Impact of Obesity and Metabolic Syndrome on Immunity

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Child abuse: Adolescent records vs. adult recall

Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,122 · see citing works

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates

Finkelstein, E. A., Trogdon, J. G., Cohen, J. W., & Dietz, W. H. (2009) · Health Affairs · doi:10.1377/hlthaff.28.5.w822 · Cited by 2,956 · see citing works

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works

Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451 · see citing works

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Park, B., Song, D., Kim, H. M., Choi, B.-S., Lee, H., & Lee, J.-O. (2009) · Nature · doi:10.1038/nature07830 · Cited by 2,421 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

A comprehensive definition for metabolic syndrome

Huang, P. L. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001180 · Cited by 2,223 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

Regulation of Adaptive Immunity by the Innate Immune System

Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,139 · see citing works

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works

Prevalence of obesity in the United States, 2009-2010.

Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2012) · PubMed · Cited by 2,070 · see citing works

Impact of Overweight on the Risk of Developing Common Chronic Diseases During a 10-Year Period

Field, A. E., Coakley, E. H., Must, A., Spadano, J. L., Laird, N., Dietz, W. H., Rimm, E., & Colditz, G. A. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.13.1581 · Cited by 1,694 · see citing works

Cytokines in cancer pathogenesis and cancer therapy

Dranoff, G. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1252 · Cited by 1,567 · see citing works

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

Obesity and the metabolic syndrome in developing countries.

Misra, A., & Khurana, L. (2008) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2008-1595 · Cited by 1,332 · see citing works

Prevalence of the metabolic syndrome in the United States, 2003-2012

Aguilar, M., Bhuket, T., Torres, S., Liu, B., & Wong, R. J. (2015) · JAMA · doi:10.1001/jama.2015.4260 · Cited by 1,267 · see citing works

Monocyte chemoattractant protein 1 in obesity and insulin resistance

Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,201 · see citing works

Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects

Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129 · cited 2× · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

Creely, S. J., McTernan, P. G., Kusminski, C. M., Fisher, F. M., Da Silva, N. F., Khanolkar, M., Evans, M., Harte, A. L., & Kumar, S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2006 · Cited by 1,043 · see citing works

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

Lumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes · doi:10.2337/db06-1076 · Cited by 1,016 · see citing works

Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006.

Ervin, R. B. (2009) · PubMed · Cited by 1,003 · see citing works

The weight of leptin in immunity

Cava, A. L., & Matarese, G. (2004) · Nature Reviews Immunology · doi:10.1038/nri1350 · Cited by 927 · cited 2× · see citing works

The metabolic syndrome: a global public health problem and a new definition.

Zimmet, P., Magliano, D., Matsuzawa, Y., Alberti, G., & Shaw, J. (2005) · Journal of atherosclerosis and thrombosis · doi:10.5551/jat.12.295 · Cited by 925 · see citing works

Adiponectin as an anti-inflammatory factor

Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 883 · see citing works

Antigen-specific memory B cell development.

McHeyzer-Williams, L. J., & McHeyzer-Williams, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115732 · Cited by 771 · see citing works

Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis

Kontush, A., & Chapman, M. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.1 · Cited by 752 · see citing works

Journey through the thymus: stromal guides for T-cell development and selection

Takahama, Y. (2006) · Nature reviews. Immunology · doi:10.1038/nri1781 · Cited by 730 · see citing works

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

Yvan‐Charvet, L., Pagler, T. A., Gautier, E. L., Avagyan, S., Siry, R., Han, S., Welch, C. L., Wang, N., Randolph, G. J., Snoeck, H. W., et al. (2010) · Science · doi:10.1126/science.1189731 · Cited by 724 · see citing works

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works

The endoplasmic reticulum stress response in immunity and autoimmunity

Todd, D. J., Lee, A., & Glimcher, L. H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2359 · Cited by 621 · see citing works

Circulating Mononuclear Cells in the Obese Are in a Proinflammatory State

Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P., & Dandona, P. (2004) · Circulation · doi:10.1161/01.cir.0000142055.53122.fa · Cited by 611 · see citing works

Obesity is associated with impaired immune response to influenza vaccination in humans

Sheridan, P. A., Paich, H. A., Handy, J., Karlsson, E. A., Hudgens, M. G., Sammon, A. B., Holland, L., Weir, S. S., Noah, T. L., & Beck, M. A. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.208 · Cited by 598 · see citing works

Obesity and cancer risk: evidence, mechanisms, and recommendations

Vučenik, I., & Stains, J. P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06750.x · Cited by 574 · see citing works

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I., & Bloom, S. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6762 · Cited by 566 · see citing works

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108024 · Cited by 501 · see citing works

In vivo protection against endotoxin by plasma high density lipoprotein.

Levine, D. M., Parker, T. S., Donnelly, T. M., Walsh, A., & Rubin, A. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.12040 · Cited by 485 · see citing works

Immunological complications of obesity

Kanneganti, T., & Dixit, V. D. (2012) · Nature Immunology · doi:10.1038/ni.2343 · Cited by 481 · see citing works

Metabolic Syndrome Is Associated with Elevated Oxidative Stress and Dysfunctional Dense High-Density Lipoprotein Particles Displaying Impaired Antioxidative Activity

Hansel, B., Giral, P., Nobécourt, E., Chantepie, S., Bruckert, É., Chapman, M. J., & Kontush, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0305 · Cited by 476 · see citing works

A role for leptin and its cognate receptor in hematopoiesis

Bennett, B. D., Solar, G. P., Yuan, J. Q., Mathias, J., Thomas, G. R., & Matthews, W. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70684-2 · Cited by 473 · see citing works

Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

Ley, K. F., & Kansas, G. S. (2004) · Nature reviews. Immunology · doi:10.1038/nri1351 · Cited by 453 · see citing works

Differences in gut microbiota composition between obese and lean children: a cross-sectional study

Bervoets, L., Hoorenbeeck, K. V., Kortleven, I., Noten, C. V., Hens, N., Vael, C., Goossens, H., Desager, K., & Vankerckhoven, V. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-10 · Cited by 452 · see citing works

The immune system and aging: A review

Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449 · cited 1× · see citing works

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

Yang, H., Youm, Y., Vandanmagsar, B., Ravussin, A., Gimble, J. M., Greenway, F. L., Stephens, J. M., Mynatt, R. L., & Dixit, V. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000021 · Cited by 441 · see citing works

Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner

de Álvaro, C., Teruel, T., Hernández, R., & Lorenzo, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312021200 · Cited by 430 · see citing works

Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP

Zhang, H., Halbleib, M., Ahmad, F., Manganiello, V. C., & Greenberg, A. S. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2929 · Cited by 429 · see citing works

Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Iwasaki, H., & Akashi, K. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.004 · Cited by 394 · see citing works

Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection

Allard, R., Leclerc, P., Tremblay, C. G., & Tannenbaum, T.-N. (2010) · Diabetes Care · doi:10.2337/dc09-2215 · Cited by 340 · see citing works

Leptin Signaling and Obesity

Yang, R., & Barouch, L. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.156596 · Cited by 331 · see citing works

Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 323 · see citing works

Obesity accelerates thymic aging

Yang, H., Youm, Y., Vandanmagsar, B., Rood, J. C., Kumar, K. G., Butler, A. A., & Dixit, V. D. (2009) · Blood · doi:10.1182/blood-2009-03-213595 · Cited by 309 · see citing works

The immune cells in adipose tissue

Ferrante, A. W. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12154 · Cited by 300 · see citing works

Memory CD4 T cells emerge from effector T-cell progenitors

Harrington, L., Janowski, K., Oliver, J., Zajac, A., & Weaver, C. (2008) · Nature · doi:10.1038/nature06672 · Cited by 290 · see citing works

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?

Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M., & Kammoun, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00470 · Cited by 278 · see citing works

T‐Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet‐Induced Obesity in C57BL/6 Mice

Strissel, K. J., DeFuria, J., Shaul, M. E., Bennett, G., Greenberg, A. S., & Obin, M. S. (2010) · Obesity · doi:10.1038/oby.2010.1 · Cited by 276 · see citing works

Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism

Norseen, J., Hosooka, T., Hammarstedt, A., Yore, M. M., Kant, S., Aryal, P., Kiernan, U. A., Phillips, D. A., Maruyama, H., Kraus, B. J., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06193-11 · Cited by 272 · see citing works

High-Density Lipoprotein Cholesterol, Size, Particle Number, and Residual Vascular Risk After Potent Statin Therapy

Mora, S., Glynn, R. J., & Ridker, P. M. (2013) · Circulation · doi:10.1161/circulationaha.113.002671 · Cited by 238 · see citing works

Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome

Delzenne, N. M., Neyrinck, A. M., & Cani, P. D. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s10 · Cited by 231 · see citing works

Leptin resistance: a prediposing factor for diet-induced obesity

Scarpace, P. J., & Zhang, Y. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90669.2008 · Cited by 214 · see citing works

Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes

Weitman, E. S., Aschen, S. Z., Farias-Eisner, G. T., Albano, N. J., Cuzzone, D. A., Ghanta, S., Zampell, J. C., Thorek, D. L. J., & Mehrara, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070703 · Cited by 210 · see citing works

Reduced tetanus antibody titers in overweight children

Eliakim, A., Swindt, C., Zaldivar, F., Casali, P., & Cooper, D. M. (2006) · Autoimmunity · doi:10.1080/08916930600597326 · Cited by 209 · see citing works

Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons

Vreugdenhil, A. C. E., Rousseau, C. H., Härtung, T., Greve, J. W. M., Veer, C. V. ′., & Buurman, W. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1399 · Cited by 206 · see citing works

Phagocytic Activity Is Impaired in Type 2 Diabetes Mellitus and Increases after Metabolic Improvement

Lecube, A., Pachón, G., Pétriz, J., Hernández, C., & Simó, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023366 · Cited by 206 · see citing works

Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey 2005-2006

Visness, C. M., London, S. J., Daniels, J. L., Kaufman, J. S., Yeatts, K., Siega‐Riz, A. M., Liu, A. H., Calatroni, A., & Zeldin, D. C. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.1126 · Cited by 205 · see citing works

Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice

Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011338 · Cited by 198 · cited 1× · see citing works

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900562 · Cited by 196 · see citing works

The Role of the Immune System in Obesity and Insulin Resistance

Patel, P., Buras, E. D., & Balasubramanyam, A. (2013) · Journal of Obesity · doi:10.1155/2013/616193 · Cited by 193 · see citing works

Adipose Tissue Dysregulation in Patients with Metabolic Syndrome

Bremer, A. A., Devaraj, S., Afify, A. M., & Jialal, I. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1577 · Cited by 190 · see citing works

Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice

White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185 · see citing works

Trends in Quality-Adjusted Life-Years Lost Contributed by Smoking and Obesity

Jia, H., & Lubetkin, E. I. (2010) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2009.09.043 · Cited by 183 · see citing works

Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice

Chandra, R. K. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.1.13 · Cited by 179 · see citing works

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

van der Weerd, K., Dik, W. A., Schrijver, B., Schweitzer, D. H., Langerak, A. W., Drexhage, H. A., Kiewiet, R. M., van Aken, M. O., van Huisstede, A., van Dongen, J. J. M., et al. (2012) · Diabetes · doi:10.2337/db11-1065 · Cited by 174 · see citing works

Potential Antiinflammatory Role of Insulin via the Preferential Polarization of Effector T Cells toward a T Helper 2 Phenotype

Viardot, A., Grey, S. T., Mackay, F., & Chisholm, D. J. (2006) · Endocrinology · doi:10.1210/en.2006-0686 · Cited by 173 · see citing works

Adiponectin in inflammatory and immune-mediated diseases

Fantuzzi, G. (2013) · Cytokine · doi:10.1016/j.cyto.2013.06.317 · Cited by 171 · see citing works

Adipose Tissue Dysfunction in Nascent Metabolic Syndrome

Bremer, A. A., & Jialal, I. (2013) · Journal of Obesity · doi:10.1155/2013/393192 · Cited by 171 · see citing works

A High-Fat Diet Increases IL-1, IL-6, and TNF-α Production by Increasing NF-κB and Attenuating PPAR-γ Expression in Bone Marrow Mesenchymal Stem Cells

Cortez, M., do Carmo, L. S., Rogero, M. M., Borelli, P., & Fock, R. A. (2012) · Inflammation · doi:10.1007/s10753-012-9557-z · Cited by 169 · see citing works

Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span

Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 158 · see citing works

Selective impairment in dendritic cell function and altered antigen‐specific CD8+ T‐cell responses in diet‐induced obese mice infected with influenza virus

Smith, A. G., Sheridan, P. A., Tseng, R. J., Sheridan, J. F., & Beck, M. A. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02895.x · Cited by 151 · see citing works

White Blood Cells Count and Incidence of Type 2 Diabetes in Young Men

Twig, G., Afek, A. B., Shamiss, A., Derazne, E., Tzur, D., Gordon, B., & Tirosh, A. (2012) · Diabetes Care · doi:10.2337/dc11-2298 · Cited by 145 · see citing works

Loss of cyclin‐dependent kinase inhibitors produces adipocyte hyperplasia and obesity

Naaz, A., Holsberger, D. R., Iwamoto, G. A., Nelson, A. J., Kiyokawa, H., & Cooke, P. S. (2004) · The FASEB Journal · doi:10.1096/fj.04-2631fje · Cited by 144 · see citing works

Ectopic and Serum Lipid Levels Are Positively Associated with Bone Marrow Fat in Obesity

Bredella, M. A., Gill, C. M., Gerweck, A. V., Landa, M. G., Kumar, V., Daley, S. M., Torriani, M., & Miller, K. K. (2013) · Radiology · doi:10.1148/radiol.13130375 · Cited by 138 · see citing works

Alterations in T-Cell Subset Frequency in Peripheral Blood in Obesity

O’Rourke, R. W., Kay, T., Scholz, M. H., et al. (2005) · Obesity Surgery · doi:10.1381/096089205774859308 · Cited by 129 · see citing works

Diet-Induced Obesity in Mice Reduces the Maintenance of Influenza-Specific CD8+ Memory T Cells ,

Karlsson, E. A., Sheridan, P. A., & Beck, M. A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123653 · Cited by 124 · see citing works

Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins

Kitchens, R. L., Thompson, P. A., Munford, R. S., & O’Keefe, G. E. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300228-jlr200 · Cited by 123 · see citing works

Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells

Deng, J., Liu, S., Zou, L., Xu, C. B., Geng, B., & Xu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299115 · Cited by 122 · see citing works

Effect of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat.

Grünfeld, C., Gulli, R., Moser, A. H., Gavin, L. A., & Feingold, K. R. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38349-8 · Cited by 116 · see citing works

ATP-Binding Cassette Transporter G1 Negatively Regulates Thymocyte and Peripheral Lymphocyte Proliferation

Armstrong, A. J., Gebre, A. K., Parks, J. S., & Hedrick, C. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902372 · Cited by 114 · see citing works

Effect of Weight Loss on Proinflammatory State of Mononuclear Cells in Obese Women

Sheu, W. H., Chang, T., Lee, W., Ou, H., Wu, C.-M., Tseng, L., Lang, H.-F., Wu, C., Wan, C., & Lee, I. (2008) · Obesity · doi:10.1038/oby.2008.37 · Cited by 112 · see citing works

Expansion of Pathogen-Specific T-Helper 1 and T-Helper 17 Cells in Pulmonary Tuberculosis With Coincident Type 2 Diabetes Mellitus

Kumar, N. P., Sridhar, R., Banurekha, V. V., Jawahar, M. S., Nutman, T. B., & Babu, S. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit241 · Cited by 110 · see citing works

Mice Chronically Fed High-Fat Diet Have Increased Mortality and Disturbed Immune Response in Sepsis

Grahnemo, L., Verdrengh, M., Enge, M., Andersson, N., Amu, S., Önnheim, K., Benrick, A., Brisslert, M., Bylund, J., Bokarewa, M. I., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007605 · Cited by 103 · see citing works

Evolving concepts of specificity in immune reactions

Eisen, H. N., & Chakraborty, A. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012051108 · Cited by 92 · see citing works

New Roles of HDL in Inflammation and Hematopoiesis

Zhu, X., & Parks, J. S. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150709 · Cited by 92 · see citing works

Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality

Teoh, H., Quan, A., Bang, K. W. A., Wang, G., Lovren, F., Vu, V. P., Haitsma, J. J., Szmitko, P. E., Al-Omran, M. A., Wang, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90384.2008 · Cited by 91 · see citing works

The role of HDL in innate immunity

Feingold, K. R., & Grünfeld, C. (2010) · Journal of Lipid Research · doi:10.1194/jlr.e012138 · Cited by 83 · see citing works

Resolution of inflammation in obesity-induced liver disease

Rius, B., López‐Vicario, C., González‐Périz, A., Morán‐Salvador, E., García‐Alonso, V., Clària, J., & Titos, E. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00257 · Cited by 79 · see citing works

Ectopic and Serum Lipid Levels Are Positively Associated with Bone Marrow Fat in Obesity

Bredella, M. A., Gill, C. M., Gerweck, A. V., et al. (2013) · Radiology · doi:10.1148/radiology.13130375 · Cited by 79 · see citing works

Chylomicrons enhance endotoxin excretion in bile

Read, T. E., Harris, H. W., Grünfeld, C., Feingold, K. R., Calhoun, M. C., Kane, J. P., & Rapp, J. H. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3496-3502.1993 · Cited by 73 · see citing works

Visceral Fat Accumulation Induced by a High‐fat Diet Causes the Atrophy of Mesenteric Lymph Nodes in Obese Mice

Kim, C. S., Lee, S. C., Kim, Y. M., Kim, B. S., Choi, H., Kawada, T., Kwon, B. S., & Yu, R. (2008) · Obesity · doi:10.1038/oby.2008.55 · Cited by 71 · see citing works

Impact of immune-metabolic interactions on age-related thymic demise and T cell senescence

Dixit, V. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.002 · Cited by 68 · see citing works

Mild weight loss reduces inflammatory cytokines, leukocyte count, and oxidative stress in overweight and moderately obese participants treated for 3 years with dietary modification

Chae, J. S., Paik, J. K., Kang, R., Kim, M., Choi, Y., Lee, S., & Lee, J. H. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.01.005 · Cited by 64 · see citing works

Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions

Zhao, Y., van Berkel, T. J. C., & Eck, M. V. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833dedaa · Cited by 58 · see citing works

The Impact of Obesity on Immune Response to Infection and Vaccine: An Insight into Plausible Mechanisms

Rajkumar, P. B. H. (2013) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000113 · Cited by 58 · see citing works

Leukocytosis in rabbits with diet-induced atherosclerosis.

Feldman, D. L., Mogelesky, T. C., Liptak, B. F., & Gerrity, R. G. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.4.985 · Cited by 57 · see citing works

Severe pulmonary metastasis in obese and diabetic mice

Mori, A., Sakurai, H., Choo, M., Obi, R., Koizumi, K., Yoshida, C., Shimada, Y., & Saiki, I. (2006) · International Journal of Cancer · doi:10.1002/ijc.22248 · Cited by 56 · see citing works

Association between Cigarette Smoking, White Blood Cell Count, and Metabolic Syndrome as Defined by the Japanese Criteria

Ishizaka, N., Ishizaka, Y., Toda, E.-I., et al. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.0136 · Cited by 52 · see citing works

Chronic TNFα and cAMP pre‐treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis

Bézaire, V., Mairal, A., Anesia, R., Lefort, C., & Langin, D. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.08.019 · Cited by 49 · see citing works

Local development of effector and memory T helper cells

Fazilleau, N., McHeyzer‐Williams, L. J., & McHeyzer‐Williams, M. G. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.04.003 · Cited by 45 · see citing works

Dietary approaches to improving atheroprotective HDL functions

Andersen, C. J., & Fernández, M. L. (2013) · Food & Function · doi:10.1039/c3fo60207a · Cited by 37 · see citing works

Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza‐related hospitalizations in the United States

Charland, K., Buckeridge, D. L., Hoen, A. G., Berry, J. G., Elixhauser, A., Melton, F., & Brownstein, J. S. (2012) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12019 · Cited by 31 · see citing works

The Prevalence of Metabolic Syndrome and Diabetes Increases through the Quartiles of White Blood Cell Count in Japanese Men and Women

Oda, E., & Kawai, R. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.2138 · Cited by 30 · see citing works

The effect of high-fat diet on the composition of the gut microbiota in cloned and non-cloned pigs of lean and obese phenotype

Pedersen, R., Andersen, A. D., Hermann-Bank, M. L., Stagsted, J., & Boyé, M. (2013) · Gut Microbes · doi:10.4161/gmic.26108 · Cited by 29 · see citing works

The evaluation of immune responses to hepatitis B vaccination in diabetic and non‐diabetic haemodialysis patients and the use of tetanus toxoid

Ocak, S., & Eskiocak, A. F. (2008) · Nephrology · doi:10.1111/j.1440-1797.2008.00936.x · Cited by 25 · see citing works

Thymic microenvironmental alterations in experimentally induced diabetes

Nagib, P. R. A., Gameiro, J., Stivanin-Silva, L. G., et al. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.02.001 · Cited by 23 · see citing works

White Blood Cell Counts Associate More Strongly to the Metabolic Syndrome in 75-Year-Old Women Than in Men: A Population Based Study

Nilsson, G., Hedberg, P., Jonason, T., et al. (2007) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2007.0012 · Cited by 18 · see citing works

Update on HDL Receptors and Cellular Cholesterol Transport

Kellner-Weibel, G., & de la Llera-Moya, M. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0169-0 · Cited by 17 · see citing works

Tackling Two Diseases with HDL

Hansson, G. K., & Björkholm, M. (2010) · Science · doi:10.1126/science.1191663 · Cited by 16 · see citing works

Altered or Impaired Immune Response to Hepatitis B Vaccine in WNIN/GR-Ob Rat: An Obese Rat Model with Impaired Glucose Tolerance

Rajkumar, P. B. H., Rajkumar, H., & Nappanveettil, G. (2011) · ISRN Endocrinology · doi:10.5402/2011/980105 · Cited by 15 · see citing works

Effect of bariatric surgery on peripheral blood lymphocyte subsets in women

Merhi, Z. O., Durkin, H. G., Feldman, J. G., et al. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.09.004 · Cited by 13 · see citing works

Accumulation of tissue macrophages and depletion of resident macrophages in the diabetic thymus in response to hyperglycemia-induced thymocyte apoptosis

Barbu–Tudoran, L., Gavriliuc, O. I., Păunescu, V., & Mic, F. A. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.10.007 · Cited by 7 · see citing works

The impact of dietary fiber on gut microbiota in host health and disease

Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.012 · Cited by 2,517 · see citing works

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00650-3 · Cited by 475 · see citing works

Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i>

Finamore, A., Palmery, M., Bensehaila, S., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3247528 · Cited by 256 · see citing works

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Kolb, R., Phan, L., Borcherding, N., Liu, Y., Yuan, F., Janowski, A. M., Xie, Q., Markan, K. R., Li, W., Potthoff, M. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13007 · Cited by 239 · see citing works

Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit

Cardoso, F., Klein Wolterink, R. G. J., Godinho-Silva, C., Domingues, R. G., Ribeiro, H., da Silva, J. A., Mahú, I., Domingos, A. I., & Veiga-Fernandes, H. (2021) · Nature · doi:10.1038/s41586-021-03830-7 · Cited by 159 · see citing works

COVID-19 in adult patients with pre-existing chronic cardiac, respiratory and metabolic disease: a critical literature review with clinical recommendations

Flaherty, G. T., Hession, P., Liew, C. H., Lim, B. C. W., Leong, T. K., Lim, V., & Sulaiman, L. H. (2020) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-020-00118-y · Cited by 127 · see citing works

Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

Jha, S. K., Jha, N. K., Kumar, D., Ambasta, R. K., & Kumar, P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.015 · Cited by 122 · see citing works

Overweight in elderly people induces impaired autophagy in skeletal muscle

Potes, Y., de Luxán-Delgado, B., Rodriguez-González, S., Guimarães, M. R. M., Solano, J. J., Fernández-Fernández, M., Bermúdez, M., Boga, J. A., Vega-Naredo, I., & Coto-Montes, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.018 · Cited by 67 · see citing works

Vaccination of immune compromised children—an overview for physicians

Pittet, L. F., & Posfay-Barbe, K. M. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-03997-1 · Cited by 31 · see citing works

The Innate Immune System

Heeg, K. M. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00205-0

Aspects of the innate and adaptive immune responses to acute infections with BVDV

Brackenbury, L. S., Carr, B. V., & Charleston, B. (2003) · Veterinary Microbiology · doi:10.1016/j.vetmic.2003.09.004 · Cited by 58 · see citing works

Do adaptive immune cells suppress or activate innate immunity?

Zhao, J., Yang, X., Auh, S. L., Kim, K. D., Tang, H., & Fu, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.10.003 · Cited by 40 · see citing works

Earthworm and innate immunity

Liu, Z., & Niu, B. (2008) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2008.04.005

Innate and adaptive immunity

Noakes, P. S., & Michaelis, L. J. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.1.3 · Cited by 12 · see citing works