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Azoreductase: a key player of xenobiotic metabolism

Misal, Santosh A., Gawai, Kachru R.·2018·Bioresources and Bioprocessing
DOI 10.1186/s40643-018-0206-8
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  • Azoreductases reduce azo dyes to their respective aromatic amines, resulting in reduced toxicity compared to the original molecules.

    “In contrast, azoreductases are a class of enzymes capable of reducing azo dyes to their respective aromatic amines, resulting in reduced toxicity compared to the original molecules [196,197].”

    From Recent Advances in the Remediation of Textile-Dye-Containing Wastewater: Prioritizing Human Health and Sustainable Wastewater Treatment (2024) · cites this paper as [197]

    The Introduction says azoreductases cleave azo bonds and metabolize azo compounds to aromatic amines. It describes degradation as a detoxification pathway but cautions that the resulting metabolites can sometimes be more carcinogenic, so it does not support the unqualified claim that the amines are less toxic than the original dyes. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Azoreductases are typically pH-stable within the range of 5-9, and their activity is at its peak under physiological conditions.

    “Azoreductases are typically pH-stable within the range of 5-9, and their activity is at its peak under physiological conditions [197]”

    From Recent Advances in the Remediation of Textile-Dye-Containing Wastewater: Prioritizing Human Health and Sustainable Wastewater Treatment (2024) · cites this paper as [197]

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Metadata

Authors
Misal, S. A., & Gawai, K. R.
Venue
Bioresources and Bioprocessing
Publisher
Springer Science and Business Media LLC
Published
2018-04-26
Volume
5
Issue
1
ISSN
2197-4365
DOI
10.1186/s40643-018-0206-8
Cited by
184
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0 (tdm)

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