The DOI matches its Crossref record; 145 of the 148 references it cites were found in a registry or an index.
Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72
Abstract
Heat shock proteins (Hsp) were first characterized as intracellular proteins, which function to limit protein aggregation, facilitate protein refolding, and chaperone proteins. During times of cellular stress, intracellular Hsp levels increase to provide cellular protection. Recently, it has been recognized that Hsp, particularly Hsp72, are also found extracellularly (eHsp72), where they exhibit potent immunomodulatory effects on innate and acquired immunity. Circulating eHsp72 levels also greatly increase during times of stress (i.e., when an organism is exposed to a physical/psychological stressor or suffers from various pathological conditions). It has been proposed that elevated eHsp72 serves a protective role by facilitating immunological responses during times of increased risk of pathogenic challenge and/or tissue damage. This review focuses on the in vivo releasing signals and immunomodulatory function(s) of endogenous eHsp72. In addition, we present data that emphasize the importance of caution when conducting in vitro immunological tests of Hsp72 function.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the release of Hsp72 (a possible DAMP) after tailshock is dependent on α-adrenergic, but not βor glucocorticoid, receptor signaling (Johnson et al, 2005;Johnson and Fleshner, 2006).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Johnson and Fleshner, 2006
Citations
Cites
Goodman & Gilman's The Pharmacological Basis of Therapeutics
Brunton, L. L. (1985) · Cited by 7,321
Goodman and Gilman's the Pharmacological Basis of Therapeutics
Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796
Lindquist, S., & Craig, E. A. (1988) · Annual Review of Genetics · doi:10.1146/annurev.ge.22.120188.003215 · Cited by 5,304
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Molecular chaperones in cellular protein folding
Hartl, F. U. (1996) · Nature · doi:10.1038/381571a0 · Cited by 3,584
Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266
A new puffing pattern induced by temperature shock and DNP in drosophila
Ritossa, F. (1962) · Cellular and Molecular Life Sciences · doi:10.1007/bf02172188 · Cited by 2,146
Asea, A. A. A., Kraeft, S., Kurt‐Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. C., & Calderwood, S. K. (2000) · Nature Medicine · doi:10.1038/74697 · Cited by 1,642
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601
Novel Signal Transduction Pathway Utilized by Extracellular HSP70
Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510
Kregel, K. C. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01267.2001 · Cited by 1,450
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
Ciocca, D. R., & Calderwood, S. K. (2005) · Cell Stress and Chaperones · doi:10.1379/csc-99r.1 · Cited by 1,420
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
Basu, S., Binder, R. J., Suto, R., Anderson, K. M., & Srivastava, P. K. (2000) · International Immunology · doi:10.1093/intimm/12.11.1539 · Cited by 1,318
The Biology of heat shock proteins and molecular chaperones.
Morimoto, R. I., Tissieres, A., & Georgopoulos, C. P. (1994) · Cited by 1,244
Heat Shock Transcription Factors: Structure and Regulation
Wu, C. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002301 · Cited by 1,231 · cited 1×
“The gene for Hsp72 contains at least two regulatory elements that interact with heat shock transcription factors (HSFs) [9, 10].”
BackgroundEscola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228
Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs
Tissieres, A., Mitchell, H. K., & Tracy, U. M. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90447-1 · Cited by 1,227
Seong, S., & Matzinger, P. (2004) · Nature reviews. Immunology · doi:10.1038/nri1372 · Cited by 1,224
The biology of heat shock proteins and molecular chaperones
Büchner, J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90065-5 · Cited by 1,215
Roles of heat-shock proteins in innate and adaptive immunity.
Srivastava, P. (2002) · Nature reviews. Immunology · doi:10.1038/nri749 · Cited by 1,069
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
Denzer, K., Kleijmeer, M. J., Heijnen, H. F. G., Stoorvogel, W., & Geuze, H. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3365 · Cited by 1,067
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
Pirkkala, L., NYKÄNEN, P., & Sistonen, L. (2001) · The FASEB Journal · doi:10.1096/fj00-0294rev · Cited by 996
HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway
Vabulas, R. M., Ahmad‐Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., & Wagner, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111204200 · Cited by 956
Heat shock proteins and the immune response
Kaufmann, S. H. E. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90050-j · Cited by 940
The Biogenesis and Functions of Exosomes
Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 848
Srivastava, P. K. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064801 · Cited by 846
Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells
Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835
A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides
Suto, R., & Srivastava, P. K. (1995) · Science · doi:10.1126/science.7545313 · Cited by 826
Heat shock proteins as regulators of the immune response
Pockley, A. G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14075-5 · Cited by 703
Gastpar, R., Gehrmann, M., Bausero, M. A., Asea, A. A. A., Groß, C. C., Schroeder, J. A., & Multhoff, G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3804 · Cited by 696
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S., & Segal, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.249 · Cited by 611
Heat shock factors and the control of the stress response
SANTORO, M. G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00299-3 · Cited by 587
Heat shock proteins transfer peptides during antigen processing and CTL priming
Srivastava, P. K., Udono, H., Blachere, N., & Li, Z. (1994) · Immunogenetics · doi:10.1007/bf00188611 · Cited by 569
Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases
Zügel, U., & Kaufmann, S. H. E. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.19 · Cited by 561
Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555
Exosome-dependent Trafficking of HSP70
Lancaster, G. I., & Febbraio, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502017200 · Cited by 547
Xiao, X., Zuo, X., Davis, A. A., McMillan, D. R., Curry, B. B., Richardson, J. A., & Benjamin, I. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5943 · Cited by 542
Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World
Srivastava, P. K., Ménoret, A., Basu, S., Binder, R. J., & McQuade, K. L. (1998) · Immunity · doi:10.1016/s1074-7613(00)80570-1 · Cited by 540
Heat-shock proteins induce T-cell regulation of chronic inflammation
van Eden, W., van der Zee, R., & Prakken, B. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1593 · Cited by 539
Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation
Westerheide, S. D., & Morimoto, R. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500010200 · Cited by 484
Induction of heat shock proteins in B-cell exosomes
Clayton, A., Turkes, A., Navabi, H., Mason, M. D., & Tabi, Z. (2005) · Journal of Cell Science · doi:10.1242/jcs.02494 · Cited by 454
Multhoff, G., Botzler, C., Wiesnet, M., Müller, E. C., Meier, T., Wilmanns, W., & Issels, R. D. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610222 · Cited by 432
Raposo, G., Tenza, D., Mecheri, S., Péronet, R., Bonnerot, C., & Desaymard, C. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2631 · Cited by 406
Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396
Hightower, L. E., & Guidon, P. T. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041380206 · Cited by 395
&cestflwr; The Hsp90 family of proteins in Arabidopsis thaliana
Krishna, P., & Gloor, G. B. (2001) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2001)006 · Cited by 360
The Hsp110 and Grp170 stress proteins: newly recognized relatives of the Hsp70s
Easton, D. P., Kaneko, Y., & Subjeck, J. R. (2000) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2000)005 · Cited by 328
Guzhova, I. V., Kislyakova, K., Moskaliova, O., Fridlanskaya, I., Tytell, M., Cheetham, M. E., & Margulis, B. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02774-3 · Cited by 321
Broquet, A. H., Thomas, G., Masliah, J., Trugnan, G., & Bachelet, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302326200 · Cited by 303
Human HSP70 promoter contains at least two distinct regulatory domains.
Wu, B. J., Kingston, R. E., & Morimoto, R. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.629 · Cited by 297
Wang, Y., Kelly, C. G., Karttunen, J. T., Whittall, T., Lehner, P. J., Duncan, L. M., MacAry, P. A., Younson, J. S., Singh, M., Oehlmann, W., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00242-4 · Cited by 270
Heat Shock Proteins, Inflammation, and Cardiovascular Disease
Pockley, A. G. (2002) · Circulation · doi:10.1161/hc0802.103729 · Cited by 266
Wang, Y., Kelly, C. G., Singh, M., McGowan, E., Carrara, A.-S., Bergmeier, L. A., & Lehner, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2422 · Cited by 264
Yoo, C., Lee, S., Lee, C.-T., Kim, Y. W., Han, S., & Shim, Y.-S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5416 · Cited by 263
Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs
Panjwani, N., Popova, L., & Srivastava, P. K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2997 · Cited by 259
Multhoff, G., Mizzen, L., Winchester, C., Milner, C. M., Wenk, S., Eissner, G., Kampinga, H. H., Laumbacher, B., & Johnson, J. P. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00104-6 · Cited by 223
Self-citationStress proteins and the immune response
Moseley, P. L. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00227-7 · Cited by 222
Gao, B., & Tsan, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303161200 · Cited by 221
Blake, M. J., Udelsman, R., Feulner, G. J., Norton, D. D., & Holbrook, N. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9873 · Cited by 219
Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation
Quintana, F. J., & Cohen, I. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2777 · Cited by 219
Pockley, A. G., Georgiades, A., Thulin, T., Fairé, U. D., & Frostegård, J. (2003) · Hypertension · doi:10.1161/01.hyp.0000086522.13672.23 · Cited by 216
Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In Vivo
Hutter, J. J., Mestril, R., Tam, E. K. W., Sievers, R. E., DILLMANN, W. H., & Wolfe, C. L. P. (1996) · Circulation · doi:10.1161/01.cir.94.6.1408 · Cited by 213
Transcriptional Repression of the Prointerleukin 1β Gene by Heat Shock Factor 1
Cahill, C. M., Waterman, W. R., Xie, Y., Auron, P. E., & Calderwood, S. K. (1996) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)40087-7 · Cited by 194
Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion
Hamilton, K. L., Staib, J. L., Phillips, T., Hess, A., Lennon, S. L., & Powers, S. K. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01431-4 · Cited by 190
Exercise induces hepatosplanchnic release of heat shock protein 72 in humans
Febbraio, M. A., Ott, P., Nielsen, H. B., Steensberg, A., Keller, C., Krustrup, P., Secher, N. H., & Pedersen, B. K. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025148 · Cited by 187
Bausero, M. A., Gastpar, R., Multhoff, G., & Asea, A. A. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2900 · Cited by 183
Epithelia Under Metabolic Stress Perceive Commensal Bacteria as a Threat
Nazli, A., Yang, P., Jury, J., Howe, K. L., Watson, J. L., Söderholm, J. D., Sherman, P. M., Perdue, M. H., & McKay, D. M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63182-3 · Cited by 183
Activation of natural killer cells by heat shock protein 70
Multhoff, G. (2009) · International Journal of Hyperthermia · doi:10.1080/02656730902902001 · Cited by 182
Bacterial translocation from the gut: a mechanism of infection.
Deitch, E. A., & Berg, R. D. (1988) · PubMed · Cited by 182
Circulating heat shock protein and heat shock protein antibody levels in established hypertension
Pockley, A. G., Fairé, U. D., Kiessling, R. W., Lemne, C. E., Thulin, T., & Frostegård, J. (2002) · Journal of Hypertension · doi:10.1097/00004872-200209000-00027 · Cited by 179
Xie, Y., Chen, C., Stevenson, M. A., Auron, P. E., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109296200 · Cited by 178
Febbraio, M. A., Steensberg, A., Walsh, R. C., Koukoulas, I., van Hall, G., Saltin, B., & Pedersen, B. K. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013145 · Cited by 174
Do heat shock proteins control the balance of T-cell regulation in inlammatory diseases?
van Eden, W., van der Zee, R., Paul, A., Prakken, B. J., Wendling, U., Anderton, S. M., & Wauben, M. H. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01283-3 · Cited by 166
Serum Levels of Hsp 72 Measured Early after Trauma Correlate with Survival
Pittet, J., Lee, H., Morabito, D. J., Howard, M., Welch, W. J., & Mackersie, R. C. (2002) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-200204000-00001 · Cited by 160
Wright, B. H., Corton, J. M., El-Nahas, A. M., Wood, R. F. M., & Pockley, A. G. (2000) · Heart and Vessels · doi:10.1007/s003800070043 · Cited by 155
Bacterial Translocation from the Gut
Deitch, E. A., & Berg, R. D. (1987) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-198708060-00005 · Cited by 145
Heneka, M. T., Gavrilyuk, V., Landreth, G. E., O’Banion, M. K., Weinberg, G. L., & Feinstein, D. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01694.x · Cited by 144
Aging reduces adaptive capacity and stress protein expression in the liver after heat stress
Hall, D. M., Xu, L., Drake, V., Oberley, L. W., Oberley, T. D., Moseley, P. L., & Kregel, K. C. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.2.749 · Cited by 140
Activation of natural killer cells by heat shock protein 70
Multhoff, G. (2002) · International Journal of Hyperthermia · doi:10.1080/0265673021000017109 · Cited by 138
Exercise Improves Postischemic Cardiac Function in Males but Not Females
Paroo, Z., Haist, J. V., Karmazyn, M., & Noble, E. G. (2002) · Circulation Research · doi:10.1161/01.res.0000016963.43856.b1 · Cited by 136
Role of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active rats
Campisi, J., & Fleshner, M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00681.2002 · Cited by 136
Self-citationVelin, Å. K., Ericson, A.-C., Braaf, Y., Wallon, C., & Söderholm, J. D. (2004) · Gut · doi:10.1136/gut.2003.028506 · Cited by 131
Housby, J. N., Cahill, C. M., Chu, B., Prevelige, R., Bickford, K., Stevenson, M. A., & Calderwood, S. K. (1999) · Cytokine · doi:10.1006/cyto.1998.0437 · Cited by 128
Immunological aspects of heat-shock proteins—the optimum stress of life
Prohászka, Z., & Füst, G. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.02.001 · Cited by 128
Kelly, S., Zhang, Z. J., Zhao, H., Xu, L., Giffard, R. G., Sapolsky, R. M., Yenari, M. A., & Steinberg, G. K. (2002) · Annals of Neurology · doi:10.1002/ana.10264 · Cited by 127
Wang, Y., Whittall, T., McGowan, E., Younson, J. S., Kelly, C. G., Bergmeier, L. A., Singh, M., & Lehner, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3306 · Cited by 125
Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice
Park, S.-H., Benlagha, K., Lee, D., Balish, E., & Bendelac, A. S. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200002)30:2 · Cited by 122
p23, a simple protein with complex activities
Felts, S. J., & Toft, D. O. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)008 · Cited by 116
Self-citationEndogenous extra-cellular heat shock protein 72: Releasing signal(s) and function
Fleshner, M., & Johnson, J. D. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500088211 · Cited by 114
Self-citationDing, X., Fernandez-Prada, C. M., Bhattacharjee, A. K., & Hoover, D. L. (2001) · Cytokine · doi:10.1006/cyto.2001.0959 · Cited by 108
Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72
Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., & Fleshner, M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00390.2005 · Cited by 108
Self-citationCampisi, J., Leem, T. H., Greenwood, B. N., Hansen, M. K., Moraska, A. F., Higgins, K., Smith, T. P., & Fleshner, M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00513.2002 · Cited by 103
Self-citationSrivastava, P. K., & Heike, M. (1991) · PubMed · Cited by 102
Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment
Sun, L., Chang, J., Kirchhoff, S. R., & Knowlton, A. A. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.4.h1091 · Cited by 96
Virally Induced Lytic Cell Death Elicits the Release of Immunogenic GRP94/gp96
Berwin, B. L., Reed, R. C., & Nicchitta, C. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101836200 · Cited by 95
Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes
Marini, M. (1996) · International Journal of Radiation Biology · doi:10.1080/095530096145076 · Cited by 93
Lehner, T., Wang, Y., Whittall, T., McGowan, E., Kelly, C. G., & Singh, M. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320629 · Cited by 91
King, Y.-T., Lin, C., Lin, J., & Lee, W.-C. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.2.273 · Cited by 91
Martin, C. A., Carsons, S. E., Kowalewski, R., Bernstein, D., Valentino, M. A., & Santiago‐Schwarz, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5736 · Cited by 90
Differential effects of exercise and heat stress on liver HSP70 accumulation with aging
Kregel, K. C., & Moseley, P. L. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.2.547 · Cited by 87
Mestril, R., Giordano, F. J., Conde, A. G., & DILLMANN, W. H. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0228 · Cited by 86
HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells
Ruchalski, K. L., Mao, H., Singh, S. K., Wang, Y., Mosser, D. D., Fang-hong, L., Schwartz, J. H., & Borkan, S. C. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00049.2003 · Cited by 85
van Eden, W. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00538-8 · Cited by 83
Meng, X. (1996) · Cardiovascular Research · doi:10.1016/0008-6363(96)00078-8 · Cited by 82
Glucocorticoid pretreatment protects cardiac function and induces cardiac heat shock protein 72
Valen, G., Kawakami, T., Tähepôld, P., Dumitrescu, A. M., Löwbeer, C., & Vaage, J. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.2.h836 · Cited by 73
The immune response under stress: the role of HSP-derived peptides
Hickman, H. D., & Hildebrand, W. H. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.05.011 · Cited by 71
Noradrenaline and α-adrenergic signaling induce thehsp70gene promoter in mollusc immune cells
Lacoste, A., Cian, M. D., Cueff, A., & Poulet, S. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.19.3557 · Cited by 71
Liu, T. S., Musch, M. W., Sugi, K., Walsh-Reitz, M. M., Ropeleski, M. J., Hendrickson, B. A., Pothoulakis, C., LaMont, J. T., & Chang, E. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00134.2002 · Cited by 70
BACTERIAL TRANSLOCATION AFTER BURN INJURY
Horton, J. W., & Walker, P. B. (1994) · Shock · doi:10.1097/00024382-199404000-00007 · Cited by 69
Endocrine control of stress-induced heat shock protein 70 expression in vivo.
Udelsman, R., Mj, B., Ca, S., & Nj, H. (1994) · PubMed · Cited by 69
β-Adrenergic signaling and thyroid hormones affect HSP72 expression during heat acclimation
Maloyan, A., & Horowitz, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01122.2001 · Cited by 66
Cold-Induced Heat Shock Protein Expression in Rat Aorta and Brown Adipose Tissue
Matz, J. M., Lavoi, K. P., Moen, R. J., & BLAKE, M. J. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00220-x · Cited by 62
Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat
Arieli, Y., Eynan, M., Gancz, H., Arieli, R., & Kashi, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03681-8 · Cited by 60
Recent advances in the molecular pharmacology of the α1-adrenergic receptors
Guarino, R. D., Perez, D. M., & Piascik, M. T. (1996) · Cellular Signalling · doi:10.1016/0898-6568(96)00066-6 · Cited by 56
Yokoyama, H., Iinuma, K., Yanai, K., Watanabe, T., Sakurai, E., & Onodera, K. (1993) · PubMed · Cited by 54
Isoproterenol potentiates exercise-induction of Hsp70 in cardiac and skeletal muscle
Paroo, Z., & Noble, E. G. (1999) · Cell Stress and Chaperones · doi:10.1054/csac.1999.0144 · Cited by 52
hsp72 Inhibits Focal Adhesion Kinase Degradation in ATP-depleted Renal Epithelial Cells
Mao, H., Li, F., Ruchalski, K. L., Mosser, D. D., Schwartz, J. H., Wang, Y., & Borkan, S. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300126200 · Cited by 50
Protection against endotoxemia by HSP70 in rodent cardiomyocytes
Lau, S. S., Griffin, T. M., & Mestril, R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.5.h1439 · Cited by 50
Adrenergic regulation of the heat shock response in brown adipose tissue.
Matz, J. M., Lavoi, K. P., & Blake, M. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13132-7 · Cited by 50
Fleshner, M., Campisi, J., & Johnson, J. D. (2003) · PubMed · Cited by 48
Self-citationRedaelli, C., Wagner, M., Kulli, C., Tian, Y., Kubulus, D., Mazzucchelli, L., Wagner, A. C. C., & Schilling, M. K. (2001) · Transplant International · doi:10.1007/s001470100000 · Cited by 47
NF-IL6 and HSF1 Have Mutually Antagonistic Effects on Transcription in Monocytic Cells
Xie, Y., Chen, C., Stevenson, M. A., Hume, D. A., Auron, P. E., & Calderwood, S. K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6562 · Cited by 46
Modulation of tolerance by mutant heat shock transcription factors
Xia, W., Vilaboa, N. E., Martin, J. W., Mestril, R., Guo, Y., & Voellmy, R. W. (1999) · Cell Stress and Chaperones · doi:10.1379/1466-1268(1999)004 · Cited by 45
Ketotifen: a histamine release inhibitor.
Martin, U., & Roemer, D. (1977) · PubMed · Cited by 44
HSF1/hsp72 pathway as an endogenous anti‐inflammatory system
Ianaro, A., Ialenti, A., Maffia, P., Pisano, B., & Rosa, M. D. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02569-8 · Cited by 43
Heat-Shock Proteins and the Immune Response
Multhoff, G., & Botzler, C. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08980.x · Cited by 42
Kemeny, M. E. (2006) · Oxford University Press eBooks · doi:10.1093/oso/9780195139594.003.0005 · Cited by 41
Oxidants differentially regulate the heat shock response
Wallen, E. S., Buettner, G. R., & Moseley, P. L. (1997) · International Journal of Hyperthermia · doi:10.3109/02656739709023550 · Cited by 40
Redaelli, C., Wagner, M., Kulli, C., et al. (2001) · Transplant International · doi:10.1111/j.1432-2277.2001.tb00073.x · Cited by 38
Adrenergic regulation of adrenal and aortic heat shock protein.
Udelsman, R., Dg, L., Ca, S., Cb, G., & Květňanský, R. (1994) · PubMed · Cited by 36
McLeish, K. R., Dean, W. L., Wellhausen, S. R., & Stelzer, G. T. (1989) · Inflammation · doi:10.1007/bf00914312 · Cited by 33
The adaptor protein shc is involved in the negative regulation of NK cell-mediated cytotoxicity
Galandrini, R., Tassi, I., Morrone, S., Lanfrancone, L., Pelicci, P. G., Piccoli, M., Frati, L., & Santoni, A. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200107)31:7 · Cited by 32
Blake, M. J., Buckley, A. R., Buckley, D. J., Lavoi, K. P., & Bartlett, T. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38502-2 · Cited by 30
Calabrese, V., Scapagnini, G., Catalano, C., Bates, T. E., Geraci, D., Pennisi, G., & Stella, A. M. G. (2001) · PubMed · Cited by 27
Kaufmann, S. H. E. (1990) · Current Opinion in Rheumatology · doi:10.1097/00002281-199002030-00003 · Cited by 27
Nettelbladt, C.-G., Katouli, M., Bark, T. H., Svenberg, T., M�llby, R., & Ljungqvist, O. H. (2003) · Shock · doi:10.1097/01.shk.0000068324.41183.c2 · Cited by 24
Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats
Katafuchi, T., Takaki, A., Take, S., Kondo, T., & Yoshimura, M. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00331-0 · Cited by 22
Potential role of heat shock transcription factor in the expression of inflammatory cytokines.
Cm, C., Hs, L., Bd, P., Bruce, J. L., & Calderwood, S. K. (1997) · PubMed · Cited by 21
Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death.
Thomas, G., Souil, E., Richard, M., Saunier, B., Polla, B. S., & Bachelet, M. (2002) · PubMed · Cited by 16
Čvoro, A., & Matić, G. M. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00117-0 · Cited by 15
The Role of the Adrenal Medulla in Neural Control of Blood Pressure in Rats
Vollmer, R. R., Meyers-Schoy, S. A., Kolibal-Pegher, S., & Edwards, D. J. (1995) · Clinical and Experimental Hypertension · doi:10.3109/10641969509037414 · Cited by 12
Effect of adrenal demedullation on urinary excretion of catecholamines in thermal trauma in rats.
Hessman, Y., Rentzhog, L., & Ekbohm, G. (1976) · PubMed · Cited by 9
Endogenous Extracellular Hsp72 Release Is an Adaptive Feature of the Acute Stress Response
Fleshner, M., Sharkey, C. M., Nickerson, M., & JOHNSON, J. D. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50055-1 · Cited by 9
Self-citationSánchez (2002) · doi:10.1379/1466-1268(2002)007
Flagged first, then by citations
3 of the 148 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Gao, 2003, Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages, J. Biol. Chem., 278, 174, 10.1074/jbc.M208742200 · DOI · Paper page
Cited by
Sorted by citations
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944
Lee, J.-W., Choi, H., Hwang, U.-K., Kang, J., Kang, Y. J., Kim, K. I., & Kim, J. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.03.010 · Cited by 527
Parainflammation, Chronic Inflammation and Age-Related Macular Degeneration
Chen, M., & Xu, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0615-239r · Cited by 381
Chen, T., Guo, J., Han, C., Yang, M., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1449 · Cited by 242
Non-targeted bystander effects induced by ionizing radiation
Morgan, W. F., & Sowa, M. B. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.11.009 · Cited by 219
Metadata
- Authors
- Johnson, J. D., & Fleshner, M.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Fleshner, Monika
- ORCID
- Fleshner, Monika
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-30
- Volume
- 79
- Issue
- 3
- Pages
- 425-434
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2165218249
- Cited by
- 251
- References
- 148
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 21 · 2014: 18 · 2013: 18 · 2012: 20
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- HSP72, secretory pathway, immunomodulation, innate immunity, adaptive immunity, stress response, molecular chaperones
- MeSH terms
- Animals, Cell Membrane, Humans, Immunity, Cellular, Immunity, Innate, Immunologic Factors, Receptors, Adrenergic, alpha, Stress, Physiological, Signal Transduction, Up-Regulation, Extracellular Fluid, HSP72 Heat-Shock Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review