The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Staging of the estrous cycle and induction of estrus in experimental rodents: an update
Open accessAbstract
Background: Determination of the phases of the estrous cycle and induction of estrus (heat) in experimental animals remains useful, especially in reproductive function research. Main body of the abstract: This review provides a detailed description and discusses extensively the variations observed in different phases of the estrous cycle in laboratory animals using rats and mice as examples. It also illustrates how these phases can be determined and how to induce estrus ‘heat’ when required. The phases of the estrous cycle can be determined using various methods such as visual assessment, vaginal smear/cytology, histology of female reproductive organs (vagina, uterus and ovaries), vaginal wall impedance assessment and determination of urine biochemical parameters. Female animals can be artificially brought to estrus phase ‘heat’ to make them receptive to male counterparts. Conclusion: Determination of the length and phases of the estrous cycle and induction of estrus are useful in teaching and research and evaluating the effects of drugs/chemicals on the reproductive functions.
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Cites
Determination of the estrous cycle phases of rats: some helpful considerations
MARCONDES, F. K., BIANCHI, F. J., & TANNO, A. P. (2002) · Brazilian Journal of Biology · doi:10.1590/s1519-69842002000400008 · Cited by 1,553
Mouse Estrous Cycle Identification Tool and Images
Byers, S. L., Wiles, M. V., Dunn, S. L., & Taft, R. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035538 · Cited by 1,210
Cora, M. C., Kooistra, L., & Travlos, G. (2015) · Toxicologic Pathology · doi:10.1177/0192623315570339 · Cited by 943
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-4-654_2 · Cited by 714
McLean, A. C., Valenzuela, N., Fai, S., & Bennett, S. A. L. (2012) · Journal of Visualized Experiments · doi:10.3791/4389 · Cited by 644
The female reproductive system
(2012) · Muir's Textbook of Pathology · doi:10.1201/b13303-23 · Cited by 525
Nelson, J. F., Felicio, L. S., Randall, P. K., Sims, C., & Finch, C. E. (1982) · Biology of Reproduction · doi:10.1095/biolreprod27.2.327 · Cited by 522
Stockard, C. R., & Papanicolaou, G. N. (1917) · American Journal of Anatomy · doi:10.1002/aja.1000220204 · Cited by 471
The Female Rat Reproductive Cycle: A Practical Histological Guide to Staging
Westwood, F. R. (2008) · Toxicologic Pathology · doi:10.1177/0192623308315665 · Cited by 428
Determining the Stage of the Estrous Cycle in the Mouse by the Appearance of the Vagina
Champlin, A. K., Dorr, D. L., & Gates, A. H. (1973) · Biology of Reproduction · doi:10.1093/biolreprod/8.4.491 · Cited by 298
Cited by
Mechanisms of sex differences in Alzheimer’s disease
Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice
Zhu, J., Yang, Q., Li, H., Wang, Y., Jiang, Y., Wang, H., Cong, L., Xu, J., Shen, Z., Chen, W., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.324 · Cited by 64
Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
Parikh, R., Sorek, E., Parikh, S., Michael, K., Bikovski, L., Tshori, S., Shefer, G., Mingelgreen, S., Zornitzki, T., Knobler, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109579 · Cited by 42
Modelling female physiology from head to Toe: impact of sex hormones, menstrual cycle, and pregnancy
Abo, S., Smith, D., Stadt, M., & Layton, A. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111074 · Cited by 35
Long-term Recordings of Arcuate Nucleus Kisspeptin Neurons Across the Mouse Estrous Cycle
Vas, S., Wall, E., Zhou, Z., Kalmar, L., Han, S. Y., & Herbison, A. E. (2024) · Endocrinology · doi:10.1210/endocr/bqae009 · Cited by 14
Metadata
- Authors
- Ajayi, A. F., & Akhigbe, R. E.
- Venue
- Fertility Research and Practice
- Published
- 2020-03-14
- Volume
- 6
- Issue
- 1
- Pages
- 5-5
- ISSN
- 2054-7099 (ISSN-L)
- OpenAlex
- W3012573213
- Cited by
- 561
- References
- 21
- FWCI
- 43.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ajayi, A. F., & Akhigbe, R. E. (2020). Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fertility Research and Practice. https://doi.org/10.1186/s40738-020-00074-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
