The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
gp130 at the nexus of inflammation, autoimmunity, and cancer
Open accessAbstract
Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp130-deficient mice are embryonically lethal. However, the best characterized facet of this receptor and its associated cytokines is the ability to promote or suppress inflammation. The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses.
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Metadata
- Authors
- Silver, J. S., & Hunter, C. A.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-07
- Volume
- 88
- Issue
- 6
- Pages
- 1145-1156
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2032835141
- Cited by
- 254
- References
- 190
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
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