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Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

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Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

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Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

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Involvement of ROS in BBB dysfunction

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Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

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How do immune cells overcome the blood-brain barrier in multiple sclerosis?

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Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

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Mechanism of alcohol-induced oxidative stress and neuronal injury

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Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase and PKB signaling

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Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood–brain barrier dysfunction

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Elevated Cytokine Expression in the Orbitofrontal Cortex of Victims of Suicide

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Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

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Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

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HIV-1 gp120 Compromises Blood–Brain Barrier Integrity and Enhance Monocyte Migration across Blood–Brain Barrier: Implication for Viral Neuropathogenesis

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Postnatal growth and morphological development of the brain: a species comparison

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Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier

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Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm

Ayer, R. E., & Zhang, J. H. (2008) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-75718-5_7 · Cited by 217

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

Lippai, D., Bala, S., Petrasek, J., Csák, T., Levin, I., Kurt‐Jones, E. A., & Szabó, G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212659 · Cited by 220

Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells

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Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

Persidsky, Y., Heilman, D., Haorah, J., Zelivyanskaya, M., Persidsky, R., Weber, G. A., Shimokawa, H., Kaibuchi, K., & Ikezu, T. (2006) · Blood · doi:10.1182/blood-2005-11-4721 · Cited by 200

Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases

Song, K., Li, Y., Zhang, H., An, N., Wei, Y., Wang, L., Tian, C., Yuan, M., Sun, Y., Xing, Y., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4356386 · Cited by 208

Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Advani, A., Huang, Q., Thai, K., Advani, S. L., White, K., Kelly, D. J., Yuen, D. A., Connelly, K. A., Marsden, P. A., & Gilbert, R. E. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.044 · Cited by 160

Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration

Enciu, A., Gherghiceanu, M., & Popescu, B. O. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/297512 · Cited by 157

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis

Tavassolifar, M. J., Vodjgani, M., Salehi, Z., & Izad, M. H. (2020) · Autoimmune Diseases · doi:10.1155/2020/5793817 · Cited by 160

Blood brain barrier: A review of its anatomy and physiology in health and disease

Sharif, Y., Jumah, F., Coplan, L., Krosser, A., Sharif, Κ., & Tubbs, R. S. (2018) · Clinical Anatomy · doi:10.1002/ca.23083 · Cited by 151

Mechanisms of C-Reactive Protein-Induced Blood–Brain Barrier Disruption

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In Situ implantable, post-trauma microenvironment-responsive, ROS Depletion Hydrogels for the treatment of Traumatic brain injury

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Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications

Wei, Y., & Shah, R. (2020) · Pharmaceuticals · doi:10.3390/ph13070155 · Cited by 140

Magnetic nanoformulation of azidothymidine 5’-triphosphate for targeted delivery across the blood–brain barrier

Nair, Saiyed, & Gandhi (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s8905 · Cited by 125

Disruption of blood–brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge‐like drinking model

Rubio‐Araiz, A., Porcu, F., Pérez‐Hernández, M., García‐Gutiérrez, M. S., Aracil‐Fernández, M. A., Gutiérrez‐López, M. D., Guerri, C., Manzanares, J., O’Shea, E., & Colado, M. I. (2016) · Addiction Biology · doi:10.1111/adb.12376 · Cited by 132

The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain

García-Suástegui, W. A., Ramos-Chávez, L. A., Rubio‐Osornio, M., Calvillo-Velasco, M., Atzin-Méndez, J. A., Guevara, J., & Silva‐Adaya, D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4680732 · Cited by 120

Alcohol‐induced blood–brain barrier dysfunction is mediated via inositol 1,4,5‐triphosphate receptor (IP 3 R)‐gated intracellular calcium release

Haorah, J., Knipe, B., Gorantla, S., Zheng, J., & Persidsky, Y. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04245.x · Cited by 119

Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1

Kim, H., Lee, G., Cho, E. Y., Chae, S., Ahn, T., & Chae, H. (2009) · Journal of Cell Science · doi:10.1242/jcs.038430 · Cited by 112

Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat

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HIV-1 infection and alcohol abuse: Neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions

Persidsky, Y., Ho, W., Ramirez, S. H., Potula, R., Abood, M. E., Unterwald, E. M., & Tuma, R. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.001 · Cited by 107

N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells

Zhang, X., Banerjee, A., Banks, W. A., & Nuran Ercal, A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.008 · Cited by 106

Activation of protein tyrosine kinases and matrix metalloproteinases causes blood‐brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse

Haorah, J., Schall, K. A., Ramirez, S. H., & Persidsky, Y. (2007) · Glia · doi:10.1002/glia.20596 · Cited by 106

Nonmuscle Myosin Light-Chain Kinase Deficiency Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice via Reduced Endothelial Barrier Dysfunction and Monocyte Migration

Sun, C., Wu, M. H., & Yuan, S. Y. (2011) · Circulation · doi:10.1161/circulationaha.110.988915 · Cited by 104

Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults

Woods, A. J., Porges, E. C., Bryant, V. E., Seider, T. R., Gongvatana, A., Kahler, C. W., de la Monte, S. M., Monti, P. M., & Cohen, R. A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13211 · Cited by 110

Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication

Pervin, Z., & Stephen, J. M. (2021) · AIMS neuroscience · doi:10.3934/neuroscience.2021021 · Cited by 110

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells

Manda, K. R., Banerjee, A., Banks, W. A., & Nuran Ercal, A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.029 · Cited by 100

Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats

Motaghinejad, M., Motevalian, M., Fatima, S., Hashemi, H., & Gholami, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.020 · Cited by 96

Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats

Peng, H., Geil, C., Chen, K. Y., McClain, J. A., & Nixon, K. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.175 · Cited by 95

Pathophysiology of the Blood–Brain Barrier: Animal Models and Methods

Hawkins, B. T., & Egleton, R. D. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)80007-x · Cited by 101

Converging Actions of Alcohol on Liver and Brain Immune Signaling

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OTA induces intestinal epithelial barrier dysfunction and tight junction disruption in IPEC-J2 cells through ROS/Ca2+-mediated MLCK activation

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Central nervous system inflammation in disease related conditions: Mechanistic prospects

Fung, A., Vizcaychipi, M. P., Lloyd, D. G., Wan, Y., & Ma, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.061 · Cited by 95

Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood–brain barrier endothelial cells

Berrout, J., Jin, M., & O’Neil, R. G. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.044 · Cited by 90

Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS

Buckner, C. M., Luers, A. J., Calderon, T. M., Eugenin, E. A., & Berman, J. W. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9017-3 · Cited by 88

Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells

Jin, M., Yu, J., Sun, H., Jin, Y.-H., Shen, G., Jin, C., Cui, Y., Lee, D., Kim, S.-U., Kim, J.-S., et al. (2019) · Antioxidants · doi:10.3390/antiox9010001 · Cited by 87

HIV‐1 neuropathogenesis: glial mechanisms revealed through substance abuse

Hauser, K. F., El‐Hage, N., Stiene‐Martin, A., Maragos, W. F., Nath, A., Persidsky, Y., Volsky, D. J., & Knapp, P. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04227.x · Cited by 86

Inhibition of the myosin light chain kinase prevents hypoxia‐induced blood–brain barrier disruption

Kuhlmann, C. R. W., Tamaki, R., Gamerdinger, M., Leßmann, V., Behl, C., Kempski, O. S., & Luhmann, H. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04506.x · Cited by 85

Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava–Bignami disease

Fernandes, L. M. P., Bezerra, F. R., Monteiro, M. C., Silva, M. L., de Oliveira, F. R., Lima, R. R., Fontes-Júnior, E. A., & Maia, C. D. S. F. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.267 · Cited by 84

Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response

Bennett, C., Mohammed, F. S., Álvarez-Ciara, A., Nguyen, M. A., Dietrich, W. D., Rajguru, S. M., Streit, W. J., & Prasad, A. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.040 · Cited by 87

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits

Zhuang, Z., Zhou, M., You, W., Zhu, L., Ma, C., Sun, X., & Shi, J. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-47 · Cited by 83

Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review

Asken, B. M., Sullan, M. J., Snyder, A., Houck, Z. M., Bryant, V. E., Hizel, L. P., McLaren, M. E., Dede, D. E., Jaffee, M. S., DeKosky, S. T., et al. (2016) · Neuropsychology Review · doi:10.1007/s11065-016-9327-z · Cited by 90

Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction

Kim, Y., Cho, A. Y., Kim, H. C., Ryu, D., Jo, S. A., & Jung, Y. (2022) · Antioxidants · doi:10.3390/antiox11020197 · Cited by 87

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System

Gauberti, M., Fournier, A. P., Docagne, F., Vivien, D., & de Lizarrondo, S. M. (2018) · Theranostics · doi:10.7150/thno.22662 · Cited by 93

Alteration of blood brain barrier permeability by T-2 toxin: Role of MMP-9 and inflammatory cytokines

Ravindran, J., Agrawal, M., Gupta, N., & Rao, P. V. (2010) · Toxicology · doi:10.1016/j.tox.2010.11.006 · Cited by 82

Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease

Yang, Y., Sangwung, P., Kondo, R., Jung, Y., McConnell, M. J., Jeong, J., Utsumi, T., Sessa, W. C., & Iwakiri, Y. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.02.028 · Cited by 79

Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem

Zhong, Y., Dong, G., Luo, H., Cao, J., Wang, C., Wu, J., Feng, Y.-Q., & Yue, J. (2012) · Toxicology · doi:10.1016/j.tox.2012.08.009 · Cited by 77

Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders

Miguel-Hidalgo, J. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00078 · Cited by 78

Gastroprotective effect of carob (Ceratonia siliqua L.) against ethanol-induced oxidative stress in rat

Rtibi, K., Jabri, M., Selmi, S., Souli, A., Sebaï, H., Benna, J. E., Amri, M., & Marzouki, L. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0819-9 · Cited by 75

Effects of chronic ethanol drinking on the blood brain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injection

Singh, A. K., Jiang, Y., Gupta, S., & Benlhabib, E. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl120 · Cited by 75

Blood–Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders

Aragón-González, A., Shaw, P. J., & Ferraiuolo, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315271 · Cited by 73

Acetyl-l-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain

Rump, T. J., Muneer, P. M. A., Szlachetka, A. M., Lamb, A., Haorei, C., Alikunju, S., Xiong, H., Keblesh, J. P., Liu, J., Zimmerman, M. C., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.011 · Cited by 70

HIV‐1 gp120 as Well as Alcohol Affect Blood–Brain Barrier Permeability and Stress Fiber Formation: Involvement of Reactive Oxygen Species

Shiu, C., Barbier, E., Cello, F. D., Choi, H. J., & Stins, M. F. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00271.x · Cited by 70

Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes

Kumar, S., Jin, M., Ande, A., Sinha, N., Silverstein, P. S., & Kumar, A. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.714366 · Cited by 70

Imidacloprid increases intestinal permeability by disrupting tight junctions

Zhao, G., Wang, X., Li, J., Wang, R., Ren, F., Pang, G., & Li, Y. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112476 · Cited by 72

HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood–brain barrier dysfunction for HIV-1-associated dementia

Ricardo-Dukelow, M., Kadiu, I., Rożek, W., Schlautman, J. D., Persidsky, Y., Ciborowski, P. S., Kanmogne, G. D., & Gendelman, H. E. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.01.004 · Cited by 67

Changes in Oxidative Damage, Inflammation and [NAD(H)] with Age in Cerebrospinal Fluid

Guest, J., Grant, R., Mori, T. A., & Croft, K. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085335 · Cited by 66

Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats

Ehrlich, D., Pirchl, M., & Humpel, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.054 · Cited by 67

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications

Steinruecke, M., Lonergan, R. M., Selvaraj, B. T., Chandran, S., Castro, B. D., & Stavrou, M. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231153281 · Cited by 63

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

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