19 · see citing works
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- Authors
- Maxwell, A. M., Yuan, P., Rivera, B. M., Schaaf, W., Mladinov, M., Prasher, V. P., Robinson, A. C., DeGrado, W. F., & Condello, C.
- Affiliations
- University of California, San Francisco (US)
- San Francisco State University (US)
- Liverpool John Moores University (GB)
- University of Manchester (GB)
- Corresponding author
- Condello, Carlo
- ORCID
- Venue
- Acta Neuropathologica Communications
- Published
- 2021-12
- Volume
- 9
- Issue
- 1
- Pages
- 201-201
- ISSN
- 2051-5960 (ISSN-L)
- PMC
- PMC8711167
- OpenAlex
- W4200501434
- Cited by
- 23
- References
- 75
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 4
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Neuropathologica Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute on Aging (RF1AG061874, P01AG002132)
- National Science Foundation (2034836)
- National Institutes of Health (GM064337)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- amyloid-beta, Down syndrome, Alzheimer's disease, tau protein, neuropathology, phenotypic heterogeneity, aging, postmortem brain
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Down Syndrome, Female, Humans, Male, Middle Aged, Amyloid beta-Peptides, tau Proteins, Young Adult
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