The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Neutrophil plasticity in the tumor microenvironment
Open accessAbstract
Neutrophils act as the body’s first line of defense against infection and respond to diverse inflammatory cues, including cancer. Neutrophils display plasticity, with the ability to adapt their function in different inflammatory contexts. In the tumor microenvironment, neutrophils have varied functions and have been classified using different terms, including N1/N2 neutrophils, tumor-associated neutrophils, and polymorphonuclear neutrophil myeloid–derived suppressor cells (PMN-MDSCs). These populations of neutrophils are primarily defined by their functional phenotype, because few specific cell surface markers have been identified. In this review, we will discuss neutrophil polarization and plasticity and the function of proinflammatory/anti-inflammatory and protumor/antitumor neutrophils in the tumor microenvironment. We will also discuss how neutrophils with the ability to suppress T-cell activation, referred to by some as PMN-MDSCs, fit into this paradigm.
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Cites
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Cited by
Chemokines and the immune response to cancer
Ozga, A. J., Chow, M. T., & Luster, A. D. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.012 · Cited by 830
Neutrophils in cancer: heterogeneous and multifaceted
Hedrick, C. C., & Malanchi, I. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00571-6 · Cited by 768
Yum, S., Li, M., Fang, Y., & Chen, Z. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100225118 · Cited by 566
Immunotherapy: Reshape the Tumor Immune Microenvironment
LV, B., Wang, Y., Ma, D., Cheng, W., Liu, J., Yong, T., Chen, H., & Wang, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844142 · Cited by 482
Tumor-associated neutrophils and neutrophil-targeted cancer therapies
Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188762 · Cited by 312
Metadata
- Authors
- Giese, M. A., Hind, L. E., & Huttenlocher, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2019-05-16
- Volume
- 133
- Issue
- 20
- Pages
- 2159-2167
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2923394609
- Cited by
- 783
- References
- 95
- FWCI
- 23.39
- Type
- journal article
- Language
- en
- Open access
- green
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