Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: A new link between leukocytes upstream of T lymphocytes
Abstract
Polymorphonuclear neutrophils (PMNs) are rapidly recruited to tissues upon injury or infection. There, they can encounter local and/or recruited immature dendritic cells (iDCs), a colocalization that could promote at least transient interactions and mutually influence the two leukocyte populations. Using human live blood PMNs and monocyte-derived iDCs, we examined if these leukocytes actually interacted and whether this influenced DC function. Indeed, coculture with live but not apoptotic PMNs led to up-regulation of membrane CD40, CD86, and human leukocyte antigen (HLA)-DR on DCs. Whereas CD40 up-regulation was dependent on soluble factors released by PMNs, as determined in cultures conducted in different chambers, cell contact was necessary for CD86 and HLA-DR up-regulation, a process that was inhibited by anti-CD18 antibodies, indicating that CD18 ligation was required. We also found that via a cell contact-dependent mechanism, DCs acquired Candida albicans-derived antigens from live as well as from apoptotic PMNs and could thus elicit antigen-specific T lymphocyte responses. Altogether, our data demonstrate the occurrence of cross-talk between human PMNs and DCs and provide new insights into the immune processes occurring upstream of the interactions between DCs and T lymphocytes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neutrophils are the transport vehicle for intracellular pathogens carrying antigens to DCs and participate in the activation of the T-cell immune response by DCs.
“Neutrophils are the transport vehicle for intracellular pathogens carrying antigens to DCs and participate in the activation of the T-cell immune response by DCs [222].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [222]
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
Albert, M. L., Sauter, B., & Bhardwaj, N. (1998) · Nature · doi:10.1038/32183 · Cited by 2,350 · see citing works
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357 · see citing works
Akbari, O., DeKruyff, R. H., & Umetsu, D. T. (2001) · Nature Immunology · doi:10.1038/90667 · Cited by 1,196 · see citing works
The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells
Steinman, R. M., Turley, S. J., Mellman, I., & Inaba, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.411 · Cited by 1,172 · see citing works
Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
Colotta, F., Re, F., Polentarutti, N., Sozzani, S., & Mantovani, A. (1992) · Blood · doi:10.1182/blood.v80.8.2012.2012 · Cited by 1,158 · see citing works
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
Denzer, K., Kleijmeer, M. J., Heijnen, H. F. G., Stoorvogel, W., & Geuze, H. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3365 · Cited by 1,067 · see citing works
Neutrophils, host defense, and inflammation: a double-edged sword
Smith, J. A. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.6.672 · Cited by 811 · see citing works
The neutrophil as a cellular source of chemokines
Scapini, P., Lapinet, J. A., Gasperini, S., Calzetti, F., Bazzoni, F., & Cassatella, M. A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17706.x · Cited by 803 · see citing works
The Plasticity of Dendritic Cell Responses to Pathogens and Their Components
Huang, Q., Liu, D., Majewski, P., Schulte, L. C., Korn, J. M., Young, R. A., Lander, E. S., & Hacohen, N. (2001) · Science · doi:10.1126/science.294.5543.870 · Cited by 747 · see citing works
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Tailleux, L., Schwartz, O., Herrmann, J., Pivert, E., Jackson, M., Amara, A., Legrès, L., Dreher, D., Nicod, L. P., Gluckman, J. C., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021468 · Cited by 643 · see citing works
Self-citationThe mannose receptor is a pattern recognition receptor involved in host defense
Stahl, P. D., & Ezekowitz, R. A. B. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80031-9 · Cited by 639 · see citing works
Spörri, R., & Sousa, C. R. E. (2005) · Nature Immunology · doi:10.1038/ni1162 · Cited by 618 · see citing works
McGuirk, P., McCann, C., & Mills, K. H. G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011288 · Cited by 617 · see citing works
Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans
d’Ostiani, C. F., Sero, G. D., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., Ricciardi‐Castagnoli, P., & Romani, L. R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1661 · Cited by 492 · see citing works
The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis
Netea, M. G., van der Graaf, C. A. A., Vonk, A. G., Verschueren, I., van der Meer, J. W. M., & Kullberg, B. J. (2002) · The Journal of Infectious Diseases · doi:10.1086/340511 · Cited by 486 · see citing works
Skokos, D., Goubran‐Botros, H., Demeure, C. E., Morin, J., Péronet, R., Birkenmeier, G., Boudaly, S., & Mécheri, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3037 · Cited by 444 · see citing works
Self-citationRoss, G. D., Cain, J. A., & Lachmann, P. J. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.5.3307 · Cited by 420 · see citing works
van Gisbergen, K. P. J. M., Sánchez‐Hernández, M., Geijtenbeek, T. B. H., & van Kooyk, Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041276 · Cited by 401 · see citing works
McWilliam, A. S., Nelson, D. J., Thomas, J. A., & Holt, P. G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1331 · Cited by 382 · see citing works
Dendritic Cells as the Terminal Stage of Monocyte Differentiation
Palucka, K. A., Taquet, N., Sanchez, F., & Gluckman, J. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4587 · Cited by 377 · see citing works
Self-citationBrach, M., deVos, S., Gruss, H., & Herrmann, F. (1992) · Blood · doi:10.1182/blood.v80.11.2920.2920 · Cited by 359 · see citing works
Abadie, V., Badell, E., Douillard, P., Ensergueix, D., Leenen, P. J. M., Tanguy, M., Fiette, L., Saeland, S., Gicquel, B., & Winter, N. (2005) · Blood · doi:10.1182/blood-2005-03-1281 · Cited by 356 · see citing works
Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival
MOULDING, D. A., Quayle, J. A., Hart, C. A., & Edwards, S. W. (1998) · Blood · doi:10.1182/blood.v92.7.2495 · Cited by 356 · see citing works
Biochemistry and cell biology of mammalian scavenger receptors
Murphy, J. E., Tedbury, P. R., Homer‐Vanniasinkam, S., Walker, J. H., & Ponnambalam, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.036 · Cited by 331 · see citing works
Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.
Dransfield, I., Buckle, A., Savill, J., McDowall, A., Haslett, C., & Hogg, N. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.3.1254 · Cited by 329 · see citing works
Bennouna, S., Bliss, S. K., Curiel, T. J., & Denkers, E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6052 · Cited by 328 · see citing works
McWilliam, A. S., Napoli, S., Marsh, A. M., Pemper, F. L., Nelson, D. J., Pimm, C. L., Stumbles, P. A., Wells, T. N. C., & Holt, P. G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2429 · Cited by 328 · see citing works
Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL
Harshyne, L. A., Watkins, S. C., Gambotto, A. A., & Barratt‐Boyes, S. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3717 · Cited by 321 · see citing works
Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L. M., Olsen, H. S., Murphy, M., Liao, F., Farber, J. M., & Cassatella, M. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4928 · Cited by 314 · see citing works
Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L. M., Olsen, H., Murphy, M., Liao, F., Farber, J. M., & Cassatella, M. A. (1999) · PubMed · Cited by 304 · see citing works
Savill, J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114328 · Cited by 291 · see citing works
Interleukin‐12 production by human polymorphonuclear leukocytes
Cassatella, M. A., Meda, L., Gasperini, S., D’Andrea, A., Ma, X., & Trinchieri, G. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250102 · Cited by 269 · see citing works
Kaplan, G., WALSH, G. P., Guido, L. S., Meyn, P., Burkhardt, R. A., Abalos, R. M., Barker, J., Frindt, P., Fajardo, T. T., & Celona, R. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.6.1717 · Cited by 262 · see citing works
Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?
Moser, M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00182-1 · Cited by 229 · see citing works
Integrin signalling in neutrophils and macrophages
Berton, G., & Lowell, C. A. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00003-0 · Cited by 224 · see citing works
Zimmerman, J. W., Lindermuth, J., Fish, P. A., Palace, G. P., Stevenson, T. T., & DeMong, D. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.22014 · Cited by 223 · see citing works
Gregory, S. H., & Wing, E. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.239 · Cited by 200 · see citing works
Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils
Al-Shami, A., Mahanna, W., & Naccache, P. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.1058 · Cited by 172 · see citing works
Diamond, R. D., Clark, R. A., & Haudenschild, C. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109958 · Cited by 163 · see citing works
Cytokine-Activated Endothelial Cells Delay Neutrophil Apoptosis in Vitro and in Vivo
Coxon, A., Tang, T., & Mayadas, T. N. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.923 · Cited by 150 · see citing works
Integrin-mediated signaling in human neutrophil functioning
Williams, M. A., & Solomkin, J. S. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.725 · Cited by 148 · see citing works
Newman, S. L., & Holly, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.6813-6822.2001 · Cited by 146 · see citing works
Salmon, S. E., Cline, M. J., Schultz, J., & Lehrer, R. I. (1970) · New England Journal of Medicine · doi:10.1056/nejm197001292820505 · Cited by 141 · see citing works
Girard, D., Paquin, R., & BEAULIEUL, A. D. (1997) · Biochemical Journal · doi:10.1042/bj3250147 · Cited by 127 · see citing works
Gregory, S., Cousens, L., van Rooijen, N., Döpp, E., Carlos, T., & Wing, E. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.1.308 · Cited by 126 · see citing works
Ramirez, M. C., & Sigal, L. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6733 · Cited by 112 · see citing works
Haslett, C., Savill, J., & Meagher, L. (1989) · Current Opinion in Immunology · doi:10.1016/0952-7915(89)90091-5 · Cited by 104 · see citing works
Marañón, C., Desoutter, J.-F., Hoeffel, G., Cohen, W. M., Hanau, D., & Hosmalin, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304860101 · Cited by 92 · see citing works
Laschinger, M., Vajkoczy, P., & Engelhardt, B. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 82 · see citing works
Interleukin-4 is a neutrophil activator
Boey, H., Rosenbaum, R., Castracane, J. M., & Borish, L. (1989) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(89)90115-2 · Cited by 80 · see citing works
Clayton, A. R., Prue, R. L., Harper, L., Drayson, M. T., & Savage, C. O. S. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11130 · Cited by 76 · see citing works
Dalgaard, J., Beckstrøm, K. J., Jahnsen, F. L., & Brinchmann, J. E. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204711 · Cited by 61 · see citing works
MOULDING, D. A., Hart, C. A., & Edwards, S. W. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.875 · Cited by 60 · see citing works
Torosantucci, A., Romagnoli, G., Chiani, P., Stringaro, A., Crateri, P., Mariotti, S., Teloni, R., Arancia, G., Cassone, A., & Nisini, R. (2004) · Infection and Immunity · doi:10.1128/iai.72.2.833-843.2004 · Cited by 48 · see citing works
Venuprasad, K., Banerjee, P. P., Chattopadhyay, S., Sharma, S., Pal, S., Parab, P. B., Mitra, D., & Saha, B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.920 · Cited by 42 · see citing works
An electron microscopic study of phagocytosis of Candida albicans by polymorphonuclear leukocytes.
Belcher, R. W., Jf, C., & Fg, M. (1973) · PubMed · Cited by 42 · see citing works
Bober, L. A., Waters, T. A., Pugliese‐Sivo, C., Sullivan, L. M., Narula, S. K., & Grace, M. J. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03483.x · Cited by 41 · see citing works
Akahoshi, T., Sasahara, T., Namai, R., Matsui, T., Watabe, H., Kitasato, H., Inoue, M., & Kondo, H. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.524-526.2003 · Cited by 34 · see citing works
Release of Candida albicans yeast antigens upon interaction with human neutrophils in vitro
Ashley, C., Morhart, M., Rennie, R. P., & Ziola, B. R. (1997) · Journal of Medical Microbiology · doi:10.1099/00222615-46-9-747 · Cited by 10 · see citing works
Post-transcriptional regulation of E2A proteins via lipopolysaccharide and CD40 signaling
Meyer, K. B., & Mufti, D. A. H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200002)30:2 · Cited by 8 · see citing works
Neidhart (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200012)43:12 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,044 · see citing works
Diverse novel functions of neutrophils in immunity, inflammation, and beyond
Mócsai, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122220 · Cited by 678 · see citing works
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
Mathias, J. R., Perrin, B. J., Liu, T.-X., Kanki, J. P., Look, A. T., & Anna Huttenlocher, A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506346 · Cited by 532 · see citing works
Neutrophils: Cinderella of innate immune system
Kumar, V., & Sharma, A. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.012 · Cited by 442 · see citing works
Tumor associated macrophages and neutrophils in tumor progression
Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24260 · Cited by 440 · see citing works
The role of neutrophils and NETosis in autoimmune and renal diseases
Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works
Calabrό, S., Tortoli, M., Baudner, B. C., Pacitto, A., Cortese, M., O’Hagan, D. T., Gregorio, E. D., Seubert, A., & Wack, A. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.090 · Cited by 431 · see citing works
Dynamics of Neutrophil Migration in Lymph Nodes during Infection
Chtanova, T., Schaeffer, M., Han, S., van Dooren, G. G., Nöllmann, M., Herzmark, P., Chan, S. W., Satija, H., Camfield, K. A., Aaron, H. L., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.012 · Cited by 389 · see citing works
Yu, J. J., Ruddy, M. J., Wong, G. C., Sfintescu, C., Baker, P. J., Smith, J. B., Evans, R. T., & Gaffen, S. L. (2007) · Blood · doi:10.1182/blood-2005-09-010116 · Cited by 372 · see citing works
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works
Silva, M. T. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809549 · Cited by 321 · see citing works
Neutrophils efficiently cross-prime naive T cells in vivo
Beauvillain, C., Delneste, Y., Scotet, M., Peres, A., Gascan, H., Guermonprez, P., Barnaba, V., & Jeannin, P. (2007) · Blood · doi:10.1182/blood-2006-12-063826 · Cited by 316 · see citing works
Hydrogen sulfide: An endogenous regulator of the immune system
Dilek, N., Papapetropoulos, A., Toliver-Kinsky, T. E., & Szabó, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105119 · Cited by 293 · see citing works
Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2
Murawski, M. R., Bowen, G. N., Cerny, A. M., Anderson, L. J., Haynes, L. M., Tripp, R. A., Kurt-Jones, E. A., & Finberg, R. W. (2009) · Journal of Virology · doi:10.1128/jvi.00671-08 · Cited by 279 · see citing works
The regulatory roles of neutrophils in adaptive immunity
Li, Y., Wang, W., Yang, F., Xu, Y., Feng, C., & Zhao, Y. X. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0471-y · Cited by 283 · see citing works
Abdallah, D. S. A., Egan, C. E., Butcher, B. A., & Denkers, E. (2011) · International Immunology · doi:10.1093/intimm/dxr007 · Cited by 265 · see citing works
CCR7 is involved in the migration of neutrophils to lymph nodes
Beauvillain, C., Cunin, P., Doni, A., Scotet, M., Jaillon, S., Loiry, M.-L., Magistrelli, G., Masternak, K., Chevailler, A., Delneste, Y., et al. (2010) · Blood · doi:10.1182/blood-2009-11-254490 · Cited by 227 · see citing works
Soehnlein, O., Kai-Larsen, Y., Frithiof, R., Sørensen, O. E., Kenne, E. M., Scharffetter‐Kochanek, K., Eriksson, E. E., Herwald, H., Agerberth, B., & Lindbom, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35740 · Cited by 222 · see citing works
IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1
de Kleijn, S., Langereis, J. D., Leentjens, J., Kox, M., Netea, M. G., Koenderman, L., Ferwerda, G., Pickkers, P., & Hermans, P. W. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072249 · Cited by 204 · see citing works
Ribeiro-Gomes, F. L., Peters, N. C., Debrabant, A., & Sacks, D. L. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002536 · Cited by 195 · see citing works
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190 · see citing works
Monteseirı́n, J. (2009) · PubMed · Cited by 186 · see citing works
The Role of Neutrophils and Monocytes in Innate Immunity
Kantari‐Mimoun, C., Pederzoli-Ribeil, M., & Witko‐Sarsat, V. (2008) · KARGER eBooks · doi:10.1159/000136335 · Cited by 168 · see citing works
Neutrophils and intracellular pathogens: beyond phagocytosis and killing
Appelberg, R. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.11.009 · Cited by 155 · see citing works
The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation
Minns, D., Smith, K. J., Alessandrini, V., Hardisty, G. R., Melrose, L. A., Jackson-Jones, L. H., MacDonald, A. S., Davidson, D. J., & Findlay, E. G. (2021) · Nature Communications · doi:10.1038/s41467-021-21533-5 · Cited by 153 · see citing works
Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs
Steinbach, K., Piédavent, M., Bauer, S., Neumann, F., & Friese, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202613 · Cited by 137 · see citing works
Neutrophils as effector cells for antibody-based immunotherapy of cancer
van Egmond, M., & Bakema, J. E. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.12.002 · Cited by 132 · see citing works
Reimer, J. M., Karlsson, K. H., Lövgren‐Bengtsson, K., Magnusson, S. E., Fuentes, A., & Stertman, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041451 · Cited by 123 · see citing works
Hufford, M. M., Richardson, G., Zhou, H., Manicassamy, B., García‐Sastre, A., Enelow, R. I., & Braciale, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046581 · Cited by 121 · see citing works
Neutrophil activation and survival are modulated by interaction with NK cells
Costantini, C., Micheletti, A., Calzetti, F., Perbellini, O., Pizzolo, G., & Cassatella, M. A. (2010) · International Immunology · doi:10.1093/intimm/dxq434 · Cited by 121 · see citing works
Leucocyte trafficking via the lymphatic vasculature—mechanisms and consequences
Jackson, D. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00471 · Cited by 120 · see citing works
Silva, M. T. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109767 · Cited by 120 · see citing works
The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis
Peters, N. C., & Sacks, D. L. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01348.x · Cited by 118 · see citing works
Costantini, C., Calzetti, F., Perbellini, O., Micheletti, A., Scarponi, C., Lonardi, S., Pelletier, M., Schäkel, K., Pizzolo, G., Facchetti, F., et al. (2010) · Blood · doi:10.1182/blood-2010-06-287243 · Cited by 118 · see citing works
Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance
Furumaya, C., Martínez-Sanz, P., Bouti, P., Kuijpers, T. W., & Matlung, H. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02100 · Cited by 113 · see citing works
Bite of the wolf: innate immune responses propagate autoimmunity in lupus
Gupta, S., & Kaplan, M. J. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144918 · Cited by 102 · see citing works
Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)
Bondt, M. D., Hellings, N., Opdenakker, G., & Struyf, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124558 · Cited by 100 · see citing works
Crosstalk between neutrophils and dendritic cells: a context-dependent process
Schuster, S., Hurrell, B. P., & Tacchini‐Cottier, F. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012540 · Cited by 92 · see citing works
Morel, C., Badell, E., Abadie, V., Robledo-Sarmiento, M., Setterblad, N., Gluckman, J. C., Gicquel, B., Boudaly, S., & Winter, N. (2008) · European Journal of Immunology · doi:10.1002/eji.200737905 · Cited by 95 · see citing works
Self-citationTate, M. D., Brööks, A. G., Reading, P. C., & Mintern, J. D. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.26 · Cited by 87 · see citing works
Horvat, J. C., Starkey, M. R., Kim, R., Beagley, K. W., Preston, J. A., Gibson, P. G., Foster, P. S., & Hansbro, P. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902287 · Cited by 86 · see citing works
Fc Receptor-Dependent Mechanisms of Monoclonal Antibody Therapy of Cancer
Bakema, J. E., & van Egmond, M. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-07911-0_17 · Cited by 85 · see citing works
Myeloid cells as effector cells for monoclonal antibody therapy of cancer
Braster, R., O’Toole, T. G., & van Egmond, M. (2013) · Methods · doi:10.1016/j.ymeth.2013.06.020 · Cited by 83 · see citing works
Understanding the multiple functions of Gr-1+ cell subpopulations during microbial infection
Egan, C. E., Sukhumavasi, W., Bierly, A., & Denkers, E. (2007) · Immunologic Research · doi:10.1007/s12026-007-0061-8 · Cited by 78 · see citing works
Innate immunity in allergic disease
Minnicozzi, M., Sawyer, R. T., & Fenton, M. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01025.x · Cited by 76 · see citing works
Polak, D., Häfner, C., Briza, P., Kitzmüller, C., Elbe‐Bürger, A., Samadi, N., Gschwandtner, M., Pfützner, W., Zlabinger, G. J., Jahn‐Schmid, B., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.005 · Cited by 76 · see citing works
Neutrophils suppress γδ T ‐cell function
Sabbione, F., Gabelloni, M. L., Ernst, G., Gori, M. S., Salamone, G. V., Oleastro, M., Trevani, A. S., Geffner, J. R., & Jancic, C. C. (2013) · European Journal of Immunology · doi:10.1002/eji.201343664 · Cited by 72 · see citing works
Neutrophil Activation During Septic Shock
Stiel, L., Meziani, F., & Helms, J. (2017) · Shock · doi:10.1097/shk.0000000000000980 · Cited by 71 · see citing works
Neutrophil‐T cell crosstalk and the control of the host inflammatory response
Bert, S., Nadkarni, S., & Perretti, M. (2022) · Immunological Reviews · doi:10.1111/imr.13162 · Cited by 65 · see citing works
Granulocytes as modulators of dendritic cell function
Breedveld, A. C., Kormelink, T. G., van Egmond, M., & de Jong, E. C. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0217-048rr · Cited by 66 · see citing works
Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents
Minns, D., Smith, K. J., & Findlay, E. G. (2019) · Mediators of Inflammation · doi:10.1155/2019/8968943 · Cited by 64 · see citing works
Two way communication between neutrophils and dendritic cells.
Ludwig, I., Geijtenbeek, T., & van Kooyk, Y. (2006) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2006.03.009 · Cited by 75 · see citing works
Neutrophilic granulocytes – promiscuous accelerators of atherosclerosis
Döring, Y., Megens, R. T. A., Soehnlein, O., & Drechsler, M. D. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-07-0501 · Cited by 63 · see citing works
Cheung, D. S., Ehlenbach, S. J., Kitchens, R. T., Riley, D., Thomas, L. L., Holtzman, M. J., & Grayson, M. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002456 · Cited by 60 · see citing works
Maffía, P. C., Zittermann, S. I., Scimone, M. L., Tateosian, N. L., Amiano, N. O., Guerrieri, D., Lutzky, V. P., Rosso, D. A., Romeo, H. E., García, V., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061043 · Cited by 58 · see citing works
Park, S. J., Burdick, M. D., Brix, W. K., Stoler, M. H., Askew, D. S., Strieter, R. M., & Mehrad, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002064 · Cited by 57 · see citing works
Doz, E., Lombard, R., Carreras, F., Buzoni–Gatel, D., & Winter, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300527 · Cited by 55 · see citing works
Khaw, Y. M., Cunningham, C., Tierney, A., Sivaguru, M., & Inoue, M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1730-y · Cited by 51 · see citing works
The role of polymorphonuclear neutrophils during HIV-1 infection
Yaseen, M. M., Abuharfeil, N. M., Yaseen, M. M., & Shabsoug, B. M. (2017) · Archives of Virology · doi:10.1007/s00705-017-3569-9 · Cited by 54 · see citing works
Mosca, M., Polentarutti, N., Mangano, G., Apicella, C., Doni, A., Mancini, F., Bortoli, M. D., Coletta, I., Polenzani, L., Santoni, G., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906576 · Cited by 53 · see citing works
Ribeiro-Gomes, F. L., Romano, A., Lee, S., Roffê, E., Peters, N. C., Debrabant, A., & Sacks, D. L. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.351 · Cited by 52 · see citing works
Park, S. J., Burdick, M. D., & Mehrad, B. (2012) · Infection and Immunity · doi:10.1128/iai.00097-12 · Cited by 51 · see citing works
The Dynamic Contribution of Neutrophils in the Chronic Respiratory Diseases
Ham, J., Kim, J., Ko, Y. G., & Kim, H. Y. (2022) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2022.14.4.361 · Cited by 49 · see citing works
Bunimovich‐Mendrazitsky, S., Gluckman, J. C., & Chaskalovic, J. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.02.008 · Cited by 49 · see citing works
Self-citationInnate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs)
McCarthy, C. G., Saha, P., Golonka, R. M., Wenceslau, C. F., Joe, B., & Vijay–Kumar, M. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200020 · Cited by 48 · see citing works
Gafa, V., Remoli, M. E., Giacomini, E., Gagliardi, M. C., Lande, R., Severa, M., Grillot, R., & Coccia, E. M. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.03.015 · Cited by 47 · see citing works
Lentini, G., Famà, A., Biondo, C., Mohammadi, N., Galbo, R., Mancuso, G., Iannello, D., Zummo, S., Giardina, M., Gaetano, G. V. D., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1901039 · Cited by 45 · see citing works
The Neutrophil: The Underdog That Packs a Punch in the Fight against Cancer
Avtenyuk, N. U., Visser, N., Bremer, E., & Wiersma, V. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217820 · Cited by 45 · see citing works
Neutrophils and their role in the aetiopathogenesis of type 1 and type 2 diabetes
Giovenzana, A., Carnovale, D., Phillips, B. E., Petrelli, A., & Giannoukakis, N. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3483 · Cited by 44 · see citing works
Épaulard, O., Adam, L., Poux, C., Zurawski, G., Salabert, N., Rosenbaum, P., Dereuddre‐Bosquet, N., Zurawski, S., Flamar, A.-L., Oh, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303339 · Cited by 44 · see citing works
Evidence for antigen presentation by human neutrophils
Moffat, A., & Findlay, E. G. (2024) · Blood · doi:10.1182/blood.2023023444 · Cited by 41 · see citing works
Alemán, M., de la Barrera, S., Schierloh, P., Yokobori, N. K., Baldini, M., Musella, R. M., Abbate, E. H., & Sasiain, M. D. C. (2007) · European Journal of Immunology · doi:10.1002/eji.200636771 · Cited by 40 · see citing works
Exposure to Leishmania braziliensis Triggers Neutrophil Activation and Apoptosis
Falcão, S. D. A. C., Weinkopff, T., Hurrell, B. P., Celes, F. S., Curvelo, R. P., Prates, D. B., Barral, A. M. P., Borges, V. M., Tacchini‐Cottier, F., & de Oliveira, C. I. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003601 · Cited by 40 · see citing works
Kesteman, N., Vansanten, G., Pajak, B., Goyert, S. M., & Moser, M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0807578 · Cited by 39 · see citing works
Opportunities to Exploit Non-Neutralizing HIV-Specific Antibody Activity
Ackerman, M. E., & Alter, G. (2013) · Current HIV Research · doi:10.2174/1570162x113116660058 · Cited by 37 · see citing works
Proteomic analysis of total cellular proteins of human neutrophils
Tomazella, G. G., da Silva, I., Laure, H. J., Rosa, J. C., Chammas, R. J., Wiker, H. G., de Souza, G. A., & Greene, L. J. (2009) · Proteome Science · doi:10.1186/1477-5956-7-32 · Cited by 37 · see citing works
Exploring Staphylococcus aureus pathways to disease for vaccine development
DeDent, A. C., Kim, H. K., Missiakas, D. M., & Schneewind, O. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0299-z · Cited by 36 · see citing works
Cytokine induced expression of programmed death ligands in human neutrophils
Bankey, P. E., Banerjee, S., Zucchiatti, A., De, M., Sleem, R. W., Lin, C.-F. L., Miller‐Graziano, C. L., & De, A. K. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.01.006 · Cited by 36 · see citing works
Kandasamy, M., Bay, B., Lee, Y. K., & Mahendran, R. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.06.004 · Cited by 35 · see citing works
Pagnoux, C., & Teixeira, L. (2007) · La Presse Médicale · doi:10.1016/j.lpm.2007.02.015 · Cited by 35 · see citing works
Dendritic Cell Modification of Neutrophil Responses to Infection after Burn Injury
Bohannon, J. K., Cui, W., Sherwood, E. R., & Toliver-Kinsky, T. E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903619 · Cited by 34 · see citing works
Fast and furious: The neutrophil and its armamentarium in health and disease
Metzemaekers, M., Malengier‐Devlies, B., Gouwy, M., Somer, L. D., Cunha, F. Q., Opdenakker, G., & Proost, P. (2023) · Medicinal Research Reviews · doi:10.1002/med.21958 · Cited by 29 · see citing works
Mannose–fucose recognition by DC-SIGN
Geurtsen, J., Driessen, N. N., & Appelmelk, B. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00034-1 · Cited by 32 · see citing works
Mouse Neutrophils Require JNK2 MAPK for Toxoplasma gondii -Induced IL-12p40 and CCL2/MCP-1 Release
Sukhumavasi, W., Egan, C. E., & Denkers, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3570 · Cited by 31 · see citing works
Hodrea, J., Majai, G. E., Doró, Z., Zahuczky, G., Pap, A., Rajnavölgyi, É., & Fésüs, L. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0511243 · Cited by 31 · see citing works
Lymphatic Regulation of Cellular Trafficking
Jackson, D. G. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000258 · Cited by 30 · see citing works
Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers
Bird, A., Chang, M., Barnard, J., Goldman, B., Meednu, N., Rangel‐Moreno, J., & Anolik, J. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700354 · Cited by 30 · see citing works
Ruff, L. E., Mahmoud, E., Sankaranarayanan, J., Morachis, J. M., Katayama, C. D., Corr, M., Hedrick, S. Μ., & Almutairi, A. (2012) · Integrative Biology · doi:10.1039/c2ib20109g · Cited by 26 · see citing works
Neutrophils-typical atypical antigen presenting cells?
Polak, D., & Bohle, B. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.04.007 · Cited by 26 · see citing works
Activation of dendritic cells by polymorphonuclear neutrophils
Boudaly, S. (2009) · Frontiers in bioscience · doi:10.2741/3326 · Cited by 26 · see citing works
Self-citationNeutrophils in antibody-based immunotherapy of cancer
van Egmond, M. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.1.83 · Cited by 26 · see citing works
Neutrophils in secondary lymphoid organs
Lok, L. S. C., & Clatworthy, M. R. (2021) · Immunology · doi:10.1111/imm.13406 · Cited by 25 · see citing works
Innate immunity in solid organ transplantation: an update and therapeutic opportunities
Béland, S., Désy, O., Vallin, P., Basoni, C., & Serres, S. A. D. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1008453 · Cited by 24 · see citing works
The ‘Danse Macabre’—Neutrophils the Interactive Partner Affecting Oral Cancer Outcomes
Hadjigol, S., Shah, B. A., & O’brien-simpson, N. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894021 · Cited by 25 · see citing works
Chronic exposure to volcanogenic air pollution as cause of lung injury
Camarinho, R., Garcia, P., & Rodrigues, A. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.05.052 · Cited by 23 · see citing works
I’m Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed
Birkle, T. J. Y., & Brown, G. C. (2021) · Infection and Immunity · doi:10.1128/iai.00476-20 · Cited by 22 · see citing works
Bhattacharya, P., Ismail, N., Saxena, A., Gannavaram, S., Dey, R., Oljuskin, T., Akue, A. D., Takeda, K., Yu, J., Karmakar, S., et al. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010224 · Cited by 22 · see citing works
Abascal, J. W., Oh, M. S., Liclican, E. L., Dubinett, S. M., Salehi‐Rad, R., & Liu, B. (2023) · Cells · doi:10.3390/cells12192404 · Cited by 21 · see citing works
Modulation of γδ T‐cell activation by neutrophil elastase
Towstyka, N. Y., Shiromizu, C. M., Keitelman, I. A., Sabbione, F., Salamone, G. V., Geffner, J. R., Trevani, A. S., & Jancic, C. C. (2017) · Immunology · doi:10.1111/imm.12835 · Cited by 21 · see citing works
Majai, G. E., Gogolák, P., Temesszentandrási‐Ambrus, C., Vereb, G., Hodrea, J., Fésüs, L., & Rajnavölgyi, É. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310144 · Cited by 21 · see citing works
- Authors
- Megiovanni, A. M., Sanchez, F., Robledo-Sarmiento, M., Morel, C., Gluckman, J. C., & Boudaly, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Boudaly, Sarah
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-24
- Volume
- 79
- Issue
- 5
- Pages
- 977-988
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2149072530
- Cited by
- 165
- References
- 65
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 15 · 2012: 13
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de Recherche sur le SIDA
- Association pour la Recherche sur le Cancer
- Comité de Paris de la Ligue Nationale Contre le Cancer
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- neutrophils, dendritic cells, dendritic cell activation, CD86, HLA-DR, antigen uptake, Candida albicans, T cell activation, soluble factors, monocyte-derived dendritic cells
- MeSH terms
- Antigens, Surface, Candida albicans, Candidiasis, Cell Communication, Cells, Cultured, Dendritic Cells, HLA-DR Antigens, Humans, Immunity, Cellular, Ligation, Lymphocyte Activation, Neutrophils, Phagocytosis, T-Lymphocytes, Signal Transduction, Up-Regulation, Immunophenotyping, Antigen Presentation, CD18 Antigens, Coculture Techniques, CD40 Antigens, B7-2 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review