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Pharmaceutical nanotechnology: from the bench to the market
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Background: Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse drug reactions. Main body: Different types of nanosystems have been fabricated including carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, etc. Physicochemical properties of the starting materials and the selected method of preparation play a significant aspect in determining the shape and characteristics of the developed nanoparticles. Dispersion of preformed polymers, coacervation, polymerization, nano-spray drying and supercritical fluid technology are among the most extensively used techniques for the preparation of nanocarriers. Particle size, surface charge, surface hydrophobicity and drug release are the main factors affecting nanoparticles physical stability and biological performance of the incorporated drug. In clinical practice, many nanodrugs have been used for both diagnostic and therapeutic applications and are being investigated for various indications in clinical trials. Nanoparticles are used for the cure of kidney diseases, tuberculosis, skin conditions, Alzheimer’s disease, different types of cancer as well as preparation of COVID-19 vaccines. Conclusion: In this review, we will confer the advantages, types, methods of preparation, characterization methods and some of the applications of nano-systems.
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“Among these, nanotechnology‐based approaches have transformed the field by enabling the engineering of nanoscale carriers capable of entrapping, encapsulating, dissolving, or binding active pharmaceutical ingredients (APIs) within their matrix [26].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [26]
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Urióstegui-Pena, A. G., Torres‐Copado, A., Ochoa-Sanchez, A., Luna‐Bárcenas, G., Sahare, P., & Paul, S. (2025) · 3 Biotech · doi:10.1007/s13205-024-04197-y · Cited by 7
Taay, Y. M., Mohammed, M. T., Alwan, A. H., & Ismail, A. H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01949-2 · Cited by 7
Emerging paradigms in nanostructured targeted drug delivery systems
Hasnain, A. N., & Telange, D. R. (2026) · Discover Nano · doi:10.1186/s11671-026-04685-5 · Cited by 10
Nanotechnology-based Drug Delivery of Topical Antifungal Agents
Singh, S., Patil, V. M., Paliwal, S., & Masand, N. (2023) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511666230818125031 · Cited by 9
Al-Btoush, H. A. (2023) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.17.4.03 · Cited by 7
History, introduction, and physiochemical properties of gold nanoparticles
Prakash, K., Manu, K. R., Rout, S. R., Almalki, W. H., Kumar, P., Sahebkar, A., Kesharwani, P., & Dandela, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19061-2.00014-6 · Cited by 7
Ngo, H. V., Nguyen, H. D., Park, C., Nguyen, V. H., & Lee, B. (2024) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-024-00689-4 · Cited by 7
Enhanced Lung Cancer Therapy via Co-Encapsulation of Docetaxel and Betulinic Acid
Saikia, T., Rajak, P., Sahu, B. P., & Patowary, L. (2024) · Drugs and Drug Candidates · doi:10.3390/ddc3030033 · Cited by 7
Nanomedicine for pediatric healthcare: A review of the current state and future prospectives
Chen, J., Zhao, Z., Alantary, D., & Huang, J. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114597 · Cited by 7
Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems
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e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7
“Among these, nanotechnology-based approaches have transformed the field by enabling the engineering of nanoscale carriers capable of entrapping, encapsulating, dissolving, or binding active pharmaceutical ingredients (APIs) within their matrix [26].”
Koush, A. A., Popa, T., Pricop, D. A., Nita, L. E., Foia, C. I., Pauna, A.-M. R., Bucă, B. R., Pavel, L. L., & Mititelu-Tarțău, L. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121574 · Cited by 6
Hamdy, S. A., Hatem, S., Elosaily, H., Hassan, A. G. A.-E., Elshimy, R. M., Osman, A. H., & El‐Shiekh, R. A. (2025) · Natural Products and Bioprospecting · doi:10.1007/s13659-025-00514-x · Cited by 6
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Metadata
- Authors
- Mazayen, Z. M., Ghoneim, A. M., Elbatanony, R. S., Basalious, E. B., & Bendas, E. R.
- Affiliations
- Future University in Egypt (EG)
- Cairo University (EG)
- Corresponding author
- Ghoneim, Amira M.
- Venue
- Future Journal of Pharmaceutical Sciences
- Published
- 2022-01-15
- Volume
- 8
- Issue
- 1
- Pages
- 12-12
- ISSN
- 2314-7245 (ISSN-L)
- 2314-7253
- PMC
- PMC8760885
- OpenAlex
- W4205766471
- Cited by
- 208
- References
- 109
- Citations by year
- 2026: 33 · 2025: 58 · 2024: 57 · 2023: 51 · 2022: 9
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Future Journal of Pharmaceutical Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- pharmaceutical nanotechnology, nanoparticles, drug delivery systems, nanocarriers, carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, coacervation, nano spray drying, supercritical fluid technology, particle size, surface charge, drug release, physical stability, clinical trials, nanotherapeutics, COVID-19 vaccines, cancer therapy, Alzheimer's disease, tuberculosis, kidney disease
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