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Cited by 357Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsSilk-based biomaterials and applications

The DOI matches its Crossref record; 315 of the 316 references it cites were found in a registry or an index.

Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

Open access
Liu, Shuai, Yu, Jiang-Ming, Gan, Yan-Chang, Qiu, Xiao-Zhong, Gao, Zhe-Chen, Wang, Huan, Chen, Shi-Xuan, Xiong, Yuan, Liu, Guo-Hui, Lin, Si-En, McCarthy, Alec, John, Johnson V., Wei, Dai-Xu, Hou, Hong-Hao·2023·Military Medical Research
DOI 10.1186/s40779-023-00448-wPMC PMC10047482
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Abstract

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such materials have mechanical adaptability, microstructure interconnectivity, and inherent bioactivity, making them ideal for the design of living implants for specific applications in TE and regenerative medicine. This paper provides an overview for recent progress of biomimetic natural biomaterials (BNBMs), including advances in their preparation, functionality, potential applications and future challenges. We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM. Moreover, we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications. Finally, we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

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Crossref · 10.1186/s40779-023-00448-w

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Fig. 1 Correlation diagram of multiple strategies and purposes of natural biomaterials for tissue engineering (TE) and regenerative medicine based on novel techniques and tools in recent years. Typical natural biomaterials include biopolyesters of polylactic acid (PLA), polyhydroxyalkanoates (PHAs) and their derivatives (e.g., PLGA, PHA-PLA); polysaccharides of hyaluronic acid (HA), alginate, cellulose and chitosan, proteins and poly (amino acid)s of collagen, gelatin, fibroin, γ-poly-glutamic acid (γ-PGA) and antimicrobial peptides (AMPs), respectively. Novel techniques and tools contain novel chassis strains/cells for biosynthesis, synthetic biology tools, metabolic engineering, artificial intelligence and machine learning, respectively. The strategies for optimized natural biomaterials are higher production and lower costs, regulation of material properties, better biosafety, design of unknown biomaterials, and optimized manufacturing of biomaterial devices, respectively. PLGA poly (lactic-co-glycolic acid), PHA-PLA polyhydroxyalkanoate-polylactic acid
Fig. 1 Correlation diagram of multiple strategies and purposes of natural biomaterials for tissue engineering (TE) and regenerative medicine based on novel techniques and tools in recent years. Typical natural biomaterials include biopolyesters of polylactic acid (PLA), polyhydroxyalkanoates (PHAs) and their derivatives (e.g., PLGA, PHA-PLA); polysaccharides of hyaluronic acid (HA), alginate, cellulose and chitosan, proteins and poly (amino acid)s of collagen, gelatin, fibroin, γ-poly-glutamic acid (γ-PGA) and antimicrobial peptides (AMPs), respectively. Novel techniques and tools contain novel chassis strains/cells for biosynthesis, synthetic biology tools, metabolic engineering, artificial intelligence and machine learning, respectively. The strategies for optimized natural biomaterials are higher production and lower costs, regulation of material properties, better biosafety, design of unknown biomaterials, and optimized manufacturing of biomaterial devices, respectively. PLGA poly (lactic-co-glycolic acid), PHA-PLA polyhydroxyalkanoate-polylactic acidCC BY · PubMed Central
Fig. 2 Schematically showing the rational design and preparation of biomimetic natural biomaterials (BNBMs) enabling with featured properties mimicking the tissue extracellular matrix (ECM)
Fig. 2 Schematically showing the rational design and preparation of biomimetic natural biomaterials (BNBMs) enabling with featured properties mimicking the tissue extracellular matrix (ECM)CC BY · PubMed Central
Fig. 3 Typical topologies and fabrication strategies of the structural biomaterials
Fig. 3 Typical topologies and fabrication strategies of the structural biomaterialsCC BY · PubMed Central

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Research works printed but not linked: 1

  1. Pazhamannil RV, Govindan P, Sooraj P. Prediction of the tensile strength of polylactic acid fused deposition models using artificial neural network technique. Mater Today. 2021;46:9187–93.

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Metadata

Authors
Liu, S., Yu, J.-M., Gan, Y.-C., Qiu, X.-Z., Gao, Z.-C., Wang, H., Chen, S.-X., Xiong, Y., Liu, G.-H., Lin, S.-E., McCarthy, A., John, J. V., Wei, D.-X., & Hou, H.-H.
Affiliations
  • Southern Medical University (CN)
  • Shanghai Jiao Tong University (CN)
  • Sun Yat-sen University (CN)
  • Huazhong University of Science and Technology (CN)
  • Terasaki Foundation (US)
  • University of Nebraska Medical Center (US)
Corresponding author
  • Wang, Huan
  • Wei, Dai-Xu
ORCID
Venue
Military Medical Research
Publisher
Elsevier BV
Published
2023-03-28
Volume
10
Issue
1
Pages
16-16
ISSN
2054-9369 (ISSN-L)
DOI
10.1186/s40779-023-00448-w
PMC
PMC10047482
OpenAlex
W4361206153
Cited by
357
References
316
Citations by year
2026: 60 · 2025: 146 · 2024: 118 · 2023: 33
FWCI
23.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Military Medical Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (52003113, 31900950, 82102334, 82002313, 82072444)
  • Guangdong Basic and Applied Basic Research Foundation (2021A1515010745, 2020A1515110356, 2019A1515111155)
  • Shenzhen Fundamental Research Program (JCYJ20190808120405672)
  • Key Program of the National Natural Science Foundation of Zhejiang Province (LZ22C100001)
  • Natural Science Foundation of Shanghai (20ZR1469800)
  • Science and Technology Projects of Guangzhou City (202102020359)
  • Startup Grant of the University of Chinese Academy of Sciences (WIUCASQD2021026)
  • National Key Research & Development Program of China (2018YFC2001502, 2018YFB1105705)
  • China Postdoctoral Science Foundation (2021TQ0118, 2022M721490)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
tissue engineering, regenerative medicine, extracellular matrix mimics, biomimetic scaffolds, biomaterial functionalization, bioactivity (biomaterials), mechanical properties
MeSH terms
Biocompatible Materials, Humans, Tissue Engineering, Biomimetics, Biomimetic Materials, Regenerative Medicine

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