The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis
Open accessAbstract
The dynamic process of pathogen transmission by the bite of an insect vector combines several biological processes that have undergone extensive co-evolution. Whereas the host response to an insect bite is only occasionally confronted with the parasitic pathogens that competent vectors might transmit, the transmitted parasites will always be confronted with the acute, wound-healing response that is initiated by the bite itself. Invariably, this response involves neutrophils. In the case of Leishmania, infection is initiated in the skin following the bite of an infected sand fly, suggesting that Leishmania must possess some means to survive their early encounter with recruited neutrophils at the bite site. Here, we review the literature regarding the impact of neutrophils on the outcome of infection with Leishmania, with special attention to the role of the sand fly bite.
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Neutrophils phagocytose and kill 80-90% of invading Leishmania parasites.
“Neutrophils phagocytose and kill 80–90% of the invading Leishmania parasites [285,286].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [285]
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Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
- Authors
- Peters, N. C., & Sacks, D. L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2009-09
- Volume
- 11
- Issue
- 9
- Pages
- 1290-1296
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- PMC
- PMC3431610
- OpenAlex
- W2036625865
- Cited by
- 118
- References
- 55
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 16 · 2016: 9 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 20
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (ZIAAI000494)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Health Sciences › Medicine › Pharmacology › Leech Biology and Applications
- Keywords
- cutaneous leishmaniasis, Leishmania, neutrophils, sandfly bite, insect vector transmission, wound healing response, host-pathogen interaction, neutrophil recruitment
- MeSH terms
- Animals, Humans, Insect Bites and Stings, Insect Vectors, Leishmania, Psychodidae, Leishmaniasis, Cutaneous, Neutrophil Infiltration
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