The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
Open accessAbstract
Lymphocytes require glucose uptake and metabolism for normal survival and function. The signals that regulate the expression and localization of glucose transporter 1 (Glut1) to allow glucose uptake in T cells are now beginning to be understood. Resting T cells require extracellular signals, such as cytokines, hormones, and growth factors, or low-level TCR stimulation to take up adequate glucose to maintain housekeeping functions. In the absence of extrinsic signals, resting T cells internalize and degrade Glut1 and cannot maintain viability. Activated T cells have dramatically increased metabolic requirements to support the energy and biosynthetic needs necessary for growth, proliferation, and effector function. In particular, glucose metabolism and aerobic glycolysis fuel this demand. Therefore, activation of T cells causes a large increase in Glut1 expression and surface localization. If glucose uptake is limited, glycolytic flux decreases to a level that no longer sustains viability, and proapoptotic Bcl-2 family members become activated, promoting cell death. However, excessive glucose uptake can promote hyperactive immune responses and possible immune pathology. Tight regulation of glucose uptake is required to maintain immune homeostasis, and understanding of these metabolic pathways may lead to therapeutic strategies to target some forms of cancer or autoimmunity.
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Cites
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Background
Cited by
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
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“This early peak in glucose uptake is consistent with other data on in vitro activated Teff-like cells (Chang et al., 2013; Maciver et al., 2008; Patsoukis et al., 2015), but the decline in glucose uptake indicates a dynamic regulation in vivo that is distinct from short-term in vitro culture.”
ResultImpact of Obesity and Metabolic Syndrome on Immunity
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Metadata
- Authors
- MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06-24
- Volume
- 84
- Issue
- 4
- Pages
- 949-957
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2129424071
- Cited by
- 505
- References
- 12
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
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- MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008). Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0108024
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