The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration
Abstract
Recent studies have demonstrated that neutrophils are not a homogenous population of cells. Here, we have identified a subset of human neutrophils with a distinct profile of cell-surface receptors [CD54high, CXC chemokine receptor 1low (CXCR1low)], which represent cells that have migrated through an endothelial monolayer and then re-emerged by reverse transmigration (RT). RT neutrophils, when in contact with endothelium, were rescued from apoptosis, demonstrate functional priming, and were rheologically distinct from neutrophils that had not undergone transendothelial migration. In vivo, 1–2% of peripheral blood neutrophils in patients with systemic inflammation exhibit a RT phenotype. A smaller population existed in healthy donors (≈0.25%). RT neutrophils were distinct from naïve circulatory neutrophils (CD54low, CXCR1high) and naïve cells after activation with formyl-Met-Leu-Phe (CD54low, CXCR1low). It is important that the RT phenotype (CD54high, CXCR1low) is also distinct from tissue-resident neutrophils (CD54low, CXCR1low). Our results demonstrate that neutrophils can migrate in a retrograde direction across endothelial cells and suggest that a population of tissue-experienced neutrophils with a distinct phenotype and function are present in the peripheral circulation in humans in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration
Springer, T. A. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.004143 · Cited by 1,496
Regulation of Dendritic Cell Migration to the Draining Lymph Node
Martín-Fontecha, A., Sebastiani, S., Höpken, U. E., Uguccioni, M., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030448 · Cited by 878
Endothelial cell interactions with granulocytes: tethering and signaling molecules
Zimmerman, G. A., Prescott, S. M., & McIntyre, T. M. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90149-2 · Cited by 747
Roumen, R. M. H., Hendriks, T., van der Ven-Jongekrijg, J., Nieuwenhuijzen, G. A. P., Sauerwein, R. W., van der Meer, J. W. M., & A. Goris, R. J. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00011 · Cited by 618
Tsuda, Y., Takahashi, H., Kobayashi, M., Hanafusa, T., Herndon, D. N., & Suzuki, F. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.006 · Cited by 425
Cooke, B. M., Usami, S., Perry, I., & Nash, G. B. (1993) · Microvascular Research · doi:10.1006/mvre.1993.1004 · Cited by 194
Self-citationGranulocyte clearance by apoptosis in the resolution ofinflammation
Savill, J., & Haslett, C. (1995) · Seminars in Cell Biology · doi:10.1016/s1043-4682(05)80009-1 · Cited by 178
Accelerated atherogenesis in autoimmune rheumatic diseases
Bacon, P. A., Stevens, R. J., Carruthers, D. M., Young, S. P., & Kitas, G. D. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00100-3 · Cited by 155
Leukocyte—endothelial cell interactions
McEver, R. P. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90109-p · Cited by 128
Brown, G. E., Stewart, M. Q., Bissonnette, S. A., Elia, A. E. H., Wilker, E., & Yaffe, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314258200 · Cited by 119
Cited by
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L., Worthen, G. S., & Albelda, S. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,371
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Neutrophil migration in infection and wound repair: going forward in reverse
de Oliveira, S., Rosowski, E. E., & Huttenlocher, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.49 · Cited by 1,058
Neutrophil plasticity in the tumor microenvironment
Giese, M. A., Hind, L. E., & Huttenlocher, A. (2019) · Blood · doi:10.1182/blood-2018-11-844548 · Cited by 783
Metadata
- Authors
- Buckley, C. D., Ross, E. A., McGettrick, H. M., Osborne, C. E., Haworth, O., Schmutz, C., Stone, P. C. W., Salmon, M., Matharu, N. M., Vohra, R. K., Nash, G. B., & Rainger, G. E.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-05
- Volume
- 79
- Issue
- 2
- Pages
- 303-311
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2099369787
- Cited by
- 340
- References
- 21
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. https://app.cochat.ai/papers/10.1189/jlb.0905496
- The paper
- Buckley, C. D., Ross, E. A., McGettrick, H. M., Osborne, C. E., Haworth, O., Schmutz, C., Stone, P. C. W., Salmon, M., Matharu, N. M., Vohra, R. K., Nash, G. B., & Rainger, G. E. (2005). Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0905496
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
