The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The paradox of the neutrophilˈs role in tissue injury
Open accessAbstract
The neutrophil is an essential component of the innate immune system, and its function is vital to human life. Its production increases in response to virtually all forms of inflammation, and subsequently, it can accumulate in blood and tissue to varying degrees. Although its participation in the inflammatory response is often salutary by nature of its normal interaction with vascular endothelium and its capability to enter tissues and respond to chemotactic gradients and to phagocytize and kill microrganisms, it can contribute to processes that impair vascular integrity and blood flow. The mechanisms that the neutrophil uses to kill microorganisms also have the potential to injure normal tissue under special circumstances. Its paradoxical role in the pathophysiology of disease is particularly, but not exclusively, notable in seven circumstances: 1) diabetic retinopathy, 2) sickle cell disease, 3) TRALI, 4) ARDS, 5) renal microvasculopathy, 6) stroke, and 7) acute coronary artery syndrome. The activated neutrophil's capability to become adhesive to endothelium, to generate highly ROS, and to secrete proteases gives it the potential to induce local vascular and tissue injury. In this review, we summarize the evidence for its role as a mediator of tissue injury in these seven conditions, making it or its products potential therapeutic targets.
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Citations
Cites
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Cited by
Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies
Jickling, G. C., Liu, D., Ander, B. P., Stamova, B., Zhan, X., & Sharp, F. R. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.45 · Cited by 644
Priming of the neutrophil respiratory burst: role in host defense and inflammation
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More friend than foe: the emerging role of neutrophils in tissue repair
Peiseler, M., & Kubes, P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124616 · Cited by 423
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Metadata
- Authors
- Segel, G. B., Halterman, M. W., & Lichtman, M. A.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-19
- Volume
- 89
- Issue
- 3
- Pages
- 359-372
- ISSN
- 0741-5400 (ISSN-L)
- OpenAlex
- W2129320523
- Cited by
- 308
- References
- 9
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Segel, G. B., Halterman, M. W., & Lichtman, M. A. (2011). The paradox of the neutrophilˈs role in tissue injury. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0910538
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