Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation
Abstract
Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate receptors. However, the role of HSPs as endogenous adjuvants has been challenged by reports claiming that pure HSPs are not innate ligands; it is only the bacterial molecules trapped by the HSPs that can signal the innate immune system. In this review, we discuss data suggesting that both views, in essence, are correct; pure HSPs are indeed innate immunostimulators, but HSPs can also function as transducers of pathogen signals. In other words, HSPs perform diverse functions in two alternative modes of inflammation: sterile inflammation, which results from endogenous stimuli and is necessary for body maintenance, and septic inflammation, which protects us from environmental pathogens. Endogenous HSPs are key players in the modulation of these two modes of inflammation, and as such, they are potential targets for new and more efficient therapies for cancer, infections, and autoimmunity.
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Prototypical DAMPs derived from necrotic cells include high-mobility group box 1 (HMGB1), heat shock proteins (HSPs), ATP, and uric acid.
“Prototypical DAMPs derived from necrotic cells include the chromatin-associated protein high-mobility group box 1 (HMGb1)10, heat shock proteins (HSPs)11, and purine metabolites, such as ATP12 and uric acid13 (TABLE 1).”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [11]
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- Authors
- Quintana, F. J., & Cohen, I. R.
- Affiliations
- Weizmann Institute of Science (IL)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 175
- Issue
- 5
- Pages
- 2777-2782
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2140403277
- Cited by
- 219
- References
- 106
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 12 · 2013: 18 · 2012: 13
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- heat shock proteins, sterile inflammation, septic inflammation, innate immunity, inflammation modulation, cancer immunotherapy, infection immunity, autoimmunity
- MeSH terms
- Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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