Cited by 219Heat shock proteins researchImmune Response and InflammationImmunotherapy and Immune Responses

Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation

Quintana, Francisco J, Cohen, Irun R·2005·The Journal of Immunology

Abstract

Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate receptors. However, the role of HSPs as endogenous adjuvants has been challenged by reports claiming that pure HSPs are not innate ligands; it is only the bacterial molecules trapped by the HSPs that can signal the innate immune system. In this review, we discuss data suggesting that both views, in essence, are correct; pure HSPs are indeed innate immunostimulators, but HSPs can also function as transducers of pathogen signals. In other words, HSPs perform diverse functions in two alternative modes of inflammation: sterile inflammation, which results from endogenous stimuli and is necessary for body maintenance, and septic inflammation, which protects us from environmental pathogens. Endogenous HSPs are key players in the modulation of these two modes of inflammation, and as such, they are potential targets for new and more efficient therapies for cancer, infections, and autoimmunity.

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Crossref · 10.4049/jimmunol.175.5.2777

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107 of 107 references verified0 citation errors · 0 not checkable

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  • Prototypical DAMPs derived from necrotic cells include high-mobility group box 1 (HMGB1), heat shock proteins (HSPs), ATP, and uric acid.

    “Prototypical DAMPs derived from necrotic cells include the chromatin-associated protein high-mobility group box 1 (HMGb1)10, heat shock proteins (HSPs)11, and purine metabolites, such as ATP12 and uric acid13 (TABLE 1).”

    From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [11]

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Authors
Quintana, F. J., & Cohen, I. R.
Affiliations
Weizmann Institute of Science (IL)
Venue
The Journal of Immunology
Published
2005-09-01
Volume
175
Issue
5
Pages
2777-2782
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W2140403277
Cited by
219
References
106
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 12 · 2013: 18 · 2012: 13
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
heat shock proteins, sterile inflammation, septic inflammation, innate immunity, inflammation modulation, cancer immunotherapy, infection immunity, autoimmunity
MeSH terms
Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Sepsis

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