The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
Abstract
We report that mitochondrial DNA (mtDNA) is inflammatogenic in vitro and in vivo as a result of the presence of unmethylated CpG sequences and its oxidative status. Purified human and murine mtDNAs induced arthritis when injected intra-articularly (i.a.) in mice. Importantly, oligodeoxynucleotide that contained a single oxidatively damaged base also induced arthritis when injected i.a. in mice. In contrast, neither human nor murine nuclear DNA induced inflammation. mtDNA-induced arthritis was neither B cell- nor T cell-dependent but was mediated by monocytes/macrophages. mtDNA-induced nuclear factor-κB stimulation resulted in the production of tumor necrosis factor α, a potent, arthritogenic factor. Finally, extracellular mtDNA was detected in the synovial fluids of rheumatoid arthritis patients but not of control subjects. We conclude that endogenous mtDNA displays inflammatogenic properties as a result of its content of unmethylated CpG motifs and oxidatively damaged adducts.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,725
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.
Williams, R. O., Feldmann, M., & Maini, R. N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9784 · Cited by 989
Mitochondrial damage induced by conditions of oxidative stress
Kowaltowski, A. J., & Vercesi, A. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00216-0 · Cited by 866
Neurath, M. F., Pettersson, S., Meyer Zum Büschenfelde, K.-H., & Strober, W. (1996) · Nature Medicine · doi:10.1038/nm0996-998 · Cited by 840
An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4
Tepper, R. I., Coffman, R. L., & Leder, P. (1992) · Science · doi:10.1126/science.1636093 · Cited by 541
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock
Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Häcker, H., Heeg, K., & Wagner, H. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270712 · Cited by 416
Bacterial DNA causes septic shock
Sparwasser, T., Miethke, T., Lipford, G., Borschert, K., Häcker, H., Heeg, K., & Wagner, H. (1997) · Nature · doi:10.1038/386336a0 · Cited by 411
The Mitochondrion in Cell Death Control: Certainties and Incognita
Loeffler, M., & Kroemer, G. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4833 · Cited by 394
The role of CpG motifs in innate immunity
Krieg, A. M. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00048-5 · Cited by 343
Cited by
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Mitochondria in innate immune responses
West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature · doi:10.1038/nature10992 · Cited by 1,201
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115
Metadata
- Authors
- Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I.-M., & Tarkowski, A.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-24
- Volume
- 75
- Issue
- 6
- Pages
- 995-1000
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2146494489
- Cited by
- 508
- References
- 25
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. https://app.cochat.ai/papers/10.1189/jlb.0703328
- The paper
- Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I.-M., & Tarkowski, A. (2004). Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0703328
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
