Cited by 208Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsPharmacology and Nanomedicine Research

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Pharmaceutical nanotechnology: from the bench to the market

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Mazayen, Zaed M., Ghoneim, Amira M., Elbatanony, Rasha S., Basalious, Emad B., Bendas, Ehab R.·2022·Future Journal of Pharmaceutical Sciences

DOI 10.1186/s43094-022-00400-0PMC PMC8760885

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Abstract

Background: Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse drug reactions. Main body: Different types of nanosystems have been fabricated including carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, etc. Physicochemical properties of the starting materials and the selected method of preparation play a significant aspect in determining the shape and characteristics of the developed nanoparticles. Dispersion of preformed polymers, coacervation, polymerization, nano-spray drying and supercritical fluid technology are among the most extensively used techniques for the preparation of nanocarriers. Particle size, surface charge, surface hydrophobicity and drug release are the main factors affecting nanoparticles physical stability and biological performance of the incorporated drug. In clinical practice, many nanodrugs have been used for both diagnostic and therapeutic applications and are being investigated for various indications in clinical trials. Nanoparticles are used for the cure of kidney diseases, tuberculosis, skin conditions, Alzheimer’s disease, different types of cancer as well as preparation of COVID-19 vaccines. Conclusion: In this review, we will confer the advantages, types, methods of preparation, characterization methods and some of the applications of nano-systems.

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Authors: Mazayen, Z. M., Ghoneim, A. M., Elbatanony, R. S., Basalious, E. B., & Bendas, E. R.
Affiliations: Future University in Egypt (EG)
Cairo University (EG)
Corresponding author: Ghoneim, Amira M.
ORCID: Ghoneim, Amira M.
Elbatanony, Rasha S.
Basalious, Emad B.
Bendas, Ehab R.
Venue: Future Journal of Pharmaceutical Sciences
Publisher: Springer Science and Business Media LLC
Published: 2022-01-15
Volume: 8
Issue: 1
Pages: 12-12
ISSN: 2314-7245 (ISSN-L)
2314-7253
DOI: 10.1186/s43094-022-00400-0
PMC: PMC8760885
OpenAlex: W4205766471
Cited by: 208
References: 109
Citations by year: 2026: 33 · 2025: 58 · 2024: 57 · 2023: 51 · 2022: 9
FWCI: 3.01
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Future Journal of Pharmaceutical Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Greater South Information System
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords: pharmaceutical nanotechnology, nanoparticles, drug delivery systems, nanocarriers, carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, coacervation, nano spray drying, supercritical fluid technology, particle size, surface charge, drug release, physical stability, clinical trials, nanotherapeutics, COVID-19 vaccines, cancer therapy, Alzheimer's disease, tuberculosis, kidney disease

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Pharmaceutical nanotechnology: from the bench to the market

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