The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The disconnect between animal models of sepsis and human sepsis
Open accessAbstract
Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy in septic humans. We describe the shortcomings of the animal models and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsis.
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Cites
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Background
Cited by
Immunodesign of experimental sepsis by cecal ligation and puncture
Rittirsch, D., Huber-Lang, M. S., Flierl, M. A., & Ward, P. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.214 · Cited by 2,209
Self-citationThe Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Cavaillon, J., Singer, M., & Skirecki, T. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201810128 · Cited by 319
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Dewitte, A., Lepreux, S., Villeneuve, J., Rigothier, C., Combe, C., Ouattara, A., & Ripoche, J. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0337-7 · Cited by 194
Rodriguez, S., Chora, A., Goumnerov, B., Mumaw, C., Goebel, W. S., Fernandez, L., Baydoun, H., HogenEsch, H., Dombkowski, D. M., Karlewicz, C. A., et al. (2009) · Blood · doi:10.1182/blood-2009-04-214916 · Cited by 135
Metadata
- Authors
- Rittirsch, D., Hoesel, L. M., & Ward, P. A.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-04
- Volume
- 81
- Issue
- 1
- Pages
- 137-143
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2125498567
- Cited by
- 406
- References
- 68
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Rittirsch, D., Hoesel, L. M., & Ward, P. A. (2007). The disconnect between animal models of sepsis and human sepsis. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0806542
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
