The DOI matches its Crossref record; 315 of the 316 references it cites were found in a registry or an index.
Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications
Open accessAbstract
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such materials have mechanical adaptability, microstructure interconnectivity, and inherent bioactivity, making them ideal for the design of living implants for specific applications in TE and regenerative medicine. This paper provides an overview for recent progress of biomimetic natural biomaterials (BNBMs), including advances in their preparation, functionality, potential applications and future challenges. We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM. Moreover, we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications. Finally, we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.
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“Biomimetic materials, including engineered scaffolds and autologous protein solutions, aim to mimic native tissue environments but require further refinement in delivery methods and long-term safety [129,130].”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [129]
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Metadata
- Authors
- Liu, S., Yu, J.-M., Gan, Y.-C., Qiu, X.-Z., Gao, Z.-C., Wang, H., Chen, S.-X., Xiong, Y., Liu, G.-H., Lin, S.-E., McCarthy, A., John, J. V., Wei, D.-X., & Hou, H.-H.
- Affiliations
- Southern Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Sun Yat-sen University (CN)
- Huazhong University of Science and Technology (CN)
- Terasaki Foundation (US)
- University of Nebraska Medical Center (US)
- Corresponding author
- Wang, Huan
- Wei, Dai-Xu
- Venue
- Military Medical Research
- Publisher
- Elsevier BV
- Published
- 2023-03-28
- Volume
- 10
- Issue
- 1
- Pages
- 16-16
- ISSN
- 2054-9369 (ISSN-L)
- PMC
- PMC10047482
- OpenAlex
- W4361206153
- Cited by
- 357
- References
- 316
- Citations by year
- 2026: 60 · 2025: 146 · 2024: 118 · 2023: 33
- FWCI
- 23.10
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Military Medical Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (52003113, 31900950, 82102334, 82002313, 82072444)
- Guangdong Basic and Applied Basic Research Foundation (2021A1515010745, 2020A1515110356, 2019A1515111155)
- Shenzhen Fundamental Research Program (JCYJ20190808120405672)
- Key Program of the National Natural Science Foundation of Zhejiang Province (LZ22C100001)
- Natural Science Foundation of Shanghai (20ZR1469800)
- Science and Technology Projects of Guangzhou City (202102020359)
- Startup Grant of the University of Chinese Academy of Sciences (WIUCASQD2021026)
- National Key Research & Development Program of China (2018YFC2001502, 2018YFB1105705)
- China Postdoctoral Science Foundation (2021TQ0118, 2022M721490)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- tissue engineering, regenerative medicine, extracellular matrix mimics, biomimetic scaffolds, biomaterial functionalization, bioactivity (biomaterials), mechanical properties
- MeSH terms
- Biocompatible Materials, Humans, Tissue Engineering, Biomimetics, Biomimetic Materials, Regenerative Medicine
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